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View article: Electric field intensity modulates keratocyte migration without altering turning dynamics
Electric field intensity modulates keratocyte migration without altering turning dynamics Open
Cell migration is a cornerstone of biological systems, enabling organisms to adapt to environmental stimuli and maintain homeostasis. Disruptions in this process can lead to functional impairment or system failure. In many cases, cells do …
View article: napariTFM: An Open-Source Tool for Traction Force Microscopy and Monolayer Stress Microscopy
napariTFM: An Open-Source Tool for Traction Force Microscopy and Monolayer Stress Microscopy Open
Cellular force generation and transmission are fundamental processes driving cell migration, division, tissue morphogenesis, and disease progression. Traction Force Microscopy (TFM) and Monolayer Stress Microscopy (MSM) have emerged as ess…
View article: Morphogenesis-on-chip: A minimal in vitro assay for cell intercalation highlights the importance of interfacial tension and migratory forces
Morphogenesis-on-chip: A minimal in vitro assay for cell intercalation highlights the importance of interfacial tension and migratory forces Open
Cell intercalation, the dynamic exchange of cellular neighbors, is fundamental to embryonic morphogenesis, tissue homeostasis, and wound healing. Despite extensive study in complex tissues, the minimal mechanical requirements driving inter…
View article: Osmotic pressure induces unexpected relaxation of contractile 3D microtissue
Osmotic pressure induces unexpected relaxation of contractile 3D microtissue Open
Cell contraction and proliferation, matrix secretion and external mechanical forces induce compression during embryogenesis and tumor growth, which in turn regulate cell proliferation, metabolism or differentiation. How compression affects…
View article: Osmotic pressure induces unexpected relaxation of contractile 3D microtissue
Osmotic pressure induces unexpected relaxation of contractile 3D microtissue Open
Cell contraction and proliferation, matrix secretion and external mechanical forces induce compression during embryogenesis and tumor growth, which in turn regulate cell proliferation, metabolism or differentiation. How compression affects…
View article: A crosstalk between adhesion and phagocytosis integrates macrophage functions into their microenvironment
A crosstalk between adhesion and phagocytosis integrates macrophage functions into their microenvironment Open
View article: Enucleated cells reveal differential roles of the nucleus in cell migration, polarity, and mechanotransduction
Enucleated cells reveal differential roles of the nucleus in cell migration, polarity, and mechanotransduction Open
The nucleus has long been postulated to play a critical physical role during cell polarization and migration, but that role has not been defined or rigorously tested. Here, we enucleated cells to test the physical necessity of the nucleus …
View article: An EpCAM/Trop2 mechanostat differentially regulates collective behaviour of human carcinoma cells
An EpCAM/Trop2 mechanostat differentially regulates collective behaviour of human carcinoma cells Open
View article: An Open-source Python Tool for Traction Force Microscopy on Micropatterned Substrates
An Open-source Python Tool for Traction Force Microscopy on Micropatterned Substrates Open
Cell-generated forces play a critical role in driving and regulating complex biological processes, such as cell migration and division and cell and tissue morphogenesis in development and disease. Traction force microscopy (TFM) is an esta…
View article: Dual topologies of myotomal collagen XV and Tenascin C act in concert to guide and shape developing motor axons
Dual topologies of myotomal collagen XV and Tenascin C act in concert to guide and shape developing motor axons Open
During development, motor axons are guided toward muscle target by various extrinsic cues including extracellular matrix (ECM) proteins whose identities and cellular source remain poorly characterized. Here, using single-cell RNAseq of sor…
View article: Force propagation between epithelial cells depends on active coupling and mechano-structural polarization
Force propagation between epithelial cells depends on active coupling and mechano-structural polarization Open
Cell-generated forces play a major role in coordinating the large-scale behavior of cell assemblies, in particular during development, wound healing, and cancer. Mechanical signals propagate faster than biochemical signals, but can have si…
View article: Dual-topology of collagen XV and tenascin C acts in concert to guide and shape developing motor axons
Dual-topology of collagen XV and tenascin C acts in concert to guide and shape developing motor axons Open
During development, motor axons are guided towards their muscle target by various extrinsic cues including extracellular matrix (ECM) proteins those identities remain poorly documented. Using single-cell RNA-sequencing of differentiating s…
View article: Author response: Force propagation between epithelial cells depends on active coupling and mechano-structural polarization
Author response: Force propagation between epithelial cells depends on active coupling and mechano-structural polarization Open
View article: Light-driven biological actuators to probe the rheology of 3D microtissues
Light-driven biological actuators to probe the rheology of 3D microtissues Open
The mechanical properties of biological tissues are key to their physical integrity and function. Although external loading or biochemical treatments allow the estimation of these properties globally, it remains difficult to assess how suc…
View article: Cell size and actin architecture determine force generation in optogenetically activated cells
Cell size and actin architecture determine force generation in optogenetically activated cells Open
Adherent cells use actomyosin contractility to generate mechanical force and to sense the physical properties of their environment, with dramatic consequences for migration, division, differentiation, and fate. However, the organization of…
View article: Optineurin links Hace1-dependent Rac ubiquitylation to integrin-mediated mechanotransduction to control bacterial invasion and cell division
Optineurin links Hace1-dependent Rac ubiquitylation to integrin-mediated mechanotransduction to control bacterial invasion and cell division Open
View article: Force tuning through regulation of clathrin-dependent integrin endocytosis
Force tuning through regulation of clathrin-dependent integrin endocytosis Open
Integrin endocytosis is essential for many fundamental cellular processes. Whether and how the internalization impacts cellular mechanics remains elusive. Whereas previous studies reported the contribution of the integrin activator, talin,…
View article: Force propagation between epithelial cells depends on active coupling and mechano-structural polarization
Force propagation between epithelial cells depends on active coupling and mechano-structural polarization Open
Cell-generated forces play a major role in coordinating the large-scale behavior of cell assemblies, in particular during development, wound healing and cancer. Mechanical signals propagate faster than biochemical signals, but can have sim…
View article: A mechano-osmotic feedback couples cell volume to the rate of cell deformation
A mechano-osmotic feedback couples cell volume to the rate of cell deformation Open
Mechanics has been a central focus of physical biology in the past decade. In comparison, how cells manage their size is less understood. Here, we show that a parameter central to both the physics and the physiology of the cell, its volume…
View article: ERRα coordinates actin and focal adhesion dynamics
ERRα coordinates actin and focal adhesion dynamics Open
View article: Cell size and actin architecture determine force generation in optogenetically activated adherent cells
Cell size and actin architecture determine force generation in optogenetically activated adherent cells Open
Adherent cells use actomyosin contractility to generate mechanical force and to sense the physical properties of their environment, with dramatic consequences for migration, division, differentiation and fate. However, the organization of …
View article: Author response: A mechano-osmotic feedback couples cell volume to the rate of cell deformation
Author response: A mechano-osmotic feedback couples cell volume to the rate of cell deformation Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract Mechanics h…
View article: Une approche de la Low-tech dans l’Enseignement Supérieur et la Recherche
Une approche de la Low-tech dans l’Enseignement Supérieur et la Recherche Open
International audience
View article: Light-driven biological actuators to probe the rheology of 3D microtissues
Light-driven biological actuators to probe the rheology of 3D microtissues Open
The mechanical properties of biological tissues are key to the regulation of their physical integrity and function. Although the application of external loading or biochemical treatments allows to estimate these properties globally, it rem…
View article: Adaptive mechanoproperties mediated by the formin FMN1 characterize glioblastoma fitness for invasion
Adaptive mechanoproperties mediated by the formin FMN1 characterize glioblastoma fitness for invasion Open
View article: Optineurin links Hace1-dependent Rac ubiquitylation to integrin-mediated mechanotransduction to control bacterial invasion and cell division
Optineurin links Hace1-dependent Rac ubiquitylation to integrin-mediated mechanotransduction to control bacterial invasion and cell division Open
SUMMARY Extracellular matrix (ECM) elasticity is perceived by cells via focal adhesion structures, which transduce mechanical cues into chemical signalling to conform cell behaviour. Although the contribution of ECM compliance to the contr…
View article: The Amot/integrin protein complex transmits mechanical forces required for vascular expansion
The Amot/integrin protein complex transmits mechanical forces required for vascular expansion Open
View article: A mechano-osmotic feedback couples cell volume to the rate of cell deformation
A mechano-osmotic feedback couples cell volume to the rate of cell deformation Open
Mechanics has been a central focus of physical biology in the past decade. In comparison, the osmotic and electric properties of cells are less understood. Here we show that a parameter central to both the physics and the physiology of the…
View article: Oscillations in collective cell migration
Oscillations in collective cell migration Open
View article: Control of SRC molecular dynamics encodes distinct cytoskeletal responses by specifying signaling pathway usage
Control of SRC molecular dynamics encodes distinct cytoskeletal responses by specifying signaling pathway usage Open
Upon activation by different transmembrane receptors, the same signaling protein can induce distinct cellular responses. A way to decipher the mechanisms of such pleiotropic signaling activity is to directly manipulate the decision-making …