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View article: Pediatric intensive care unit admissions network (PIA)—report of the first results of the nationwide collaborative pediatric intensive care research network in Germany
Pediatric intensive care unit admissions network (PIA)—report of the first results of the nationwide collaborative pediatric intensive care research network in Germany Open
Purpose The pediatric intensive care unit admissions (PIA) network was initiated to interconnect pediatric intensive care units (PICUs) and establish a research infrastructure for pediatric intensive care in Germany. The primary aim is to …
View article: Thrombectomy versus Medical Management for Pediatric Acute Ischemic Stroke Due to Isolated <scp>M2</scp> Occlusion: A Multicenter Cohort Study
Thrombectomy versus Medical Management for Pediatric Acute Ischemic Stroke Due to Isolated <span>M2</span> Occlusion: A Multicenter Cohort Study Open
Objective Endovascular thrombectomy (EVT) is increasingly used for pediatric large vessel occlusion (LVO) stroke, however, its role in isolated M2 occlusions remains underexplored. This study compared clinical outcomes in children with iso…
View article: Emicizumab prophylaxis in pups and mtps with severe haemophilia: The pednet real world experience in 80 infants
Emicizumab prophylaxis in pups and mtps with severe haemophilia: The pednet real world experience in 80 infants Open
Emicizumab (Hemlibra®, Roche) is a humanized bispecific antibody used for subcutaneous prophylaxis in children of any age and adults with haemophilia A (HA). While the HAVEN-7 trial provided primary data on 55 infants with severe HA withou…
View article: HAEMFIX: Impact of Switching From SHL‐FIX to EHL‐FIX in Patients With Haemophilia B
HAEMFIX: Impact of Switching From SHL‐FIX to EHL‐FIX in Patients With Haemophilia B Open
Introduction Haemophilia B is an X‐linked recessive bleeding disorder caused by coagulation factor IX (FIX) deficiency. Treatment involves intravenous replacement of FIX. Recently, extended half‐life (EHL) FIX products have been introduced…
View article: Intravenous Thrombolysis for Pediatric Acute Ischemic Stroke
Intravenous Thrombolysis for Pediatric Acute Ischemic Stroke Open
This cohort study examines function and safety outcomes among children with pediatric acute ischemic stroke treated with intravenous tissue plasminogen activator compared with standard care.
View article: Comparing Real-World Outcomes of Prophylaxis with Extended Half-life Factor IX (rIX-FP vs. rFIXFc and N9-GP) for Haemophilia B: An Analysis of Medical Chart Data from Germany
Comparing Real-World Outcomes of Prophylaxis with Extended Half-life Factor IX (rIX-FP vs. rFIXFc and N9-GP) for Haemophilia B: An Analysis of Medical Chart Data from Germany Open
rIX-FP prophylaxis was associated with significantly lower FIX consumption and numerically (but not significantly) lower bleeding rates compared with rFIXFc. Compared to N9-GP, prophylaxis with rIX-FP was associated with similar FIX consum…
View article: Bleomycin Electrosclerotherapy (BEST) of Slow-Flow Vascular Malformations (SFVMs) in Children
Bleomycin Electrosclerotherapy (BEST) of Slow-Flow Vascular Malformations (SFVMs) in Children Open
BEST is effective for paediatric SFVMs by objective and subjective measures while maintaining low complication rates. Notably, BEST achieves therapeutic success even in infiltrative SFVMs expanding the range of available treatment options.
View article: Benchmarking prophylaxis with factor concentrates: reference data on annualized bleeding rates in children with severe hemophilia
Benchmarking prophylaxis with factor concentrates: reference data on annualized bleeding rates in children with severe hemophilia Open
Not available.
View article: Real-World Prophylaxis Outcomes with rIX-FP and rFIXFc for Males with Hemophilia B: Pooled Analysis of Medical Chart Data from Germany and Italy
Real-World Prophylaxis Outcomes with rIX-FP and rFIXFc for Males with Hemophilia B: Pooled Analysis of Medical Chart Data from Germany and Italy Open
View article: Impact of Family History of Haemophilia on Diagnosis, Management and Outcomes in Severe Haemophilia
Impact of Family History of Haemophilia on Diagnosis, Management and Outcomes in Severe Haemophilia Open
Introduction Patients with severe haemophilia A (HA) with no family history of haemophilia will be diagnosed upon their first bleeding event. Methods Herein, we studied the effects of lack of family history in HA and the subsequent delay o…
View article: Landscape and Spectrum of VWF Variants in Type 2 Von Willebrand Disease: Insights from a German Patient Cohort
Landscape and Spectrum of VWF Variants in Type 2 Von Willebrand Disease: Insights from a German Patient Cohort Open
von Willebrand disease (VWD) type 2 arises from variants in von Willebrand factor (VWF) that disrupt its essential hemostatic functions. As per ISTH guidelines, it is classified as type 2A, 2B, 2M, and 2N based on the affected VWF roles. T…
View article: Treatment pathways and rebound-rate of prehospital viral croup attacks—data from a prehospital pediatric physician led emergency service—a prospective observational follow-up study
Treatment pathways and rebound-rate of prehospital viral croup attacks—data from a prehospital pediatric physician led emergency service—a prospective observational follow-up study Open
Introduction Respiratory illnesses, often caused by upper or lower airway obstruction, represent one of the most common pediatric emergencies. Croup syndrome is the most frequent cause of inspiratory stridor. The study aims to record the i…
View article: Hematopoietic stem cell transplantation in a newborn suffering from severe combined immunodeficiency and severe hemophilia A: a case report and review of the literature
Hematopoietic stem cell transplantation in a newborn suffering from severe combined immunodeficiency and severe hemophilia A: a case report and review of the literature Open
This is the first case report of a newborn suffering from both SCID and severe hemophilia A. HSCT is feasible in this situation without bleeding complications if an individual substitution regimen with FVIII is applied.
View article: Time delay and risk of toxicity of intraosseous anaesthesia use for awake intraosseous access in children
Time delay and risk of toxicity of intraosseous anaesthesia use for awake intraosseous access in children Open
Introduction Intraosseous access (IO) is a crucial, life-saving alternative vascular access in paediatric emergency medicine. In awake paediatric patients, the pain of drilling and flushing the marrow cavity are barriers to the use of the …
View article: Intracranial hemorrhage before start of prophylaxis in children with hemophilia: incidence, timing, and potential for prevention
Intracranial hemorrhage before start of prophylaxis in children with hemophilia: incidence, timing, and potential for prevention Open
Children with hemophilia have a significantly higher risk of intracranial hemorrhage (ICH) compared to the normal population. Prophylaxis reduces the risk of ICH and earlier initiation of prophylaxis may now be feasible, especially in hemo…
View article: Expert Opinion for Defining a Severe Bleeding Phenotype to Guide Prophylaxis in Patients with Nonsevere Hemophilia
Expert Opinion for Defining a Severe Bleeding Phenotype to Guide Prophylaxis in Patients with Nonsevere Hemophilia Open
Prophylaxis is the standard of care for patients with severe hemophilia, patients with moderate hemophilia, or those with another congenital bleeding disorder that is associated with a severe bleeding phenotype and/or a high risk of sponta…
View article: Endovascular thrombectomy for childhood stroke (Save ChildS Pro): an international, multicentre, prospective registry study
Endovascular thrombectomy for childhood stroke (Save ChildS Pro): an international, multicentre, prospective registry study Open
None.
View article: Unravelling the spectrum of von Willebrand factor variants in quantitative von Willebrand disease: results from a German cohort study
Unravelling the spectrum of von Willebrand factor variants in quantitative von Willebrand disease: results from a German cohort study Open
View article: Patient perspective on living with mild hemophilia in Germany: results from a nationwide survey
Patient perspective on living with mild hemophilia in Germany: results from a nationwide survey Open
Introduction The disease burden and bleeding risk of patients with mild hemophilia may be underestimated. Their health-related quality of life (QoL) may be negatively impacted by insufficient treatment and bleed-related joint damage connec…
View article: Pediatric intensive care unit admissions network—rationale, framework and method of operation of a nationwide collaborative pediatric intensive care research network in Germany
Pediatric intensive care unit admissions network—rationale, framework and method of operation of a nationwide collaborative pediatric intensive care research network in Germany Open
The Pediatric Intensive Care Unit Admissions (PIA) network aims to establish a nationwide database in Germany to gather epidemiological, clinical, and outcome data on pediatric critical illness. The heterogeneity of pediatric patients in i…
View article: Factors influencing the success and complications of intraosseous access in pediatric patients—a prospective nationwide surveillance study in Germany
Factors influencing the success and complications of intraosseous access in pediatric patients—a prospective nationwide surveillance study in Germany Open
Background Vascular access is essential for the efficient treatment of critically ill children, but it can be difficult to obtain. Our study was conducted to analyze the feasibility and short-term safety of intraosseous access (IO) use as …
View article: Teamwork and mental workload in postsurgical pediatric patient handovers: Prospective effect evaluation of an improvement intervention for OR-PICU patient transitions
Teamwork and mental workload in postsurgical pediatric patient handovers: Prospective effect evaluation of an improvement intervention for OR-PICU patient transitions Open
View article: OC 43.1 A Survey on Clinical Praxis in Initiating Emicizumab Prophylaxis in Previously Untreated Patients in the PedNet Centers
OC 43.1 A Survey on Clinical Praxis in Initiating Emicizumab Prophylaxis in Previously Untreated Patients in the PedNet Centers Open
View article: PB0670 Nationwide Survey on the Care Reality of People with Mild Hemophilia A and B in Germany - The Burden of Mild Hemophilia
PB0670 Nationwide Survey on the Care Reality of People with Mild Hemophilia A and B in Germany - The Burden of Mild Hemophilia Open
Conclusion(s): rFIXFc is effective and safe for subjects with SHB aged ≥50 years.rFIXFc prophylaxis resulted in low ABR and improved quality of life, suggesting long-term benefit of rFIXFc in this subgroup.Data are consistent with overall …
View article: PB1255 An Update on Real-World use of rVIII-SingleChain in Patients with Haemophilia A in Germany: Interim Results from a Prospective, Non- Interventional Study
PB1255 An Update on Real-World use of rVIII-SingleChain in Patients with Haemophilia A in Germany: Interim Results from a Prospective, Non- Interventional Study Open
treated episodically.None of these 15 patients had a recorded inhibitor titer ≥ 0.6 BU/ml while treating with BAY 94-9027.(Table 1) For BAY 81-8973, 58 (16.4%) patients had an inhibitor titer ≥ 0.6 BU/ml, ranging from 0.6 BU/ml to 2150 BU/…
View article: Dilemmas on emicizumab in children with haemophilia A: A survey of strategies from PedNet centres
Dilemmas on emicizumab in children with haemophilia A: A survey of strategies from PedNet centres Open
Introduction Haemophilia A care has changed with the introduction of emicizumab. Experience on the youngest children is still scarce and clinical practice varies between haemophilia treatment centres. Aim We aimed to assess the current cli…
View article: Gerinnungsdiagnostik bei Kindeswohlgefährdung
Gerinnungsdiagnostik bei Kindeswohlgefährdung Open
View article: First detected geographical cluster of BoDV-1 encephalitis from same small village in two children: therapeutic considerations and epidemiological implications
First detected geographical cluster of BoDV-1 encephalitis from same small village in two children: therapeutic considerations and epidemiological implications Open
View article: Erratum: Gentherapie der Hämophilie: Empfehlung der Gesellschaft für Thrombose- und Hämostaseforschung (GTH)
Erratum: Gentherapie der Hämophilie: Empfehlung der Gesellschaft für Thrombose- und Hämostaseforschung (GTH) Open
Correction to: Gentherapie der Hämophilie: Empfehlung der Gesellschaft für Thrombose- und Hämostaseforschung (GTH)Hamostaseologie 2023; 43(03): 196-207DOI: 10.1055/a-1957-4477
View article: Gentherapie der Hämophilie: Empfehlung der Gesellschaft für Thrombose- und Hämostaseforschung (GTH)
Gentherapie der Hämophilie: Empfehlung der Gesellschaft für Thrombose- und Hämostaseforschung (GTH) Open
Zusammenfassung Die Gentherapie hat sich in den vergangenen Jahren zu einer realistischen Behandlungsoption für Patienten mit Hämophilie entwickelt. Unter Berücksichtigung der verfügbaren Literatur und der persönlichen Erfahrungen aus klin…