Martin K. Church
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View article: Mast cell silencing: A novel therapeutic approach for urticaria and other mast cell‐mediated diseases
Mast cell silencing: A novel therapeutic approach for urticaria and other mast cell‐mediated diseases Open
Chronic urticaria (CU) is a mast cell (MC)‐dependent disease with limited therapeutic options. Current management strategies are directed at inhibiting IgE‐mediated activation of MCs and antagonizing effects of released mediators. Due to t…
View article: An international Delphi study on the burden of allergic rhinoconjunctivitis and urticaria and the role of bilastine among current treatment options
An international Delphi study on the burden of allergic rhinoconjunctivitis and urticaria and the role of bilastine among current treatment options Open
The high degree of agreement obtained suggests a wide awareness of the burden of allergic rhinoconjunctivitis and chronic urticaria among experts from all over the world and reflects a broad consensus on the role of second-generation antih…
View article: Evidence for histamine release in chronic inducible urticaria – A systematic review
Evidence for histamine release in chronic inducible urticaria – A systematic review Open
Background Chronic inducible urticaria (CIndU) constitutes a group of nine different CIndUs in which pruritic wheals and/or angioedema occur after exposure to specific and definite triggers. Histamine released from activated and degranulat…
View article: Urticaria in Pregnancy and Lactation
Urticaria in Pregnancy and Lactation Open
Chronic urticaria (CU) is a mast cell-driven chronic inflammatory disease with a female predominance. Since CU affects mostly females in reproductive age, pregnancy is an important aspect to consider in the context of this disease. Sex hor…
View article: A European survey of management approaches in chronic urticaria in children: EAACI pediatric urticaria taskforce
A European survey of management approaches in chronic urticaria in children: EAACI pediatric urticaria taskforce Open
Background Although well described in adults, there are scarce and heterogeneous data on the diagnosis and management of chronic urticaria (CU) in children (0–18 years) throughout Europe. Our aim was to explore country differences and iden…
View article: A European survey of management approaches in chronic urticaria in children: EAACI Paediatric Urticaria Taskforce
A European survey of management approaches in chronic urticaria in children: EAACI Paediatric Urticaria Taskforce Open
Background: Although well described in adults, there are scarce and heterogeneous data on the diagnosis and management of chronic urticaria (CU) in children (0-18 years) throughout Europe. Our aim was to explore country differences and ide…
View article: The international EAACI/GA²LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria
The international EAACI/GA²LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria Open
This update and revision of the international guideline for urticaria was developed following the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is a join…
View article: Predictors of treatment response in chronic spontaneous urticaria
Predictors of treatment response in chronic spontaneous urticaria Open
The current therapeutic algorithm for chronic spontaneous urticaria (CSU), endorsed by the international guideline, entails treatment escalation from second‐generation H 1 ‐antihistamines (sgAHs) to omalizumab and cyclosporine until comple…
View article: The EAACI/GA²LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria
The EAACI/GA²LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria Open
This evidence- and consensus-based guideline was developed following the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. The conference was held on 1 December…
View article: Total IgE as a Marker for Chronic Spontaneous Urticaria
Total IgE as a Marker for Chronic Spontaneous Urticaria Open
The results of our review suggest that total IgE is a valuable marker for CSU, and we recommend its assessment in the routine diagnostic workup of CSU patients.
View article: IgM and IgA in addition to IgG autoantibodies against FcɛRIα are frequent and associated with disease markers of chronic spontaneous urticaria
IgM and IgA in addition to IgG autoantibodies against FcɛRIα are frequent and associated with disease markers of chronic spontaneous urticaria Open
Background IgG autoantibodies against the high‐affinity IgE receptor, FcɛRIα, contribute the pathogenesis of autoimmune chronic spontaneous urticaria (CSU). However, it is not known whether such patients also exhibit IgM or IgA autoantibod…
View article: COMPARISON OF ARTIFICIAL HYDROPHILIC AND LIPOPHILIC MEMBRANES AND HUMAN SKIN TO EVALUATE NIACINAMIDE PENETRATION IN VITRO
COMPARISON OF ARTIFICIAL HYDROPHILIC AND LIPOPHILIC MEMBRANES AND HUMAN SKIN TO EVALUATE NIACINAMIDE PENETRATION IN VITRO Open
Assessment of skin penetration of topically applied drugs is an important problem in the development of dermal creams and ointments.To evaluate this in humans in vivo, several models have been developed including suction blister fluid, tap…
View article: Figure source data for Cold-induced urticarial autoinflammatory syndrome related to factor XII activation
Figure source data for Cold-induced urticarial autoinflammatory syndrome related to factor XII activation Open
In the accompanying paper, an autosomal dominant disease characterized by cold-induced urticarial rash and systemic inflammation is described. The disease is associated with a mutation in the human coagulation Factor 12 gene (F12), and the…
View article: Angioedema and prescribing of omalizumab for chronic urticaria in countries with limited financial resources
Angioedema and prescribing of omalizumab for chronic urticaria in countries with limited financial resources Open
Urticaria comprises a spectrum of conditions characterized by the appearance of itchy wheals. If the symptoms recur for longer than 6 weeks (average duration is 5–7 years), the condition falls within the definition of chronic urticaria.1Zu…
View article: Bilastine: a lifetime companion for the treatment of allergies
Bilastine: a lifetime companion for the treatment of allergies Open
Objective: Bilastine is a potent and highly selective H1-antihistamine approved for the treatment of allergic rhinoconjunctivitis and urticaria. This article summarizes available data on the use of bilastine in the treatment of allergic di…
View article: Biomarkers and clinical characteristics of autoimmune chronic spontaneous urticaria: Results of the PURIST Study
Biomarkers and clinical characteristics of autoimmune chronic spontaneous urticaria: Results of the PURIST Study Open
Background Autoimmune chronic spontaneous urticaria (aiCSU) is an important subtype of chronic spontaneous urticaria (CSU) in which functional IgG autoantibodies to IgE or its high‐affinity receptor (FcεRI) induces mast cell degranulation …
View article: Skin microdialysis: methods, applications and future opportunities—an EAACI position paper
Skin microdialysis: methods, applications and future opportunities—an EAACI position paper Open
Skin microdialysis (SMD) is a versatile sampling technique that can be used to recover soluble endogenous and exogenous molecules from the extracellular compartment of human skin. Due to its minimally invasive character, SMD can be applied…
View article: On the Lipophilic Nature of Autoreactive IgE in Chronic Spontaneous Urticaria
On the Lipophilic Nature of Autoreactive IgE in Chronic Spontaneous Urticaria Open
Chronic spontaneous urticaria (CSU) is a skin disease related to autoreactive IgE in at least a subgroup of patients. However, the nature of this autoreactive IgE remains poorly characterized. This investigation had three objectives: first…
View article: Comparison of extended intervals and dose reduction of omalizumab for asthma control
Comparison of extended intervals and dose reduction of omalizumab for asthma control Open
The necessary treatment duration of omalizumab in patients with severe asthma remains unclear. Currently, common practice is life-long therapy without adjustment of dose or treatment intervals. This study evaluated asthma control after eit…
View article: The Role of Histamine and Histamine Receptors in Mast Cell-Mediated Allergy and Inflammation: The Hunt for New Therapeutic Targets
The Role of Histamine and Histamine Receptors in Mast Cell-Mediated Allergy and Inflammation: The Hunt for New Therapeutic Targets Open
Histamine and its receptors (H1R-H4R) play a crucial and significant role in the development of various allergic diseases. Mast cells are multifunctional bone marrow-derived tissue-dwelling cells that are the major producer of histamine in…
View article: Immunoglobulin E-Mediated Autoimmunity
Immunoglobulin E-Mediated Autoimmunity Open
The study of autoimmunity mediated by immunoglobulin E (IgE) autoantibodies, which may be termed autoallergy, is in its infancy. It is now recognized that systemic lupus erythematosus, bullous pemphigoid (BP), and chronic urticaria, both s…
View article: The EAACI/GA²LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria
The EAACI/GA²LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria Open
This evidence‐ and consensus‐based guideline was developed following the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation ( GRADE ) working group. The conference was held on 1 Decemb…
View article: Potential blood biomarkers in chronic spontaneous urticaria
Potential blood biomarkers in chronic spontaneous urticaria Open
Summary Chronic spontaneous urticaria ( CSU ) is a mast cell‐driven disease that is defined as the recurrence of weals, angioedema or both for > 6 weeks due to known or unknown causes. As of yet, disease diagnosis is purely clinical. Objec…