Martin Cramer Pedersen
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View article: Anti-hyperuniform critical states of active topological defects
Anti-hyperuniform critical states of active topological defects Open
Topological defects are fundamental to the collective dynamics of non-equilibrium systems and in active matter, mediating spontaneous flows, dynamic self-organization, and emergent pattern formation. Here, we reveal critical states in acti…
View article: Beyond Dipolar Activity: Quadrupolar Stress Drives Collapse of Nematic Order on Frictional Substrates
Beyond Dipolar Activity: Quadrupolar Stress Drives Collapse of Nematic Order on Frictional Substrates Open
The field of active nematics has traditionally employed descriptions based on dipolar activity, with interactions that align along a single axis. However, it has been theoretically predicted that interactions with a substrate, prevalent in…
View article: Active particles knead three-dimensional gels into open crumbs
Active particles knead three-dimensional gels into open crumbs Open
Colloidal gels are prime examples of functional materials exhibiting disordered, amorphous, yet meta-stable forms. They maintain stability through short-range attractive forces and their material properties are tunable by external forces. …
View article: Structural characterisation of α-synuclein-membrane interactions and the resulting aggregation using small angle scattering
Structural characterisation of α-synuclein-membrane interactions and the resulting aggregation using small angle scattering Open
The presence of amyloid fibrils is a hallmark of several neurodegenerative diseases. Some amyloidogenic proteins, such as α-synuclein and amyloid β, can interact with lipids, and this interaction can strongly favor the formation of amyloid…
View article: Shape2SAS -- a web application to simulate small-angle scattering data and pair distance distributions from user-defined shapes
Shape2SAS -- a web application to simulate small-angle scattering data and pair distance distributions from user-defined shapes Open
Shape2SAS is a web application that allows researchers and students to build intuition and understanding of small-angle scattering. It is available at https://somo.chem.utk.edu/shape2sas. The user defines a model of arbitrary shape by comb…
View article: Refining structural models of membrane proteins with disordered domains in phospholipid nanodiscs
Refining structural models of membrane proteins with disordered domains in phospholipid nanodiscs Open
Small-angle scattering can be used to derive structural information about membrane proteins reconstituted in suitable carrier systems enabling solubilization of the membrane proteins in question. Since the studies are done in solution, the…
View article: Author response: Mg2+-dependent conformational equilibria in CorA and an integrated view on transport regulation
Author response: Mg2+-dependent conformational equilibria in CorA and an integrated view on transport regulation Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract The CorA family of proteins reg…
View article: Mg <sup>2+</sup> -dependent conformational equilibria in CorA: an integrated view on transport regulation
Mg <sup>2+</sup> -dependent conformational equilibria in CorA: an integrated view on transport regulation Open
The CorA family of proteins regulates the homeostasis of divalent metal ions in many bacteria, archaea, and eukaryotic mitochondria, making it an important target in the investigation of the mechanisms of transport and its functional regul…
View article: Schwarzites.arc from Schwarzite nets: a wealth of 3-valent examples sharing similar topologies and symmetries
Schwarzites.arc from Schwarzite nets: a wealth of 3-valent examples sharing similar topologies and symmetries Open
Systre keys for all of the presented structures in archive format
View article: Supplementary material from "Schwarzite nets: a wealth of 3-valent examples sharing similar topologies and symmetries"
Supplementary material from "Schwarzite nets: a wealth of 3-valent examples sharing similar topologies and symmetries" Open
We enumerate trivalent reticulations of two- and three-periodic hyperbolic surfaces by equal-sided n-gonal faces, (n, 3), where n = 7, 8, 9, 10, 12. These are the simplest hyperbolic generalizations of the planar graphene net, (6, 3) and d…
View article: Experimental noise in small-angle scattering can be assessed and corrected using the Bayesian Indirect Fourier Transformation
Experimental noise in small-angle scattering can be assessed and corrected using the Bayesian Indirect Fourier Transformation Open
Small-angle X-ray and neutron scattering are widely used to investigate soft matter and biophysical systems. The experimental errors are essential when assessing how well a hypothesized model fits the data. Likewise, they are important whe…
View article: Experimental noise in small-angle scattering can be assessed using the Bayesian indirect Fourier transformation
Experimental noise in small-angle scattering can be assessed using the Bayesian indirect Fourier transformation Open
Small-angle X-ray and neutron scattering are widely used to investigate soft matter and biophysical systems. The experimental errors are essential when assessing how well a hypothesized model fits the data. Likewise, they are important whe…
View article: Order and disorder – an integrative structure of the full-length human growth hormone receptor
Order and disorder – an integrative structure of the full-length human growth hormone receptor Open
Despite the many physiological and pathophysiological functions of the human growth hormone receptor (hGHR), a detailed understanding of its modus operandi is hindered by the lack of structural information of the entire receptor at the mol…
View article: PSX: Protein-Solvent Exchange - Software for calculation of deuterium-exchange effects in SANS measurements from protein coordinates
PSX: Protein-Solvent Exchange - Software for calculation of deuterium-exchange effects in SANS measurements from protein coordinates Open
Recent developments in neutron scattering instrumentation and sample handling have enabled studies of more complex biological samples and measurements at shorter exposure times. The experiments are typically conducted in D 2 O-based buffer…
View article: Three-dimensional Euclidean crystallography and hyperbolic orbifolds
Three-dimensional Euclidean crystallography and hyperbolic orbifolds Open
Point and plane groups characterise isometries of the two-dimensional sphere and flat plane.Two-dimensional orbifolds afford a useful unifying concept to include also the third two-dimensional geometry: hyperbolic.For example, the same dec…
View article: Invisible detergents for structure determination of membrane proteins by small‐angle neutron scattering
Invisible detergents for structure determination of membrane proteins by small‐angle neutron scattering Open
A novel and generally applicable method for determining structures of membrane proteins in solution via small‐angle neutron scattering (SANS) is presented. Common detergents for solubilizing membrane proteins were synthesized in isotope‐su…
View article: PET/CT Based In Vivo Evaluation of 64Cu Labelled Nanodiscs in Tumor Bearing Mice
PET/CT Based In Vivo Evaluation of 64Cu Labelled Nanodiscs in Tumor Bearing Mice Open
64Cu radiolabelled nanodiscs based on the 11 α-helix MSP1E3D1 protein and 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylcholine lipids were, for the first time, followed in vivo by positron emission tomography for evaluating the biodistrib…
View article: Small-Angle X-Ray Scattering of the Cholesterol Incorporation into Human ApoA1-POPC Discoidal Particles
Small-Angle X-Ray Scattering of the Cholesterol Incorporation into Human ApoA1-POPC Discoidal Particles Open