Martin Dedicoat
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View article: Previously treated latent tuberculosis infection is associated with less severe acute COVID-19: a cohort study
Previously treated latent tuberculosis infection is associated with less severe acute COVID-19: a cohort study Open
Introduction There is significant potential for respiratory infections, such as tuberculosis (TB) and COVID-19, to overlap but little is known about such co-infection. We aimed to study the impact of active TB and latent TB on the incidenc…
View article: Screening for latent tuberculosis infection in patients with chronic kidney disease: a review of evidence and current practice in the UK
Screening for latent tuberculosis infection in patients with chronic kidney disease: a review of evidence and current practice in the UK Open
Tuberculosis (TB) and Chronic Kidney disease (CKD) represent an extant local and global syndemic, with TB incidence rates in the UK end-stage renal failure population far surpassing those of the general population in endemic countries. Pat…
View article: Differential control of mycobacterial growth ex vivo by COVID-19 patients is associated with CD8+ CD28+ T cells
Differential control of mycobacterial growth ex vivo by COVID-19 patients is associated with CD8+ CD28+ T cells Open
Diseases caused by SARS-CoV-2 and Mycobacterium tuberculosis (M.tb) represent two public health emergencies. In severe presentations of disease, both pathogens may share a biological niche in the lower respiratory tract. There is significa…
View article: A micro-costing of latent tuberculosis infection testing and treatment in adults in secondary care in England
A micro-costing of latent tuberculosis infection testing and treatment in adults in secondary care in England Open
Background Latent TB infection (LTBI) screening and treatment of population groups at high risk for TB is part of England’s Tuberculosis Action Plan, which has succeeded in increasing testing volumes. However, analysis of the cost-effectiv…
View article: Differential control of mycobacteria among COVID-19 patients is associated with CD28+ CD8+ T cells
Differential control of mycobacteria among COVID-19 patients is associated with CD28+ CD8+ T cells Open
Diseases caused by SARS-CoV-2 and Mycobacterium tuberculosis ( M.tb ) represent two public health emergencies. In severe disease, both pathogens may share a biological niche in the lower respiratory tract. There is significant potential fo…
View article: First use of Bedaquiline, Linezolid, and Pretomanid (BPaL) in a family cluster of multi-drug resistant (MDR) TB infection.
First use of Bedaquiline, Linezolid, and Pretomanid (BPaL) in a family cluster of multi-drug resistant (MDR) TB infection. Open
View article: Population-Level Frequency of Fluoroquinolone Resistance by Whole-Genome Sequencing Drug Predictions in <i>Mycobacterium tuberculosis</i> Complex Isolates in England From 2017 Through 2023
Population-Level Frequency of Fluoroquinolone Resistance by Whole-Genome Sequencing Drug Predictions in <i>Mycobacterium tuberculosis</i> Complex Isolates in England From 2017 Through 2023 Open
Fluoroquinolones are increasingly important for anti-tuberculosis (TB) treatment. Identifying fluoroquinolone resistance (FR) is essential. Using sequencing data from over 16 000 unselected isolates, this first English survey of FR, found …
View article: Drug-resistant tuberculosis treatments, the case for a phase III platform trial
Drug-resistant tuberculosis treatments, the case for a phase III platform trial Open
Most phase III trials in drug-resistant tuberculosis have either been underpowered to quantify differences in microbiological endpoints or have taken up to a decade to complete. Composite primary endpoints, dominated by differences in trea…
View article: Correction: The effect of M. tuberculosis lineage on clinical phenotype
Correction: The effect of M. tuberculosis lineage on clinical phenotype Open
[This corrects the article DOI: 10.1371/journal.pgph.0001788.].
View article: Disseminated <i>Mycobacterium abscessus</i> with endocarditis
Disseminated <i>Mycobacterium abscessus</i> with endocarditis Open
We present an uncommon case of endocarditis caused by Mycobacterium abscessus in an immunocompetent patient following a caesarean section. We discuss her turbulent admission course leading to her diagnosis following persistent M. abscessus…
View article: IgG glycosylation associates with risk of progression from latent to active tuberculosis
IgG glycosylation associates with risk of progression from latent to active tuberculosis Open
View article: Extrapulmonary nontuberculous mycobacterial infections: a guide for the general physician
Extrapulmonary nontuberculous mycobacterial infections: a guide for the general physician Open
View article: The effect of M. tuberculosis lineage on clinical phenotype
The effect of M. tuberculosis lineage on clinical phenotype Open
Six lineages of Mycobacterium tuberculosis sensu stricto (which excludes M . africanum) are described. Single-country or small observational data suggest differences in clinical phenotype between lineages. We present strain lineage and cli…
View article: Outcomes of TB contact tracing and predictors of success: a 10-year retrospective cohort analysis in Birmingham, UK
Outcomes of TB contact tracing and predictors of success: a 10-year retrospective cohort analysis in Birmingham, UK Open
BACKGROUND: Contacts of TB cases in Birmingham and Solihull, UK, are offered screening for TB infection. Between 1990 and 2010, only 59.1% of contacts completed screening. The service has since increased screening staff numbers, changed sc…
View article: Vulnerability and tuberculosis treatment outcomes in urban settings in England: A mixed-methods study
Vulnerability and tuberculosis treatment outcomes in urban settings in England: A mixed-methods study Open
Background Evidence on factors contributing to poor treatment outcome and healthcare priorities in vulnerable populations affected by tuberculosis (TB) in urban areas of England other than London is needed to inform setting-specific preven…
View article: Clinical standards for the management of adverse effects during treatment for TB
Clinical standards for the management of adverse effects during treatment for TB Open
BACKGROUND: Adverse effects (AE) to TB treatment cause morbidity, mortality and treatment interruption. The aim of these clinical standards is to encourage best practise for the diagnosis and management of AE. METHODS: 65/81 invited expert…
View article: Impact of COVID-19 on NHS tuberculosis services: Results of a UK-wide survey
Impact of COVID-19 on NHS tuberculosis services: Results of a UK-wide survey Open
View article: The effect of<i>M. tuberculosis</i>lineage on clinical phenotype
The effect of<i>M. tuberculosis</i>lineage on clinical phenotype Open
Eight lineages of Mycobacterium tuberculosis sensu stricto are described. Single-country or small observational data suggest differences in clinical phenotype between lineages. We present strain lineage and clinical phenotype data from 12,…
View article: Challenges to Delivering Tuberculosis Care in Urban Settings in England: A Qualitative Study
Challenges to Delivering Tuberculosis Care in Urban Settings in England: A Qualitative Study Open
View article: Peritoneal dialysis associated non tuberculous mycobacterial peritonitis at a tertiary care hospital in the UK
Peritoneal dialysis associated non tuberculous mycobacterial peritonitis at a tertiary care hospital in the UK Open
Background: Peritonitis remains a significant cause of peritoneal dialysis (PD)-associated morbidity, and technique failure. Non-tuberculous mycobacteria (NTM), commonly found in the environment (soil and water sources), are a rare cause o…
View article: 2 Tuberculosis-associated immune reconstitution inflammatory syndrome management
2 Tuberculosis-associated immune reconstitution inflammatory syndrome management Open
View article: 3 Outcomes of Tuberculosis contact tracing and predictors of success: a 10-year retrospective cohort analysis
3 Outcomes of Tuberculosis contact tracing and predictors of success: a 10-year retrospective cohort analysis Open
View article: Clinical standards for drug-susceptible pulmonary TB
Clinical standards for drug-susceptible pulmonary TB Open
BACKGROUND: The aim of these clinical standards is to provide guidance on ‘best practice´ for diagnosis, treatment and management of drug-susceptible pulmonary TB (PTB). METHODS: A panel of 54 global experts in the field of TB care, public…
View article: Mycobacterium tuberculosis transmission in Birmingham, UK, 2009–19: An observational study
Mycobacterium tuberculosis transmission in Birmingham, UK, 2009–19: An observational study Open
Wellcome Trust, MRC, UKHSA.
View article: Host Immune-Metabolic Adaptations Upon Mycobacterial Infections and Associated Co-Morbidities
Host Immune-Metabolic Adaptations Upon Mycobacterial Infections and Associated Co-Morbidities Open
Mycobacterial diseases are a major public health challenge. Their causative agents include, in order of impact, members of the Mycobacterium tuberculosis complex (causing tuberculosis), Mycobacterium leprae (causing leprosy), and non-tuber…
View article: Distinct blood transcriptomic signature of treatment in latent tuberculosis infected individuals at risk of developing active disease
Distinct blood transcriptomic signature of treatment in latent tuberculosis infected individuals at risk of developing active disease Open
View article: Phase I Trial Evaluating the Safety and Immunogenicity of Candidate TB Vaccine MVA85A, Delivered by Aerosol to Healthy M.tb-Infected Adults
Phase I Trial Evaluating the Safety and Immunogenicity of Candidate TB Vaccine MVA85A, Delivered by Aerosol to Healthy M.tb-Infected Adults Open
The immunogenicity of the candidate tuberculosis (TB) vaccine MVA85A may be enhanced by aerosol delivery. Intradermal administration was shown to be safe in adults with latent TB infection (LTBI), but data are lacking for aerosol-delivered…
View article: Prosthetic hip joint infection by Bacillus Calmette-Guerin therapy following intravesical instillation for bladder cancer identified using whole-genome sequencing: a case report
Prosthetic hip joint infection by Bacillus Calmette-Guerin therapy following intravesical instillation for bladder cancer identified using whole-genome sequencing: a case report Open
View article: Donor acquired visceral leishmaniasis following liver transplantation
Donor acquired visceral leishmaniasis following liver transplantation Open
Patients who undergo solid organ transplantation are at risk of opportunistic infection associated with immunosuppression. We report a case of confirmed donor derived visceral leishmaniasis (VL), in a patient following liver transplantatio…
View article: Mycobacterium Tuberculosis Transmission in Birmingham, UK, 2009-19: A Prospective Observational Study
Mycobacterium Tuberculosis Transmission in Birmingham, UK, 2009-19: A Prospective Observational Study Open