Marta Nowacka-Chmielewska
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View article: Dose-dependent effects of testosterone on proteins related to nitric oxide signaling pathway and trophic factors in the spinal cord of adolescent trained rats
Dose-dependent effects of testosterone on proteins related to nitric oxide signaling pathway and trophic factors in the spinal cord of adolescent trained rats Open
Introduction Endurance training plays an important role in, for example, triathlon, marathon, or road cycling and in combination with strength training. Adolescence has been associated with increased interest among of young people, especia…
View article: The role of adipose tissue in critical illness-induced skeletal muscle wasting—new considerations for treatment approaches
The role of adipose tissue in critical illness-induced skeletal muscle wasting—new considerations for treatment approaches Open
Critical illness-induced muscle wasting is associated with poor in-hospital and long-term outcomes, but prevention strategies are lacking. Critical illness elicits muscle wasting through upregulation of protein degradation and downregulati…
View article: Protective impact of physical exercise on methamphetamine-induced neuroinflammation and neurogenesis impairment depends on the activity level
Protective impact of physical exercise on methamphetamine-induced neuroinflammation and neurogenesis impairment depends on the activity level Open
One of the outcomes of methamphetamine (METH) misuse is impaired hippocampal function. In addition, regular physical exercise has been proposed as an effective behavioral intervention with numerous health benefits, particularly in the trea…
View article: Changes in proBDNF and Mature BDNF Levels After Medium-Intensity Functional Motor Rehabilitation Program in Patients with Parkinson’s Disease
Changes in proBDNF and Mature BDNF Levels After Medium-Intensity Functional Motor Rehabilitation Program in Patients with Parkinson’s Disease Open
Physical rehabilitation complements the treatment of Parkinson’s disease (PD). The applied physical exercises are effective in PD by promoting activity-dependent neuroplasticity. The main aim of this study was to assess the effect of a 16-…
View article: „Brain doping” substances: prohibited or not in sports?
„Brain doping” substances: prohibited or not in sports? Open
There is increasing interest in the area of brain doping among athletes. The term 'brain doping' refers to enhancing mental performance through the non-medical use of specific pharmacological substances, such as drugs and medicines. Despit…
View article: Muscle–brain crosstalk mediated by exercise-induced myokines - insights from experimental studies
Muscle–brain crosstalk mediated by exercise-induced myokines - insights from experimental studies Open
Over the past couple of decades, it has become apparent that skeletal muscles might be engaged in endocrine signaling, mostly as a result of exercise or physical activity in general. The importance of this phenomenon is currently studied i…
View article: Relationship of Non-Invasive Arterial Stiffness Parameters with 10-Year Atherosclerotic Cardiovascular Disease Risk Score in Post-COVID-19 Patients—The Results of a Cross-Sectional Study
Relationship of Non-Invasive Arterial Stiffness Parameters with 10-Year Atherosclerotic Cardiovascular Disease Risk Score in Post-COVID-19 Patients—The Results of a Cross-Sectional Study Open
This study evaluated the relationship of non-invasive arterial stiffness parameters with an individual 10-year risk of fatal and non-fatal atherosclerotic cardiovascular disease (ASCVD) events in the cohort post-coronavirus disease 2019 (C…
View article: Stress and the gut-brain axis: an inflammatory perspective
Stress and the gut-brain axis: an inflammatory perspective Open
The gut-brain axis (GBA) plays a dominant role in maintaining homeostasis as well as contributes to mental health maintenance. The pathways that underpin the axis expand from macroscopic interactions with the nervous system, to the molecul…
View article: Ketogenic diet and behavior: insights from experimental studies
Ketogenic diet and behavior: insights from experimental studies Open
As a journal page for full details. The ketogenic diet (KD) has been established as a treatment for epilepsy, but more recently it has been explored as an alternative or add-on therapy for many other diseases ranging from weight loss to ne…
View article: Cardiac status and atherosclerotic cardiovascular risk of convalescents after COVID-19 in Poland
Cardiac status and atherosclerotic cardiovascular risk of convalescents after COVID-19 in Poland Open
Data collected in the convalescents indicate a relatively small number of cardiac problems that could be associated with a history of COVID‑19 in either sex, and a high risk of ASCVD, especially in men.
View article: Effect of Whole-Body Vibration Training on Selected Intrinsic Risk Factors in Women Aged 60+ at Fall Risk: A Randomized Controlled Trial
Effect of Whole-Body Vibration Training on Selected Intrinsic Risk Factors in Women Aged 60+ at Fall Risk: A Randomized Controlled Trial Open
The aim of the study was to determine whether Whole Body Vibration Training (WBVT) affects intrinsic risk factors for falls in women aged 60+ at fall risk. Design: Randomized controlled clinical trial. Blinding was applied to the persons i…
View article: Role of microRNAs in the regulation of blood-brain barrier function in ischemic stroke and under hypoxic conditions in vitro
Role of microRNAs in the regulation of blood-brain barrier function in ischemic stroke and under hypoxic conditions in vitro Open
The blood-brain barrier (BBB) is a highly specialized structure that separates the brain from the blood and allows the exchange of molecules between these two compartments through selective channels. The breakdown of the BBB is implicated …
View article: Running from Stress: Neurobiological Mechanisms of Exercise-Induced Stress Resilience
Running from Stress: Neurobiological Mechanisms of Exercise-Induced Stress Resilience Open
Chronic stress, even stress of a moderate intensity related to daily life, is widely acknowledged to be a predisposing or precipitating factor in neuropsychiatric diseases. There is a clear relationship between disturbances induced by stre…
View article: Global Proteome Profiling of the Temporal Cortex of Female Rats Exposed to Chronic Stress and the Western Diet
Global Proteome Profiling of the Temporal Cortex of Female Rats Exposed to Chronic Stress and the Western Diet Open
The increasing consumption of highly processed foods with high amounts of saturated fatty acids and simple carbohydrates is a major contributor to the burden of overweight and obesity. Additionally, an unhealthy diet in combination with ch…
View article: Effects of Simultaneous Exposure to a Western Diet and Wheel-Running Training on Brain Energy Metabolism in Female Rats
Effects of Simultaneous Exposure to a Western Diet and Wheel-Running Training on Brain Energy Metabolism in Female Rats Open
Background: In the pathogenesis of central nervous system disorders (e.g., neurodegenerative), an important role is attributed to an unhealthy lifestyle affecting brain energy metabolism. Physical activity in the prevention and treatment o…
View article: Differential Response of Hippocampal and Cerebrocortical Autophagy and Ketone Body Metabolism to the Ketogenic Diet
Differential Response of Hippocampal and Cerebrocortical Autophagy and Ketone Body Metabolism to the Ketogenic Diet Open
Experimental and clinical data support the neuroprotective properties of the ketogenic diet and ketone bodies, but there is still a lot to discover to comprehensively understand the underlying mechanisms. Autophagy is a key mechanism for m…
View article: Physical Activity Reduces Anxiety And Regulates Brain Fatty Acid Synthesis
Physical Activity Reduces Anxiety And Regulates Brain Fatty Acid Synthesis Open
Physical activity impacts brain functions, but the direct mechanisms of this effect are not fully recognized or understood. Among multidimensional changes induced by physical activity, brain fatty acids (FA) appear to play an important rol…
View article: Physical Activity Reduces Anxiety And Regulates Brain Fatty Acid Synthesis
Physical Activity Reduces Anxiety And Regulates Brain Fatty Acid Synthesis Open
Physical activity impacts brain functions, but the direct mechanisms of this effect are not fully recognized or understood. Among multidimensional changes induced by physical activity, brain fatty acids (FA) appear to play an important rol…
View article: Decreased hippocampal efficiency in obese rats is expressed by impaired cognition, neurogenesis and proteomic changes
Decreased hippocampal efficiency in obese rats is expressed by impaired cognition, neurogenesis and proteomic changes Open
Obesity associates with plethora of dysfunctions including changes in the brain structures, like hippocampus which is particularly susceptible to metabolic or inflammatory alterations. The is a need to expand knowledge about the obesity re…
View article: Brain macroautophagy on the ketogenic diet
Brain macroautophagy on the ketogenic diet Open
The ketogenic diet has been shown to be very effective in managing drug-resistant epilepsy, treatment of obesity, improving symptoms of diabetes and reducing cardiovascular risk. Growing evidence supports the use of the ketogenic diet as a…
View article: Methamphetamine-associated cognitive decline is attenuated by neutralizing IL-1 signaling
Methamphetamine-associated cognitive decline is attenuated by neutralizing IL-1 signaling Open
Methamphetamine (METH) abusers are prone to develop a variety of comorbidities, including cognitive disabilities, and the immunological responses have been recognized as an important component involved in the toxicity of this drug. Cytokin…
View article: The effect of endurance training and testosterone supplementation on the expression of blood spinal cord barrier proteins in rats
The effect of endurance training and testosterone supplementation on the expression of blood spinal cord barrier proteins in rats Open
The present study aimed to estimate the effect of endurance training, two doses of testosterone, and the combination of these stimuli on the level of the endothelial proteins claudin, occludin, JAM-1, VE-cadherin, ZO-1, ZO-2, and P-glycopr…
View article: The modification of the ketogenic diet mitigates its stunting effects in rodents
The modification of the ketogenic diet mitigates its stunting effects in rodents Open
The high-fat and low-carbohydrate ketogenic diet (HFKD) is extensively studied within the fields of numerous diseases, including cancer and neurological disorders. Since most studies incorporate animal models, ensuring the quality of ketog…
View article: Alterations in VEGF expression induced by antidepressant drugs in female rats under chronic social stress
Alterations in VEGF expression induced by antidepressant drugs in female rats under chronic social stress Open
Vascular endothelial growth factor (VEGF) is thought to serve a role in neurogenesis and the stress response. Although a definite link between the action of antidepressants and VEGF has not been identified, it is assumed that VEGF, as a ne…
View article: Expression of a novel splicing variant of Pcp2 in closely related laboratory rodents
Expression of a novel splicing variant of Pcp2 in closely related laboratory rodents Open
Purkinje cell protein-2 (PCP2), also known as L7, is a member of the GoLoco protein family with highly cell-specific expression, being restricted to cerebellar Purkinje cells and retinal bipolar neurons in various species. However, its fun…