Martín Beaumont
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View article: The Diversity of Oligosaccharide Composition in Rabbit Milk and Its Association with the Development of the Cecal Microbiota and the Survival of Young Rabbits
The Diversity of Oligosaccharide Composition in Rabbit Milk and Its Association with the Development of the Cecal Microbiota and the Survival of Young Rabbits Open
Rabbit MOs are variable among individuals and across lactation stages, with certain MOs linked to early microbiota composition of the offspring, highlighting their potential prebiotic role in neonatal development.
View article: A Single-Cell Atlas of Transcriptome Changes in the Intestinal Epithelium at the Suckling-to-Weaning Transition in Male Rabbits
A Single-Cell Atlas of Transcriptome Changes in the Intestinal Epithelium at the Suckling-to-Weaning Transition in Male Rabbits Open
View article: Transcriptomic analysis of the interactions between Fibrobacter succinogenes S85, Selenomonas ruminantium PC18 and a live yeast strain used as a ruminant feed additive
Transcriptomic analysis of the interactions between Fibrobacter succinogenes S85, Selenomonas ruminantium PC18 and a live yeast strain used as a ruminant feed additive Open
View article: Disruption of IgA-mediated aggregation at weaning favors mucus encroachment by commensal bacteria
Disruption of IgA-mediated aggregation at weaning favors mucus encroachment by commensal bacteria Open
Disruption of the gut mucus barrier is a critical step in the development of infec-tious or chronic inflammatory diseases. However, there are no clear links between developmental stages, diet, and the mechanical and biochemical properties …
View article: Single cell transcriptomics reveals that air-liquid interface culture promotes goblet cell differentiation and inhibits glycolysis in cell monolayers derived from rabbit caecum organoids
Single cell transcriptomics reveals that air-liquid interface culture promotes goblet cell differentiation and inhibits glycolysis in cell monolayers derived from rabbit caecum organoids Open
Faithfully recapitulating the cellular heterogeneity of the intestinal epithelium is essential when using organoid models. Air-liquid interface (ALI) culture has been shown to promote secretory cell differentiation but its impact on gene e…
View article: The gut microbiota metabolite isovalerate enhances the epithelial barrier function in cell monolayers derived from porcine ileum organoids
The gut microbiota metabolite isovalerate enhances the epithelial barrier function in cell monolayers derived from porcine ileum organoids Open
The gut microbiota produces numerous metabolites that influence the epithelial barrier function. Bacterial catabolism of amino acids produces a wide variety of metabolites whose effects on the intestinal epithelium remain to be fully ident…
View article: A single-cell atlas of transcriptome changes in the intestinal epithelium at the suckling-to-weaning transition
A single-cell atlas of transcriptome changes in the intestinal epithelium at the suckling-to-weaning transition Open
The suckling-to-weaning dietary transition is a key step in mammalian intestinal development. However, the relative contributions of genetically wired and nutritional factors in this maturation process remain to be elucidated. Moreover, th…
View article: Butyrate reduces epithelial barrier dysfunction induced by the foodborne mycotoxin deoxynivalenol in cell monolayers derived from pig jejunum organoids
Butyrate reduces epithelial barrier dysfunction induced by the foodborne mycotoxin deoxynivalenol in cell monolayers derived from pig jejunum organoids Open
The foodborne mycotoxin deoxynivalenol (DON) produced by Fusarium species threats animal and human health through disruption of the intestinal barrier. Targeting the gut microbiota and its products appears as a promising strategy to…
View article: A multi-omics dataset of the response to early plant polysaccharide ingestion in rabbits
A multi-omics dataset of the response to early plant polysaccharide ingestion in rabbits Open
View article: The transplantation of the gut microbiome of fat-1 mice protects against colonic mucus layer disruption and endoplasmic reticulum stress induced by high fat diet
The transplantation of the gut microbiome of fat-1 mice protects against colonic mucus layer disruption and endoplasmic reticulum stress induced by high fat diet Open
High-fat diets alter gut barrier integrity, leading to endotoxemia by impacting epithelial functions and inducing endoplasmic reticulum (ER) stress in intestinal secretory goblet cells. Indeed, ER stress, which is an important contributor …
View article: Coprophagia in early life tunes expression of immune genes after weaning in rabbit ileum
Coprophagia in early life tunes expression of immune genes after weaning in rabbit ileum Open
Coprophagia by suckling rabbits, i.e. ingestion of feces from their mother, reduces mortality after weaning. We hypothesized that this beneficial effect of coprophagia is immune-mediated at the intestinal level. Therefore, this study inves…
View article: La transcriptomique en cellule unique révèle les processus de maturation induits dans chaque type de cellule épithéliale intestinale lors de l'introduction de l'alimentation solide
La transcriptomique en cellule unique révèle les processus de maturation induits dans chaque type de cellule épithéliale intestinale lors de l'introduction de l'alimentation solide Open
International audience
View article: Effect of diet supplemented with functional amino acids and polyphenols on gut health in broilers subjected to a corticosterone-induced stress
Effect of diet supplemented with functional amino acids and polyphenols on gut health in broilers subjected to a corticosterone-induced stress Open
View article: L’introduction précoce d’aliment solide au début de la vie, une stratégie de pilotage du microbiote pour construire et préserver la santé du lapin
L’introduction précoce d’aliment solide au début de la vie, une stratégie de pilotage du microbiote pour construire et préserver la santé du lapin Open
En réponse aux enjeux de durabilité des filières animales, la filière cunicole française poursuit activement ses engagements de réduction de l’usage des antimicrobiens. Les antibiotiques en particulier sont généralement utilisés pour trait…
View article: Disruption of the primocolonizing microbiota alters epithelial homeostasis and imprints stem cells in the colon of neonatal piglets
Disruption of the primocolonizing microbiota alters epithelial homeostasis and imprints stem cells in the colon of neonatal piglets Open
The gut microbiota plays a key role in the postnatal development of the intestinal epithelium. However, the bacterial members of the primocolonizing microbiota driving these effects are not fully identified and the mechanisms underlying th…
View article: The Early Life Microbiota Is Not a Major Factor Underlying the Susceptibility to Postweaning Diarrhea in Piglets
The Early Life Microbiota Is Not a Major Factor Underlying the Susceptibility to Postweaning Diarrhea in Piglets Open
This study shows that the fecal microbiota composition and metabolic activity are similar in suckling piglets (13 days after birth) that either later develop post-weaning diarrhea (PWD) or not, which is a major threat for animal welfare th…
View article: VARIABILITE DE LA COMPOSITION EN OLIGOSACCHARIDES DU LAIT ET LIEN AVEC LA CARRIERE REPRODUCTIVE DES LAPINES ET LA VIABILITE DES LAPEREAUX AU SEVRAGE
VARIABILITE DE LA COMPOSITION EN OLIGOSACCHARIDES DU LAIT ET LIEN AVEC LA CARRIERE REPRODUCTIVE DES LAPINES ET LA VIABILITE DES LAPEREAUX AU SEVRAGE Open
International audience
View article: Une supplémentation en polyphenols module la maturation du microbiote et de l’épithélium intestinal lors de l'introduction de l'alimentation solide chez le lapin
Une supplémentation en polyphenols module la maturation du microbiote et de l’épithélium intestinal lors de l'introduction de l'alimentation solide chez le lapin Open
International audience
View article: Culture of Piglet Intestinal 3D Organoids from Cryopreserved Epithelial Crypts and Establishment of Cell Monolayers
Culture of Piglet Intestinal 3D Organoids from Cryopreserved Epithelial Crypts and Establishment of Cell Monolayers Open
Intestinal organoids are increasingly being used to study the gut epithelium for digestive disease modeling, or to investigate interactions with drugs, nutrients, metabolites, pathogens, and the microbiota. Methods to culture intestinal or…
View article: Selective nourishing of gut microbiota with amino acids: A novel prebiotic approach?
Selective nourishing of gut microbiota with amino acids: A novel prebiotic approach? Open
Prebiotics are dietary substrates which promote host health when utilized by desirable intestinal bacteria. The most commonly used prebiotics are non-digestible oligosaccharides but the prebiotic properties of other types of nutrients such…
View article: Divergent selection for feed efficiency in pigs altered the duodenum transcriptome and DNA methylation profiles, resulting in greater responses to feed intake in the most efficient line
Divergent selection for feed efficiency in pigs altered the duodenum transcriptome and DNA methylation profiles, resulting in greater responses to feed intake in the most efficient line Open
Feed efficiency is a trait of interest in pigs as it contributes to lowering the ecological and economical costs of pig production. A divergent genetic selection experiment from a Large White pig population was performed for 10 generations…
View article: The phenotype of the gut region is more stably retained than developmental stage in piglet intestinal organoids
The phenotype of the gut region is more stably retained than developmental stage in piglet intestinal organoids Open
Intestinal organoids are innovative in vitro tools to study the digestive epithelium. The objective of this study was to generate jejunum and colon organoids from suckling and weaned piglets in order to determine the extent to which organo…
View article: Single-Cell RNA-Sequencing
Single-Cell RNA-Sequencing Open
View article: P216. Transcriptomic and DNA methylation response to feed intake in the duodenum in high- and low-feed efficiency pig lines
P216. Transcriptomic and DNA methylation response to feed intake in the duodenum in high- and low-feed efficiency pig lines Open
View article: Developmental Stage, Solid Food Introduction, and Suckling Cessation Differentially Influence the Comaturation of the Gut Microbiota and Intestinal Epithelium in Rabbits
Developmental Stage, Solid Food Introduction, and Suckling Cessation Differentially Influence the Comaturation of the Gut Microbiota and Intestinal Epithelium in Rabbits Open
In rabbits, the maturation of the microbiota at the suckling-to-weaning transition is driven by the introduction of solid food and, to a lesser extent, by the developmental stage. In contrast, the maturation of the intestinal epithelium at…
View article: Stimulation of early solid feed ingestion in the nest accelerates the maturation of the rabbits caecal microbiota
Stimulation of early solid feed ingestion in the nest accelerates the maturation of the rabbits caecal microbiota Open
International audience
View article: Pathogen Challenge and Dietary Shift Alter Microbiota Composition and Activity in a Mucin-Associated in vitro Model of the Piglet Colon (MPigut-IVM) Simulating Weaning Transition
Pathogen Challenge and Dietary Shift Alter Microbiota Composition and Activity in a Mucin-Associated in vitro Model of the Piglet Colon (MPigut-IVM) Simulating Weaning Transition Open
Enterotoxigenic Escherichia coli (ETEC) is the principal pathogen responsible for post-weaning diarrhea in newly weaned piglets. Expansion of ETEC at weaning is thought to be the consequence of various stress factors such as transient anor…
View article: Weaning-associated feed deprivation stress causes microbiota disruptions in a novel mucin-containing in vitro model of the piglet colon (MPigut-IVM)
Weaning-associated feed deprivation stress causes microbiota disruptions in a novel mucin-containing in vitro model of the piglet colon (MPigut-IVM) Open
Background Risk factors for the etiology of post-weaning diarrhea, a major problem in swine industry associated with enormous economic losses, remain to be fully elucidated. In concordance with the ethical concerns raised by animal experim…
View article: A Collaborative Model to Implement Flexible, Accessible and Efficient Oncogenetic Services for Hereditary Breast and Ovarian Cancer: The C-MOnGene Study
A Collaborative Model to Implement Flexible, Accessible and Efficient Oncogenetic Services for Hereditary Breast and Ovarian Cancer: The C-MOnGene Study Open
Medical genetic services are facing an unprecedented demand for counseling and testing for hereditary breast and ovarian cancer (HBOC) in a context of limited resources. To help resolve this issue, a collaborative oncogenetic model was rec…
View article: Functional Amino Acids in Pigs and Chickens: Implication for Gut Health
Functional Amino Acids in Pigs and Chickens: Implication for Gut Health Open
In pigs and broiler chickens, the gastrointestinal tract or gut is subjected to many challenges which alter performance, animal health, welfare and livability. Preventive strategies are needed to mitigate the impacts of these challenges on…