Matthias Egger
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View article: The effect of long-acting cabotegravir and rilpivirine treatment on drug resistance in South Africa: a modelling study
The effect of long-acting cabotegravir and rilpivirine treatment on drug resistance in South Africa: a modelling study Open
US National Institutes of Health National Institute of Allergy and Infectious Diseases and the Swiss National Science Foundation.
View article: Immunodeficiency, HIV Viremia, and Incident Anal Cancer Among People With HIV in South Africa
Immunodeficiency, HIV Viremia, and Incident Anal Cancer Among People With HIV in South Africa Open
Among 130 992 people with HIV (PWH) in South Africa, 60 anal cancers were diagnosed. Lower CD4 counts and, to a lesser extent, higher HIV RNA viral loads were associated with an increased anal cancer risk. Maintaining high CD4 counts may c…
View article: Strengthening the reporting of observational studies in epidemiology using Mendelian randomization (STROBE-MR): a Korean translation of explanation and elaboration
Strengthening the reporting of observational studies in epidemiology using Mendelian randomization (STROBE-MR): a Korean translation of explanation and elaboration Open
멘델 무작위화(Mendelian randomization, MR) 연구는 조절 가능한 노출(modifiable exposure)이 건강결과에 미치는 인과효과(causal effect)를 더 잘 이해하게 해 주지만, 그 근거는 종종 보고가 불충분함으로 인하여연구 결과의 해석과 적용에 한계가 있을 수 있다. 보고지침은 흔히 무슨 연구를 하고 무엇을 발견했는지 독자가 쉽게 이해하도록 돕는다. STROBE-MR(관찰연구의 멘델 무작…
View article: Novel integrase mutations linked to genotypic DTG resistance in non-B HIV-1 strains from African participants: The DTG RESIST study
Novel integrase mutations linked to genotypic DTG resistance in non-B HIV-1 strains from African participants: The DTG RESIST study Open
Background Integrase mutations associated with dolutegravir resistance have been well characterized, but based on limited data from non-B subtypes. Objectives We aim to identify integrase mutations not currently classified as integrase str…
View article: Absences, Symptoms and Respiratory Viruses in a Swiss School: Longitudinal Study With Serial Saliva Sampling
Absences, Symptoms and Respiratory Viruses in a Swiss School: Longitudinal Study With Serial Saliva Sampling Open
Background Viral respiratory infections contribute to sick days in school children. We monitored respiratory infections, absences, and symptoms in a Swiss school. Methods Serial saliva sampling (three per week) and daily recording of absen…
View article: Incidence and prognostic factors of self-harm and subsequent unnatural death in South Africa: A cohort study
Incidence and prognostic factors of self-harm and subsequent unnatural death in South Africa: A cohort study Open
Background Self-harm is a major public health concern globally and in South Africa. Individuals with a history of self-harm are at increased risk of unnatural death, including suicide and fatal accidents. This study investigates the incide…
View article: Transparent reporting of observational studies emulating a target trial: the TARGET Statement
Transparent reporting of observational studies emulating a target trial: the TARGET Statement Open
Importance When randomized trials are unavailable or not feasible, observational studies can be used to answer causal questions about the comparative effects of interventions by attempting to emulate a hypothetical pragmatic randomized tri…
View article: Anal Cancer Incidence Rates Among Men and Women With and Without HIV in South Africa
Anal Cancer Incidence Rates Among Men and Women With and Without HIV in South Africa Open
Background More than 7.5 million people in South Africa have HIV, but little is known about the association of HIV and anal cancer incidence. We examined anal cancer incidence in a large South African cohort of insured men and women. Metho…
View article: Life‐years lost associated with mental disorders in people with HIV: a cohort study in South Africa, Canada and the United States
Life‐years lost associated with mental disorders in people with HIV: a cohort study in South Africa, Canada and the United States Open
INTRODUCTION: People with HIV (PWH) have a high burden of mental health disorders, which contribute to increased mortality due to elevated rates of physical illness, suicide or fatal accidents. Additionally, mental health disorders can adv…
View article: The relative contribution of close-proximity contacts, shared classroom exposure and indoor air quality to respiratory virus transmission in schools.
The relative contribution of close-proximity contacts, shared classroom exposure and indoor air quality to respiratory virus transmission in schools. Open
Close-proximity interactions are considered a key risk factor for respiratory virus transmission, but their importance relative to shared space and air quality remains unclear. We conducted a six-week longitudinal study in a Swiss secondar…
View article: Life‐years lost associated with mental disorders in people with HIV: a cohort study in South Africa, Canada and the United States
Life‐years lost associated with mental disorders in people with HIV: a cohort study in South Africa, Canada and the United States Open
Introduction People with HIV (PWH) have a high burden of mental health disorders, which contribute to increased mortality due to elevated rates of physical illness, suicide or fatal accidents. Additionally, mental health disorders can adve…
View article: Gender and Discipline Shape Length, Content and Tone of Grant Peer Review Reports
Gender and Discipline Shape Length, Content and Tone of Grant Peer Review Reports Open
Peer review by experts is central to the evaluation of grant proposals, but little is known about how gender and disciplinary differences shape the content and tone of grant peer review reports. We analyzed 39,280 review reports submitted …
View article: Contributions to Data Collection and Data Processing for Energy- and Product-optimised Operation in Mobile Crushing
Contributions to Data Collection and Data Processing for Energy- and Product-optimised Operation in Mobile Crushing Open
This contribution presents the current results of a PhD research project aimed at enabling an energy- and product-optimised operation of mobile impact crushers through advanced data collection and processing. The study focuses on systemati…
View article: Drug Resistance in People With Viremia on Dolutegravir-based Antiretroviral Therapy in Sub-Saharan Africa: The DTG RESIST Study
Drug Resistance in People With Viremia on Dolutegravir-based Antiretroviral Therapy in Sub-Saharan Africa: The DTG RESIST Study Open
Dolutegravir resistance is an increasing concern. An analysis of the DTG RESIST study found that among 227 integrase sequences from 7 African countries (all non-B subtypes), 59 (26.0%) had at least 1 major drug resistance mutation (primari…
View article: Measuring the Performance of Survival Models to Personalize Treatment Choices
Measuring the Performance of Survival Models to Personalize Treatment Choices Open
Various statistical and machine learning algorithms can be used to predict treatment effects at the patient level using data from randomized clinical trials (RCTs). Such predictions can facilitate individualized treatment decisions. Recent…
View article: Type I interferon autoantibody footprints reveal neutralizing mechanisms and allow inhibitory decoy design
Type I interferon autoantibody footprints reveal neutralizing mechanisms and allow inhibitory decoy design Open
Autoantibodies neutralizing type I interferons (IFN-Is; IFNα or IFNω) exacerbate severe viral disease, but specific treatments are unavailable. With footprint profiling, we delineate two dominant IFN-I faces commonly recognized by neutrali…
View article: Estimating Mycobacterium tuberculosis transmission in a South African clinic: Spatiotemporal model based on person movements
Estimating Mycobacterium tuberculosis transmission in a South African clinic: Spatiotemporal model based on person movements Open
The risk of Mycobacterium tuberculosis (Mtb) transmission can be high in crowded clinics. We developed a spatiotemporal model of airborne Mtb transmission based on the Wells-Riley equation. We collected environmental, clinical and person-t…
View article: Field evaluation of nanopore targeted next-generation sequencing to predict drug-resistant tuberculosis from native sputum in South Africa and Zambia
Field evaluation of nanopore targeted next-generation sequencing to predict drug-resistant tuberculosis from native sputum in South Africa and Zambia Open
Rapid and comprehensive drug susceptibility testing (DST) is essential for diagnosing and treating drug-resistant tuberculosis effectively, and next-generation sequencing can be an effective genotypic DST method. We implemented and evaluat…
View article: Patterns of incident Burkitt lymphoma during the HIV epidemic among the Black African and White population in South Africa
Patterns of incident Burkitt lymphoma during the HIV epidemic among the Black African and White population in South Africa Open
Background Burkitt lymphoma (BL) may be HIV-associated but data on BL trends in South Africa (SA), where HIV is highly prevalent, are scarce. We compared BL incidence trends over 36 years among Black African and White individuals. Methods …
View article: Benefits, Challenges, and Opportunities of the Digital Automatic Coupling
Benefits, Challenges, and Opportunities of the Digital Automatic Coupling Open
To combat climate change and to improve and diversify transportation across Europe, the EU has started initiatives to assist the railway industry in meeting its intended role in the modal split. The Shift2Rail and the European Rail Joint U…
View article: A supervised machine learning approach for assessing grant peer review reports
A supervised machine learning approach for assessing grant peer review reports Open
Peer review is essential to the research lifecycle, yet the contents of grant peer review reports remain underexplored. Our study addresses this gap by developing a pipeline to systematically analyze these reports using natural language pr…
View article: Diagnosis of postpartum depression and associated factors in South Africa: a cohort study of 47,697 women
Diagnosis of postpartum depression and associated factors in South Africa: a cohort study of 47,697 women Open
Aims About one-third of South African women have clinically significant symptoms of postpartum depression (PPD). Several socio-demographic risk factors for PPD exist, but data on medical and obstetric risk factors remain scarce for low- an…
View article: HIV-1 Viremia and Cancer Risk in 2.8 Million People: The South African HIV Cancer Match Study
HIV-1 Viremia and Cancer Risk in 2.8 Million People: The South African HIV Cancer Match Study Open
Background Most research on human immunodeficiency virus-1 (HIV-1) viremia and cancer risk is from high-income countries. We evaluated the association between HIV-1 viremia and the risk of various cancer types among people with HIV (PWH) i…