Martha E. Hensel
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View article: Brain-type natriuretic peptide is a useful biomarker of cardiovascular disease and predictor of cardiac-related mortality in chimpanzees (Pan troglodytes)
Brain-type natriuretic peptide is a useful biomarker of cardiovascular disease and predictor of cardiac-related mortality in chimpanzees (Pan troglodytes) Open
OBJECTIVE To validate the use of brain-type natriuretic peptide (BNP) for detecting and monitoring cardiac dysfunction in captive chimpanzees ( Pan troglodytes ). METHODS We analyzed cross-sectional (N = 175) and longitudinal (N = 76) BNP,…
View article: Three novel neoplasms in Nancy Ma’s owl monkeys ( <i>Aotus nancymaae</i> )
Three novel neoplasms in Nancy Ma’s owl monkeys ( <i>Aotus nancymaae</i> ) Open
Neoplasms are only sporadically reported in New World primates and rarely in owl monkeys ( Aotus spp. ), specifically. Previous reports of neoplasms in owl monkeys are primarily restricted to lymphoma induced by Herpesvirus saimiri infecti…
View article: Anti-tumor activity of camptothecin analog conjugate of a RSPO4-based peptibody targeting LGR4/5/6 in preclinical models of colorectal cancer
Anti-tumor activity of camptothecin analog conjugate of a RSPO4-based peptibody targeting LGR4/5/6 in preclinical models of colorectal cancer Open
Antibody-drug conjugates (ADCs) have emerged as a major modality of targeted cancer therapy, yet no ADC has been approved specifically for colorectal cancer (CRC). LGR4/5/6 (leucine-rich repeat containing, G protein-coupled receptor 4, 5, …
View article: Rapid <i>in vitro</i> activity of telavancin against <i>Bacillus anthracis</i> and <i>in vivo</i> protection against inhalation anthrax infection in the rabbit model
Rapid <i>in vitro</i> activity of telavancin against <i>Bacillus anthracis</i> and <i>in vivo</i> protection against inhalation anthrax infection in the rabbit model Open
Inhalation anthrax is the most severe form of Bacillus anthracis infection, often progressing to fatal conditions if left untreated. While recommended antibiotics can effectively treat anthrax when promptly administered, strains engineered…
View article: Oral supplementation of gut microbial metabolite indole-3-acetate alleviates diet-induced steatosis and inflammation in mice
Oral supplementation of gut microbial metabolite indole-3-acetate alleviates diet-induced steatosis and inflammation in mice Open
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in Western countries. There is growing evidence that dysbiosis of the intestinal microbiota and disruption of microbiota-host interactions contribute to the…
View article: Gastrointestinal tract pathology of the owl monkey (<i>Aotus</i> spp.)
Gastrointestinal tract pathology of the owl monkey (<i>Aotus</i> spp.) Open
Owl monkeys are small nocturnal new world primates in the genus Aotus that are most used in biomedical research for malaria. Cardiomyopathy and nephropathy are well-described common diseases contributing to their morbidity and mortality; l…
View article: Proceedings of the 2023 Division of Translational Toxicology Satellite Symposium
Proceedings of the 2023 Division of Translational Toxicology Satellite Symposium Open
The 2023 annual Division of Translational Toxicology (DTT) Satellite Symposium, entitled “Pathology Potpourri,” was held in Summerlin, Nevada, at the Society of Toxicologic Pathology’s 41st annual meeting. The goal of this symposium was to…
View article: Author Response: Oral supplementation of gut microbial metabolite indole-3-acetate alleviates diet-induced steatosis and inflammation in mice
Author Response: Oral supplementation of gut microbial metabolite indole-3-acetate alleviates diet-induced steatosis and inflammation in mice Open
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in Western countries. There is growing evidence that dysbiosis of the intestinal microbiota and disruption of microbiota-host interactions contribute to the…
View article: Oral supplementation of gut microbial metabolite indole-3-acetate alleviates diet-induced steatosis and inflammation in mice
Oral supplementation of gut microbial metabolite indole-3-acetate alleviates diet-induced steatosis and inflammation in mice Open
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in Western countries. There is growing evidence that dysbiosis of the intestinal microbiota and disruption of microbiota-host interactions contribute to the…
View article: Oral supplementation of gut microbial metabolite indole-3-acetate alleviates diet-induced steatosis and inflammation in mice
Oral supplementation of gut microbial metabolite indole-3-acetate alleviates diet-induced steatosis and inflammation in mice Open
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in Western countries. There is growing evidence that dysbiosis of the intestinal microbiota and disruption of microbiota-host interactions contribute to the…
View article: Reviewer #1 (Public Review): Microbially-derived indole-3-acetate alleviates diet induced steatosis and inflammation in mice
Reviewer #1 (Public Review): Microbially-derived indole-3-acetate alleviates diet induced steatosis and inflammation in mice Open
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in Western countries. There is growing evidence that dysbiosis of the intestinal microbiota and disruption of microbiota-host interactions contribute to the…
View article: Microbially-derived indole-3-acetate alleviates diet induced steatosis and inflammation in mice
Microbially-derived indole-3-acetate alleviates diet induced steatosis and inflammation in mice Open
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in Western countries. There is growing evidence that dysbiosis of the intestinal microbiota and disruption of microbiota-host interactions contribute to the…
View article: Supplementary Figures 1-6 from Loss of Aryl Hydrocarbon Receptor Promotes Colon Tumorigenesis in <i>Apc<sup>S580/+</sup>; Kras<sup>G12D/+</sup></i> Mice
Supplementary Figures 1-6 from Loss of Aryl Hydrocarbon Receptor Promotes Colon Tumorigenesis in <i>Apc<sup>S580/+</sup>; Kras<sup>G12D/+</sup></i> Mice Open
S1. Characterization of genotypes. S2. Loss of AhR increases non-phosphorylated β-catenin. S3. Intestinal pathology analysis from ACK and HACK mice. S4. AhR deletion promotes cell proliferation. S5. Intestinal pathology analysis from ACKG …
View article: Data from Loss of Aryl Hydrocarbon Receptor Promotes Colon Tumorigenesis in <i>Apc<sup>S580/+</sup>; Kras<sup>G12D/+</sup></i> Mice
Data from Loss of Aryl Hydrocarbon Receptor Promotes Colon Tumorigenesis in <i>Apc<sup>S580/+</sup>; Kras<sup>G12D/+</sup></i> Mice Open
The mutational genetic landscape of colorectal cancer has been extensively characterized; however, the ability of “cooperation response genes” to modulate the function of cancer “driver” genes remains largely unknown. In this study, we inv…
View article: Supplementary Figures 1-6 from Loss of Aryl Hydrocarbon Receptor Promotes Colon Tumorigenesis in <i>Apc<sup>S580/+</sup>; Kras<sup>G12D/+</sup></i> Mice
Supplementary Figures 1-6 from Loss of Aryl Hydrocarbon Receptor Promotes Colon Tumorigenesis in <i>Apc<sup>S580/+</sup>; Kras<sup>G12D/+</sup></i> Mice Open
S1. Characterization of genotypes. S2. Loss of AhR increases non-phosphorylated β-catenin. S3. Intestinal pathology analysis from ACK and HACK mice. S4. AhR deletion promotes cell proliferation. S5. Intestinal pathology analysis from ACKG …
View article: Data from Loss of Aryl Hydrocarbon Receptor Promotes Colon Tumorigenesis in <i>Apc<sup>S580/+</sup>; Kras<sup>G12D/+</sup></i> Mice
Data from Loss of Aryl Hydrocarbon Receptor Promotes Colon Tumorigenesis in <i>Apc<sup>S580/+</sup>; Kras<sup>G12D/+</sup></i> Mice Open
The mutational genetic landscape of colorectal cancer has been extensively characterized; however, the ability of “cooperation response genes” to modulate the function of cancer “driver” genes remains largely unknown. In this study, we inv…
View article: Oral supplementation of gut microbial metabolite indole-3-acetate alleviates diet-induced steatosis and inflammation in mice
Oral supplementation of gut microbial metabolite indole-3-acetate alleviates diet-induced steatosis and inflammation in mice Open
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in Western countries. There is growing evidence that dysbiosis of the intestinal microbiota and disruption of microbiota-host interactions contribute to the…
View article: Rapid<i>in vitro</i>activity of telavancin against<i>Bacillus anthracis</i>and<i>in vivo</i>protection against inhalation anthrax infection in the rabbit model
Rapid<i>in vitro</i>activity of telavancin against<i>Bacillus anthracis</i>and<i>in vivo</i>protection against inhalation anthrax infection in the rabbit model Open
Anthrax, caused by the bacterium Bacillus anthracis , is a zoonotic disease that manifests in various forms in human infection, depending on the route of infection. Inhalation anthrax, the most detrimental form of the disease, comes about …
View article: Intratracheal inoculation results in Brucella-associated reproductive disease in male mouse and guinea pig models of infection
Intratracheal inoculation results in Brucella-associated reproductive disease in male mouse and guinea pig models of infection Open
Brucella species are considered a significant cause of reproductive pathology in male and female animals. Importantly, Brucella melitensis can induce reproductive disease in humans. Reproductive pathogenesis and evaluation of newly develop…
View article: Primary and memory immune responses against rough Brucella canis are less robust compared to smooth B. abortus and B. melitensis following intratracheal infection in mice
Primary and memory immune responses against rough Brucella canis are less robust compared to smooth B. abortus and B. melitensis following intratracheal infection in mice Open
Brucella canis is the cause of canine brucellosis, a globally distributed, zoonotic pathogen which primarily causes disease in dogs. B. canis is unique amongst the zoonotic Brucella spp. with its rough lipopolysaccharide, a trait typically…
View article: Pathology in Practice
Pathology in Practice Open
In collaboration with the American College of Veterinary Pathologists
View article: Role of the Aryl Hydrocarbon Receptor (AhR) in Mediating the Effects of Coffee in the Colon
Role of the Aryl Hydrocarbon Receptor (AhR) in Mediating the Effects of Coffee in the Colon Open
Scope This study investigates the mechanism of action and functional effects of coffee extracts in colonic cells, on intestinal stem cell growth, and inhibition of dextran sodium sulfate (DSS)‐induced intestinal barrier damage in mice. Met…
View article: Loss of Aryl Hydrocarbon Receptor Promotes Colon Tumorigenesis in <i>ApcS580/+; KrasG12D/+</i> Mice
Loss of Aryl Hydrocarbon Receptor Promotes Colon Tumorigenesis in <i>ApcS580/+; KrasG12D/+</i> Mice Open
The mutational genetic landscape of colorectal cancer has been extensively characterized; however, the ability of “cooperation response genes” to modulate the function of cancer “driver” genes remains largely unknown. In this study, we inv…
View article: Characterization of epididymal and testicular histologic lesions and use of immunohistochemistry and PCR on formalin-fixed tissues to detect <i>Brucella canis</i> in male dogs
Characterization of epididymal and testicular histologic lesions and use of immunohistochemistry and PCR on formalin-fixed tissues to detect <i>Brucella canis</i> in male dogs Open
In male dogs, Brucella canis frequently causes epididymitis, ultimately resulting in testicular atrophy and infertility. Although B. canis predominantly affects the epididymis, the misleading term “orchitis” is still commonly used by clini…
View article: INTRATRACHEAL INOCULATION OF THE GUINEA PIG IS AN IMPROVED MODEL FOR BRUCELLOSIS
INTRATRACHEAL INOCULATION OF THE GUINEA PIG IS AN IMPROVED MODEL FOR BRUCELLOSIS Open
B. melitensis is considered the most virulent of the Brucella species, and a need exists for an improved laboratory animal model of infection that mimics natural transmission and disease. Previous research has shown that guinea pigs are hi…
View article: Brucella abortus and Pregnancy in Mice: Impact of Chronic Infection on Fertility and the Role of Regulatory T Cells in Tissue Colonization
Brucella abortus and Pregnancy in Mice: Impact of Chronic Infection on Fertility and the Role of Regulatory T Cells in Tissue Colonization Open
Stealthy intracellular bacterial pathogens are known to establish persistent and sometimes lifelong infections. Some of these pathogens also have a tropism for the reproductive system, thereby increasing the risk of reproductive disease an…