Martin Guillemet
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View article: Host Competitive Asymmetries Accelerate Viral Evolution in a Microbe–Virus Coevolutionary System
Host Competitive Asymmetries Accelerate Viral Evolution in a Microbe–Virus Coevolutionary System Open
Microbial host populations evolve traits conferring specific resistance to viral predators via various defence mechanisms, while viruses reciprocally evolve traits to evade these defences. Such coevolutionary dynamics often involve diversi…
View article: Emergent epistasis mediates the role of negative frequency-dependent selection in bacterial strain structure
Emergent epistasis mediates the role of negative frequency-dependent selection in bacterial strain structure Open
Strain structure is a well-documented phenomenon in many pathogenic and commensal bacterial species, where distinct strains persist over time exhibiting stable associations between genetic or phenotypic traits. This structure is surprising…
View article: Host Competitive Asymmetries Accelerate Viral Evolution in a Microbe-Virus Coevolutionary System
Host Competitive Asymmetries Accelerate Viral Evolution in a Microbe-Virus Coevolutionary System Open
Microbial host populations evolve traits conferring specific resistance to viral predators via various defense mechanisms, while viruses reciprocally evolve traits to evade these defenses. Such co-evolutionary dynamics often involve divers…
View article: Lethal mutagenesis and the transient within-host dynamics of viral adaptation
Lethal mutagenesis and the transient within-host dynamics of viral adaptation Open
Beneficial mutations drive the within-host adaptation of viral populations and can prolong the duration of host infection. Yet, most mutations are not adaptive and the increase of the mean fitness of viral populations is hampered by delete…
View article: Transient evolutionary epidemiology of viral adaptation and lethal mutagenesis
Transient evolutionary epidemiology of viral adaptation and lethal mutagenesis Open
Beneficial mutations drive the within-host adaptation of viral populations and can prolong the duration of host infection. Yet, most mutations are not adaptive and the increase of the mean fitness of viral populations is hampered by delete…
View article: Building pyramids against the evolutionary emergence of pathogens
Building pyramids against the evolutionary emergence of pathogens Open
Mutations allowing pathogens to escape host immunity promote the spread of infectious diseases in heterogeneous host populations and can lead to major epidemics. Understanding the conditions that slow down this evolution is key for the dev…
View article: Chance Favors the Prepared Genomes: Horizontal Transfer Shapes the Emergence of Antibiotic Resistance Mutations in Core Genes
Chance Favors the Prepared Genomes: Horizontal Transfer Shapes the Emergence of Antibiotic Resistance Mutations in Core Genes Open
Bacterial lineages acquire novel traits at diverse rates in part because the genetic background impacts the successful acquisition of novel genes by horizontal transfer. Yet, how horizontal transfer affects the subsequent evolution of core…
View article: Dynamique de l'adaptation virale : approches théoriques et experimentales
Dynamique de l'adaptation virale : approches théoriques et experimentales Open
La plupart des organismes vivants peuvent être infectés par des virus. Cette omniprésence est due à différents facteurs, notamment des taux de mutation élevés, des populations de grande taille et des temps de génération courts, qui permett…
View article: Data for the paper "Building pyramids against the evolutionary emergence of pathogens"
Data for the paper "Building pyramids against the evolutionary emergence of pathogens" Open
This file shows the data from the paper "Building pyramids against the evolutionary emergence of pathogens". It shows, out of 96 replicates for each conditions, the number of observed emergence events. Column 'wtest': the type of o…
View article: Chance favors the prepared genomes: horizontal transfer shapes the emergence of antibiotic resistance mutations in core genes
Chance favors the prepared genomes: horizontal transfer shapes the emergence of antibiotic resistance mutations in core genes Open
Bacterial lineages vary in the frequency with which they acquire novel traits, like antibiotic resistance or virulence. While previous studies have highlighted the impact of the genetic background on the successful acquisition of novel tra…
View article: Competition and coevolution drive the evolution and the diversification of CRISPR immunity
Competition and coevolution drive the evolution and the diversification of CRISPR immunity Open
View article: Building pyramids against the evolutionary emergence of pathogens
Building pyramids against the evolutionary emergence of pathogens Open
Summary Mutations allowing pathogens to escape host immunity promote the spread of infectious diseases in heterogeneous host populations and can lead to major epidemics. Understanding the conditions favoring these evolutionary emergences i…
View article: Competition and coevolution drive the evolution and the diversification of CRISPR immunity
Competition and coevolution drive the evolution and the diversification of CRISPR immunity Open
Data for the paper : "Competition and coevolution drive the evolution and the diversification of CRISPR immunity" Does NOT contain sequencing data (they are available on NCBI, BioProject PRJNA8435…
View article: Competition and coevolution drive the evolution and the diversification of CRISPR immunity
Competition and coevolution drive the evolution and the diversification of CRISPR immunity Open
The diversity of resistance challenges the ability of pathogens to spread and to exploit host populations [1–3]. Yet, how this host diversity evolves over time remains unclear because it depends on the interplay between intraspecific compe…
View article: Competition and coevolution drive the evolution and the diversification of CRISPR immunity
Competition and coevolution drive the evolution and the diversification of CRISPR immunity Open
Data for the paper : "Competition and coevolution drive the evolution and the diversification of CRISPR immunity" Does NOT contain sequencing data. Bacteria.csv Density of bacteri…
View article: La transmission de la maladie carieuse des parents à l'enfant : étude quantitative menée dans un service hospitalier d'odontologie
La transmission de la maladie carieuse des parents à l'enfant : étude quantitative menée dans un service hospitalier d'odontologie Open
Introduction: Recently several studies have been carried out at the University of Bordeaux to study early childhood caries (CPE). Our study aims to assess the knowledge and impact of risk of behaviors on the transmission of caries disease …
View article: Plant Nutrient Resource Use Strategies Shape Active Rhizosphere Microbiota Through Root Exudation
Plant Nutrient Resource Use Strategies Shape Active Rhizosphere Microbiota Through Root Exudation Open
Plant strategies for soil nutrient uptake have the potential to strongly influence plant-microbiota interactions, due to the competition between plants and microorganisms for soil nutrient acquisition and/or conservation. In the present st…
View article: Le système CRISPR/Cas : un outil d’édition des génomes pour le développement de modèles animaux d’infections virales
Le système CRISPR/Cas : un outil d’édition des génomes pour le développement de modèles animaux d’infections virales Open
miner ensuite les cellules exprimant le virus.La réactivation ciblée de ces provirus par CRISPR/Cas9 SAM pourrait ainsi s'avérer être une stratégie efficace pour l'élimination des réservoirs de l'infection.‡ CRISPR/Cas9 SAM (synergic activ…