Martin Holcmann
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View article: TYK2 Promotes Immunosurveillance of Colorectal Cancer Liver Metastasis
TYK2 Promotes Immunosurveillance of Colorectal Cancer Liver Metastasis Open
Colorectal cancer liver metastasis (CRLM) is a major clinical problem. The regulators of immunosurveillance of CRLM could hold potential for developing therapeutic strategies to prevent or treat metastasis. In this study, using a murine co…
View article: The anticancer thiosemicarbazone triapine exerts immune-enhancing activities via immunogenic cell death induction and FAS upregulation
The anticancer thiosemicarbazone triapine exerts immune-enhancing activities via immunogenic cell death induction and FAS upregulation Open
The anticancer thiosemicarbazone Triapine is currently in a phase III clinical trial in combination with radiation therapy and cisplatin. Noteworthy, while radiotherapy induces an immune-activating cell death, so called immunogenic cell de…
View article: EGFR controls transcriptional and metabolic rewiring in KRASG12D colorectal cancer
EGFR controls transcriptional and metabolic rewiring in KRASG12D colorectal cancer Open
Inhibition of the epidermal growth factor receptor (EGFR) shows clinical benefit in metastatic colorectal cancer (CRC) patients, but KRAS-mutations are known to confer resistance. However, recent reports highlight EGFR as a crucial target …
View article: The histone deacetylase HDAC1 controls dendritic cell development and anti-tumor immunity
The histone deacetylase HDAC1 controls dendritic cell development and anti-tumor immunity Open
Dendritic cell (DC) progenitors adapt their transcriptional program during development, generating different subsets. How chromatin modifications modulate these processes is unclear. Here, we investigate the impact of histone deacetylation…
View article: Scarring hair follicle destruction is driven by the collapse of EGFR-protected JAK-STAT1-sensitive stem cell immune privilege
Scarring hair follicle destruction is driven by the collapse of EGFR-protected JAK-STAT1-sensitive stem cell immune privilege Open
The hair follicle stem cell niche is an immune-privileged microenvironment, characterised by suppressed antigen presentation, thus shielding against permanent immune-mediated tissue damage. In this study, we demonstrate the protective role…
View article: Inducible overexpression of a FAM3C/ILEI transgene has pleiotropic effects with shortened life span, liver fibrosis and anemia in mice
Inducible overexpression of a FAM3C/ILEI transgene has pleiotropic effects with shortened life span, liver fibrosis and anemia in mice Open
FAM3C/ILEI is an important factor in epithelial-to-mesenchymal transition (EMT) induction, tumor progression and metastasis. Overexpressed in many cancers, elevated ILEI levels and secretion correlate with poor patient survival. Although I…
View article: <scp>FAM3C</scp> / <scp>ILEI</scp> protein is elevated in psoriatic lesions and triggers psoriasiform hyperproliferation in mice
<span>FAM3C</span> / <span>ILEI</span> protein is elevated in psoriatic lesions and triggers psoriasiform hyperproliferation in mice Open
FAM3C/ILEI is an important cytokine for tumor progression and metastasis. However, its involvement in inflammation remains elusive. Here, we show that ILEI protein is highly expressed in psoriatic lesions. Inducible keratinocyte‐specific I…
View article: Data Supplement from Calpain-Mediated Integrin Deregulation as a Novel Mode of Action for the Anticancer Gallium Compound KP46
Data Supplement from Calpain-Mediated Integrin Deregulation as a Novel Mode of Action for the Anticancer Gallium Compound KP46 Open
Supplementary Figure 1. Role of p53 status and mitochondrial membrane depolarization in KP46-induced cell death Supplementary Figure 2. Expression and localization changes of pro- and anti-apoptotic Bcl-2 family members in response to KP46…
View article: Data Supplement from Calpain-Mediated Integrin Deregulation as a Novel Mode of Action for the Anticancer Gallium Compound KP46
Data Supplement from Calpain-Mediated Integrin Deregulation as a Novel Mode of Action for the Anticancer Gallium Compound KP46 Open
Supplementary Figure 1. Role of p53 status and mitochondrial membrane depolarization in KP46-induced cell death Supplementary Figure 2. Expression and localization changes of pro- and anti-apoptotic Bcl-2 family members in response to KP46…
View article: Data Supplement from Calpain-Mediated Integrin Deregulation as a Novel Mode of Action for the Anticancer Gallium Compound KP46
Data Supplement from Calpain-Mediated Integrin Deregulation as a Novel Mode of Action for the Anticancer Gallium Compound KP46 Open
Supplementary Video 1. Impact of calpain inhibition on the dynamics of KP64-induced rapid cell death of A427 cells
View article: Data from Calpain-Mediated Integrin Deregulation as a Novel Mode of Action for the Anticancer Gallium Compound KP46
Data from Calpain-Mediated Integrin Deregulation as a Novel Mode of Action for the Anticancer Gallium Compound KP46 Open
On the basis of enhanced tumor accumulation and bone affinity, gallium compounds are under development as anticancer and antimetastatic agents. In this study, we analyzed molecular targets of one of the lead anticancer gallium complexes [K…
View article: Data Supplement from Calpain-Mediated Integrin Deregulation as a Novel Mode of Action for the Anticancer Gallium Compound KP46
Data Supplement from Calpain-Mediated Integrin Deregulation as a Novel Mode of Action for the Anticancer Gallium Compound KP46 Open
Supplementary Video 1. Impact of calpain inhibition on the dynamics of KP64-induced rapid cell death of A427 cells
View article: Data from Calpain-Mediated Integrin Deregulation as a Novel Mode of Action for the Anticancer Gallium Compound KP46
Data from Calpain-Mediated Integrin Deregulation as a Novel Mode of Action for the Anticancer Gallium Compound KP46 Open
On the basis of enhanced tumor accumulation and bone affinity, gallium compounds are under development as anticancer and antimetastatic agents. In this study, we analyzed molecular targets of one of the lead anticancer gallium complexes [K…
View article: Data Supplement from Calpain-Mediated Integrin Deregulation as a Novel Mode of Action for the Anticancer Gallium Compound KP46
Data Supplement from Calpain-Mediated Integrin Deregulation as a Novel Mode of Action for the Anticancer Gallium Compound KP46 Open
Legends to all supplementary figures and the video
View article: Data Supplement from Calpain-Mediated Integrin Deregulation as a Novel Mode of Action for the Anticancer Gallium Compound KP46
Data Supplement from Calpain-Mediated Integrin Deregulation as a Novel Mode of Action for the Anticancer Gallium Compound KP46 Open
Legends to all supplementary figures and the video
View article: Supplementary Figure 4 from hVps37A Status Affects Prognosis and Cetuximab Sensitivity in Ovarian Cancer
Supplementary Figure 4 from hVps37A Status Affects Prognosis and Cetuximab Sensitivity in Ovarian Cancer Open
PDf file - 99K
View article: Data from hVps37A Status Affects Prognosis and Cetuximab Sensitivity in Ovarian Cancer
Data from hVps37A Status Affects Prognosis and Cetuximab Sensitivity in Ovarian Cancer Open
Purpose: Although prognostic and predictive factors in ovarian cancer have been extensively studied for decades, only few have been identified and introduced to clinical practice. Here, we evaluate hVps37A (HCRP1) as a possible novel predi…
View article: Supplementary Figure 2 from hVps37A Status Affects Prognosis and Cetuximab Sensitivity in Ovarian Cancer
Supplementary Figure 2 from hVps37A Status Affects Prognosis and Cetuximab Sensitivity in Ovarian Cancer Open
PDF file - 68K
View article: Supplementary Figure Legends 1-5 from hVps37A Status Affects Prognosis and Cetuximab Sensitivity in Ovarian Cancer
Supplementary Figure Legends 1-5 from hVps37A Status Affects Prognosis and Cetuximab Sensitivity in Ovarian Cancer Open
PDF file - 81K
View article: Data from hVps37A Status Affects Prognosis and Cetuximab Sensitivity in Ovarian Cancer
Data from hVps37A Status Affects Prognosis and Cetuximab Sensitivity in Ovarian Cancer Open
Purpose: Although prognostic and predictive factors in ovarian cancer have been extensively studied for decades, only few have been identified and introduced to clinical practice. Here, we evaluate hVps37A (HCRP1) as a possible novel predi…
View article: Supplementary Figure 1 from hVps37A Status Affects Prognosis and Cetuximab Sensitivity in Ovarian Cancer
Supplementary Figure 1 from hVps37A Status Affects Prognosis and Cetuximab Sensitivity in Ovarian Cancer Open
PDF file - 55K
View article: Supplementary Figure Legends 1-5 from hVps37A Status Affects Prognosis and Cetuximab Sensitivity in Ovarian Cancer
Supplementary Figure Legends 1-5 from hVps37A Status Affects Prognosis and Cetuximab Sensitivity in Ovarian Cancer Open
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View article: Supplementary Figure 4 from hVps37A Status Affects Prognosis and Cetuximab Sensitivity in Ovarian Cancer
Supplementary Figure 4 from hVps37A Status Affects Prognosis and Cetuximab Sensitivity in Ovarian Cancer Open
PDf file - 99K
View article: Supplementary Figure 2 from hVps37A Status Affects Prognosis and Cetuximab Sensitivity in Ovarian Cancer
Supplementary Figure 2 from hVps37A Status Affects Prognosis and Cetuximab Sensitivity in Ovarian Cancer Open
PDF file - 68K
View article: Supplementary Figure 5 from hVps37A Status Affects Prognosis and Cetuximab Sensitivity in Ovarian Cancer
Supplementary Figure 5 from hVps37A Status Affects Prognosis and Cetuximab Sensitivity in Ovarian Cancer Open
PDF file - 186K