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View article: Endurance Exercise Attenuates Plasma Level of Neurofilament Light Chain and Prevents Body Weight Loss in a Rat Model of Tauopathy
Endurance Exercise Attenuates Plasma Level of Neurofilament Light Chain and Prevents Body Weight Loss in a Rat Model of Tauopathy Open
Although its effectiveness and underlying mechanisms are not fully understood, regular physical exercise (PE) is a potential low-cost strategy to prevent or delay neurodegeneration. Plasma neurofilament light chain (NfL), an established bi…
View article: Angiotensin I and II Stimulate Cell Invasion of SARS-CoV-2: Potential Mechanism via Inhibition of ACE2 Arm of RAS
Angiotensin I and II Stimulate Cell Invasion of SARS-CoV-2: Potential Mechanism via Inhibition of ACE2 Arm of RAS Open
Angiotensin-converting enzyme 2 (ACE2), one of the key enzymes of the renin-angiotensin system (RAS), plays an important role in SARS-CoV-2 infection by functioning as a virus receptor. Angiotensin peptides Ang I and Ang II, the substrates…
View article: Rickettsia Deregulates Genes Coding for the Neurotoxic Cell Response Pathways in Cerebrocortical Neurons In Vitro
Rickettsia Deregulates Genes Coding for the Neurotoxic Cell Response Pathways in Cerebrocortical Neurons In Vitro Open
Rickettsial infections of the central nervous system (CNS) are manifested by severe neurological symptoms and represent a serious life-threatening condition. Despite the considerable health danger, only a few studies have been conducted fo…
View article: Association of Nonconcussive Repetitive Head Impacts and Intense Physical Activity With Levels of Phosphorylated Tau<sub>181</sub> and Total Tau in Plasma of Young Elite Soccer Players
Association of Nonconcussive Repetitive Head Impacts and Intense Physical Activity With Levels of Phosphorylated Tau<sub>181</sub> and Total Tau in Plasma of Young Elite Soccer Players Open
Importance Head impacts resulting in traumatic brain injury (TBI) lead to the elevation of phosphorylated tau protein (p-tau 181 ) in plasma. To our knowledge, this study is the first to investigate dynamics of p-tau 181 levels and the rat…
View article: Non-concussive Repetitive Head Impacts and Intense Physical Activity Elevate pT181-Tau and pT181/total-Tau in Plasma of Young Adults
Non-concussive Repetitive Head Impacts and Intense Physical Activity Elevate pT181-Tau and pT181/total-Tau in Plasma of Young Adults Open
IMPORTANCE Head impacts resulting in traumatic brain injury (TBI) lead to elevation of phosphorylated tau protein in plasma, the biomarkers for patients with acute and chronic TBI. Dynamics of phosphorylated tau protein level (pTau) and ra…
View article: Changes in circulating microRNAs following head impacts in soccer
Changes in circulating microRNAs following head impacts in soccer Open
To explore the short-term effects of accidental head impacts and repetitive headers on circulating microRNAs, accounting for the effects of high-intensity exercise alone. Blood samples were collected from professional soccer players at res…
View article: 015 Biomarkers in serum after head impact exposure in football
015 Biomarkers in serum after head impact exposure in football Open
Background The link between head-impact exposure in football and neurological sequelae remains controversial. Blood-based biomarkers can provide valuable information in traumatic brain injuries, reflecting e.g. axonal damage. Objective To …
View article: Transcriptomic signature of Alzheimer’s disease tau seed-induced pathology
Transcriptomic signature of Alzheimer’s disease tau seed-induced pathology Open
Spreading of tau pathology to anatomical distinct regions in Alzheimer's disease (AD) is associated with progression of the disease. Studies in recent decade have strived to understand the processes involved in this characteristic spread. …
View article: Hypertension does not alter disturbances in leptin signalling observed in experimental model of tauopathy
Hypertension does not alter disturbances in leptin signalling observed in experimental model of tauopathy Open
Neurodegeneration is associated with hypertension and disturbance in fat metabolism. The complex interaction of neurodegenerative processes with both metabolic changes and blood pressure is still not fully elucidated. Here we demonstrate t…
View article: Head impacts in youth national hockey leagues in Slovakia: a retrospective analysis of four seasons
Head impacts in youth national hockey leagues in Slovakia: a retrospective analysis of four seasons Open
Traumatic brain injury in contact sports can lead to serious health consequences either immediately or later in the life of injured subjects. The objective of this study was to estimate the incidence of head impacts in the Under 18 (U18) a…
View article: Peripheral microRNA alteration and pathway signaling after mild traumatic brain injur
Peripheral microRNA alteration and pathway signaling after mild traumatic brain injur Open
Discovering novel diagnostic biomarkers and signatures for traumatic brain injury (TBI) represents a major challenge in the brain trauma research. Detailed analysis of post-concussive molecular pathways based on experimental data could pro…
View article: Poster Filip Humenik fin.pdf
Poster Filip Humenik fin.pdf Open
Adult stem cells have become prominent candidates for treating various diseases in veterinary practice. The main goal of our study was therefore to provide a comprehensive study of canine bone marrow-derived mesenchymal stem cells (BMMSC) …
View article: Canine Bone Marrow-derived Mesenchymal Stem Cells: Genomics, Proteomics and Functional Analyses of Paracrine Factors
Canine Bone Marrow-derived Mesenchymal Stem Cells: Genomics, Proteomics and Functional Analyses of Paracrine Factors Open
Adult stem cells have become prominent candidates for treating various diseases in veterinary practice. The main goal of our study was therefore to provide a comprehensive study of canine bone marrow-derived mesenchymal stem cells (BMMSC) …
View article: Trafficking of immune cells across the blood-brain barrier is modulated by neurofibrillary pathology in tauopathies
Trafficking of immune cells across the blood-brain barrier is modulated by neurofibrillary pathology in tauopathies Open
Tauopathies represent a heterogeneous group of neurodegenerative disorders characterized by abnormal deposition of the hyperphosphorylated microtubule-associated protein tau. Chronic neuroinflammation in tauopathies is driven by glial cell…
View article: miRNAs as biofluid markers for diagnostics of Alzheimer’s disease: recent status and perspectives
miRNAs as biofluid markers for diagnostics of Alzheimer’s disease: recent status and perspectives Open
After many decades of research in the field of neurodegeneration, we have no effective cure for Alzheimer's disease (AD), a major form of dementia. It is mainly due to the lack of early, reliable and sensitive biomarkers and incomplete und…
View article: Tau hyperphosphorylation in synaptosomes and neuroinflammation are associated with canine cognitive impairment
Tau hyperphosphorylation in synaptosomes and neuroinflammation are associated with canine cognitive impairment Open
Canine cognitive impairment syndrome (CDS) represents a group of symptoms related to the aging of the canine brain. These changes ultimately lead to a decline of memory function and learning abilities, alteration of social interaction, imp…