Pauline Ho
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View article: High prevalence and distinct patterns of metabolic syndrome in rheumatoid arthritis, psoriatic arthritis, and axial spondyloarthritis: a population-based study
High prevalence and distinct patterns of metabolic syndrome in rheumatoid arthritis, psoriatic arthritis, and axial spondyloarthritis: a population-based study Open
Introduction: Metabolic syndrome (MetS) in inflammatory arthritis (IA) directly impacts its management and associated morbidity and mortality. MetS is a well-recognised comorbidity in PsA, but the epidemiology across IA is unclear. This st…
View article: Misdiagnosis and prevalence of rheumatological diseases in early inflammatory arthritis clinic: results from a UK single-centre retrospective cohort study
Misdiagnosis and prevalence of rheumatological diseases in early inflammatory arthritis clinic: results from a UK single-centre retrospective cohort study Open
View article: P189 Misdiagnosis and prevalence of rheumatological diseases in early inflammatory arthritis clinic: Results from a UK single-centre retrospective cohort study
P189 Misdiagnosis and prevalence of rheumatological diseases in early inflammatory arthritis clinic: Results from a UK single-centre retrospective cohort study Open
Background/Aims Polygenic risk scores (PRS) have been developed to aid diagnosis and reduce misdiagnosis in research and limited real-world settings. However, the accuracy of these tools depends on reliable estimates of disease prevalence.…
View article: GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets
GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets Open
View article: Baseline synovitis–tenosynovitis is associated with remission in early rheumatoid arthritis, but discordance with disease activity is a changeable state
Baseline synovitis–tenosynovitis is associated with remission in early rheumatoid arthritis, but discordance with disease activity is a changeable state Open
Objectives The objectives of this study were to investigate the association between baseline joint-complex inflammation [power Doppler–detected joint synovitis (PDUS) and/or tenosynovitis (PDTS)] and remission in treatment-naïve, new-onset…
View article: Multi-omics analysis in primary T cells elucidates mechanisms behind disease-associated genetic loci
Multi-omics analysis in primary T cells elucidates mechanisms behind disease-associated genetic loci Open
Background Genome-wide association studies (GWAS) have uncovered the genetic basis behind many diseases and conditions. However, most of these genetic loci affect regulatory regions, making the interpretation challenging. Chromatin conform…
View article: Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial
Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial Open
View article: How do patient reported outcome measures affect treatment intensification and patient satisfaction in the management of psoriatic arthritis? A cross sectional study of 503 patients
How do patient reported outcome measures affect treatment intensification and patient satisfaction in the management of psoriatic arthritis? A cross sectional study of 503 patients Open
International audience
View article: How do patient-reported outcome measures affect treatment intensification and patient satisfaction in the management of psoriatic arthritis? A cross sectional study of 503 patients
How do patient-reported outcome measures affect treatment intensification and patient satisfaction in the management of psoriatic arthritis? A cross sectional study of 503 patients Open
Objectives The AsseSSing Impact in pSoriatic Treatment (ASSIST) study investigated prescribing in routine PsA care and whether the patient-reported outcome—PsA Impact of Disease questionnaire (PsAID-12)—impacted treatment. This study also …
View article: Psoriatic arthritis: the role of self-reported non-adherence, non-trough drug levels, immunogenicity and conventional synthetic DMARD co-therapy in adalimumab and etanercept response
Psoriatic arthritis: the role of self-reported non-adherence, non-trough drug levels, immunogenicity and conventional synthetic DMARD co-therapy in adalimumab and etanercept response Open
Objective The aim of this study was to assess the relationship between self-reported non-adherence, non-trough drug levels, immunogenicity and conventional synthetic DMARD (csDMARD) co-therapy in TNF inhibitor (TNF-i) drug response in PsA.…
View article: An international multicentre analysis of current prescribing practices and shared decision-making in psoriatic arthritis
An international multicentre analysis of current prescribing practices and shared decision-making in psoriatic arthritis Open
Objectives Shared decision-making (SDM) is advocated to improve patient outcomes in PsA. We analysed current prescribing practices and the extent of SDM in PsA across Europe. Methods The ASSIST study was a cross-sectional observational stu…
View article: Using Polygenic Risk Scores to Aid Diagnosis of Patients With Early Inflammatory Arthritis: Results From the Norfolk Arthritis Register
Using Polygenic Risk Scores to Aid Diagnosis of Patients With Early Inflammatory Arthritis: Results From the Norfolk Arthritis Register Open
Objective There is growing evidence that genetic data are of benefit in the rheumatology outpatient setting by aiding early diagnosis. A genetic probability tool (G‐PROB) has been developed to aid diagnosis has not yet been tested in a rea…
View article: Harnessing genetics in the outpatient clinic using polygenic risk scores to aid diagnosis of patients with early inflammatory arthritis: results from the Norfolk Arthritis Register
Harnessing genetics in the outpatient clinic using polygenic risk scores to aid diagnosis of patients with early inflammatory arthritis: results from the Norfolk Arthritis Register Open
View article: A case of ANCA-associated vasculitis presenting as a chronic cough with night sweats in an adult male
A case of ANCA-associated vasculitis presenting as a chronic cough with night sweats in an adult male Open
View article: Stratification of biological therapies by pathobiology in biologic-naive patients with rheumatoid arthritis (STRAP and STRAP-EU): two parallel, open-label, biopsy-driven, randomised trials
Stratification of biological therapies by pathobiology in biologic-naive patients with rheumatoid arthritis (STRAP and STRAP-EU): two parallel, open-label, biopsy-driven, randomised trials Open
View article: GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets
GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets Open
Psoriasis is a common, debilitating immune-mediated skin disease. Genetic studies have identified biological mechanisms of psoriasis risk, including those targeted by effective therapies. However, the genetic liability to psoriasis is not …
View article: P12 A periorbital and upper back rash on a female patient of West African descent: a case of NXP2 dermatomyositis initially misdiagnosed as an allergic reaction
P12 A periorbital and upper back rash on a female patient of West African descent: a case of NXP2 dermatomyositis initially misdiagnosed as an allergic reaction Open
Introduction Idiopathic inflammatory myopathies (IIM) are a group of conditions characterised by immune-driven muscular inflammation, often in the presence of specific autoantibodies. NXP2 dermatomyositis is a subtype of IIM characterised …
View article: Multi-omics analysis in primary T cells elucidates mechanisms behind disease associated genetic loci
Multi-omics analysis in primary T cells elucidates mechanisms behind disease associated genetic loci Open
In this study, we present the most extensive dataset of chromatin conformation with matching gene expression and chromatin accessibility from primary T cells to date. We use this data to enhance our understanding of the mechanisms by which…
View article: Utility of Musculoskeletal Ultrasound in Psoriatic Arthritis
Utility of Musculoskeletal Ultrasound in Psoriatic Arthritis Open
As ultrasound technology continues to advance, and associated costs decrease, it is likely that ultrasound will become more integrated into the clinical journeys of patients with PsA.
View article: Multi-omics analysis in primary T cells elucidates mechanisms behind disease associated genetic loci
Multi-omics analysis in primary T cells elucidates mechanisms behind disease associated genetic loci Open
In this study, we present the most extensive dataset of chromatin conformation data with matching gene expression and chromatin accessibility from primary T cells to date. We use this data to enhance our understanding of the different mech…
View article: POS0890 USING POLYGENIC RISK SCORES TO AID DIAGNOSIS OF PATIENTS WITH EARLY INFLAMMATORY ARTHRITIS: RESULTS FROM THE NORFOLK ARTHRITIS REGISTER
POS0890 USING POLYGENIC RISK SCORES TO AID DIAGNOSIS OF PATIENTS WITH EARLY INFLAMMATORY ARTHRITIS: RESULTS FROM THE NORFOLK ARTHRITIS REGISTER Open
View article: OP0130 ABATACEPT IN INDIVIDUALS AT RISK OF DEVELOPING RHEUMATOID ARTHRITIS: RESULTS FROM THE ARTHRITIS PREVENTION IN THE PRE-CLINICAL PHASE OF RA WITH ABATACEPT (APIPPRA) TRIAL
OP0130 ABATACEPT IN INDIVIDUALS AT RISK OF DEVELOPING RHEUMATOID ARTHRITIS: RESULTS FROM THE ARTHRITIS PREVENTION IN THE PRE-CLINICAL PHASE OF RA WITH ABATACEPT (APIPPRA) TRIAL Open
Background:
While genetic and epidemiological factors have been used traditionally to evaluate the risk of developing rheumatoid arthritis (RA), the definition of higher risk states has been refined in more recent years through inclusi…
While genetic and epidemiological factors have been used traditionally to evaluate the risk of developing rheumatoid arthritis (RA), the definition of higher risk states has been refined in more recent years through inclusi…
View article: OP0099 UNVEILING THE COMPLEX GENE REGULATORY MECHANISMS OF PSORIATIC ARTHRITIS THROUGH CHROMATIN CONFORMATION, GENE EXPRESSION AND CHROMATIN ACCESSIBILITY ANALYSIS IN PRIMARY CELLS
OP0099 UNVEILING THE COMPLEX GENE REGULATORY MECHANISMS OF PSORIATIC ARTHRITIS THROUGH CHROMATIN CONFORMATION, GENE EXPRESSION AND CHROMATIN ACCESSIBILITY ANALYSIS IN PRIMARY CELLS Open
Background GWAS have identified genetic variants associated with many complex diseases. These primarily affect regulatory elements that can affect expression of distal genes through chromatin interaction mechanisms. Previous studies have u…
View article: The stool microbiome in patients with psoriatic arthritis is altered but, unlike the skin microbiome, does not change following treatment: evidence for an underlying inflammatory drive from the intestine
The stool microbiome in patients with psoriatic arthritis is altered but, unlike the skin microbiome, does not change following treatment: evidence for an underlying inflammatory drive from the intestine Open
Objectives There is growing recognition that interactions between bacteria and the immune response may contribute to inflammation in psoriatic arthritis (PsA). To identify how the skin and stool microbiota may contribute to pathogenesis, w…
View article: E015 A case of ocular myasthenia gravis seen by rheumatology as suspected mononeuritis multiplex in an adult male shortly after Pfizer-BioNTech SARS-CoV-2 vaccination
E015 A case of ocular myasthenia gravis seen by rheumatology as suspected mononeuritis multiplex in an adult male shortly after Pfizer-BioNTech SARS-CoV-2 vaccination Open
Background/Aims Myasthenia gravis (MG) is an antibody-mediated autoimmune disease targeting proteins at the postsynaptic membrane of the neuromuscular junction. MG is thought to occur in genetically susceptible individuals following an env…
View article: OA16 Identification of surrogate serum proteomic biomarkers associated with ultrasound power Doppler in psoriatic arthritis
OA16 Identification of surrogate serum proteomic biomarkers associated with ultrasound power Doppler in psoriatic arthritis Open
Background/Aims An area of key unmet need in psoriatic arthritis (PsA) is the identification of biomarker(s) which predict those likely to respond to a specific therapy; in order to achieve that, an objective measure of disease activity wo…
View article: P042 Using a Genetic PROBability tool (G-PROB) to aid diagnosis of patients with inflammatory arthritis: results from the Norfolk Arthritis Register
P042 Using a Genetic PROBability tool (G-PROB) to aid diagnosis of patients with inflammatory arthritis: results from the Norfolk Arthritis Register Open
Background/Aims Recent translational advances in genetics report the ability to accurately predict the diagnosis of patients presenting with synovitis, providing potential to accelerate treatment and improve patient outcomes. One tool is G…
View article: P174 Psoriatic arthritis patients in the UK have a lower quality of life than patients in mainland Europe - an analysis from the ASSIST study
P174 Psoriatic arthritis patients in the UK have a lower quality of life than patients in mainland Europe - an analysis from the ASSIST study Open
Background/Aims Psoriatic arthritis (PsA) is a heterogeneous, multi-dimensional disease. Treatment pathways are not well defined and have to be tailored to the individual; however, little is known about the factors underpinning a decision …
View article: P178 Current prescribing practices in psoriatic arthritis - comparison between the UK and Europe
P178 Current prescribing practices in psoriatic arthritis - comparison between the UK and Europe Open
Background/Aims Psoriatic arthritis (PsA) is a multi-system disease with a range of management options. Treatment may vary by geographic location. We compared disease characteristics and prescribing practices in the UK and Europe in the po…
View article: P179 Shared decision-making in psoriatic arthritis consultations
P179 Shared decision-making in psoriatic arthritis consultations Open
Background/Aims A personalised approach is required to optimise management of psoriatic arthritis (PsA). Shared decision-making between physician and patient is key, resulting in greater patient satisfaction and outcomes. We assessed the d…