Marta Overchuk
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View article: Chronic PFAS exposure induces chemotherapy resistance by promoting mitochondria-related alterations in ovarian cancer cells
Chronic PFAS exposure induces chemotherapy resistance by promoting mitochondria-related alterations in ovarian cancer cells Open
Resistance to chemotherapy is a major barrier to the effective treatment of ovarian cancer; however, the role of environmental exposures in the onset of chemoresistance remains elusive. Our previous work in ovarian cancer cells suggests th…
View article: Overcoming the effects of fluid shear stress in ovarian cancer cell lines: Doxorubicin alone or photodynamic priming to target platinum resistance
Overcoming the effects of fluid shear stress in ovarian cancer cell lines: Doxorubicin alone or photodynamic priming to target platinum resistance Open
Resistance to platinum-based chemotherapies remains a significant challenge in advanced-stage high-grade serous ovarian carcinoma, and patients with malignant ascites face the poorest outcomes. It is, therefore, important to understand the…
View article: Comparison of Photodynamic Priming Efficacy, with BPD or ALA-PpIX, to Overcome PFAS-Induced Platinum Resistance in Ovarian Cancer
Comparison of Photodynamic Priming Efficacy, with BPD or ALA-PpIX, to Overcome PFAS-Induced Platinum Resistance in Ovarian Cancer Open
Ovarian cancer is the most lethal gynecologic cancer, largely due to the development of platinum-based chemotherapy resistance. Understanding sources of chemoresistance and the development of mechanism-based treatments are critical. In a r…
View article: Quantitative Pharmacokinetics Reveal Impact of Lipid Composition on Microbubble and Nanoprogeny Shell Fate
Quantitative Pharmacokinetics Reveal Impact of Lipid Composition on Microbubble and Nanoprogeny Shell Fate Open
Microbubble‐enabled focused ultrasound (MB‐FUS) has revolutionized nano and molecular drug delivery capabilities. Yet, the absence of longitudinal, systematic, quantitative studies of microbubble shell pharmacokinetics hinders progress wit…
View article: Methods to Evaluate Changes in Mitochondrial Structure and Function in Cancer
Methods to Evaluate Changes in Mitochondrial Structure and Function in Cancer Open
Mitochondria are regulators of key cellular processes, including energy production and redox homeostasis. Mitochondrial dysfunction is associated with various human diseases, including cancer. Importantly, both structural and functional ch…
View article: X-ray-Activatable Photodynamic Nanoconstructs
X-ray-Activatable Photodynamic Nanoconstructs Open
ADVERTISEMENT RETURN TO ISSUEPREVFirst ReactionsNEXTX-ray-Activatable Photodynamic NanoconstructsX-ray induced photodynamic therapy enables chemotherapy-free treatment of deep-tissue cancer with a low dose of X-ray radiation.Marta Overchuk…
View article: Use of Porphysomes to detect primary tumour, lymph node metastases, intra-abdominal metastases and as a tool for image-guided lymphadenectomy: proof of concept in endometrial cancer
Use of Porphysomes to detect primary tumour, lymph node metastases, intra-abdominal metastases and as a tool for image-guided lymphadenectomy: proof of concept in endometrial cancer Open
Objective: To investigate Porphysome fluorescence image-guided resection (PYRO-FGR) for detection of uterine tumour, metastatic lymph nodes and abdominal metastases in a model of endometrial cancer. Methods: White New Zealand…
View article: How Nanomedicine Can Be Used in the Treatment of Tumors: an Interview With Dr Gang Zheng
How Nanomedicine Can Be Used in the Treatment of Tumors: an Interview With Dr Gang Zheng Open
Dr Zheng received his PhD in 1999 from SUNY Buffalo in Medicinal Chemistry. Following 2 years of postdoctoral training in photodynamic therapy at the Roswell Park Cancer Institute, he joined the University of Pennsylvania in 2001 as an Ass…
View article: Tailored theranostic apolipoprotein E3 porphyrin-lipid nanoparticles target glioblastoma
Tailored theranostic apolipoprotein E3 porphyrin-lipid nanoparticles target glioblastoma Open
Size-controlled discoidal and cholesteryl oleated-loaded spherical, intrinsically multimodal porphyrin-lipid nanoparticles targeted glioblastomaviaapoE3 and LDLR.
View article: Correction: Tailored theranostic apolipoprotein E3 porphyrin-lipid nanoparticles target glioblastoma
Correction: Tailored theranostic apolipoprotein E3 porphyrin-lipid nanoparticles target glioblastoma Open
Correction for ‘Tailored theranostic apolipoprotein E3 porphyrin-lipid nanoparticles target glioblastoma’ by M. A. Rajora et al., Chem. Sci., 2017, DOI: 10.1039/c7sc00732a.
View article: Graphisches Inhaltsverzeichnis: Angew. Chem. 21/2016
Graphisches Inhaltsverzeichnis: Angew. Chem. 21/2016 Open