Martin J. Rutkowski
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View article: Presentation of extranodal NK/T-cell lymphoma as a pituitary mass: A case report and review of the literature
Presentation of extranodal NK/T-cell lymphoma as a pituitary mass: A case report and review of the literature Open
Background Primary pituitary lymphomas are uncommon neoplasms that are typically derived from a B-cell lineage. Extranodal natural killer (NK)/T-cell lymphoma is distinct from B- and T-cell lymphomas and is associated with Epstein–Barr vir…
View article: The Emotional Impact of Educational Productivity Videos on YouTube: A Global, Cross-Sectional Survey
The Emotional Impact of Educational Productivity Videos on YouTube: A Global, Cross-Sectional Survey Open
Introduction YouTube is the most popular video-sharing website, and many students use it as a resource to find educational content. One type of video category is "productivity," in which the creator teaches viewers how to lead a more produ…
View article: Data from Gliomas Promote Immunosuppression through Induction of B7-H1 Expression in Tumor-Associated Macrophages
Data from Gliomas Promote Immunosuppression through Induction of B7-H1 Expression in Tumor-Associated Macrophages Open
Purpose: Gliomas are known to induce local and systemic immunosuppression, inhibiting T-cell–mediated cytotoxic responses to tumor growth. Tumor-associated macrophages are a significant component of the immune infiltrate in gliomas …
View article: Supplementary Figure 1 from Gliomas Promote Immunosuppression through Induction of B7-H1 Expression in Tumor-Associated Macrophages
Supplementary Figure 1 from Gliomas Promote Immunosuppression through Induction of B7-H1 Expression in Tumor-Associated Macrophages Open
PDF file - 22K, Figure S1. Glioma cells induce B7-H1 expression in peripheral monocytes from healthy donors. Monocytes from healthy donors were cultured alone in normal media or in co-culture with U251 glioma cells in contact or through a …
View article: Supplementary Figure 1 from Gliomas Promote Immunosuppression through Induction of B7-H1 Expression in Tumor-Associated Macrophages
Supplementary Figure 1 from Gliomas Promote Immunosuppression through Induction of B7-H1 Expression in Tumor-Associated Macrophages Open
PDF file - 22K, Figure S1. Glioma cells induce B7-H1 expression in peripheral monocytes from healthy donors. Monocytes from healthy donors were cultured alone in normal media or in co-culture with U251 glioma cells in contact or through a …
View article: Supplementary Figure Legend from Gliomas Promote Immunosuppression through Induction of B7-H1 Expression in Tumor-Associated Macrophages
Supplementary Figure Legend from Gliomas Promote Immunosuppression through Induction of B7-H1 Expression in Tumor-Associated Macrophages Open
PDF file - 70K
View article: Supplementary Figure Legend from Gliomas Promote Immunosuppression through Induction of B7-H1 Expression in Tumor-Associated Macrophages
Supplementary Figure Legend from Gliomas Promote Immunosuppression through Induction of B7-H1 Expression in Tumor-Associated Macrophages Open
PDF file - 70K
View article: Supplementary Figure 2 from Gliomas Promote Immunosuppression through Induction of B7-H1 Expression in Tumor-Associated Macrophages
Supplementary Figure 2 from Gliomas Promote Immunosuppression through Induction of B7-H1 Expression in Tumor-Associated Macrophages Open
PDF file - 42K, Figure S2. Glioma-derived soluble factors can further induce B7-H1 expression in non-autologous GBM patient peripheral monocytes, but not in autologous patient monocytes. Quantification of mean fluorescence intensity for B7…
View article: Supplementary Figure 2 from Gliomas Promote Immunosuppression through Induction of B7-H1 Expression in Tumor-Associated Macrophages
Supplementary Figure 2 from Gliomas Promote Immunosuppression through Induction of B7-H1 Expression in Tumor-Associated Macrophages Open
PDF file - 42K, Figure S2. Glioma-derived soluble factors can further induce B7-H1 expression in non-autologous GBM patient peripheral monocytes, but not in autologous patient monocytes. Quantification of mean fluorescence intensity for B7…
View article: Data from Gliomas Promote Immunosuppression through Induction of B7-H1 Expression in Tumor-Associated Macrophages
Data from Gliomas Promote Immunosuppression through Induction of B7-H1 Expression in Tumor-Associated Macrophages Open
Purpose: Gliomas are known to induce local and systemic immunosuppression, inhibiting T-cell–mediated cytotoxic responses to tumor growth. Tumor-associated macrophages are a significant component of the immune infiltrate in gliomas …
View article: Diploic Bone Channel Drilling Facilitates Dissection of the Midline Dura and Protects the Superior Sagittal Sinus in Hyperostosis Frontalis Interna
Diploic Bone Channel Drilling Facilitates Dissection of the Midline Dura and Protects the Superior Sagittal Sinus in Hyperostosis Frontalis Interna Open
View article: Endoscope-assisted far lateral craniotomy for resection of posterior fossa neurocysticercosis: illustrative case
Endoscope-assisted far lateral craniotomy for resection of posterior fossa neurocysticercosis: illustrative case Open
BACKGROUND Neurocysticercosis is a parasitic infection that commonly affects the ventricles, subarachnoid spaces, and spinal cord of the central nervous system. The authors report an unusual manifestation of purely posterior fossa neurocys…
View article: Expert surgeons and deep learning models can predict the outcome of surgical hemorrhage from 1 min of video
Expert surgeons and deep learning models can predict the outcome of surgical hemorrhage from 1 min of video Open
Major vascular injury resulting in uncontrolled bleeding is a catastrophic and often fatal complication of minimally invasive surgery. At the outset of these events, surgeons do not know how much blood will be lost or whether they will suc…
View article: Risk of Early Versus Later Rebleeding From Dural Arteriovenous Fistulas With Cortical Venous Drainage
Risk of Early Versus Later Rebleeding From Dural Arteriovenous Fistulas With Cortical Venous Drainage Open
Background: Cranial dural arteriovenous fistulas with cortical venous drainage are rare lesions that can present with hemorrhage. A high rate of rebleeding in the early period following hemorrhage has been reported, but published long-term…
View article: Expert Surgeons and Deep Learning Models Can Predict the Outcome of Surgical Hemorrhage from One Minute of Video
Expert Surgeons and Deep Learning Models Can Predict the Outcome of Surgical Hemorrhage from One Minute of Video Open
Background Major vascular injury resulting in uncontrolled bleeding is a catastrophic and often fatal complication of minimally invasive surgery. At the outset of these events, surgeons do not know how much blood will be lost or whether th…
View article: Inhalant Cannabidiol Inhibits Glioblastoma Progression Through Regulation of Tumor Microenvironment
Inhalant Cannabidiol Inhibits Glioblastoma Progression Through Regulation of Tumor Microenvironment Open
Introduction: Glioblastoma (GBM) is the most common invasive brain tumor composed of diverse cell types with poor prognosis. The highly complex tumor microenvironment (TME) and its interaction with tumor cells play important roles i…
View article: Endoscopic third ventriculostomy may decrease shunt-dependency in patients with post-hemorrhagic hydrocephalus following aneurysmal subarachnoid hemorrhage
Endoscopic third ventriculostomy may decrease shunt-dependency in patients with post-hemorrhagic hydrocephalus following aneurysmal subarachnoid hemorrhage Open
Objective: Ventriculoperitoneal shunting (VPS) is associated with high complication rates. Here, we investigate whether endoscopic third ventriculostomy (ETV) can reduce shunt-dependency in patients suffering from hydrocephalus following a…
View article: Melanoma metastasis to a nonfunctioning pituitary macroadenoma: illustrative case
Melanoma metastasis to a nonfunctioning pituitary macroadenoma: illustrative case Open
BACKGROUND Metastases to the central nervous system are often multiple in number and typically favor the gray-white matter junction. Collision tumors, defined as the coexistence of two morphologically different tumors, such as metastases t…
View article: Pretemporal Transcavernous Approach for Resection of an Orbito-Cavernous Oculomotor Schwannoma
Pretemporal Transcavernous Approach for Resection of an Orbito-Cavernous Oculomotor Schwannoma Open
The following operative video demonstrates surgical tenets and nuances of the pretemporal transcavernous approach in an unusual case of a 33-year-old patient suffering new onset diplopia and a third nerve palsy due to an orbito-cavernous o…
View article: <scp>CSF</scp> Leak After <scp>COVID</scp>‐19 Nasopharyngeal Swab: A Case Report
<span>CSF</span> Leak After <span>COVID</span>‐19 Nasopharyngeal Swab: A Case Report Open
The nasopharyngeal swab has been used with increased frequency since the beginning of the COVID‐19 pandemic. Little has been written in the literature regarding the complications arising from this procedure, as it is generally accepted as …
View article: Development and clinical validation of a grading system for pituitary adenoma consistency
Development and clinical validation of a grading system for pituitary adenoma consistency Open
OBJECTIVE Pituitary adenoma (PA) consistency, or texture, is an important intraoperative characteristic that may dictate operative dissection techniques and/or instruments used for tumor removal during endoscopic endonasal approaches (EEAs…
View article: Impact of tumor characteristics and pre- and postoperative hormone levels on hormonal remission following endoscopic transsphenoidal surgery in patients with acromegaly
Impact of tumor characteristics and pre- and postoperative hormone levels on hormonal remission following endoscopic transsphenoidal surgery in patients with acromegaly Open
OBJECTIVE Acromegaly is a disease of acral enlargement and elevated serum levels of insulin-like growth factor–1 (IGF-1) and growth hormone (GH), usually caused by a pituitary adenoma. A lack of consensus on factors that reliably predict o…
View article: SUN-135 Characterization of Transcription Factor Immunostaining and Null Cell Adenoma Status in Hormone Negative Pituitary Adenomas
SUN-135 Characterization of Transcription Factor Immunostaining and Null Cell Adenoma Status in Hormone Negative Pituitary Adenomas Open
Introduction: Since the 2017 W.H.O. classification of pituitary adenomas redefined null cell adenomas (NCAs) as negative for all adenohypophyseal hormones and the transcription factors (TFs) SF-1, PIT-1, and T-PIT, limited data exist chara…
View article: MON-319 Impact of Tumor Characteristics and Preoperative IGF-1 Levels on Postoperative Hormonal Remission Following Endoscopic Transsphenoidal Surgery in Patients with Acromegaly: A Single-Surgeon Series
MON-319 Impact of Tumor Characteristics and Preoperative IGF-1 Levels on Postoperative Hormonal Remission Following Endoscopic Transsphenoidal Surgery in Patients with Acromegaly: A Single-Surgeon Series Open
Introduction: Acromegaly is a potentially fatal neuro-endocrinopathy caused by a growth hormone (GH)-secreting pituitary adenoma (PA). A lack of consensus on factors that reliably predict patient outcomes in acromegalic patients following …
View article: Comparative preoperative characteristics and postoperative outcomes at a private versus a safety-net hospital following endoscopic endonasal transsphenoidal resection of pituitary adenomas
Comparative preoperative characteristics and postoperative outcomes at a private versus a safety-net hospital following endoscopic endonasal transsphenoidal resection of pituitary adenomas Open
OBJECTIVE Sociodemographic disparities in health outcomes are well documented, but the effects of such disparities on preoperative presentation of pituitary adenomas (PA) and surgical outcomes following resection are not completely underst…
View article: Acromegaly Due to McCune–Albright Syndrome
Acromegaly Due to McCune–Albright Syndrome Open
View article: Correction: Stratifying nonfunctional pituitary adenomas into two groups distinguished by macrophage subtypes
Correction: Stratifying nonfunctional pituitary adenomas into two groups distinguished by macrophage subtypes Open
View article: TMIC-04. NONFUNCTIONAL PITUITARY ADENOMAS DEMONSTRATE TWO SUBTYPES BASED ON MACROPHAGE POLARIZATION STATUS
TMIC-04. NONFUNCTIONAL PITUITARY ADENOMAS DEMONSTRATE TWO SUBTYPES BASED ON MACROPHAGE POLARIZATION STATUS Open
Nonfunctional pituitary adenomas (NFPAs), while typically benign, display variable invasiveness, and can present with devastating symptoms of intercranial mass effect. Tumor-associated macrophages (TAMs) have long been accepted as active p…
View article: The Association of Postoperative Prolactin Serum Concentration with Recurrence of Prolactinoma
The Association of Postoperative Prolactin Serum Concentration with Recurrence of Prolactinoma Open
Background While tumor size and postoperative prolactin concentration have been associated with recurrence of prolactinoma following transsphenoidal resection, little modern data exist regarding the role of immediate postoperative prolacti…
View article: “Organization is what you do before you do something, so that when you do it, it’s not all mixed up.” : An investigation of behaviours using digital visual planning.
“Organization is what you do before you do something, so that when you do it, it’s not all mixed up.” : An investigation of behaviours using digital visual planning. Open
This thesis sets out to investigate and understand behaviours and interactions between individuals while using a large touch screen to plan a holiday trip. By using this approach, the tool digital visual planning by Yolean is indirectly ex…