Marta Sacchetti
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View article: The History of Nerve Growth Factor: From Molecule to Drug
The History of Nerve Growth Factor: From Molecule to Drug Open
Nerve growth factor (NGF), the first neurotrophin to be discovered, has a long and eventful research journey with a series of turning points, setbacks, and achievements. Since the groundbreaking investigations led by Nobel Prize winner Rit…
View article: 1953-2023. Seventy Years of the Nerve Growth Factor: A Potential Novel Treatment in Neurological Diseases?
1953-2023. Seventy Years of the Nerve Growth Factor: A Potential Novel Treatment in Neurological Diseases? Open
Rita Levi-Montalcini's 1953 discovery of nerve growth factor (NGF) in mouse sarcoma tumors marked a groundbreaking moment in neuroscience. NGF, a key signaling molecule, became the first identified neurotrophic factor, influencing the grow…
View article: Issue Information
Issue Information Open
Movement Disorders Clinical Practice-is an online-only journal committed to publishing high quality peer reviewed articles related to clinical aspects of movement disorders which broadly include phenomenology (interesting case/case series/…
View article: Visuospatial Deficits Are Associated with Pisa Syndrome and not Camptocormia in Parkinson's Disease
Visuospatial Deficits Are Associated with Pisa Syndrome and not Camptocormia in Parkinson's Disease Open
Background Pisa syndrome (PS) and camptocormia (CC) are postural abnormalities frequently associated with Parkinson's disease (PD). Their pathophysiology remains unclear, but the role of cognitive deficits has been postulated. Objectives T…
View article: Evaluation of the Effectiveness of BNT162b2 Primary Vaccination and Booster Dose to SARS-CoV-2 in Eliciting Stable Mucosal Immunity
Evaluation of the Effectiveness of BNT162b2 Primary Vaccination and Booster Dose to SARS-CoV-2 in Eliciting Stable Mucosal Immunity Open
The waning effectiveness of the primary vaccination for SARS-CoV-2 led to administration of an additional booster dose (BD). The efficacy of the BD in stimulating humoral systemic immune response is well established, but its effectiveness …
View article: NEW INSIGHTS ON THE DIAGNOSIS AND MANAGEMENT OF MALIGNANT TUMORS OF THE OCULAR SURFACE
NEW INSIGHTS ON THE DIAGNOSIS AND MANAGEMENT OF MALIGNANT TUMORS OF THE OCULAR SURFACE Open
Tumors of the ocular surface encompass a wide spectrum of conditions involving the conjunctiva and cornea, ranging from benign lesions to life-threatening malignancies. These tumors are rare; however, they are commonly seen in the ophthalm…
View article: Understanding Vernal Keratoconjunctivitis: Beyond Allergic Mechanisms
Understanding Vernal Keratoconjunctivitis: Beyond Allergic Mechanisms Open
Vernal keratoconjunctivitis (VKC) is a chronic, recurrent, inflammatory disease of the cornea and conjunctiva mostly affecting boys in prepubertal age. VKC recurrence is characterized by intense symptoms of itching, redness, and photophobi…
View article: The long-term clinical efficacy of recombinant human nerve growth factor in the treatment of neurotrophic keratitis
The long-term clinical efficacy of recombinant human nerve growth factor in the treatment of neurotrophic keratitis Open
Topical recombinant human nerve growth factor (rhNGF) is FDA-approved to treat patients with neurotrophic keratitis (NK), but current clinical trial data only encompasses 1 year of follow up. We hypothesize that a single course of rhNGF ca…
View article: Validation of a novel single-use esthesiometer to test corneal sensitivity
Validation of a novel single-use esthesiometer to test corneal sensitivity Open
Purpose : Assessment of corneal sensitivity (CS) allows to identify alterations of ocular surface sensory innervation associated with several conditions including neurotrophic keratopathy (NK) and dry eye disease (DED). Currently, Cochet-B…
View article: A Modified Femtosecond Laser Technique for Anterior Capsule Contraction Syndrome
A Modified Femtosecond Laser Technique for Anterior Capsule Contraction Syndrome Open
Anterior capsule contraction syndrome (ACCS) is a rare, late complication of cataract surgery, associated with impairment of visual function. In this paper, we describe a new surgical technique to treat ACCS by femtosecond laser procedure.…
View article: Neurotrophic Factors in Glaucoma and Innovative Delivery Systems
Neurotrophic Factors in Glaucoma and Innovative Delivery Systems Open
Glaucoma is a neurodegenerative disease and a worldwide leading cause of irreversible vision loss. In the last decades, high efforts have been made to develop novel treatments effective in inducing protection and/or recovery of neural func…
View article: Hyperpigmented Spots at Fundus Examination: A New Ocular Sign in Neurofibromatosis Type I
Hyperpigmented Spots at Fundus Examination: A New Ocular Sign in Neurofibromatosis Type I Open
Background: Neurofibromatosis Type I (NF1), also termed von Recklinghausen disease, is a rare genetic disorder that is transmitted by autosomal dominant inheritance, with complete penetrance and variable expressivity. It is caused by mutat…
View article: Molecular Insights and Emerging Strategies for Treatment of Metastatic Uveal Melanoma
Molecular Insights and Emerging Strategies for Treatment of Metastatic Uveal Melanoma Open
Uveal melanoma (UM) is the most common intraocular cancer. In recent decades, major advances have been achieved in the diagnosis and prognosis of UM allowing for tailored treatments. However, nearly 50% of patients still develop metastatic…
View article: Evidence of Pepsin-Related Ocular Surface Damage and Dry Eye (PROD Syndrome) in Patients with Laryngopharyngeal Reflux
Evidence of Pepsin-Related Ocular Surface Damage and Dry Eye (PROD Syndrome) in Patients with Laryngopharyngeal Reflux Open
Background: patients with laryngopharyngeal reflux (LPR) showed detectable levels of tear pepsin that explain the nasolacrimal obstruction. The purpose of this study was to determine whether patients with LPR show ocular surface changes an…
View article: Clinical and Epidemiological Study on Tubercular Uveitis in a Tertiary Eye Care Centre in Italy
Clinical and Epidemiological Study on Tubercular Uveitis in a Tertiary Eye Care Centre in Italy Open
Purpose . To describe frequency, clinical characteristics, and visual prognosis of tubercular uveitis (TBU) in a nonendemic country. Methods . We retrospectively reviewed 3743 charts of patients with endogenous uveitis visited from 2008 to…
View article: Evaluation of <scp>IL</scp>8 pathway on the ocular surface: new insights in patients with ocular mucous membrane pemphigoid
Evaluation of <span>IL</span>8 pathway on the ocular surface: new insights in patients with ocular mucous membrane pemphigoid Open
Purpose To evaluate the expression of IL 8/ CXCL 8 cytokine and its receptor CXCR 1 in tear film and ocular surface of patients with ocular mucous membrane pemphigoid (oMMP). Methods Ten patients with oMMP in the quiescent phase, 20 patien…
View article: Issue Information ‐ TOC
Issue Information ‐ TOC Open
Local rhinitis needs allergen-challenges for diagnosis, late infancy supplementation of probiotics prevents eczema, and milk oral immunotherapy is effective in the long term P. Eigenmann 259 Guidance for assessment of erythroderma in neona…
View article: Effect of recombinant human nerve growth factor eye drops in patients with dry eye: a phase IIa, open label, multiple-dose study
Effect of recombinant human nerve growth factor eye drops in patients with dry eye: a phase IIa, open label, multiple-dose study Open
Background Dry eye disease (DED) affects more than 14% of the elderly population causing decrease of quality of life, high costs and vision impairment. Current treatments for DED aim at lubricating and controlling inflammation of the ocula…
View article: Autoimmune Diseases and the Anterior Segment of the Eye
Autoimmune Diseases and the Anterior Segment of the Eye Open
This special issue focuses on the current approaches for diagnosis, evaluation, and management of autoimmune diseases of the anterior segment of the eye, which range from immune keratoconjunctivitis to anterior uveitis. Immune diseases of …
View article: Tear Ferning Test and Pathological Effects on Ocular Surface before and after Topical Cyclosporine in Vernal Keratoconjunctivitis Patients
Tear Ferning Test and Pathological Effects on Ocular Surface before and after Topical Cyclosporine in Vernal Keratoconjunctivitis Patients Open
Background . Vernal keratoconjunctivitis (VKC) is a rare ocular surface inflammatory disease that affects mainly boys in the first decade of life. Clinical observations show that it generally regresses spontaneously with the onset of puber…