Martin Lagging
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View article: Immunogenicity of the Comirnaty Omicron XBB.1.5 booster COVID-19 mRNA vaccine in patients with cirrhosis
Immunogenicity of the Comirnaty Omicron XBB.1.5 booster COVID-19 mRNA vaccine in patients with cirrhosis Open
Conclusions: A fifth mRNA-based COVID-19 booster dose significantly augments both humoral and cellular immunity in patients with liver cirrhosis. These findings support the use of a single annual booster dose to maintain adequate im…
View article: Influence of viral load on severity and mortality in COVID-19
Influence of viral load on severity and mortality in COVID-19 Open
This study identified high viral load at first sampling as a predictor of severe infection and/or death across age groups of SARS-CoV-2-infected patients.
View article: Distinct distribution of HEV-3 subtypes across humans, animals, and environmental waters in Sweden
Distinct distribution of HEV-3 subtypes across humans, animals, and environmental waters in Sweden Open
We previously observed a notable discrepancy in the distribution of HEV-3 subtypes between wastewater and clinical samples in Sweden. To confirm this observation and comprehensively elucidate HEV-3 circulation patterns across humans, anima…
View article: Remdesivir is active <i>in vitro</i> against tick-borne encephalitis virus and selects for resistance mutations in the viral RNA-dependent RNA polymerase
Remdesivir is active <i>in vitro</i> against tick-borne encephalitis virus and selects for resistance mutations in the viral RNA-dependent RNA polymerase Open
RDV exhibits potent in vitro antiviral activity against TBEV via specific targeting of the viral RdRp as confirmed by the emergence of resistance-associated double NS5 substitutions in vitro in the presence of RDV. While the …
View article: Number of people treated for hepatitis C virus infection in 2014-2023 and applicable lessons for new HBV and HDV therapies
Number of people treated for hepatitis C virus infection in 2014-2023 and applicable lessons for new HBV and HDV therapies Open
Long-term hepatitis C virus (HCV) infection can lead to cirrhosis and liver cancer. Since 2014, these infections can be effectively treated with 8-12 weeks of oral therapies. In 2015, the World Health Organization established targets to el…
View article: Immunogenicity of Comirnaty Omicron XBB.1.5 booster COVID-19 mRNA vaccine in long-term survivors after allogeneic hematopoietic stem cell transplantation
Immunogenicity of Comirnaty Omicron XBB.1.5 booster COVID-19 mRNA vaccine in long-term survivors after allogeneic hematopoietic stem cell transplantation Open
View article: Corrigendum to: “High prevalence of hepatitis E and rat hepatitis E viruses in wastewater in Gothenburg, Sweden” [One Health, volume 19, article number 100882]
Corrigendum to: “High prevalence of hepatitis E and rat hepatitis E viruses in wastewater in Gothenburg, Sweden” [One Health, volume 19, article number 100882] Open
[This corrects the article DOI: 10.1016/j.onehlt.2024.100882.].
View article: High prevalence of hepatitis E and rat hepatitis E viruses in wastewater in Gothenburg, Sweden
High prevalence of hepatitis E and rat hepatitis E viruses in wastewater in Gothenburg, Sweden Open
View article: Adjusted estimate of the prevalence of hepatitis delta virus in 25 countries and territories
Adjusted estimate of the prevalence of hepatitis delta virus in 25 countries and territories Open
View article: Presence of MDSC associates with impaired antigen-specific T cell reactivity following COVID-19 vaccination in cirrhotic patients
Presence of MDSC associates with impaired antigen-specific T cell reactivity following COVID-19 vaccination in cirrhotic patients Open
Background and aims Cirrhosis entails high risk of serious infections and abated efficiency of vaccination, but the underlying mechanisms are only partially understood. This study aimed at characterizing innate and adaptive immune function…
View article: Impaired T-cell response to mRNA vaccination heralds risk of COVID-19 in long-term allogeneic hematopoietic stem cell transplantation survivors
Impaired T-cell response to mRNA vaccination heralds risk of COVID-19 in long-term allogeneic hematopoietic stem cell transplantation survivors Open
Not available.
View article: High Exposure to Perfluoroalkyl Substances and Antibody Responses to SARS-CoV-2 mRNA Vaccine—an Observational Study in Adults from Ronneby, Sweden
High Exposure to Perfluoroalkyl Substances and Antibody Responses to SARS-CoV-2 mRNA Vaccine—an Observational Study in Adults from Ronneby, Sweden Open
Following a strict study protocol, rigorous study design, and few dropouts, we found no indication that PFAS exposure negatively affected antibody responses to COVID-19 mRNA vaccination for up to 6 months after vaccination. https://doi.org…
View article: Catch-up antibody responses and hybrid immunity in mRNA vaccinated patients at risk of severe COVID-19
Catch-up antibody responses and hybrid immunity in mRNA vaccinated patients at risk of severe COVID-19 Open
Three doses of the Covid-19 mRNA vaccine entailed high antibody concentrations even in immunocompromised individuals, and hybrid-immunity resulted further augmented levels than vaccination alone. Clinical trial registration: EudraCT…
View article: Measures against COVID-19 affected the spread of human enteric viruses in a Swedish community, as found when monitoring wastewater
Measures against COVID-19 affected the spread of human enteric viruses in a Swedish community, as found when monitoring wastewater Open
View article: Hepatitis D double reflex testing of all hepatitis B carriers in low-HBV- and high-HBV/HDV-prevalence countries
Hepatitis D double reflex testing of all hepatitis B carriers in low-HBV- and high-HBV/HDV-prevalence countries Open
View article: Induction and subsequent decline of S1-specific T cell reactivity after COVID-19 vaccination
Induction and subsequent decline of S1-specific T cell reactivity after COVID-19 vaccination Open
We analyzed magnitude and duration of SARS-CoV-2-specific T cell responses in healthy, infection-naïve subjects receiving COVID-19 vaccines. Overlapping peptides spanning the N-terminal spike 1 (S1) domain of the spike protein triggered se…
View article: Hepatitis E Virus Infection, a Risk for Liver Transplant Recipients in Sweden
Hepatitis E Virus Infection, a Risk for Liver Transplant Recipients in Sweden Open
Background. Following exposure to hepatitis E virus (HEV), liver transplant (LT) recipients have an increased risk of developing chronic infection, which may rapidly progress to severe liver damage if not treated. The prevalence of HEV inf…
View article: High real-world effectiveness of 12-week elbasvir/grazoprevir without resistance testing in the treatment of patients with HCV genotype 1a infection in Norway
High real-world effectiveness of 12-week elbasvir/grazoprevir without resistance testing in the treatment of patients with HCV genotype 1a infection in Norway Open
We observed high SVR rates among patients with HCV GT1a infection treated with EBR/GZR for 12 weeks without ribavirin, with no regard to baseline viral load and no RAS testing.
View article: The amount of SARS-CoV-2 RNA in wastewater relates to the development of the pandemic and its burden on the health system
The amount of SARS-CoV-2 RNA in wastewater relates to the development of the pandemic and its burden on the health system Open
View article: Transient and durable T cell reactivity after COVID-19
Transient and durable T cell reactivity after COVID-19 Open
This study analyzed whole blood samples ( n = 56) retrieved from 30 patients at 1 to 21 (median 9) mo after verified COVID-19 to determine the polarity and duration of antigen-specific T cell reactivity against severe acute respiratory syn…
View article: Humoral and cellular immunity after vaccination against SARS-CoV-2 is reduced in patients with chronic liver disease
Humoral and cellular immunity after vaccination against SARS-CoV-2 is reduced in patients with chronic liver disease Open
View article: COVID-19 vaccine-induced adverse events predict immunogenicity among recipients of allogeneic hematopoietic stem cell transplantation
COVID-19 vaccine-induced adverse events predict immunogenicity among recipients of allogeneic hematopoietic stem cell transplantation Open
COVID-19 vaccine-induced adverse events predict immunogenicity among recipients of allogeneic hematopoietic stem cell transplantation][5][6][7] Previous studies in healthy individuals support an association between adverse reactions after …
View article: Impaired SARS-CoV-2-specific T-cell reactivity in patients with cirrhosis following mRNA COVID-19 vaccination
Impaired SARS-CoV-2-specific T-cell reactivity in patients with cirrhosis following mRNA COVID-19 vaccination Open
View article: Deficiency of SARS-CoV-2 T-cell responses after vaccination in long-term allo-HSCT survivors translates into abated humoral immunity
Deficiency of SARS-CoV-2 T-cell responses after vaccination in long-term allo-HSCT survivors translates into abated humoral immunity Open
Recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for hematological diseases are at risk of severe disease and death from COVID-19. To determine the safety and immunogenicity of BNT162b2 and mRNA-1273 COVID-19 va…
View article: Reduced immunogenicity of a third COVID-19 vaccination among recipients of allogeneic hematopoietic stem cell transplantation
Reduced immunogenicity of a third COVID-19 vaccination among recipients of allogeneic hematopoietic stem cell transplantation Open
Not available.
View article: Rapid Cytokine Release Assays for Analysis of Severe Acute Respiratory Syndrome Coronavirus 2–Specific T Cells in Whole Blood
Rapid Cytokine Release Assays for Analysis of Severe Acute Respiratory Syndrome Coronavirus 2–Specific T Cells in Whole Blood Open
Background Waning of immunoglobulin G (IgG) antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) complicates the diagnosis of past infection. The durability of T-cell memory against SARS-CoV-2 remains unclear, an…
View article: Presence of interferon-λ 4, male gender, absent/mild steatosis and low viral load augment antibody levels to hepatitis C virus
Presence of interferon-λ 4, male gender, absent/mild steatosis and low viral load augment antibody levels to hepatitis C virus Open
To our knowledge, this is the first report that demonstrates that the ability to produce IFN-λ4, in addition to male gender, absent/mild steatosis, and lower viral load, augments antibody levels against HCV. This indicates that IFN-λ4 may …
View article: Hepatitis C elimination in Sweden: Progress, challenges and opportunities for growth in the time of COVID‐19
Hepatitis C elimination in Sweden: Progress, challenges and opportunities for growth in the time of COVID‐19 Open
Background & Aims In 2014, the burden of hepatitis C virus (HCV) in Sweden was evaluated, to establish a baseline and inform public health interventions. Considering the changing landscape of HCV treatment, prevention, and care, and in lig…
View article: Absence of interferon-λ 4 enhances spontaneous clearance of acute hepatitis C virus genotypes 1-3 infection
Absence of interferon-λ 4 enhances spontaneous clearance of acute hepatitis C virus genotypes 1-3 infection Open
Absence of IFN-λ4 entails an enhanced likelihood of spontaneous resolution both following primary acute infection and repeated re-exposure to HCV across genotypes 1-3. Among men lacking IFN-λ4, reduced ITPase activity improved outcome.
View article: Surveillance of wastewater revealed peaks of SARS-CoV-2 preceding those of hospitalized patients with COVID-19
Surveillance of wastewater revealed peaks of SARS-CoV-2 preceding those of hospitalized patients with COVID-19 Open