Martin Bolin
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View article: In vivo quantification of [ <sup>11</sup> C]BIO-1819578 in non-human primates, a novel radioligand for O-GlcNAcase
In vivo quantification of [ <sup>11</sup> C]BIO-1819578 in non-human primates, a novel radioligand for O-GlcNAcase Open
Neurofibrillary tangles (NFTs), composed of aggregated tau protein, in the brain is a neuropathological hallmark and feature of Alzheimer’s disease (AD) and other tauopathies. One promising approach to prevent tau aggregates is to inhibit …
View article: Good Manufacturing Practice Validation and Radiation Dosimetry for the Clinical Application of a Novel α7-nAChR Radioligand: [11C]KIn83
Good Manufacturing Practice Validation and Radiation Dosimetry for the Clinical Application of a Novel α7-nAChR Radioligand: [11C]KIn83 Open
Nicotinic acetylcholine receptor (α7-nAChR) plays a crucial role in cognitive functions like memory and attention. Positron emission tomography (PET) imaging of α7-nAChR is gaining attraction for understanding and monitoring central nervou…
View article: NO DIFFERENCES IN SYNAPTIC DENSITY IN TWINS WITH AUTISM AND THEIR NON-AUTISTIC CO-TWINS. HOWEVER, ARE DIFFERENCES IN SV2A BINDING POTENTIAL IN AUTISTIC BRAINS A MATTER OF WHITE MATTER?
NO DIFFERENCES IN SYNAPTIC DENSITY IN TWINS WITH AUTISM AND THEIR NON-AUTISTIC CO-TWINS. HOWEVER, ARE DIFFERENCES IN SV2A BINDING POTENTIAL IN AUTISTIC BRAINS A MATTER OF WHITE MATTER? Open
Background Autism, a highly heritable psychiatric condition, is hypothesised believed to be associated with altered synaptic structure and function, as indicated by findings from genetic, post-mortem, and pre-clinical studies. Aims & Objec…
View article: Radiolabeling and Preliminary In Vivo Evaluation of the Candidate CCR2 Targeting PET Radioligand [11C]AZD2423
Radiolabeling and Preliminary In Vivo Evaluation of the Candidate CCR2 Targeting PET Radioligand [11C]AZD2423 Open
Background: AZD2423 is a high-affinity and selective negative allosteric modulator of the chemokine receptor type 2 (CCR2). This receptor plays important roles in the extravasation and transmigration of monocytes under inflammatory conditi…
Evaluating the effect of rapamycin treatment in Alzheimer's Disease and aging using<i>in vivo</i>imaging: the ERAP phase IIa clinical study protocol Open
Background Rapamycin is an inhibitor of the mechanistic target of rapamycin (mTOR) protein kinase, and pre-clinical data demonstrate that it is a promising candidate for a general gero- and neuroprotective treatment in humans. Results from…
View article: Development of a PET Tracer for OGA with Improved Kinetics in the Living Brain
Development of a PET Tracer for OGA with Improved Kinetics in the Living Brain Open
O-GlcNAcylation is thought to play a role in the development of tau pathology in Alzheimer's disease because of its ability to modulate tau's aggregation propensity. O-GlcNAcylation is regulated by 2 enzymes: O-GlcNAc transferase and O-Glc…
View article: Development of a Novel [<sup>11</sup>C]CO-Labeled Positron Emission Tomography Radioligand [<sup>11</sup>C]BIO-1819578 for the Detection of <i>O</i>-GlcNAcase Enzyme Activity
Development of a Novel [<sup>11</sup>C]CO-Labeled Positron Emission Tomography Radioligand [<sup>11</sup>C]BIO-1819578 for the Detection of <i>O</i>-GlcNAcase Enzyme Activity Open
Imaging O-GlcNAcase OGA by positron emission tomography (PET) could provide information on the pathophysiological pathway of neurodegenerative diseases and important information on drug-target engagement and be helpful in dose selection of…
View article: Proof of lung muscarinic receptor occupancy by tiotropium: Translational Positron Emission Tomography studies in non-human primates and humans
Proof of lung muscarinic receptor occupancy by tiotropium: Translational Positron Emission Tomography studies in non-human primates and humans Open
Introduction Molecular imaging has not been used to support the development of drugs for the treatment of pulmonary disorders. The aim of the present translational study was to advance quantitative pulmonary PET imaging by demonstrating oc…
View article: Lung muscarinic receptor occupancy by tiotropium: translational Positron Emission Tomography studies in non-human primates and humans
Lung muscarinic receptor occupancy by tiotropium: translational Positron Emission Tomography studies in non-human primates and humans Open
Purpose Molecular imaging has not been used to support the development of drugs for the treatment of pulmonary disorders. The aim of the present translational study was to advance quantitative pulmonary PET imaging by demonstrating occupan…
View article: Lung muscarinic receptor occupancy by tiotropium: translational PET studies in non-human primates and humans
Lung muscarinic receptor occupancy by tiotropium: translational PET studies in non-human primates and humans Open
Background The aim of the present translational PET study was to estimate occupancy of tiotropium at muscarinic acetylcholine receptors (mAChR) in the lungs in vivo . The relationship between the tiotropium exposure and receptor occupancy …
View article: PET imaging of beta-secretase 1 in the human brain: radiation dosimetry, quantification, and test-retest examination of [18F]PF-06684511
PET imaging of beta-secretase 1 in the human brain: radiation dosimetry, quantification, and test-retest examination of [18F]PF-06684511 Open
Purpose Beta-secretase 1 (BACE1) enzyme is implicated in the pathophysiology of Alzheimer’s disease. [ 18 F]PF-06684511 is a positron emission tomography (PET) radioligand for imaging BACE1. Despite favorable brain kinetic properties, the …