Martin Köhrmann
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View article: Recent intake of direct oral anticoagulants and acute ischemic stroke: real world data from a comprehensive stroke center
Recent intake of direct oral anticoagulants and acute ischemic stroke: real world data from a comprehensive stroke center Open
Background Deciding on intravenous thrombolysis (IVT) in acute ischemic stroke (AIS) patients with reported recent direct oral anticoagulant (DOAC) intake remains challenging due to concerns about hemorrhagic risk and the absence of random…
View article: Photon-Counting CT Angiography vs. Energy-Integrating CT Angiography for Intracranial Vascular Implant Imaging
Photon-Counting CT Angiography vs. Energy-Integrating CT Angiography for Intracranial Vascular Implant Imaging Open
Purpose Photon-counting detector (PCD) CT angiography (CTA) is an emerging technology that improves spatial resolution and reduces artifacts, potentially enhancing imaging of intracranial implants. No in vivo intra-individual comparisons w…
View article: Prediction of Recurrence and Rupture Risk of Ruptured and Unruptured Intracranial Aneurysms of the Posterior Circulation: A Machine Learning-Based Analysis
Prediction of Recurrence and Rupture Risk of Ruptured and Unruptured Intracranial Aneurysms of the Posterior Circulation: A Machine Learning-Based Analysis Open
Background: Intracranial aneurysms of the posterior circulation are of particular clinical significance due to their higher risk of rupture-associated morbidity and mortality compared to anterior circulation aneurysms. Moreover, they exhib…
View article: Recent Intake of Direct Oral Anticoagulants and Acute Ischemic Stroke: Real World Data from a Comprehensive Stroke Center
Recent Intake of Direct Oral Anticoagulants and Acute Ischemic Stroke: Real World Data from a Comprehensive Stroke Center Open
Background Deciding on intravenous thrombolysis (IVT) in acute ischemic stroke (AIS) patients with reported recent direct oral anticoagulant (DOAC) intake remains challenging due to concerns about hemorrhagic risk and limited real-world ev…
View article: Randomized controlled trials of endovascular therapy for acute ischemic stroke with medium or distal vessel occlusion: a study level metaanalysis
Randomized controlled trials of endovascular therapy for acute ischemic stroke with medium or distal vessel occlusion: a study level metaanalysis Open
View article: Baseline characteristics of patients with acute ischaemic stroke included in the randomised controlled Find-AF 2 trial
Baseline characteristics of patients with acute ischaemic stroke included in the randomised controlled Find-AF 2 trial Open
Background In the Find-AF 2 randomised controlled trial, we investigate whether a risk-adapted intensified heart rhythm monitoring with subsequent initiation of oral anticoagulation in ischaemic stroke patients leads to a reduction of recu…
View article: Impact of bridging intravenous thrombolysis and infarct core growth rate on early neurological improvement in patients with acute anterior circulation ischemic stroke and mechanical thrombectomy
Impact of bridging intravenous thrombolysis and infarct core growth rate on early neurological improvement in patients with acute anterior circulation ischemic stroke and mechanical thrombectomy Open
Purpose The aim of this study is to assess the impact of bridging intravenous thrombolysis (IVT), infarct core growth rate (ICGR) and their interaction on neurological outcomes in patients undergoing endovascular thrombectomy (EVT) in acut…
View article: Recurrent stroke in patients with history of stroke/transient ischemic attack and device-detected atrial fibrillation: A systematic review and meta-analysis
Recurrent stroke in patients with history of stroke/transient ischemic attack and device-detected atrial fibrillation: A systematic review and meta-analysis Open
Introduction: Prolonged cardiac monitoring after stroke increases the detection of device-detected atrial fibrillation (DDAF), leading to a clinical dilemma regarding anticoagulation for secondary stroke prevention. While anticoagulation r…
View article: Optimizing selectivity of the Cerebellar Cognitive Affective Syndrome Scale by use of correction formulas, and validation of its German version
Optimizing selectivity of the Cerebellar Cognitive Affective Syndrome Scale by use of correction formulas, and validation of its German version Open
Background Cerebellar disease may result in Cerebellar Cognitive Affective Syndrome (CCAS) . The CCAS-Scale, designed to screen for CCAS, has been validated in English Hoche (Brain 141:248–270, 2018) and adapted to other languages. Methods…
View article: The cerebellum contributes to prediction error coding in reinforcement learning - complementary evidence from stroke patients and from cerebellar transcranial magnetic stimulation
The cerebellum contributes to prediction error coding in reinforcement learning - complementary evidence from stroke patients and from cerebellar transcranial magnetic stimulation Open
To survive and thrive in our ever-changing environment, we need to be able to predict the consequences of our actions. We update these predictions by learning through trial and error, and associated prediction errors (PEs). Recent rodent d…
View article: Sex Differences in Clinical Presentation of Women and Men Evaluated at a Comprehensive Stroke Center for Suspected Stroke
Sex Differences in Clinical Presentation of Women and Men Evaluated at a Comprehensive Stroke Center for Suspected Stroke Open
Introduction: Understanding sex differences in the clinical presentation of patients with suspected stroke is important to reduce sex-related disparities and improve care. We aimed to characterize presenting symptoms in women and men with …
View article: Analyzing temporal imaging patterns in acute ischemic stroke via DICOM-timestamps
Analyzing temporal imaging patterns in acute ischemic stroke via DICOM-timestamps Open
View article: Subtypes of cognitive impairment in cerebellar disease identified by cross-diagnostic cluster-analysis: results from a German multicenter study
Subtypes of cognitive impairment in cerebellar disease identified by cross-diagnostic cluster-analysis: results from a German multicenter study Open
View article: Virtual reality-guided therapy on a stroke unit: a feasibility study
Virtual reality-guided therapy on a stroke unit: a feasibility study Open
Background VR (Virtual Reality) has emerged as a recent treatment approach in neurorehabilitation. The feasibility of VR-guided therapy in the acute phase after stroke has not been assessed. Methods This was a cohort study of consecutive p…
View article: Establishing Medical Intelligence—Leveraging Fast Healthcare Interoperability Resources to Improve Clinical Management: Retrospective Cohort and Clinical Implementation Study
Establishing Medical Intelligence—Leveraging Fast Healthcare Interoperability Resources to Improve Clinical Management: Retrospective Cohort and Clinical Implementation Study Open
Background FHIR (Fast Healthcare Interoperability Resources) has been proposed to enable health data interoperability. So far, its applicability has been demonstrated for selected research projects with limited data. Objective This study a…
View article: Impact of post-thrombectomy isolated subarachnoid hemorrhage on neurological outcomes in patients with anterior ischemic stroke – a retrospective single-center observational study
Impact of post-thrombectomy isolated subarachnoid hemorrhage on neurological outcomes in patients with anterior ischemic stroke – a retrospective single-center observational study Open
View article: Endovascular Thrombectomy Versus Intravenous Thrombolysis of Posterior Cerebral Artery Occlusion Stroke
Endovascular Thrombectomy Versus Intravenous Thrombolysis of Posterior Cerebral Artery Occlusion Stroke Open
Background and Purpose Posterior cerebral artery occlusion (PCAo) can cause long-term disability, yet randomized controlled trials to guide optimal reperfusion strategy are lacking. We compared the outcomes of PCAo patients treated with en…
View article: Media coverage of COVID-19 vaccination-associated cerebral venous sinus thrombosis was followed by a surge in emergency presentations due to headache – observations from a university hospital in Germany
Media coverage of COVID-19 vaccination-associated cerebral venous sinus thrombosis was followed by a surge in emergency presentations due to headache – observations from a university hospital in Germany Open
Nocebo effects describe all negative outcomes for well-being brought about by negative health-related expectations. Media coverage of drug side effects can fuel nocebo effects and lead to increased symptom reports. This retrospective obser…
View article: The cerebellum contributes to prediction error coding in reinforcement learning - complementary evidence from stroke patients and from cerebellar transcranial magnetic stimulation
The cerebellum contributes to prediction error coding in reinforcement learning - complementary evidence from stroke patients and from cerebellar transcranial magnetic stimulation Open
To survive and thrive in our ever-changing environment, we need to be able to predict the consequences of our actions. We update these predictions by learning through trial and error, and associated prediction errors (PEs). Recent rodent d…
View article: Endovascular Versus Medical Therapy in Posterior Cerebral Artery Stroke: Role of Baseline NIHSS Score and Occlusion Site
Endovascular Versus Medical Therapy in Posterior Cerebral Artery Stroke: Role of Baseline NIHSS Score and Occlusion Site Open
BACKGROUND: Acute ischemic stroke with isolated posterior cerebral artery occlusion (iPCAO) lacks management evidence from randomized trials. We aimed to evaluate whether the association between endovascular treatment (EVT) and outcomes in…
View article: Impact of Vaccination Status on Outcome of Patients With COVID‐19 and Acute Ischemic Stroke Undergoing Mechanical Thrombectomy
Impact of Vaccination Status on Outcome of Patients With COVID‐19 and Acute Ischemic Stroke Undergoing Mechanical Thrombectomy Open
Background Data on impact of COVID‐19 vaccination and outcomes of patients with COVID‐19 and acute ischemic stroke undergoing mechanical thrombectomy are scarce. Addressing this subject, we report our multicenter experience. Methods and Re…
View article: Reducing False-Positives in CT Perfusion Infarct Core Segmentation Using Contralateral Local Normalization
Reducing False-Positives in CT Perfusion Infarct Core Segmentation Using Contralateral Local Normalization Open
The proposed method of local normalization can reduce overestimation of the infarct core, especially in the deep WM and in cases with obvious microangiopathy. False-positives in CTP infarct core segmentation might lead to less-than-optimal…
View article: Validation of a German-language modified Rankin Scale structured telephone interview at 3 months in a real-life stroke cohort
Validation of a German-language modified Rankin Scale structured telephone interview at 3 months in a real-life stroke cohort Open
Background The modified Rankin scale (mRS) at 3 months is established as the primary outcome measure in clinical stroke trials. Traditionally, the mRS is assessed through an unstructured face-to-face interview. This approach can be labor-i…
View article: First‐Line Stent Retriever Versus Contact Aspiration or Combined Technique for Endovascular Therapy of Posterior Cerebral Artery Occlusion Stroke: The PLATO Study
First‐Line Stent Retriever Versus Contact Aspiration or Combined Technique for Endovascular Therapy of Posterior Cerebral Artery Occlusion Stroke: The PLATO Study Open
Background The optimal reperfusion technique in patients with isolated posterior cerebral artery (PCA) occlusion is uncertain. We compared clinical and technical outcomes with first‐line stent retriever (SR), contact aspiration (CA), or co…
View article: Frequency and Characteristics of Non-Neurological and Neurological Stroke Mimics in the Emergency Department
Frequency and Characteristics of Non-Neurological and Neurological Stroke Mimics in the Emergency Department Open
Background: Stroke mimics are common in the emergency department (ED) and early detection is important to initiate appropriate treatment and withhold unnecessary procedures. We aimed to compare the frequency, clinical characteristics and p…
View article: Abstract 012: First‐line Stent Retriever Versus Contact Aspiration or Combined Technique for Posterior Cerebral Artery Occlusion EVT
Abstract 012: First‐line Stent Retriever Versus Contact Aspiration or Combined Technique for Posterior Cerebral Artery Occlusion EVT Open
Introduction The optimal reperfusion technique in patients with isolated posterior cerebral artery (PCA) occlusion is uncertain. Previous studies in LVO and MeVO have demonstrated a correlation between good clinical outcomes and the first …
View article: O15/151 Impact of post-thrombectomy isolated subarachnoid hemorrhage and other types of intracranial hemorrhage on neurological outcomes in patients with anterior circulation ischemic stroke – reperfusion grade determines
O15/151 Impact of post-thrombectomy isolated subarachnoid hemorrhage and other types of intracranial hemorrhage on neurological outcomes in patients with anterior circulation ischemic stroke – reperfusion grade determines Open
Introduction Subarachnoid hemorrhage is a common finding, ranging from 5.2% to 15.2% in ischemic stroke patients after mechanical thrombectomy. Aim of Study We aimed to evaluate neurological outcomes in patient groups without intracranial …
View article: Penumbral Rescue by normobaric O = O administration in patients with ischemic stroke and target mismatch proFile (PROOF): Study protocol of a phase IIb trial
Penumbral Rescue by normobaric O = O administration in patients with ischemic stroke and target mismatch proFile (PROOF): Study protocol of a phase IIb trial Open
Rationale: Oxygen is essential for cellular energy metabolism. Neurons are particularly vulnerable to hypoxia. Increasing oxygen supply shortly after stroke onset could preserve the ischemic penumbra until revascularization occurs. Aims: P…
View article: Intensive heart rhythm monitoring to decrease ischemic stroke and systemic embolism—the Find-AF 2 study—rationale and design
Intensive heart rhythm monitoring to decrease ischemic stroke and systemic embolism—the Find-AF 2 study—rationale and design Open
View article: Brainstem Infarction in Immunodeficiency Identified as Adenosine Deaminase 2 Deficiency: Case Report
Brainstem Infarction in Immunodeficiency Identified as Adenosine Deaminase 2 Deficiency: Case Report Open
Purpose We present the case of a 24-year-old male with CNS granulomatosis due to an immunodeficiency syndrome which was identified as deficiency of adenosine deaminase 2 (DADA2) as a cause of brainstem infarction. Methods Case report and d…