Martin A. Lodge
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View article: Comparison of standardized uptake value and standardized uptake lean body mass metrics in 18F-fluorodeoxyglucose positron emission tomography for assessing transformation in chronic lymphocytic leukemia and follicular lymphoma
Comparison of standardized uptake value and standardized uptake lean body mass metrics in 18F-fluorodeoxyglucose positron emission tomography for assessing transformation in chronic lymphocytic leukemia and follicular lymphoma Open
Both SUVmax and SULmax can be reliably used for assessing the transformation of CLL and FL to aggressive lymphomas on 18F-FDG PET/CT. Given SULmax's stability with respect to weight changes, it may be more appropriate for assessing therape…
View article: 18F-Fluorodeoxysorbitol PET for noninvasive detection of invasive mold infections: preclinical and first-in-human studies
18F-Fluorodeoxysorbitol PET for noninvasive detection of invasive mold infections: preclinical and first-in-human studies Open
Invasive mold infections are a major cause of mortality in immunosuppressed and cancer patients. Diagnosis is challenging, requiring invasive procedures or reliance on fungal biomarkers with limited sensitivity and an inability to detect n…
View article: Dynamic <sup>11</sup>C–<i>Para</i>–Aminobenzoic Acid Positron Emission Tomography/Computed Tomography for Visualizing Pulmonary <i>Mycobacteroides abscessus</i> Infections
Dynamic <sup>11</sup>C–<i>Para</i>–Aminobenzoic Acid Positron Emission Tomography/Computed Tomography for Visualizing Pulmonary <i>Mycobacteroides abscessus</i> Infections Open
Rationale: Mycobacteroides abscessus infections affect immunocompromised patients and those with underlying pulmonary disease. Conventional imaging cannot distinguish M. abscessus infections from underlying pulmonary d…
View article: 18F-Fluorodeoxysorbitol PET for Noninvasive Detection of Invasive Mold Infections in Patients
18F-Fluorodeoxysorbitol PET for Noninvasive Detection of Invasive Mold Infections in Patients Open
Invasive mold infections are a major cause of mortality in immunosuppressed and cancer patients. Diagnosis is challenging, requiring invasive procedures or reliance on fungal biomarkers with limited sensitivity and an inability to detect n…
View article: Myeloid cell MHC I expression drives CD8+ T cell activation in nonalcoholic steatohepatitis
Myeloid cell MHC I expression drives CD8+ T cell activation in nonalcoholic steatohepatitis Open
Background & aims: Activated CD8+ T cells are elevated in Nonalcoholic steatohepatitis (NASH) and are important for driving fibrosis and inflammation. Despite this, mechanisms of CD8+ T cell activation in NASH are largely limited. Specific…
View article: Comparison of Multiple Segmentation Methods for Volumetric Delineation of Primary Prostate Cancer with Prostate-Specific Membrane Antigen–Targeted<sup>18</sup>F-DCFPyL PET/CT
Comparison of Multiple Segmentation Methods for Volumetric Delineation of Primary Prostate Cancer with Prostate-Specific Membrane Antigen–Targeted<sup>18</sup>F-DCFPyL PET/CT Open
This study aimed to assess the accuracy of intraprostatic tumor volume measurements on prostate-specific membrane antigen-targeted 18F-DCFPyL PET/CT made with various segmentation methods. An accurate understanding of tumor volu…
View article: Test–retest repeatability of organ uptake on PSMA‐targeted <sup>18</sup>F‐DCFPyL PET/CT in patients with prostate cancer
Test–retest repeatability of organ uptake on PSMA‐targeted <sup>18</sup>F‐DCFPyL PET/CT in patients with prostate cancer Open
Objectives We evaluated 18 F‐DCFPyL test–retest repeatability of uptake in normal organs. Methods Twenty‐two prostate cancer (PC) patients underwent two 18 F‐DCFPyL PET scans within 7 days within a prospective clinical trial (NCT03793543).…
View article: Lack of repeatability of radiomic features derived from PET scans: Results from a <sup>18</sup>F‐DCFPyL test–retest cohort
Lack of repeatability of radiomic features derived from PET scans: Results from a <sup>18</sup>F‐DCFPyL test–retest cohort Open
Objectives PET‐based radiomic metrics are increasingly utilized as predictive image biomarkers. However, the repeatability of radiomic features on PET has not been assessed in a test–retest setting. The prostate‐specific membrane antigen‐t…
View article: Dynamic 18F-Pretomanid PET imaging in animal models of TB meningitis and human studies
Dynamic 18F-Pretomanid PET imaging in animal models of TB meningitis and human studies Open
View article: Dynamic 18F-Pretomanid PET imaging reveals excellent brain penetration in animal models of TB meningitis and first-in-human studies
Dynamic 18F-Pretomanid PET imaging reveals excellent brain penetration in animal models of TB meningitis and first-in-human studies Open
Pretomanid is a nitroimidazole antimicrobial with potent activity against drug-resistant Mycobacterium tuberculosis and approved in combination with bedaquiline and linezolid (BPaL) for the treatment of multidrug-resistant (MDR) pulmonary …
View article: PET Imaging of the cannabinoid receptor type 2 in humans using [11C]MDTC
PET Imaging of the cannabinoid receptor type 2 in humans using [11C]MDTC Open
Purpose: We report findings from the first-in-human study of [ 11 C]MDTC, a radiotracer developed to image the cannabinoid receptor type 2 (CB2R) with positron emission tomography (PET). Methods: Ten healthy adults were imaged according to…
View article: High SUVs Have More Robust Repeatability in Patients with Metastatic Prostate Cancer: Results from a Prospective Test-Retest Cohort Imaged with <sup>18</sup>F-DCFPyL
High SUVs Have More Robust Repeatability in Patients with Metastatic Prostate Cancer: Results from a Prospective Test-Retest Cohort Imaged with <sup>18</sup>F-DCFPyL Open
Objectives. In patients with prostate cancer (PC) receiving prostate-specific membrane antigen- (PSMA-) targeted radioligand therapy (RLT), higher baseline standardized uptake values (SUVs) are linked to improved outcome. Thus, readers dec…
View article: Dynamic PET-facilitated modeling and high-dose rifampin regimens for <i>Staphylococcus aureus</i> orthopedic implant–associated infections
Dynamic PET-facilitated modeling and high-dose rifampin regimens for <i>Staphylococcus aureus</i> orthopedic implant–associated infections Open
Current rifampin dosing achieves subtherapeutic concentrations within S. aureus –infected bone, which can be overcome with higher rifampin dosing.
View article: 125. Dynamic PET facilitated Pharmacokinetic Modeling and High-dose Rifampin Regimens for <i>Staphylococcus aureus</i> Orthopedic Implant Associated Infections: Bench to Bedside
125. Dynamic PET facilitated Pharmacokinetic Modeling and High-dose Rifampin Regimens for <i>Staphylococcus aureus</i> Orthopedic Implant Associated Infections: Bench to Bedside Open
Background Rifampin, has potent, dose-dependent sterilizing activity against Gram-positive bacteria with the area under the concentration-time curve (AUC) being the most predictive of bactericidal activity. Combination therapy with rifampi…
View article: Effect of Point-Spread Function Reconstruction for Indeterminate PSMA-RADS-3A Lesions on PSMA-Targeted PET Imaging of Men with Prostate Cancer
Effect of Point-Spread Function Reconstruction for Indeterminate PSMA-RADS-3A Lesions on PSMA-Targeted PET Imaging of Men with Prostate Cancer Open
Purpose: Prostate-specific membrane antigen (PSMA) positron emission tomography (PET) is emerging as an important modality for imaging patients with prostate cancer (PCa). As with any imaging modality, indeterminate findings will arise. Th…
View article: Phantom Preparation Using a Dilution Technique
Phantom Preparation Using a Dilution Technique Open
Physical phantoms with compartments containing different concentrations of radioactivity are widely used in PET methodology research, system performance assessment, and routine quality assurance. Accreditation bodies such as the American C…
View article: Measurement of PET Quantitative Bias In Vivo
Measurement of PET Quantitative Bias In Vivo Open
Quantitative imaging biomarkers are widely used in PET for both research and clinical applications, yet bias in the underlying image data has not been well characterized. In the absence of a readily available reference standard for in vivo…
View article: Dynamic imaging in patients with tuberculosis reveals heterogeneous drug exposures in pulmonary lesions
Dynamic imaging in patients with tuberculosis reveals heterogeneous drug exposures in pulmonary lesions Open
View article: The QIBA Profile for FDG PET/CT as an Imaging Biomarker Measuring Response to Cancer Therapy
The QIBA Profile for FDG PET/CT as an Imaging Biomarker Measuring Response to Cancer Therapy Open
The Quantitative Imaging Biomarkers Alliance (QIBA) Profile for fluorodeoxyglucose (FDG) PET/CT imaging was created by QIBA to both characterize and reduce the variability of standardized uptake values (SUVs). The Profile provides two comp…
View article: Human Radiation Dosimetry for Orally and Intravenously Administered <sup>18</sup>F-FDG
Human Radiation Dosimetry for Orally and Intravenously Administered <sup>18</sup>F-FDG Open
Intravenous access is difficult in some patients referred for 18F-FDG PET imaging. Extravasation at the injection site and accumulation in central catheters can lead to limited tumor 18F-FDG uptake, erroneous quantita…
View article: Imager-4D: New Software for Viewing Dynamic PET Scans and Extracting Radiomic Parameters from PET Data
Imager-4D: New Software for Viewing Dynamic PET Scans and Extracting Radiomic Parameters from PET Data Open
View article: Semiquantitative Parameters in PSMA-Targeted PET Imaging with [18F]DCFPyL: Impact of Tumor Burden on Normal Organ Uptake
Semiquantitative Parameters in PSMA-Targeted PET Imaging with [18F]DCFPyL: Impact of Tumor Burden on Normal Organ Uptake Open
View article: Semiquantitative Parameters in PSMA-Targeted PET Imaging with [18F]DCFPyL: Intrapatient and Interpatient Variability of Normal Organ Uptake
Semiquantitative Parameters in PSMA-Targeted PET Imaging with [18F]DCFPyL: Intrapatient and Interpatient Variability of Normal Organ Uptake Open
View article: Erratum: Measuring temporal stability of positron emission tomography standardized uptake value bias using long-lived sources in a multicenter network
Erratum: Measuring temporal stability of positron emission tomography standardized uptake value bias using long-lived sources in a multicenter network Open
This erratum corrects an error in “Measuring temporal stability of positron emission tomography standardized uptake value bias using long-lived sources in a multicenter network,” by D. Byrd et al.
View article: Novel Functional Renal PET Imaging With 18F-FDS in Human Subjects
Novel Functional Renal PET Imaging With 18F-FDS in Human Subjects Open
The novel PET probe 2-deoxy-2- 18 F-fluoro- d -sorbitol ( 18 F-FDS) has demonstrated favorable renal kinetics in animals. We aimed to elucidate its imaging properties in 2 human volunteers. 18 F-FDS was produced by a simple 1-step reductio…
View article: Impact of Tumor Burden on Quantitative [68Ga] DOTATOC Biodistribution
Impact of Tumor Burden on Quantitative [68Ga] DOTATOC Biodistribution Open
There is no significant impact on normal organ biodistribution with increasing tumor burden on [68Ga] DOTATOC PET/CT. Potential implications include increased normal organ dose with [177Lu-DOTA]0-D-Phe…
View article: Measuring PET Spatial Resolution Using a Cylinder Phantom Positioned at an Oblique Angle
Measuring PET Spatial Resolution Using a Cylinder Phantom Positioned at an Oblique Angle Open
A cylinder phantom positioned at a slightly oblique angle with respect to the z-axis of a PET scanner allows for fine sampling of the edge-spread function. We show how this technique can be used to measure the spatial resolution tha…
View article: Dynamic whole-body PET imaging: principles, potentials and applications
Dynamic whole-body PET imaging: principles, potentials and applications Open
PURPOSE:In this article, we discuss dynamic whole-body (DWB) positron emission tomography (PET) as an imaging tool with significant clinical potential, in relation to conventional standard uptake value (SUV) imaging.BACKGROUND:DWB PET invo…
View article: Biodistribution and Radiation Dosimetry of <sup>124</sup>I-DPA-713, a PET Radiotracer for Macrophage-Associated Inflammation
Biodistribution and Radiation Dosimetry of <sup>124</sup>I-DPA-713, a PET Radiotracer for Macrophage-Associated Inflammation Open
Whole-body PET/CT was performed using 124I-DPA-713, a radioligand for the 18-kDa translocator protein (TSPO), to determine biodistribution and radiation dosimetry. Methods: Healthy subjects aged 18-65 y underwent whole-bo…
View article: Feasibility of state of the art PET/CT systems performance harmonisation
Feasibility of state of the art PET/CT systems performance harmonisation Open