Martin Orr
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View article: A retrospective study of the impact of comorbidity, polypharmacy and demographic factors on patient inclusion and healthcare delivery in phase I oncology trials
A retrospective study of the impact of comorbidity, polypharmacy and demographic factors on patient inclusion and healthcare delivery in phase I oncology trials Open
Background Phase I trials include patients with metastatic cancer and complex health conditions. Understanding baseline comorbidity and demographic features is critical to improving trial design. Methods We used electronic patient records …
View article: The large Galois orbits conjecture under multiplicative degeneration
The large Galois orbits conjecture under multiplicative degeneration Open
We establish the PEL type large Galois orbits conjecture for Hodge generic curves in $\mathcal{A}_g$ possessing multiplicative degeneration. Combined with our earlier works, this concludes the proof of the Zilber-Pink conjecture in $\mathc…
View article: Zilber-Pink in a product of modular curves assuming multiplicative degeneration
Zilber-Pink in a product of modular curves assuming multiplicative degeneration Open
We prove the Zilber--Pink conjecture for curves in $Y(1)^n$ whose Zariski closure in $(\mathbb{P}^1)^n$ passes through the point $(\infty, \ldots, \infty)$, going beyond the asymmetry condition of Habegger and Pila. Our proof is based on a…
View article: The Incidence and Costs of Adverse Events Associated with Antidepressants: Results from a Systematic Review, Network Meta-Analysis and Multi-Country Economic Model
The Incidence and Costs of Adverse Events Associated with Antidepressants: Results from a Systematic Review, Network Meta-Analysis and Multi-Country Economic Model Open
Trazodone generally had the best safety profile of the antidepressants evaluated. This led to healthcare costs being lowest for trazodone in all nine European countries, emphasising the importance of considering rates of adverse events whe…
View article: The ethical role of computational linguistics in digital psychological formulation and suicide prevention.
The ethical role of computational linguistics in digital psychological formulation and suicide prevention. Open
Formulation is central to clinical practice. Formulation has a factor weighing, pattern recognition and explanatory hypothesis modelling focus. Formulation attempts to make sense of why a person presents in a certain state at a certain tim…
View article: Lattices with skew-Hermitian forms over division algebras and unlikely intersections
Lattices with skew-Hermitian forms over division algebras and unlikely intersections Open
This paper has two objectives. First, we study lattices with skew-Hermitian forms over division algebras with positive involutions. For division algebras of Albert types I and II, we show that such a lattice contains an "orthogonal" basis …
View article: Junior Doctor Communication Systems and the Deterioration Communication Management Theory
Junior Doctor Communication Systems and the Deterioration Communication Management Theory Open
Inadequate communication is a factor in suboptimal junior doctor management of deteriorating ward patients. Junior doctors' information and communication technology (ICT) systems are not the sole cause or cure for this. However, junior doc…
View article: Media Marginalization of Racial Minorities: "Conspiracy Theorists" in U.S. Ghettos and on the "Arab Street"
Media Marginalization of Racial Minorities: "Conspiracy Theorists" in U.S. Ghettos and on the "Arab Street" Open
The epithet conspiracy theorist can be understood as what C. Wright Mills called a "vocabulary of motive:' This vocabulary of motive is routinely used to dismiss scholars, journalists, and citizens who question, or worse yet document, the …
View article: A Multiscale Computational Model of the Heart: Exploring Space Medicine and Terrestrial Applications
A Multiscale Computational Model of the Heart: Exploring Space Medicine and Terrestrial Applications Open
View article: Viewpoint: Health literacy and patient portals
Viewpoint: Health literacy and patient portals Open
Health literacy has been described as the capacity to obtain, process, and understand basic health information and services needed to make appropriate health decisions. Improving health literacy may serve to promote concordance with therap…
View article: Advanced Electrocardiography Identifies Left Ventricular Systolic Dysfunction in Non-Ischemic Cardiomyopathy and Tracks Serial Change over Time
Advanced Electrocardiography Identifies Left Ventricular Systolic Dysfunction in Non-Ischemic Cardiomyopathy and Tracks Serial Change over Time Open
Electrocardiogram (ECG)-based detection of left ventricular systolic dysfunction (LVSD) has poor specificity and positive predictive value, even when including major ECG abnormalities, such as left bundle branch block (LBBB) within the cri…