Martin Mžik
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View article: A case report of fatal chlormequat poisoning: Identification of potential additional mechanism of toxicity
A case report of fatal chlormequat poisoning: Identification of potential additional mechanism of toxicity Open
Chlormequat is a quaternary ammonium salt used as a plant growth-regulating agent. It is structurally similar to choline, acting at muscarinic and nicotinic receptors. Herein, we present the case of suicidal poisoning with an unknown dose …
View article: Acute inflammation induced by the <i>Escherichia coli</i> lipopolysaccharide considerably increases the systemic and brain exposure of olanzapine after oral administration in mice
Acute inflammation induced by the <i>Escherichia coli</i> lipopolysaccharide considerably increases the systemic and brain exposure of olanzapine after oral administration in mice Open
Background A detailed understanding of alterations in olanzapine pharmacokinetics during acute inflammatory states, associated with infections, remains lacking. This study aimed to investigate the impact of endotoxemia on the pharmacokinet…
View article: Lipopolysaccharide induced acute inflammation leads to a higher systemic and brain exposure to olanzapine in mice
Lipopolysaccharide induced acute inflammation leads to a higher systemic and brain exposure to olanzapine in mice Open
Introduction Pro-inflammatory mediators inhibit drug metabolism and transport. Detailed knowledge is lacking on the mechanism and extent of alterations in olanzapine pharmacokinetics during acute inflammatory states accompanying infections…
View article: Multifunctional, Fluorene‐Based Modulator of Cholinergic and GABAergic Neurotransmission as a Novel Drug Candidate for Palliative Treatment of Alzheimer's Disease
Multifunctional, Fluorene‐Based Modulator of Cholinergic and GABAergic Neurotransmission as a Novel Drug Candidate for Palliative Treatment of Alzheimer's Disease Open
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory loss and behavioral and psychological symptoms of dementia (BPSD). Given that cholinergic neurons are predominantly affected in AD, current treatments primari…
View article: Multifunctional, Fluorene‐Based Modulator of Cholinergic and GABAergic Neurotransmission as a Novel Drug Candidate for Palliative Treatment of Alzheimer's Disease
Multifunctional, Fluorene‐Based Modulator of Cholinergic and GABAergic Neurotransmission as a Novel Drug Candidate for Palliative Treatment of Alzheimer's Disease Open
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory loss and behavioral and psychological symptoms of dementia (BPSD). Given that cholinergic neurons are predominantly affected in AD, current treatments primari…
View article: Serum Citrulline and Ornithine: Potential Markers of Coeliac Disease Activity
Serum Citrulline and Ornithine: Potential Markers of Coeliac Disease Activity Open
Introduction: To date, there is not generally accepted and universal indicator of activity, and functional integrity of the small intestine in patients with coeliac disease. The aim of our study was to investigate whether serum concentrati…
View article: Interaction of Cucurbit[7]uril with Oxime K027, Atropine, and Paraoxon: Risky or Advantageous Delivery System?
Interaction of Cucurbit[7]uril with Oxime K027, Atropine, and Paraoxon: Risky or Advantageous Delivery System? Open
Antidotes against organophosphates often possess physicochemical properties that mitigate their passage across the blood–brain barrier. Cucurbit[7]urils may be successfully used as a drug delivery system for bisquaternary oximes and improv…
View article: Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease Open
View article: The New Acetylcholinesterase Inhibitors <scp>PC</scp>‐37 and <scp>PC</scp>‐48 (7‐Methoxytacrine‐Donepezil‐Like Compounds): Characterization of Their Metabolites in Human Liver Microsomes, Pharmacokinetics and <i>In Vivo</i> Formation of the Major Metabolites in Rats
The New Acetylcholinesterase Inhibitors <span>PC</span>‐37 and <span>PC</span>‐48 (7‐Methoxytacrine‐Donepezil‐Like Compounds): Characterization of Their Metabolites in Human Liver Microsomes, Pharmacokinetics and <i>In Vivo</i> Formation of the Major Metabolites in Rats Open
The objective of this study was to elucidate the pharmacokinetics and metabolite formation of newly developed non‐selective AC hE/ BC hE 7‐ MEOTA ‐donepezil‐like inhibitors for potential therapeutic use in Alzheimer's disease (AD) patients…
View article: Importance of Tumour Suppressor Gene Methylation in Sinonasal Carcinomas
Importance of Tumour Suppressor Gene Methylation in Sinonasal Carcinomas Open
Epigenetic changes are considered to be a frequent event during tumour development. Hypermethylation of promoter CpG islands represents an alternative mechanism for inactivation of tumour suppressor genes, DNA repair genes, cell cycle regu…