Explanipedia

HEIP1 orchestrates pro-crossover protein activity during mammalian meiosis Open

Arnaud De Muyt, Sun‐Kyung Lee, Sushil Khanal, Laurine Dal Toe, Céline Adam , et al. · 2025

Meiotic crossovers (COs) are needed to produce genetically balanced gametes. In mammals, CO formation is mediated by a conserved set of pro-CO proteins via mechanisms that remain unclear. Here, we characterize a mammalian pro-CO factor HEI…

Primary human ovarian interstitial cells contribute to murine follicle growth through follicle-interstitial paracrine crosstalk Open

Monica M. Laronda, Elizabeth Tsui, Diane C. Saunders, Lina Lü, Tara Kennedy , et al. · 2025

Protecting double Holliday junctions ensures crossing over during meiosis Open

Shangming Tang, Sara Hariri, R. G. Bohn, John E.G. McCarthy, Jennifer Koo , et al. · 2025

Chromosomal linkages formed through crossover recombination are essential for the accurate segregation of homologous chromosomes during meiosis 1 . The DNA events of recombination are linked to structural components of meiotic chromosomes …

HEIP1 orchestrates pro-crossover protein activity during mammalian meiosis Open

Arnaud De Muyt, Sun‐Kyung Lee, Sushil Khanal, Laurine Dal Toe, Céline Adam , et al. · 2025

Meiotic crossovers are needed to produce genetically balanced gametes. In mammals, crossover formation is mediated by a conserved set of pro-crossover proteins via mechanisms that remain unclear. Here, we characterize a mammalian pro-cross…

Recruitment of Mre11 to recombination sites during meiosis Open

Corentin Claeys Bouuaert, Priyanka Priyadarshini, Mahesh Survi, Wael El Yazidi Mouloud, R. G. Bohn , et al. · 2025

The Mre11 nuclease is part of the highly conserved MRX complex involved in the repair of DNA double-strand breaks (DSBs). During meiosis in budding yeast, MRX is also required for the programmed induction of DSBs by Spo11, thereby initiati…

Recruitment of Mre11 to recombination sites during meiosis Open

Priyanka Priyadarshini, Mahesh Survi, Wael El Yazidi Mouloud, R. G. Bohn, Steven Ballet , et al. · 2025

The Mre11 nuclease, part of the conserved MRX complex involved in the repair of DNA double-strand breaks (DSBs), is also essential to initiate meiotic recombination in budding yeast by promoting Spo11-induced DSBs. Recruitment of Mre11 to …

An Epigenomic Roadmap Primes Non-Growing Oocytes for Maturation and Early Embryogenesis Open

Mengwen Hu, Yasuhisa Munakata, Yu-Han Yeh, Han Wang, Neil Hunter , et al. · 2025

Summary Female reproductive lifespan is defined by long-lived, non-growing oocytes (NGOs) that comprise the ovarian reserve. NGOs are assumed to acquire the epigenetic marks that will define the early embryo only after they exit the ovaria…

SPO11 cuts! Open

Sara Hariri, Neil Hunter · 2025

Distinct and interdependent functions of three RING proteins regulate recombination during mammalian meiosis Open

Masaru Ito, Yan Yun, Dhananjaya S. Kulkarni, Sun‐Kyung Lee, Sumit Sandhu , et al. · 2025

During meiosis, each pair of homologous chromosomes becomes connected by at least one crossover, as required for accurate segregation, and adjacent crossovers are widely separated thereby limiting total numbers. In coarsening models, this …

An Epigenomic Roadmap Primes Non-Growing Oocytes for Maturation and Early Embryogenesis Open

Mengwen Hu, Yasuhisa Munakata, Yu-Han Yeh, Han Wang, Neil Hunter , et al. · 2025

Mitochondria facilitate neuronal differentiation by metabolising nuclear-encoded RNA Open

Filip Vujovic, Mary Simonian, William E. Hughes, Claire E. Shepherd, Neil Hunter , et al. · 2024

Protection of double-Holliday junctions ensures crossing over during meiosis Open

Shangming Tang, Jennifer Koo, Mohammad S. Pourhosseinzadeh, Emerald Nguyen, Natalie Liu , et al. · 2024

Chromosomal linkages formed through crossover recombination are essential for accurate segregation of homologous chromosomes during meiosis 1 . The DNA events of recombination are linked to structural components of meiotic chromosomes 2 . …

Distinct and interdependent functions of three RING proteins regulate recombination during mammalian meiosis Open

Masaru Ito, Yan Yun, Dhananjaya S. Kulkarni, Sumit Sandhu, Briana Nuñez , et al. · 2023

During meiosis, each pair of homologous chromosomes becomes connected by at least one crossover, as required for accurate segregation, and adjacent crossovers are widely separated thereby limiting total numbers. In coarsening models, this …

Oocyte Development and Quality in Young and Old Mice following Exposure to Atrazine Open

Yan Yun, Sunkyung Lee, Christina So, Rushali Manhas, Carol H. Kim , et al. · 2022

Low-level atrazine exposure caused persistent changes to the female mammalian germline in mice, with potential consequences for reproductive lifespan and congenital disease. https://doi.org/10.1289/EHP11343.

Reduced oocyte quality and exacerbation of the maternal age effect are enduring consequences of low-level atrazine exposure in mouse Open

Yan Yun, Sukhyang Lee, Christina So, Rushali Manhas, Carol H. Kim , et al. · 2022

BACKGROUND Egg development has unique features that render it vulnerable to environmental perturbation. The herbicide atrazine is an endocrine disruptor shown to have detrimental effects on reproduction across a number of vertebrate specie…

PRC1-mediated epigenetic programming is required to generate the ovarian reserve Open

Mengwen Hu, Yu-Han Yeh, Yasuhisa Munakata, Hironori Abe, Akihiko Sakashita , et al. · 2022

Cellular self‐organization: An overdrive in Cambrian diversity? Open

Filip Vujovic, Neil Hunter, Ramin Hamidi Farahani · 2022

During the early Cambrian period metazoan life forms diverged at an accelerated rate to occupy multiple ecological niches on earth. A variety of explanations have been proposed to address this major evolutionary phenomenon termed the “Camb…

Yeast ORC sumoylation status fine-tunes origin licensing Open

Gemma L. Regan-Mochrie, Timothy Hoggard, Nikhil R. Bhagwat, Gerard Lynch, Neil Hunter , et al. · 2022

Sumoylation is emerging as a posttranslation modification important for regulating chromosome duplication and stability. The origin recognition complex (ORC) that directs DNA replication initiation by loading the MCM replicative helicase o…

Programmed genomic instability regulates neural transdifferentiation of human brain microvascular pericytes Open

Saba Rezaei‐Lotfi, Filip Vujovic, Mary Simonian, Neil Hunter, Ramin Hamidi Farahani · 2021

Centrosome dysfunction associated with somatic expression of the synaptonemal complex protein TEX12 Open

Sumit Sandhu, Ieng Fong Sou, Jill V. Hunter, Lucy J. Salmon, Caroline Wilson , et al. · 2021

The fate of notch-1 transcript is linked to cell cycle dynamics by activity of a natural antisense transcript Open

Filip Vujovic, Saba Rezaei‐Lotfi, Neil Hunter, Ramin Hamidi Farahani · 2021

A core imprint of metazoan life is that perturbations of cell cycle are offset by compensatory changes in successive cellular generations. This trait enhances robustness of multicellular growth and requires transmission of signaling cues w…

Effects of Antiplatelet Therapy After Stroke Caused by Intracerebral Hemorrhage Open

Rustam Al‐Shahi Salman, Martin Dennis, Peter Sandercock, Cathie Sudlow, Joanna M. Wardlaw , et al. · 2021

isrctn.org Identifier: ISRCTN71907627.

SUMO fosters assembly and functionality of the MutSγ complex to facilitate meiotic crossing over Open

Wei He, Falk Gerrik Verhees, Nikhil R. Bhagwat, Ye Yang, Dhananjaya S. Kulkarni , et al. · 2021

Breaking a species barrier by enabling hybrid recombination Open

G. Ozan Bozdag, Jasmine Ono, Jai A. Denton, Emre Karakoç, Neil Hunter , et al. · 2021

Author response: SUMO is a pervasive regulator of meiosis Open

Nikhil R. Bhagwat, Shannon Owens, Masaru Ito, Jay V Boinapalli, Philip Poa , et al. · 2021

Article Figures and data Abstract eLife digest Introduction Results and discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Protein modification by S…

Association of baseline hematoma and edema volumes with one-year outcome and long-term survival after spontaneous intracerebral hemorrhage: A community-based inception cohort study Open

James JM Loan, Angus B. Gane, Laura E. Middleton, Brendan Sargent, Tom J. Moullaali , et al. · 2020

Background Hospital-based studies have reported variable associations between outcome after spontaneous intracerebral hemorrhage and peri-hematomal edema volume. Aims In a community-based study, we aimed to investigate the existence, stren…

PCNA activates the MutLγ endonuclease to promote meiotic crossing over Open

Dhananjaya S. Kulkarni, Shannon Owens, Masayoshi Honda, Masaru Ito, Ye Yang , et al. · 2020

Proline-rich protein PRR19 functions with cyclin-like CNTD1 to promote meiotic crossing over in mouse Open

Anastasiia Bondarieva, Kavya Raveendran, Vladyslav Telychko, H. B. D. Prasada Rao, Ramya Ravindranathan , et al. · 2020

Orderly chromosome segregation is enabled by crossovers between homologous chromosomes in the first meiotic division. Crossovers arise from recombination-mediated repair of programmed DNA double-strand breaks (DSBs). Multiple DSBs initiate…

Regulated Proteolysis of MutSγ Controls Meiotic Crossing Over Open

Wei He, H. B. D. Prasada Rao, Shangming Tang, Nikhil R. Bhagwat, Dhananjaya S. Kulkarni , et al. · 2020

PCNA activates the MutLγ endonuclease to promote meiotic crossing over Open

Dhananjaya S. Kulkarni, Shannon Owens, Masayoshi Honda, Masaru Ito, Ye Yang , et al. · 2020

During meiosis, crossover recombination connects homologous chromosomes to direct their accurate segregation 1 . Defects in crossing over cause infertility, miscarriage and congenital disease. Accordingly, each pair of chromosomes attains …

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