Marta Pace
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View article: NKCC1 inhibition improves sleep quality and EEG information content in a Down syndrome mouse model
NKCC1 inhibition improves sleep quality and EEG information content in a Down syndrome mouse model Open
In several brain disorders, the hyperpolarizing/inhibitory effects of GABA signaling through Cl-permeable GABAA receptors are compromised, leading to an imbalance between neuronal excitation and inhibition. For example, the Ts65Dn mouse mo…
View article: Postacute administration of the GABA <sub>A</sub> α5 antagonist S44819 promotes recovery of peripheral limb fine motor skills after permanent distal middle cerebral artery occlusion in rats
Postacute administration of the GABA <sub>A</sub> α5 antagonist S44819 promotes recovery of peripheral limb fine motor skills after permanent distal middle cerebral artery occlusion in rats Open
Background: Ischemic stroke causes hypoexcitability in the peri-infarct motor neocortex that stems from increased tonic γ-amino-butyric acid (GABA) activity in neurons. This hypoexcitability, while neuroprotective in the acute phase, may i…
View article: Loss of Snord116 alters cortical neuronal activity in mice: a preclinical investigation of Prader–Willi syndrome
Loss of Snord116 alters cortical neuronal activity in mice: a preclinical investigation of Prader–Willi syndrome Open
Prader–Willi syndrome (PWS) is a neurodevelopmental disorder that is characterized by metabolic alteration and sleep abnormalities mostly related to rapid eye movement (REM) sleep disturbances. The disease is caused by genomic imprinting d…
View article: Loss of Snord116 impacts lateral hypothalamus, sleep, and food-related behaviors
Loss of Snord116 impacts lateral hypothalamus, sleep, and food-related behaviors Open
Imprinted genes are highly expressed in the hypothalamus; however, whether specific imprinted genes affect hypothalamic neuromodulators and their functions is unknown. It has been suggested that Prader-Willi syndrome (PWS), a neurodevelopm…
View article: Paternally expressed imprinted<i>Snord116</i>and<i>Peg3</i>regulate hypothalamic orexin neurons
Paternally expressed imprinted<i>Snord116</i>and<i>Peg3</i>regulate hypothalamic orexin neurons Open
Imprinted genes are highly expressed in the hypothalamus; however, whether specific imprinted genes affect hypothalamic neuromodulators and their functions is unknown. It has been suggested that Prader-Willi syndrome (PWS), a neurodevelopm…
View article: The paternally imprinted gene<i>Snord116</i>regulates cortical neuronal activity
The paternally imprinted gene<i>Snord116</i>regulates cortical neuronal activity Open
Prader-Willi syndrome (PWS) is a neurodevelopmental disorder that is characterized by rapid eye movement (REM) sleep abnormalities. The disease is caused by genomic imprinting defects that are inherited through the paternal line. Among the…
View article: Post-acute administration of the GABA<sub>A</sub> α5 antagonist S44819 promotes recovery of peripheral limb fine motor skills after permanent distal middle cerebral artery occlusion in rats
Post-acute administration of the GABA<sub>A</sub> α5 antagonist S44819 promotes recovery of peripheral limb fine motor skills after permanent distal middle cerebral artery occlusion in rats Open
Background Ischemic stroke induces hypoexcitability of the peri-infarct cortex by increased tonic GABA activity, which impairs stroke recovery. The GABA A α5 antagonist S44819 has recently been shown to promote post-ischemic motor-coordina…
View article: Rapid eye movements sleep as a predictor of functional outcome after stroke: a translational study
Rapid eye movements sleep as a predictor of functional outcome after stroke: a translational study Open
http://clinicaltrials.gov. Unique identifier: NCT01097967.
View article: pD-l1 expression in oral squamous cell carcinoma microenvironment and prognostic correlations
pD-l1 expression in oral squamous cell carcinoma microenvironment and prognostic correlations Open
Backgroun of this study is to investigate the PD-l1 expression in the Microenvironment of oral Squamous cell carcinoma (oScc) samples and its correlation to prognostic data.
View article: Sleep- related electrophysiological activity of cortical cultures on MEA
Sleep- related electrophysiological activity of cortical cultures on MEA Open
Event Abstract Back to Event Sleep- related electrophysiological activity of cortical cultures on MEA Ilaria Colombi1, 2*, Marta Pace1, Valter Tucci1 and Michela Chiappalone1 1 Fondazione Istituto Italiano di Technologia, Italy 2 Universit…
View article: Changes in sleep EEG during the first 24h after interventions.
Changes in sleep EEG during the first 24h after interventions. Open
(A) The time line of the experiment. Sleep was analysed at the baseline before SD and after 24h from either ischemia or sham surgery; 12h dark,12h light periods. (B) The amount of total sleep (mean ± SEM) is represented by vertical bars. D…
View article: Role of REM Sleep, Melanin Concentrating Hormone and Orexin/Hypocretin Systems in the Sleep Deprivation Pre-Ischemia
Role of REM Sleep, Melanin Concentrating Hormone and Orexin/Hypocretin Systems in the Sleep Deprivation Pre-Ischemia Open
Our data indicates that REM sleep may be involved in the neuroprotective effect of SD pre-ischemia, and that both MCH and OX systems were increased during the acute phase of stroke. Future studies should assess the role of REM sleep as a p…