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View article: Spatially distributed circumferential strain measurement in an artificial spinal disc using fibre Bragg gratings
Spatially distributed circumferential strain measurement in an artificial spinal disc using fibre Bragg gratings Open
Artificial disc replacements (ADRs) are orthopaedic implants designed to replace degenerated intervertebral discs, a common aetiology of chronic back pain. ADRs which emulate the biomechanics of the natural disc promote the natural physiol…
View article: Geometric constraint of mechanosensing by modification of hydrogel thickness prevents stiffness-induced differentiation in bone marrow stromal cells
Geometric constraint of mechanosensing by modification of hydrogel thickness prevents stiffness-induced differentiation in bone marrow stromal cells Open
Extracellular matrix (ECM) stiffness is fundamental in cell division, movement and differentiation. The stiffness that cells sense is determined not only by the elastic modulus of the ECM material but also by ECM geometry and cell density.…
View article: OpenHands: An Open-Source Statistical Shape Model of the Finger Bones
OpenHands: An Open-Source Statistical Shape Model of the Finger Bones Open
This paper presents statistical shape models of the four fingers of the hand, with an emphasis on anatomic analysis of the proximal and distal interphalangeal joints. A multi-body statistical shape modelling pipeline was implemented on an …
View article: Depth profiling via nanoindentation for characterisation of the elastic modulus and hydraulic properties of thin hydrogel layers
Depth profiling via nanoindentation for characterisation of the elastic modulus and hydraulic properties of thin hydrogel layers Open
The accurate determination of the mechanical properties of hydrogels is of fundamental importance for a range of applications, including in assessing the effect of stiffness on cell behaviour. This is a particular issue when using thin hyd…
View article: Geometric constraint of mechanosensing in bone marrow stromal cell cultures prevents stiffness-induced differentiation
Geometric constraint of mechanosensing in bone marrow stromal cell cultures prevents stiffness-induced differentiation Open
Extracellular matrix (ECM) stiffness is fundamental in cell division, movement and differentiation. The stiffness that cells sense is determined not only by the elastic modulus of the ECM material, but also by ECM geometry and cell density…
View article: Mechanical and tribological characterisations of PEG-based hydrogel coatings on XLPE surfaces
Mechanical and tribological characterisations of PEG-based hydrogel coatings on XLPE surfaces Open
Hydrophilic hydrogel coatings can impart enhanced tribological and antifouling properties to biomedical device surfaces. The influence of crosslinking on the elastic moduli of poly (ethylene glycol) (PEG) hydrogels is well established, how…
View article: Measuring the elastic modulus of soft biomaterials using nanoindentation
Measuring the elastic modulus of soft biomaterials using nanoindentation Open
The measurement of the elastic modulus of soft biomaterials via nanoindentation relies on the accurate determination of the zero-point of the tip-sample interaction on which the depth of penetration into the sample is based. Non-cantilever…
View article: Decreased stress shielding with a PEEK femoral total knee prosthesis measured in validated computational models
Decreased stress shielding with a PEEK femoral total knee prosthesis measured in validated computational models Open
Due to their high stiffness, metal femoral implants in total knee arthroplasty may cause stress shielding of the peri-prosthetic bone, which can lead to loss of bone stock. Using a polymer (PEEK) femoral implant reduces the stiffness misma…
View article: Key considerations for finite element modelling of the residuum–prosthetic socket interface
Key considerations for finite element modelling of the residuum–prosthetic socket interface Open
Background: Finite element modelling has long been proposed to support prosthetic socket design. However, there is minimal detail in the literature to inform practice in developing and interpreting these complex, highly nonlinear models. O…
View article: Measurement of Internal Implantation Strains in Analogue Bone Using DVC
Measurement of Internal Implantation Strains in Analogue Bone Using DVC Open
The survivorship of cementless orthopaedic implants may be related to their initial stability; insufficient press-fit can lead to excessive micromotion between the implant and bone, joint pain, and surgical revision. However, too much inte…
View article: Developing an Analogue Residual Limb for Comparative DVC Analysis of Transtibial Prosthetic Socket Designs
Developing an Analogue Residual Limb for Comparative DVC Analysis of Transtibial Prosthetic Socket Designs Open
Personalised prosthetic sockets are fabricated by expert clinicians in a skill- and experience-based process, with research providing tools to support evidence-based practice. We propose that digital volume correlation (DVC) may offer a de…
View article: Key considerations for finite element modelling of the residuum-prosthetic socket interface
Key considerations for finite element modelling of the residuum-prosthetic socket interface Open
Study Design: Computational modellingBackground: Finite element (FE) modelling has long been proposed to support the design of prosthetics sockets. However, there is minimal detail in the literature to inform practice in developing and int…
View article: Predictive prosthetic socket design: part 2—generating person-specific candidate designs using multi-objective genetic algorithms
Predictive prosthetic socket design: part 2—generating person-specific candidate designs using multi-objective genetic algorithms Open
In post-amputation rehabilitation, a common goal is to return to ambulation using a prosthetic limb, suspended by a customised socket. Prosthetic socket design aims to optimise load transfer between the residual limb and mechanical limb, b…
View article: Characterising the compressive anisotropic properties of analogue bone using optical strain measurement
Characterising the compressive anisotropic properties of analogue bone using optical strain measurement Open
The validity of conclusions drawn from pre-clinical tests on orthopaedic devices depends upon accurate characterisation of the support materials: frequently, polymer foam analogues. These materials often display anisotropic mechanical beha…
View article: Dataset for paper "Predictive Prosthetic Socket Design: Part 1âpopulation-based evaluation of transtibial prosthetic sockets by FEA-driven Surrogate Modelling"
Dataset for paper "Predictive Prosthetic Socket Design: Part 1âpopulation-based evaluation of transtibial prosthetic sockets by FEA-driven Surrogate Modelling" Open
This is a dataset for the publication "Predictive Prosthetic Socket Design: Part 1—population-based evaluation of transtibial prosthetic sockets by FEA-driven Surrogate Modelling". A readme is supplied to assist with opening the data file,…
View article: Dataset for paper "Predictive Prosthetic Socket Design: Part 2â generating person-specific candidate designs using multi-objective Genetic Algorithms"
Dataset for paper "Predictive Prosthetic Socket Design: Part 2â generating person-specific candidate designs using multi-objective Genetic Algorithms" Open
This is a dataset for the publication "Predictive Prosthetic Socket Design: Part 2— generating person-specific candidate designs using multi-objective Genetic Algorithms" in Biomechanics and Modeling in Mechanobiology. A readme is supplied…
View article: Dataset for Paper 'The potential of statistical shape modelling for geometric morphometric analysis of human teeth in archaeological research'
Dataset for Paper 'The potential of statistical shape modelling for geometric morphometric analysis of human teeth in archaeological research' Open
Dataset corresponding to evidence presented in journal paper: Woods, C. et al (2017). The potential of statistical shape modelling for geometric morphometric analysis of human teeth in archaeological research. PLoS ONE.#Dataset also relate…
View article: Image-based high strain rate testing of orthopaedic bone cement
Image-based high strain rate testing of orthopaedic bone cement Open
Bone cement is widely used for the fixation of orthopaedic implants. It is a multi-component material that consists of a PMMA base with a small proportion of (usually ceramic) radiopacifier to enable the cement to be observed by X-ray. Bon…
View article: The role of microconstituents on the fatigue failure of bone cement
The role of microconstituents on the fatigue failure of bone cement Open
Implant fixation via the use of acrylic bone cement is now a well-established practice in orthopaedics. Excellent long-term clinical results are evidenced in national joint registers based on over 5 decades of clinical experience. Increase…
View article: The potential of statistical shape modelling for geometric morphometric analysis of human teeth in archaeological research
The potential of statistical shape modelling for geometric morphometric analysis of human teeth in archaeological research Open
This paper introduces statistical shape modelling (SSM) for use in osteoarchaeology research. SSM is a full field, multi-material analytical technique, and is presented as a supplementary geometric morphometric (GM) tool. Lower mandibular …
View article: Assessing the Effect of Unicondylar Knee Arthroplasty on Proximal Tibia Bone Strains Using Digital Image Correlation
Assessing the Effect of Unicondylar Knee Arthroplasty on Proximal Tibia Bone Strains Using Digital Image Correlation Open
In order to develop computational models of implanted constructs to predict prosthesis performance, robust experimental tests need to be devised.In the case of unicondylar knee arthroplasty (UKA), where uptake of the procedure has been rel…
View article: Dataset for publication "Characterising the compressive anisotropic properties of analogue bone using optical strain measurement"
Dataset for publication "Characterising the compressive anisotropic properties of analogue bone using optical strain measurement" Open
These are the raw data behind the mean, range and standard deviation summaries presented in the main manuscript of this publication.
View article: IgM multiple myeloma with an extremely rare non-aggressive presentation: A case report
IgM multiple myeloma with an extremely rare non-aggressive presentation: A case report Open
In the present study, the case of a 41-year-old man with immunoglobulin (Ig)M multiple myeloma (MM) that presented with an unusually non-aggressive clinical course who has survived for >9 years to date, is presented. Initial diagnosis of s…
View article: Damage mechanisms at the cement-implant interface of polished cemented femoral stems
Damage mechanisms at the cement-implant interface of polished cemented femoral stems Open
The occurrence of damage on polished femoral stems has been widely reported in the literature, and bone cement has been implicated in a tribocorrosive failure process. However, the mechanisms of cement-mediated damage and the impact of cem…