Mårten Wikström
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View article: Quantum entanglement and classical correlation have the same form
Quantum entanglement and classical correlation have the same form Open
In agreement with the data, the quantum correlation between spins violates Bell’s inequality by following a cosine curve when one analyzer is rotated relative to the other. In contrast, the linear correlation attributed to hidden variables…
View article: Structures of the intermediates in the catalytic cycle of mitochondrial cytochrome c oxidase
Structures of the intermediates in the catalytic cycle of mitochondrial cytochrome c oxidase Open
Cytochrome c oxidase is the terminal complex of the respiratory chains in the mitochondria of nearly all eu-karyotes. It catalyzes the reduction of molecular O-2 to water using electrons from the respiratory chain, delivered via cytochrome…
View article: Dark matter and dark energy denote the gravitation of the expanding universe
Dark matter and dark energy denote the gravitation of the expanding universe Open
We reason that it is the gravitation of all ordinary matter, extending from the dense distant past to the sparse present, rather than dark matter, that shows up in galaxy rotation and velocity dispersion. Likewise, we argue that it is this…
View article: On the role of ubiquinone in the proton translocation mechanism of respiratory complex I
On the role of ubiquinone in the proton translocation mechanism of respiratory complex I Open
Complex I converts oxidoreduction energy into a proton electrochemical gradient across the inner mitochondrial or bacterial cell membrane. This gradient is the primary source of energy for aerobic synthesis of ATP. Oxidation of reduced nic…
View article: Electric fields control water-gated proton transfer in cytochrome <i>c</i> oxidase
Electric fields control water-gated proton transfer in cytochrome <i>c</i> oxidase Open
Aerobic life is powered by membrane-bound enzymes that catalyze the transfer of electrons to oxygen and protons across a biological membrane. Cytochrome c oxidase (C c O) functions as a terminal electron acceptor in mitochondrial and bacte…
View article: Correction to: Patterns of prevalence and contemporary clinical management strategies in complicated acute biliary calculous disease: an ESTES ‘snapshot audit’ of practice
Correction to: Patterns of prevalence and contemporary clinical management strategies in complicated acute biliary calculous disease: an ESTES ‘snapshot audit’ of practice Open
The original version of this article unfortunately contained a mistake.
View article: Self-reported and actual adherence to the Tokyo guidelines in the European snapshot audit of complicated calculous biliary disease
Self-reported and actual adherence to the Tokyo guidelines in the European snapshot audit of complicated calculous biliary disease Open
Background Complicated acute biliary calculous disease poses clinical challenges. The European Society of Trauma and Emergency Surgery (ESTES) snapshot audit of complicated biliary calculous disease aims to make novel comparisons between s…
View article: Redox-coupled quinone dynamics in the respiratory complex I
Redox-coupled quinone dynamics in the respiratory complex I Open
Significance Complex I is the primary energy-converting enzyme of aerobic respiratory chains. By reducing quinone to quinol, this gigantic enzyme pumps protons across its membrane domain, which in turn powers ATP synthesis and active trans…
View article: Density and distribution of a brown bear (Ursus arctos) population within the Caucasus biodiversity hotspot
Density and distribution of a brown bear (Ursus arctos) population within the Caucasus biodiversity hotspot Open
Population declines and extirpations of large mammalian carnivores are major concerns for global biodiversity conservation. Many large carnivores are vulnerable to conflict with humans and attract conservation attention for their flagship …
View article: Oxygen Activation and Energy Conservation by Cytochrome <i>c</i> Oxidase
Oxygen Activation and Energy Conservation by Cytochrome <i>c</i> Oxidase Open
This review focuses on the type A cytochrome c oxidases (C cO), which are found in all mitochondria and also in several aerobic bacteria. C cO catalyzes the respiratory reduction of dioxygen (O2) to water by an intriguing mechanism, the de…
View article: Bladder irrigation with Chlorhexidine reduces bacteriuria in persons with spinal cord injury
Bladder irrigation with Chlorhexidine reduces bacteriuria in persons with spinal cord injury Open
Bladder irrigation with chlorhexidine, using intermittent self-catheterization, reduced bacteriuria in the majority of subjects with spinal cord injury and bacteriuria. The addition of bladder irrigation was practically feasible in the sho…
View article: Understanding the essential proton-pumping kinetic gates and decoupling mutations in cytochrome <i>c</i> oxidase
Understanding the essential proton-pumping kinetic gates and decoupling mutations in cytochrome <i>c</i> oxidase Open
Significance Understanding the molecular mechanism that enables the high proton-pumping efficiency of cytochrome c oxidase (C c O) is not only fundamentally important but also potentially useful in providing design principles for bio-inspi…
View article: Multiscale simulations reveal key features of the proton-pumping mechanism in cytochrome <i>c</i> oxidase
Multiscale simulations reveal key features of the proton-pumping mechanism in cytochrome <i>c</i> oxidase Open
Significance The long-studied proton-pumping mechanism in cytochrome c oxidase (C c O) continues to be a source of debate. This work provides a comprehensive computational characterization of the internal proton transport dynamics, while e…
View article: Multiscale simulations reveal key features of the proton pumping mechanism in cytochrome<i>c</i>oxidase
Multiscale simulations reveal key features of the proton pumping mechanism in cytochrome<i>c</i>oxidase Open
Cytochrome c oxidase (C c O) reduces oxygen to water and uses the released free energy to pump protons across the membrane, contributing to the transmembrane proton electrochemical gradient that drives ATP synthesis. We have used multiscal…
View article: Redox-induced activation of the proton pump in the respiratory complex I
Redox-induced activation of the proton pump in the respiratory complex I Open
Significance Complex I is a redox-driven proton pump, central for aerobic energy transduction. We show here by large-scale quantum and classical molecular simulations how reduction of quinone (Q) in the hydrophilic domain of complex I acti…
View article: Proton-coupled electron transfer and the role of water molecules in proton pumping by cytochrome <i>c</i> oxidase
Proton-coupled electron transfer and the role of water molecules in proton pumping by cytochrome <i>c</i> oxidase Open
Significance Classical atomistic molecular dynamics simulations and free-energy calculations performed on cytochrome c oxidase in an explicit membrane–solvent environment show that the water molecules in the nonpolar cavity near the active…