Explanipedia

Protocol for 3D bioprinting of a 3D in vitro model of neuroblastoma Open

Mehdi Salar Amoli, Sarah Rezapourdamanab, Linqi Jin, Melissa Cadena, Kaveeta Kaw , et al. · 2025

Here, we present a protocol for developing an in vitro 3D model of neuroblastoma through bioprinting, incorporating key components of the tumor microenvironment (TME), including vasculature and cancer cell line spheroids. We describe steps…

Microbial Changes Occurring During Oronasal Fistula Wound Healing Open

Steven L. Goudy, Heath L. Bradley, C. Anthony Gacasan, Afra I. Toma, K. Sekar , et al. · 2025

The oral microbiome is a complex community that matures with dental development and is recognized as a risk factor for systemic disease. Despite the oral cavity having a substantial microbial burden, healing of superficial oral wounds occu…

Image-Guided Cardiac Regeneration Via a 3d Bioprinted Vascular Patch with Built-In Ct Visibility Open

Carmen J. Gil, Alex J. Allphin, Martin L. Tomov, Mehdi Salar Amoli, Sarah Rezapourdamanab , et al. · 2025

Protocol for 3D bioprinting of nanoparticle-laden hydrogels to enhance antibacterial and imaging properties Open

Mehdi Salar Amoli, Linqi Jin, Sarah Rezapourdamanab, Maher Saadeh, Yamini Singh , et al. · 2024

This protocol describes the preparation of a nanoparticle-encapsulated bioink capable of protecting tissue-engineered constructs against bacterial infections while also providing contrast for magnetic resonance (MR) imaging modalities. The…

Patient-specific 3D in vitro modeling and fluid dynamic analysis of primary pulmonary vein stenosis Open

Christian Devlin, Martin L. Tomov, Huang Chen, Sindhu Nama, Siraj M. Ali , et al. · 2024

Introduction Primary pulmonary vein stenosis (PVS) is a rare congenital heart disease that proves to be a clinical challenge due to the rapidly progressive disease course and high rates of treatment complications. PVS intervention is frequ…

A 3D Bioprinted Cortical Organoid Platform for Modeling Human Brain Development Open

Melissa Cadena, Anson Sing, Kylie M. Taylor, Linqi Jin, Liqun Ning , et al. · 2024

The ability to promote three‐dimensional (3D) self‐organization of induced pluripotent stem cells into complex tissue structures called organoids presents new opportunities for the field of developmental biology. Brain organoids have been …

Targeted Rapamycin Delivery via Magnetic Nanoparticles to Address Stenosis in a 3D Bioprinted in Vitro Model of Pulmonary Veins Open

Liqun Ning, S. Zanella, Martin L. Tomov, Mehdi Salar Amoli, Linqi Jin , et al. · 2024

Vascular cell overgrowth and lumen size reduction in pulmonary vein stenosis (PVS) can result in elevated PV pressure, pulmonary hypertension, cardiac failure, and death. Administration of chemotherapies such as rapamycin have shown promis…

Leveraging 3D Bioprinting and Photon‐Counting Computed Tomography to Enable Noninvasive Quantitative Tracking of Multifunctional Tissue Engineered Constructs Open

Carmen J. Gil, Connor J. Evans, Lan Li, Alex J. Allphin, Martin L. Tomov , et al. · 2023

3D bioprinting is revolutionizing the fields of personalized and precision medicine by enabling the manufacturing of bioartificial implants that recapitulate the structural and functional characteristics of native tissues. However, the lac…

Microbial Changes occurring during oronasal fistula wound healing Open

Steven L. Goudy, Heath L. Bradley, C. Anthony Gacasan, Afra Toma, Crystal Naudin , et al. · 2023

Summary The oral microbiome is a complex community that matures with dental development while oral health is also a recognized risk factor for systemic disease. Despite the oral cavity having a substantial microbial burden, healing of supe…

Extrusion‐Based 3D Bioprinting of Adhesive Tissue Engineering Scaffolds Using Hybrid Functionalized Hydrogel Bioinks Open

Shuai Chen, Martin L. Tomov, Liqun Ning, Carmen J. Gil, Boeun Hwang , et al. · 2023

Adhesive tissue engineering scaffolds (ATESs) have emerged as an innovative alternative means, replacing sutures and bioglues, to secure the implants onto target tissues. Relying on their intrinsic tissue adhesion characteristics, ATES sys…

3D bioprinting of nanoparticle-laden hydrogel scaffolds with enhanced antibacterial and imaging properties Open

Andrea S. Theus, Liqun Ning, Gabriella Kabboul, Boeun Hwang, Martin L. Tomov , et al. · 2022

A 3D Bioprinted in vitro Model of Neuroblastoma Recapitulates Dynamic Tumor‐Endothelial Cell Interactions Contributing to Solid Tumor Aggressive Behavior (Adv. Sci. 23/2022) Open

Liqun Ning, Jenny Shim, Martin L. Tomov, Rui Liu, Riya Mehta , et al. · 2022

3D Bioprinted in vitro Model of Neuroblastoma Neuroblastoma (NB) accounts for 50% of all cancers in infants with substantial mortality. Due to the lack of robust experimental models, the role of NB microenvironment in tumor progression is …

A 3D Bioprinted In Vitro Model of Pulmonary Artery Atresia to Evaluate Endothelial Cell Response to Microenvironment Open

Martin L. Tomov, Lilanni Perez, Liqun Ning, Chen Huang, Bowen Jing , et al. · 2022

Adv. Healthcare Mater. 2021, 10, 2100968 https://doi.org/10.1002/adhm.202100968 In the original version of this article, the last sentence of the Acknowledgements is missing a funding source. The correct sentence at the end of the Acknowle…

Methacrylate‐Modified Gold Nanoparticles Enable Noninvasive Monitoring of Photocrosslinked Hydrogel Scaffolds Open

Lan Li, Carmen J. Gil, Tyler A. Finamore, Connor J. Evans, Martin L. Tomov , et al. · 2022

BiofabricationIn article number 2200022, Ryan K. Roeder and co-workers introduce photopolymerizable nanoparticles that can be incorporated into bioinks when bioprinting scaffolds. The nanoparticles are covalently linked to the hydrogel net…

Methacrylate‐Modified Gold Nanoparticles Enable Noninvasive Monitoring of Photocrosslinked Hydrogel Scaffolds Open

Lan Li, Carmen J. Gil, Tyler A. Finamore, Connor J. Evans, Martin L. Tomov , et al. · 2022

Photocrosslinked hydrogels, such as methacrylate‐modified gelatin (gelMA) and hyaluronic acid (HAMA), are widely utilized as tissue engineering scaffolds and/or drug delivery vehicles, but lack a suitable means for noninvasive, longitudina…

A 3D Bioprinted in vitro Model of Neuroblastoma Recapitulates Dynamic Tumor‐Endothelial Cell Interactions Contributing to Solid Tumor Aggressive Behavior Open

Liqun Ning, Jenny Shim, Martin L. Tomov, Rui Liu, Riya Mehta , et al. · 2022

Neuroblastoma (NB) is the most common extracranial tumor in children resulting in substantial morbidity and mortality. A deeper understanding of the NB tumor microenvironment (TME) remains an area of active research but there is a lack of …

Methacrylate-Modified Gold Nanoparticles Enable Non-Invasive Monitoring of Photocrosslinked Hydrogel Scaffolds Open

Lan Li, Carmen J. Gil, Tyler A. Finamore, Connor J. Evans, Martin L. Tomov , et al. · 2022

Photocrosslinked hydrogels, such as methacrylate-modified gelatin (gelMA) and hyaluronic acid (HAMA), are widely utilized as tissue engineering scaffolds and/or drug delivery vehicles, but lack a suitable means for non-invasive, longitudin…

Editorial: Bioengineering and Biotechnology Approaches in Cardiovascular Sciences Open

Jianyi Zhang, Martin L. Tomov, James J.H. Chong, Philippe Menasché, Vahid Serpooshan · 2021

EDITORIAL article Front. Bioeng. Biotechnol., 20 August 2021 | https://doi.org/10.3389/fbioe.2021.746435

A 3D Bioprinted In Vitro Model of Pulmonary Artery Atresia to Evaluate Endothelial Cell Response to Microenvironment Open

Martin L. Tomov, Lilanni Perez, Liqun Ning, Huang Chen, Bowen Jing , et al. · 2021

Vascular atresia are often treated via transcatheter recanalization or surgical vascular anastomosis due to congenital malformations or coronary occlusions. The cellular response to vascular anastomosis or recanalization is, however, large…

Adhesive Tissue Engineered Scaffolds: Mechanisms and Applications Open

Shuai Chen, Carmen J. Gil, Liqun Ning, Linqi Jin, Lilanni Perez , et al. · 2021

A variety of suture and bioglue techniques are conventionally used to secure engineered scaffold systems onto the target tissues. These techniques, however, confront several obstacles including secondary damages, cytotoxicity, insufficient…

Resolving cell state in iPSC-derived human neural samples with multiplexed fluorescence imaging Open

Martin L. Tomov, Alison O’Neil, Hamdah Shafqat Abbasi, Beth A. Cimini, Anne E. Carpenter , et al. · 2021

Publisher's Note: “Biomechanical factors in three-dimensional tissue bioprinting” [Appl. Phys Rev. <b>7</b>, 041319 (2020)] Open

Liqun Ning, Carmen J. Gil, Boeun Hwang, Andrea S. Theus, Lilanni Perez , et al. · 2021

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3D Bioprinted Bacteriostatic Hyperelastic Bone Scaffold for Damage-Specific Bone Regeneration Open

Mohammadreza Shokouhimehr, Andrea S. Theus, Archana Kamalakar, Liqun Ning, Cong Cao , et al. · 2021

Current strategies for regeneration of large bone fractures yield limited clinical success mainly due to poor integration and healing. Multidisciplinary approaches in design and development of functional tissue engineered scaffolds are req…

Resolving cell state in iPSC-derived human neural samples with multiplexed fluorescence imaging Open

Martin L. Tomov, Alison O’Neil, Hamdah Shafqat Abbasi, Beth A. Cimini, Anne E. Carpenter , et al. · 2021

Human induced pluripotent stem cell-derived (iPSC) neural cultures offer clinically relevant models of human diseases, including Amyotrophic Lateral Sclerosis, Alzheimer’s, and Autism Spectrum Disorder. In situ characterization of the spat…

Patient‐Specific 3D Bioprinted Models of Developing Human Heart Open

Alexander D. Cetnar, Martin L. Tomov, Liqun Ning, Bowen Jing, Andrea S. Theus , et al. · 2020

The heart is the first organ to develop in the human embryo through a series of complex chronological processes, many of which critically rely on the interplay between cells and the dynamic microenvironment. Tight spatiotemporal regulation…

Biomechanical factors in three-dimensional tissue bioprinting Open

Liqun Ning, Carmen J. Gil, Boeun Hwang, Andrea S. Theus, Lilanni Perez , et al. · 2020

3D bioprinting techniques have shown great promise in various fields of tissue engineering and regenerative medicine. Yet, creating a tissue construct that faithfully represents the tightly regulated composition, microenvironment, and func…

Ventilated Upper Airway Endoscopic Endonasal Procedure Mask: Surgical Safety in the COVID-19 Era Open

Samuel N. Helman, Roberto M. Soriano, Martin L. Tomov, Vahid Serpooshan, Joshua M. Levy , et al. · 2020

BACKGROUND COVID-19 poses a risk to the endoscopic skull base surgeon. Significant efforts to improving safety have been employed, including the use of personal protective equipment, preoperative COVID-19 testing, and recently the use of a…

Patient‐Specific 3‐Dimensional–Bioprinted Model for In Vitro Analysis and Treatment Planning of Pulmonary Artery Atresia in Tetralogy of Fallot and Major Aortopulmonary Collateral Arteries Open

Martin L. Tomov, Alexander Cetnar, Katherine Do, Holly Bauser‐Heaton, Vahid Serpooshan · 2019

Background Tetralogy of Fallot with major aortopulmonary collateral arteries is a heterogeneous form of pulmonary artery (PA) stenosis that requires multiple forms of intervention. We present a patient‐specific in vitro platform capable of…

In Vivo Tracking of Tissue Engineered Constructs Open

Carmen J. Gil, Martin L. Tomov, Andrea S. Theus, Alexander Cetnar, Morteza Mahmoudi , et al. · 2019

To date, the fields of biomaterials science and tissue engineering have shown great promise in creating bioartificial tissues and organs for use in a variety of regenerative medicine applications. With the emergence of new technologies suc…

Cardiovascular tissue bioprinting: Physical and chemical processes Open

James B. Hu, Martin L. Tomov, Jan W. Buikema, Caressa Chen, Morteza Mahmoudi , et al. · 2018

Three-dimensional (3D) cardiac tissue bioprinting occupies a critical crossroads position between the fields of materials engineering, cardiovascular biology, 3D printing, and rational organ replacement design. This complex area of researc…

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