Martin O. C. Ota
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View article: Concurrent evaluation of cytokines improves the accuracy of antibodies against Mycobacterium tuberculosis antigens in the diagnosis of active tuberculosis
Concurrent evaluation of cytokines improves the accuracy of antibodies against Mycobacterium tuberculosis antigens in the diagnosis of active tuberculosis Open
View article: Within-Host Diversity and Vertical Transmission of Group B <i>Streptococcus</i> Among Mother-infant Dyads in The Gambia
Within-Host Diversity and Vertical Transmission of Group B <i>Streptococcus</i> Among Mother-infant Dyads in The Gambia Open
Introduction Understanding mother-to-infant transmission of Group B Streptococcus (GBS) is vital to the prevention and control of GBS disease. We investigated the transmission and phylogenetic relationships of mothers colonised by GBS and …
View article: Strengthening national health research systems in the WHO African Region – progress towards universal health coverage
Strengthening national health research systems in the WHO African Region – progress towards universal health coverage Open
View article: Immunogenicity of pneumococcal conjugate vaccine formulations containing pneumococcal proteins, and immunogenicity and reactogenicity of co-administered routine vaccines – A phase II, randomised, observer-blind study in Gambian infants
Immunogenicity of pneumococcal conjugate vaccine formulations containing pneumococcal proteins, and immunogenicity and reactogenicity of co-administered routine vaccines – A phase II, randomised, observer-blind study in Gambian infants Open
Immune responses to the 10 PHiD-CV polysaccharide conjugates and co-administered vaccines were not altered by addition of dPly and PhtD. ClinicalTrials.gov identifier NCT01262872.
View article: Metabolite changes in blood predict the onset of tuberculosis
Metabolite changes in blood predict the onset of tuberculosis Open
View article: Strengthening the Acute Flaccid Paralysis (AFP) Surveillance Component of the Polio Eradication Initiative through Short Message Service (SMS) Reminders; Experience from Sokoto State, Nigeria 2014
Strengthening the Acute Flaccid Paralysis (AFP) Surveillance Component of the Polio Eradication Initiative through Short Message Service (SMS) Reminders; Experience from Sokoto State, Nigeria 2014 Open
Eradication of poliomyelitis remains a public health priority due to the paralytic effects of the virus on children and impact on global health system. However, existing gaps in surveillance can hinder eradication. Improved timeliness of i…
View article: Four-Gene Pan-African Blood Signature Predicts Progression to Tuberculosis
Four-Gene Pan-African Blood Signature Predicts Progression to Tuberculosis Open
Rationale: Contacts of patients with tuberculosis (TB) constitute an important target population for preventive measures because they are at high risk of infection with Mycobacterium tuberculosis and progression to disease.
View article: Africa-wide evaluation of host biomarkers in QuantiFERON supernatants for the diagnosis of pulmonary tuberculosis
Africa-wide evaluation of host biomarkers in QuantiFERON supernatants for the diagnosis of pulmonary tuberculosis Open
View article: Kinetics of antibodies against pneumococcal proteins and their relationship to nasopharyngeal carriage in the first two months of life
Kinetics of antibodies against pneumococcal proteins and their relationship to nasopharyngeal carriage in the first two months of life Open
Naturally induced antibodies against the three pneumococcal protein antigens were transferred from mother to child. The proportion of infants with nasopharyngeal carriage and the bacterial density of S. pneumoniae increased with age within…
View article: Swaziland National Health Research Agenda: The Formulation Process
Swaziland National Health Research Agenda: The Formulation Process Open
Background: The objectives of this article are to describe the process followed in development of the Swaziland’s national health research agenda (NHRA); and to provide an overview of the health research priorities that emerged from that p…
View article: A population-based national estimate of the prevalence and risk factors associated with hypertension in Rwanda: implications for prevention and control
A population-based national estimate of the prevalence and risk factors associated with hypertension in Rwanda: implications for prevention and control Open
The findings of this study indicate that the prevalence of hypertension is high in Rwanda, suggesting the need for prevention and control interventions aimed at decreasing the incidence taking into consideration the risk factors documented…
View article: Mycobacterium tuberculosis Infection in Close Childhood Contacts of Adults with Pulmonary Tuberculosis is Increased by Secondhand Exposure to Tobacco
Mycobacterium tuberculosis Infection in Close Childhood Contacts of Adults with Pulmonary Tuberculosis is Increased by Secondhand Exposure to Tobacco Open
Tobacco use is a major risk factor for tuberculosis (TB). Secondhand smoke (SHS) is also a risk factor for TB and to a lesser extent, Mycobacterium tuberculosis infection without disease. We investigated the added risk of M. tuberculosis i…
View article: Efficacy of a novel, protein-based pneumococcal vaccine against nasopharyngeal carriage of Streptococcus pneumoniae in infants: A phase 2, randomized, controlled, observer-blind study
Efficacy of a novel, protein-based pneumococcal vaccine against nasopharyngeal carriage of Streptococcus pneumoniae in infants: A phase 2, randomized, controlled, observer-blind study Open
PATH, GlaxoSmithKline Biologicals SA. ClinicalTrials.gov identifier NCT01262872.
View article: MATCHING FOR THE NON-CONVENTIONAL MHC-I MICA GENE SIGNIFICANTLY REDUCES THE INCIDENCE OF ACUTE AND CHRONIC GVHD
MATCHING FOR THE NON-CONVENTIONAL MHC-I MICA GENE SIGNIFICANTLY REDUCES THE INCIDENCE OF ACUTE AND CHRONIC GVHD Open
Graft-versus-host disease (GVHD) is among the most challenging complications in unrelated donor hematopoietic cell transplantation (HCT). The highly polymorphic "MHC class I chain-related gene A", MICA, encodes a stress-induced glycoprotei…
View article: Association of slow recovery of Mycobacterium africanum-infected patients posttreatment with high content of Persister-Like bacilli in pretreatment sputum
Association of slow recovery of Mycobacterium africanum-infected patients posttreatment with high content of Persister-Like bacilli in pretreatment sputum Open
The slow clinical recovery of M. africanum-infected patients compared with M. tuberculosis-infected patients posttreatment may be at least partially associated with the persistence of drug-tolerant "fat and lazy" bacilli.
View article: Acceptance of multiple injectable vaccines in a single immunization visit in The Gambia pre and post introduction of inactivated polio vaccine
Acceptance of multiple injectable vaccines in a single immunization visit in The Gambia pre and post introduction of inactivated polio vaccine Open
View article: The contribution of the polio eradication initiative to narrowing the gaps in the health workforce in the African Region
The contribution of the polio eradication initiative to narrowing the gaps in the health workforce in the African Region Open
GPEI investment achieved far beyond its primary goal, and contributed to narrowing the gaps in the health workforce in countries of the African Region, as demonstrated by the best practice documentation exercise. We recommend that expertis…
View article: Evaluation of cytokine responses against novel Mtb antigens as diagnostic markers for TB disease
Evaluation of cytokine responses against novel Mtb antigens as diagnostic markers for TB disease Open
View article: Associations between nasopharyngeal carriage of Group B Streptococcus and other respiratory pathogens during early infancy
Associations between nasopharyngeal carriage of Group B Streptococcus and other respiratory pathogens during early infancy Open
This study provides baseline data on the carriage of GBS in two month old infants from West Africa. The dominant serotypes of GBS in this setting are serotypes V and II. This may be important for future GBS vaccine development for the West…
View article: Host Immune Responses Differ between M. africanum- and M. tuberculosis-Infected Patients following Standard Anti-tuberculosis Treatment
Host Immune Responses Differ between M. africanum- and M. tuberculosis-Infected Patients following Standard Anti-tuberculosis Treatment Open
Epidemiological differences exist between Mycobacterium africanum (Maf)- and Mycobacterium tuberculosis (Mtb)-infected patients, but to date, contributing host factors have not been characterised. We analysed clinical outcomes, as well as …
View article: A blood RNA signature for tuberculosis disease risk: a prospective cohort study
A blood RNA signature for tuberculosis disease risk: a prospective cohort study Open
View article: C-reactive protein, Neopterin and Beta2 microglobulin levels pre and post TB treatment in The Gambia
C-reactive protein, Neopterin and Beta2 microglobulin levels pre and post TB treatment in The Gambia Open
View article: Elevated serum 25-hydroxy (OH) vitamin D levels are associated with risk of TB progression in Gambian adults
Elevated serum 25-hydroxy (OH) vitamin D levels are associated with risk of TB progression in Gambian adults Open
In The Gambia, an equatorial country, 25(OH) D levels are higher in serum of TB progressors and those with active disease compared to latently infected and uninfected subjects. These results contrast to findings in non-equatorial countries.
View article: Concise gene signature for point‐of‐care classification of tuberculosis
Concise gene signature for point‐of‐care classification of tuberculosis Open
View article: Differences in RT-MLPA gene expression levels in progressors and non-progressors.
Differences in RT-MLPA gene expression levels in progressors and non-progressors. Open
Data expressed as median[interquartile range]. Fold difference is shown as expression in progressors compared to non-progressors. BPI showed the highest fold increase and FCGR1A the lowest.
View article: Analysis of cytokine levels in the plasma of progressors and non-progressors.
Analysis of cytokine levels in the plasma of progressors and non-progressors. Open
7-plex Luminex analysis was performed on cryopreserved plasma samples. Data shown are for IL-18 (A) and IFN-γ (B). Bars indicate median of 13 progressors at recruitment, 3 and 18 months and 31 non-progressors. Data were analysed using a Kr…
View article: Hematological and Immunological peripheral blood analysis: comparison of non-progressors with total progressors, early progressors and late progressors at the recruitment time-point.
Hematological and Immunological peripheral blood analysis: comparison of non-progressors with total progressors, early progressors and late progressors at the recruitment time-point. Open
Data expressed as median[interquartile range]. WBC = White Blood Cells; MCV = Mean Corpuscular Volume; Early Progressors (≤507 days to progression); Late Progressors (>507 days to progression); CM = central memory; EM = effector memory; TE…
View article: Percentage of T, B and NK cells in progressors and non-progressors.
Percentage of T, B and NK cells in progressors and non-progressors. Open
Cryopreserved PBMC were thawed and analysed. Representative FACS plots indicating our gating strategy are shown in (A): following gating on the lymphocyte population as determined by the FSC/SSC profile, we analysed lymphocyte populations.…
View article: Risk factors for delay in age-appropriate vaccinations among Gambian children
Risk factors for delay in age-appropriate vaccinations among Gambian children Open
View article: Differential transcriptomic and metabolic profiles of M. africanum- and M. tuberculosis-infected patients after, but not before, drug treatment
Differential transcriptomic and metabolic profiles of M. africanum- and M. tuberculosis-infected patients after, but not before, drug treatment Open