Maricela Valerio
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View article: When do thymocytes perceive IFN signaling during development? 2485
When do thymocytes perceive IFN signaling during development? 2485 Open
Description T cells need to be tolerant to self in both homeostatic and inflammatory contexts, like type I IFN mediated inflammation. In the thymus, type I IFNs are constantly produced in a sterile manner, which activates APC and enables p…
View article: Comparative effectiveness of echinocandins and liposomal amphotericin B for fluconazole-resistant <i>Candida parapsilosis</i> bloodstream infections
Comparative effectiveness of echinocandins and liposomal amphotericin B for fluconazole-resistant <i>Candida parapsilosis</i> bloodstream infections Open
Current therapeutic options for fluconazole-resistant Candida parapsilosis (FLZR-CP) bloodstream infections (BSI) are limited to echinocandins and liposomal amphotericin B (L-AmB). To the best of our knowledge, no real-world comparative ef…
View article: Rezafungin Utilisation in Real Life—<scp>FungiScope</scp> Results From Europe and the United States
Rezafungin Utilisation in Real Life—<span>FungiScope</span> Results From Europe and the United States Open
Background Rezafungin, a novel echinocandin with once‐weekly intravenous dosing, offers potential advantages for outpatient parenteral antifungal therapy (OPAT) in invasive candidiasis (IC). While clinical trial data support its efficacy a…
View article: Persistent candidemia caused by different Candida species: Data from a multicenter contemporary cohort
Persistent candidemia caused by different Candida species: Data from a multicenter contemporary cohort Open
Persistent candidemia affects one in four patients with Candida BSI. Infections caused by Candida parapsilosis or Candida auris require individualized management, with early source control being essential to reduce the risk of persistence.
View article: Neurologic Manifestations Associated with Parvovirus B19 Epidemic, Madrid, Spain, 2024
Neurologic Manifestations Associated with Parvovirus B19 Epidemic, Madrid, Spain, 2024 Open
A reemergence of parvovirus B19 infections in Spain in early 2024 prompted a 10-year review of the virus at a tertiary center. We identified 8 case-patients with neurologic manifestations who had parvovirus B19 in cerebrospinal fluid. Earl…
View article: Current trends on antifungal prophylaxis in solid organ transplantation: a study from ESCMID-EFISG, ESCMID-ESGICH, SITA, and SEIMC-GESITRA-IC
Current trends on antifungal prophylaxis in solid organ transplantation: a study from ESCMID-EFISG, ESCMID-ESGICH, SITA, and SEIMC-GESITRA-IC Open
Introduction Invasive fungal diseases (IFD) present serious risks to solid organ transplant recipients, particularly in the first 180 days post-transplant. Existing European and US guidelines offer limited evidence, prompting a shift away …
View article: Mortality of <i>Pneumocystis jirovecii</i> pneumonia in intensive care units: a post-hoc analysis of an international multicenter study by ESGCIP and EFISG
Mortality of <i>Pneumocystis jirovecii</i> pneumonia in intensive care units: a post-hoc analysis of an international multicenter study by ESGCIP and EFISG Open
PJP mortality remains high in ICU patients. Conditions other than HIV infection are emerging not only as non-classical risk factors for PJP development, but also as important mortality predictors. A better understanding of the reasons unde…
View article: Evolution of postsurgical mediastinitis after Major Heart Surgery (MHS) in the last 12 years: Are we improving?
Evolution of postsurgical mediastinitis after Major Heart Surgery (MHS) in the last 12 years: Are we improving? Open
Background: Postsurgical mediastinitis (PSM) is a serious and potentially life-threatening complication of Major Heart Surgery (MHS). Data on the evolution of the incidence of PSM after MHS in large series of operated patients in recent ye…
View article: Direct collaboration between hospitals and NGOs, an essential tool to reinforce linkage to care in people living with HIV
Direct collaboration between hospitals and NGOs, an essential tool to reinforce linkage to care in people living with HIV Open
With the aim of improving access and engagement to healthcare in people living with HIV (PLHIV), in 2022 Gregorio Marañón Hospital and the NGO COGAM developed a circuit for recruitment and referral to hospital. Program targeted PLHIV who w…
View article: Direct collaboration between hospitals and NGOs, an essential tool to reinforce linkage to care in People living with HIV
Direct collaboration between hospitals and NGOs, an essential tool to reinforce linkage to care in People living with HIV Open
With the aim of improving access and engagement to healthcare in people living with HIV (PLHIV), in 2022 Gregorio Marañón Hospital and the NGO COGAM developed a circuit for recruitment and referral to hospital. Program targeted PLHIV who w…
View article: Management of cytomegalovirus in adult solid organ transplant patients: GESITRA-IC-SEIMC, CIBERINFEC, and SET recommendations update
Management of cytomegalovirus in adult solid organ transplant patients: GESITRA-IC-SEIMC, CIBERINFEC, and SET recommendations update Open
Cytomegalovirus (CMV) infection remains a significant challenge in solid organ transplantation (SOT). The last international consensus guidelines on the management of CMV in SOT were published in 2018, highlighting the need for revision to…
View article: Proper assignation of reactivation in a COVID-19 recurrence initially interpreted as a reinfection
Proper assignation of reactivation in a COVID-19 recurrence initially interpreted as a reinfection Open
A 77-year-old male (Case R) who had had a previous diagnosis of mild COVID-19 episode, with fever without developing pneumonia or other complications, was hospitalized 57 days later, due to an acute cholangitis. He had a prolonged hospital…
View article: Infectious complications following major heart surgery from the day of the surgery to hospital discharge
Infectious complications following major heart surgery from the day of the surgery to hospital discharge Open
Background At some point in their lives, many people will require major heart surgery (MHS). Patients are generally older adults with various risk factors for infection. However, the incidence of infection after MHS is poorly known, as rep…
View article: <i>Aspergillus granulosus</i> femoral osteomyelitis in a cardiac transplant patient: first reported case and literature review
<i>Aspergillus granulosus</i> femoral osteomyelitis in a cardiac transplant patient: first reported case and literature review Open
Aspergillus osteomyelitis is a rare complication of extrapulmonary invasive aspergillosis, which usually presents as spondylodiscitis. The clinical picture is usually paucisymptomatic and of long evolution, which leads to diagnostic diffic…
View article: Alternative molecular and genomic strategies to provide a rapid response to alerts concerning the introduction of new emerging SARS-CoV-2 variants: the Omicron alert
Alternative molecular and genomic strategies to provide a rapid response to alerts concerning the introduction of new emerging SARS-CoV-2 variants: the Omicron alert Open
During the COVID-19 pandemic, several SARS-CoV-2 variants of concern (VOCs) of particular relevance emerged. Early detection of VOCs entering a country is essential to control spread. The alert triggered by the first suspected case of the …
View article: Systematic influenza screening in cardiac intensive care units during the influenza season: A prospective study in Spain
Systematic influenza screening in cardiac intensive care units during the influenza season: A prospective study in Spain Open
Influenza seems to be a frequently underdiagnosed underlying condition in admissions to the C-ICU. Influenza should be screened for at C-ICU admission during influenza epidemics.
View article: Non-nosocomial Healthcare-Associated Infective Endocarditis: A Distinct Entity? Data From the GAMES Series (2008–2021)
Non-nosocomial Healthcare-Associated Infective Endocarditis: A Distinct Entity? Data From the GAMES Series (2008–2021) Open
Background Patients who acquire infective endocarditis (IE) following contact with the healthcare system, but outside the hospital, are classified as having non-nosocomial healthcare-associated IE (HCIE). Our aim was to characterize HCIE a…
View article: Clinical impact of time to results from the microbiology laboratory in bloodstream infections caused by carbapenemase-producing Enterobacterales (TIME-CPE STUDY)
Clinical impact of time to results from the microbiology laboratory in bloodstream infections caused by carbapenemase-producing Enterobacterales (TIME-CPE STUDY) Open
Objectives To evaluate the impact of time to results (TTR) on the outcome of patients with carbapenemase-producing Enterobacterales bloodstream infections (CPE-BSI). Methods Times-series study conducted from January 2014 to December 2021, …
View article: Frequent Emergence of Resistance Mutations Following Complex Intra-Host Genomic Dynamics in SARS-CoV-2 Patients Receiving Sotrovimab
Frequent Emergence of Resistance Mutations Following Complex Intra-Host Genomic Dynamics in SARS-CoV-2 Patients Receiving Sotrovimab Open
The emergence of the Omicron variant of SARS-CoV-2 represented a challenge to the treatment of COVID-19 using monoclonal antibodies. Only Sotrovimab maintained partial activity, allowing it to be used in high-risk patients infected with th…
View article: Nosocomial Infections in Adult Patients Supported by Extracorporeal Membrane Oxygenation in a Cardiac Intensive Care Unit
Nosocomial Infections in Adult Patients Supported by Extracorporeal Membrane Oxygenation in a Cardiac Intensive Care Unit Open
The use of venoarterial (VA) extracorporeal membrane oxygenation therapy (ECMO) in patients admitted to cardiac intensive care units (CICU) has increased. Data regarding infections in this population are scarce. In this retrospective study…
View article: Pneumocystis jirovecii Pneumonia Diagnostic Approach: Real-Life Experience in a Tertiary Centre
Pneumocystis jirovecii Pneumonia Diagnostic Approach: Real-Life Experience in a Tertiary Centre Open
Pneumocystis jirovecii pneumonia (PJP) in immunocompromised patients entails high mortality and requires adequate laboratory diagnosis. We compared the performance of a real time-PCR assay against the immunofluorescence assay (IFA) in the …
View article: Cost analysis of disease including treatment with dalbavancin in a Spanish hospital: ECODAL ANALYSIS
Cost analysis of disease including treatment with dalbavancin in a Spanish hospital: ECODAL ANALYSIS Open
The economic impact of the management of these infections is high. The cost of dalbavancin is offset by the decreased length of stay.
View article: Validation of the INCREMENT‐SOT‐CPE score in a large cohort of liver transplant recipients with carbapenem‐resistant Enterobacterales infection
Validation of the INCREMENT‐SOT‐CPE score in a large cohort of liver transplant recipients with carbapenem‐resistant Enterobacterales infection Open
Background Management of infections due to carbapenemase‐resistant Enterobacterales (CRE) in solid organ transplant (SOT) recipients remains a difficult challenge. The INCREMENT‐SOT‐CPE score has been specifically developed from SOT recipi…