Marta Miarons
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View article: Towards Personalized Lymphodepletion: A Population Pharmacokinetic Fludarabine Model in Patients Receiving CAR T-Cell Therapy
Towards Personalized Lymphodepletion: A Population Pharmacokinetic Fludarabine Model in Patients Receiving CAR T-Cell Therapy Open
Background/Objectives: Optimal fludarabine dosing in the conditioning regimen based on population pharmacokinetic analysis (popPK) can predict outcomes in patients receiving hematopoietic stem cell transplantation. To date, there is no pop…
View article: Pharmacogenetic Implications for Antidepressant Therapy in Major Depression: A Systematic Review Covering 2019–2024
Pharmacogenetic Implications for Antidepressant Therapy in Major Depression: A Systematic Review Covering 2019–2024 Open
Background/Objectives: Major depressive disorder (MDD), including late-onset forms, is a prevalent and disabling condition. Despite multiple pharmacological treatment options, over half of patients fail to achieve full remission. This syst…
View article: [Translated article] Influence of the UGT1A1 gene polymorphism on treatment with sacituzumab govitecan. Narrative review
[Translated article] Influence of the UGT1A1 gene polymorphism on treatment with sacituzumab govitecan. Narrative review Open
Patients homozygous for the UGT1A1*28 allele are at significantly increased risk of developing serious adverse events. Despite the clear relationship between UGT1A1 polymorphisms and sacituzumab-govitecan toxicity, the review suggests that…
View article: Long-Term Effectiveness and Safety of Proactive Therapeutic Drug Monitoring of Infliximab in Paediatric Inflammatory Bowel Disease: A Real-World Study
Long-Term Effectiveness and Safety of Proactive Therapeutic Drug Monitoring of Infliximab in Paediatric Inflammatory Bowel Disease: A Real-World Study Open
Background: This study evaluated the long-term effectiveness and safety of a multidisciplinary early proactive therapeutic drug monitoring (TDM) program combined with Bayesian forecasting for infliximab (IFX) dose adjustment in a real-worl…
View article: [Translated article] Therapeutic Drug Monitoring of antibiotic and antifungical drugs in paediatric and newborn patients. Consensus Guidelines of the Spanish Society of Hospital Pharmacy (SEFH) and the Spanish Society of Paediatric Infectious Diseases (SEIP)
[Translated article] Therapeutic Drug Monitoring of antibiotic and antifungical drugs in paediatric and newborn patients. Consensus Guidelines of the Spanish Society of Hospital Pharmacy (SEFH) and the Spanish Society of Paediatric Infectious Diseases (SEIP) Open
Therapeutic monitoring of antibiotics and antifungals based on pharmacokinetic and pharmacodynamic (PK/PD) parameters is a strategy increasingly used for the optimization of therapy to improve efficacy, reduce the occurrence of toxicities,…
View article: Therapeutic Drug Monitoring of antibiotic and antifungical drugs in paediatric and newborn patients. Consensus Guidelines of the Spanish Society of Hospital Pharmacy (SEFH) and the Spanish Society of Paediatric Infectious Diseases (SEIP)
Therapeutic Drug Monitoring of antibiotic and antifungical drugs in paediatric and newborn patients. Consensus Guidelines of the Spanish Society of Hospital Pharmacy (SEFH) and the Spanish Society of Paediatric Infectious Diseases (SEIP) Open
Therapeutic monitoring of antibiotics and antifungals based on pharmacokinetic and pharmacodynamic (PK/PD) parameters is a strategy increasingly used for the optimization of therapy to improve efficacy, reduce the occurrence of toxicities,…
View article: [Translated article] Pharmacokinetics of eculizumab in adult and pediatric patients with atypical hemolytic uremic syndrome and C3 glomerulopathy
[Translated article] Pharmacokinetics of eculizumab in adult and pediatric patients with atypical hemolytic uremic syndrome and C3 glomerulopathy Open
The present study reports supratherapeutic concentrations of eculizumab in patients with aHUS, and defines higher concentrations than those described in the data sheet to achieve blockade, thus encouraging the personalization of treatment …
View article: Comparison of Three Renal Function Formulas for Ganciclovir/Valganciclovir Dose Individualization in CMV-Infected Solid Organ Transplantation Patients Using a Population Approach
Comparison of Three Renal Function Formulas for Ganciclovir/Valganciclovir Dose Individualization in CMV-Infected Solid Organ Transplantation Patients Using a Population Approach Open
The model based on the more accurate estimation of the renal function with the CKD-EPI formula and body weight as a size metric most used in the clinical practice can refine initial dose recommendations and contribute to GCV and VGCV dose …
View article: Allelic Frequency of <i>DPYD</i> Genetic Variants in Patients With Cancer in Spain: The PhotoDPYD Study
Allelic Frequency of <i>DPYD</i> Genetic Variants in Patients With Cancer in Spain: The PhotoDPYD Study Open
Introduction Identifying polymorphisms in the dihydropyrimidine dehydrogenase (DPYD) gene is gaining importance to be able to predict fluoropyrimidine-associated toxicity. The aim of this project was to describe the frequency of the DPYD v…
View article: P153 Association between ustekinumab trough concentrations and clinical, biochemical, and endoscopic outcomes in patients with Inflammatory Bowel Disease
P153 Association between ustekinumab trough concentrations and clinical, biochemical, and endoscopic outcomes in patients with Inflammatory Bowel Disease Open
Background Ustekinumab (UST), an inhibitor of the p40 subunit of interleukins 12 and 23, is an effective treatment for patients with Crohn’s disease (CD) and ulcerative colitis (UC). There is limited data on therapeutic outcomes and UST tr…
View article: Use of chronic medications and risk of death due to COVID-19 in hospitalised patients
Use of chronic medications and risk of death due to COVID-19 in hospitalised patients Open
This study investigated the association between chronic exposure to drugs and the risk of death in COVID-19 patients. Our results have shed some light on the impact of chronic drug exposure on the risk of severe COVID-19; however, further …
View article: Safety of Drugs Used during the First Wave of COVID-19: A Hospital-Registry-Based Study
Safety of Drugs Used during the First Wave of COVID-19: A Hospital-Registry-Based Study Open
The emergency of the coronavirus disease 2019 (COVID-19) pandemic led to the off-label use of drugs without data on their toxicity profiles in patients with COVID-19, or on their concomitant use. Patients included in the COVID-19 Patient R…
View article: Rapid and accurate method for quantifying busulfan in plasma samples by isocratic liquid chromatography-tandem mass spectrometry (LC-MS/MS)
Rapid and accurate method for quantifying busulfan in plasma samples by isocratic liquid chromatography-tandem mass spectrometry (LC-MS/MS) Open
Objectives Administration of busulfan is extending rapidly as a part of a conditioning regimen in patients undergoing hematopoietic stem cell transplantation (HSCT). Monitoring blood plasma levels of busulfan is recommended for identifying…
View article: 5PSQ-041 Safety and efficacy of high doses of irinotecan in patients with metastatic colorectal cancer treated with FOLFIRI scheme based on UGT1A1 genotype: a systematic review
5PSQ-041 Safety and efficacy of high doses of irinotecan in patients with metastatic colorectal cancer treated with FOLFIRI scheme based on UGT1A1 genotype: a systematic review Open
Background and importance Irinotecan's antineoplastic activity, as well as its safety, depends on the action of its active metabolite, SN-38, which is inactivated by UDP-glucuronosyltransferase (UGT), an enzyme encoded by the UGT1A1 gene. …
View article: 4CPS-051 Pharmacokinetics alterations in two critically ill patients on extracorporeal membrane oxygenation receiving isavuconazol
4CPS-051 Pharmacokinetics alterations in two critically ill patients on extracorporeal membrane oxygenation receiving isavuconazol Open
Background and importance Extracorporeal membrane oxygenation (ECMO) can modify drug pharmacokinetics and pharmacodynamics. We report two cases of critically ill patients on ECMO receiving isavuconazol. Aim and objectives Primary aim: to a…
View article: P322 Effectiveness of Tumor Necrosis Factor-alpha inhibitors and Thiopurines combination therapy according to, 6-thioguanine nucleotides plasma levels: A Systematic Review
P322 Effectiveness of Tumor Necrosis Factor-alpha inhibitors and Thiopurines combination therapy according to, 6-thioguanine nucleotides plasma levels: A Systematic Review Open
Background Inflammatory bowel diseases (IBD), Crohn’s disease (CD) and Ulcerative Colitis (CU), have a progressive course with a significant percentage of primary or secondary failure to anti- tumor necrosis factor (TNF). It is already kno…
View article: COVID-19 Clinical Profile in Latin American Migrants Living in Spain: Does the Geographical Origin Matter?
COVID-19 Clinical Profile in Latin American Migrants Living in Spain: Does the Geographical Origin Matter? Open
The aim of this study was to describe and compare the clinical characteristics of hospitalized patients with COVID-19 pneumonia according to their geographical origin. This is a retrospective case-control study of hospitalized patients wit…
View article: Comparison of three cohorts of COVID-19 patients with different severity: exposure to antihypertensive, antidiabetic and lipid-lowering agents
Comparison of three cohorts of COVID-19 patients with different severity: exposure to antihypertensive, antidiabetic and lipid-lowering agents Open
Aim: The association between COVID-19 disease severity and certain medicines for the treatment of chronic diseases is currently under discussion. We herein evaluated if previous exposure to antihypertensive, hypoglycaemic, and lipid-loweri…
View article: Long‐term effects of COVID‐19 in solid organ transplantation recipients
Long‐term effects of COVID‐19 in solid organ transplantation recipients Open
The authors declare that there is no conflict of interest.
View article: Safety of tocilizumab in COVID‐19 pregnant women and their newborn: A retrospective study
Safety of tocilizumab in COVID‐19 pregnant women and their newborn: A retrospective study Open
It does not appear that tocilizumab has detrimental effects for the mother and newborn. Close monitoring of infections should be considered, especially if other immunosuppressive agents are used.
View article: The role of pro‐, pre‐ and symbiotics in cancer: A systematic review
The role of pro‐, pre‐ and symbiotics in cancer: A systematic review Open
Pro-, pre- and symbiotics may potentially be efficacious in reducing complications associated with chemotherapy, radiotherapy and surgery in patients with cancer.
View article: Pharmaceutical interventions in the emergency department: cost-effectiveness and cost-benefit analysis
Pharmaceutical interventions in the emergency department: cost-effectiveness and cost-benefit analysis Open
These results show that clinical pharmacist can positively identify and reduce medication errors and costs associated, considering the number of interventions observed and those of clinical relevance. Based on these results, drug safety th…
View article: New direct-acting antivirals for hepatitis C treatment and neuropsychiatric symptoms in psychiatric risk groups
New direct-acting antivirals for hepatitis C treatment and neuropsychiatric symptoms in psychiatric risk groups Open
We found a moderate prevalence of neuropsychiatric symptoms in the psychiatric risk group. The neuropsychiatric symptoms more frequently reported were insomnia (17%), irritability (15%) and depression (13%). Neuropsychiatric symptoms in pa…