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View article: Variation in the Involvement of Hippocampal Pyramidal Cell Subtypes in Spatial Learning Tasks
Variation in the Involvement of Hippocampal Pyramidal Cell Subtypes in Spatial Learning Tasks Open
Hippocampal pyramidal cells are involved in spatial coding and memory formation. Recent evidence shows that they can be classified according to the origin of their axon, either emerging from the soma (non-AcD for “nonaxon-carrying dendrite…
View article: Diversity of axon initial segment geometry in the mouse hippocampus and its predicted influence on neuronal excitability
Diversity of axon initial segment geometry in the mouse hippocampus and its predicted influence on neuronal excitability Open
Action potentials, the primary information units of the nervous system, are usually generated at the axon initial segment. Changes in the length and position of the axon initial segment are associated with alterations in neuronal excitabil…
View article: A tactile discrimination task to study neuronal dynamics in freely-moving mice
A tactile discrimination task to study neuronal dynamics in freely-moving mice Open
View article: Syntalos: a software for precise synchronization of simultaneous multi-modal data acquisition and closed-loop interventions
Syntalos: a software for precise synchronization of simultaneous multi-modal data acquisition and closed-loop interventions Open
View article: Variability of axon initial segment geometry and its impact on hippocampal pyramidal cell function
Variability of axon initial segment geometry and its impact on hippocampal pyramidal cell function Open
Action potentials, the primary information units of the nervous system, are usually generated at the axon initial segment (AIS). Changes in the length and position of the AIS are associated with alterations in neuronal excitability but the…
View article: A tactile discrimination task to study neuronal dynamics in freely-moving mice
A tactile discrimination task to study neuronal dynamics in freely-moving mice Open
Sensory discrimination tasks are valuable tools to study neuronal mechanisms of perception and learning. Most discrimination tasks for electrophysiological and imaging studies in rodents require the animals to be head-fixed. However, imple…
View article: A dendrite is a dendrite is a dendrite? Dendritic signal integration beyond the “antenna” model
A dendrite is a dendrite is a dendrite? Dendritic signal integration beyond the “antenna” model Open
Neurons in central nervous systems receive multiple synaptic inputs and transform them into a largely standardized output to their target cells—the action potential. A simplified model posits that synaptic signals are integrated by linear …
View article: Biphasic Npas4 expression promotes inhibitory plasticity and suppression of fear memory consolidation in mice
Biphasic Npas4 expression promotes inhibitory plasticity and suppression of fear memory consolidation in mice Open
View article: Syntalos: A software for precise simultaneous multi-modal data acquisition and closed-loop interventions
Syntalos: A software for precise simultaneous multi-modal data acquisition and closed-loop interventions Open
Complex experimental protocols often require multi-modal data acquisition with precisely aligned timing, as well as state- and behavior-dependent interventions. Tailored solutions are mostly restricted to individual experimental setups and…
View article: Increased Interhemispheric Connectivity of a Distinct Type of Hippocampal Pyramidal Cells
Increased Interhemispheric Connectivity of a Distinct Type of Hippocampal Pyramidal Cells Open
Neurons typically generate action potentials at their axon initial segment based on the integration of synaptic inputs. In many neurons, the axon extends from the soma, equally weighting dendritic inputs. A notable exception is found in a …
View article: Biphasic Npas4 expression promotes inhibitory plasticity and suppression of fear memory consolidation in mice
Biphasic Npas4 expression promotes inhibitory plasticity and suppression of fear memory consolidation in mice Open
Long-term memories are believed to be encoded by unique transcriptional signatures in the brain. The expression of immediate early genes (IEG) promotes structural and molecular changes required for memory consolidation. Recent evidence has…
View article: Function follows form: how the structure of neurons determines cortical network activity
Function follows form: how the structure of neurons determines cortical network activity Open
View article: Enriched Environment Modulates Sharp Wave-Ripple (SPW-R) Activity in Hippocampal Slices
Enriched Environment Modulates Sharp Wave-Ripple (SPW-R) Activity in Hippocampal Slices Open
Behavioral flexibility depends on neuronal plasticity which forms and adapts the central nervous system in an experience-dependent manner. Thus, plasticity depends on interactions between the organism and its environment. A key experimenta…
View article: Transient Oxygen-Glucose Deprivation Causes Region- and Cell Type-Dependent Functional Deficits in the Mouse Hippocampus<i>In Vitro</i>
Transient Oxygen-Glucose Deprivation Causes Region- and Cell Type-Dependent Functional Deficits in the Mouse Hippocampus<i>In Vitro</i> Open
Neurons are highly vulnerable to conditions of hypoxia-ischemia (HI) such as stroke or transient ischemic attacks. Recovery of cognitive and behavioral functions requires re-emergence of coordinated network activity, which, in turn, relies…
View article: Author Correction: Voltage-independent GluN2A-type NMDA receptor Ca2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice
Author Correction: Voltage-independent GluN2A-type NMDA receptor Ca2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice Open
A Correction to this paper has been published: https://doi.org/10.1038/s42003-021-01717-x
View article: Voltage-independent GluN2A-type NMDA receptor Ca2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice
Voltage-independent GluN2A-type NMDA receptor Ca2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice Open
View article: Synchronicity of excitatory inputs drives hippocampal networks to distinct oscillatory patterns
Synchronicity of excitatory inputs drives hippocampal networks to distinct oscillatory patterns Open
The rodent hippocampus expresses a variety of neuronal network oscillations depending on the behavioral state of the animal. Locomotion and active exploration are accompanied by theta‐nested gamma oscillations while resting states and slow…
View article: Mild metabolic stress is sufficient to disturb the formation of pyramidal cell ensembles during gamma oscillations
Mild metabolic stress is sufficient to disturb the formation of pyramidal cell ensembles during gamma oscillations Open
Disturbances of cognitive functions occur rapidly during acute metabolic stress. However, the underlying mechanisms are not fully understood. Cortical gamma oscillations (30–100 Hz) emerging from precise synaptic transmission between excit…
View article: Local oxygen homeostasis during various neuronal network activity states in the mouse hippocampus
Local oxygen homeostasis during various neuronal network activity states in the mouse hippocampus Open
Cortical information processing comprises various activity states emerging from timed synaptic excitation and inhibition. However, the underlying energy metabolism is widely unknown. We determined the cerebral metabolic rate of oxygen (CMR…
View article: Heteromeric channels formed by <scp>TRPC</scp> 1, <scp>TRPC</scp> 4 and <scp>TRPC</scp> 5 define hippocampal synaptic transmission and working memory
Heteromeric channels formed by <span>TRPC</span> 1, <span>TRPC</span> 4 and <span>TRPC</span> 5 define hippocampal synaptic transmission and working memory Open
View article: Amyloid Precursor Protein Protects Neuronal Network Function after Hypoxia via Control of Voltage-Gated Calcium Channels
Amyloid Precursor Protein Protects Neuronal Network Function after Hypoxia via Control of Voltage-Gated Calcium Channels Open
Amyloid precursor protein (APP) is involved in the pathophysiology of Alzheimer's disease, but its normal function in the brain remains elusive. Here, we describe a neuroprotective role of the protein in acute hypoxia. Functional recovery …
View article: Activity-dependent plasticity of mouse hippocampal assemblies in vitro
Activity-dependent plasticity of mouse hippocampal assemblies in vitro Open
Memory formation is associated with the generation of transiently stable neuronal assemblies. In hippocampal networks, such groups of functionally coupled neurons express highly ordered spatiotemporal activity patterns which are coordinate…