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View article: Characterization of the HDAC/PI3K inhibitor CUDC-907 as a novel senolytic
Characterization of the HDAC/PI3K inhibitor CUDC-907 as a novel senolytic Open
The accumulation of senescent cells has an important role in the phenotypical changes observed in ageing and in many age-related pathologies. Thus, the strategies designed to prevent these effects, collectively known as senotherapies, have…
View article: Senescence-induced endothelial phenotypes underpin immune-mediated senescence surveillance
Senescence-induced endothelial phenotypes underpin immune-mediated senescence surveillance Open
Senescence is a stress-responsive tumor suppressor mechanism associated with expression of the senescence-associated secretory phenotype (SASP). Through the SASP, senescent cells trigger their own immune-mediated elimination, which if evad…
View article: Snapshot imprinting as a tool for surface mapping and identification of novel biomarkers of senescent cells
Snapshot imprinting as a tool for surface mapping and identification of novel biomarkers of senescent cells Open
An effective snapshot imprinting procedure was developed for analysis of proteins expressed by a cell or tissue. As an example, the proteins differentially expressed by senescent cells were identified and compared with standard proteomics …
View article: Targeted clearance of senescent cells using an antibody-drug conjugate against a specific membrane marker
Targeted clearance of senescent cells using an antibody-drug conjugate against a specific membrane marker Open
View article: Evaluation of Pirfenidone and Nintedanib in a Human Lung Model of Fibrogenesis
Evaluation of Pirfenidone and Nintedanib in a Human Lung Model of Fibrogenesis Open
Introduction: Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal lung disease with a poor prognosis and increasing incidence. Pirfenidone and nintedanib are the only approved treatments for IPF but have limited efficacy and their …
View article: Snapshot imprinting: rapid identification of cancer cell surface proteins and epitopes using molecularly imprinted polymers
Snapshot imprinting: rapid identification of cancer cell surface proteins and epitopes using molecularly imprinted polymers Open
Proteomic mapping of cell surfaces is an invaluable tool for drug development and clinical diagnostics. This work describes a new ‘snapshot imprinting’ method designed to obtain proteomic maps of cell surfaces, with the aim of identifying …
View article: New approaches to target cellular senescence for the amelioration of age-related pathologies.
New approaches to target cellular senescence for the amelioration of age-related pathologies. Open
Aging has been broadly defined as a functional decline that progresses with time and leads to impaired function and increased vulnerability to death. Cellular senescence is one of the main factors involved in this age-related functional de…
View article: Amelioration of age‐related brain function decline by Bruton's tyrosine kinase inhibition
Amelioration of age‐related brain function decline by Bruton's tyrosine kinase inhibition Open
One of the hallmarks of aging is the progressive accumulation of senescent cells in organisms, which has been proposed to be a contributing factor to age‐dependent organ dysfunction. We recently reported that Bruton's tyrosine kinase (BTK)…
View article: Detecting and targeting senescent cells using molecularly imprinted nanoparticles
Detecting and targeting senescent cells using molecularly imprinted nanoparticles Open
Nanoparticles (MIPs) specifically detect and target senescent cells by binding to a surface protein, showing also specificityin vivo.