Martin R. Jakobsen
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View article: The Danish Turner Syndrome Cryopreservation study: PROTOCOL for a prospective cohort Study on reproductive outcomes after ovarian tissue cryopreservation in girls with Turner syndrome
The Danish Turner Syndrome Cryopreservation study: PROTOCOL for a prospective cohort Study on reproductive outcomes after ovarian tissue cryopreservation in girls with Turner syndrome Open
Background Turner syndrome (TS) is a chromosomal disorder caused by complete or partial loss of one X chromosome, resulting in a high risk of premature ovarian insufficiency (POI) and infertility. While the underlying mechanisms are not fu…
View article: STING and Nonnecroptotic MLKL‐Mediated Mechanisms Improve Dendritic Cell Maturation and Killing of Cancer Cells
STING and Nonnecroptotic MLKL‐Mediated Mechanisms Improve Dendritic Cell Maturation and Killing of Cancer Cells Open
Activation of the cGAS‐STING pathway plays an important role in antitumor immunity through maturation of tumor‐infiltrating DCs. DCs engulf extracellular DNA released by dying cancer cells, supporting activation of the cGAS‐STING pathway a…
View article: Wide variations in the alpha angle reporting of the hip in asymptomatic individuals—a systematic review
Wide variations in the alpha angle reporting of the hip in asymptomatic individuals—a systematic review Open
The alpha angle is commonly used to quantify cam-type morphologies in hips. However, the threshold values that define a pathological alpha angle remains disputed. To identify the threshold values for the alpha angle measured on X-ray, comp…
View article: Distinctive CD8+ T cell activation by antigen-presenting plasmacytoid dendritic cells compared to conventional dendritic cells
Distinctive CD8+ T cell activation by antigen-presenting plasmacytoid dendritic cells compared to conventional dendritic cells Open
Plasmacytoid dendritic cells (pDCs) play a pivotal role in immune responses, particularly against viral infections. pDCs exhibit diverse functions, including interferon production, cytokine secretion, and antigen presentation. Here, we inv…
View article: IFNλ1 is a STING-dependent mediator of DNA damage and induces immune activation in lung cancer
IFNλ1 is a STING-dependent mediator of DNA damage and induces immune activation in lung cancer Open
Introduction The importance of the cGAS-STING pathway and type I interferon (IFN) in anti-tumor immunity has been widely studied. However, there is limited knowledge about the role of type III IFNs in cancer settings. Type III IFNs, compri…
View article: Anatomical, subset, and HIV-dependent expression of viral sensors and restriction factors
Anatomical, subset, and HIV-dependent expression of viral sensors and restriction factors Open
View article: 417 Design of programmable immune reactive cells (PIRCs) with precision type I interferon and cytotoxicity response in solid tumors
417 Design of programmable immune reactive cells (PIRCs) with precision type I interferon and cytotoxicity response in solid tumors Open
View article: Cholesterol-binding motifs in STING that control endoplasmic reticulum retention mediate anti-tumoral activity of cholesterol-lowering compounds
Cholesterol-binding motifs in STING that control endoplasmic reticulum retention mediate anti-tumoral activity of cholesterol-lowering compounds Open
View article: 442-E A novel targeted, type I interferon producing, innate lymphocyte therapy with potent anti-tumor activity
442-E A novel targeted, type I interferon producing, innate lymphocyte therapy with potent anti-tumor activity Open
Background Plasmacytoid Dendritic Cells (pDCs) - sometimes referred to as type I interferon producing innate lymphocyte cells - are known as a master regulator of the immune system. The pDCs are responsible for the body's Interferon (IFN) …
View article: Single cell analysis reveals a subset of cytotoxic-like plasmacytoid dendritic cells in people with HIV-1
Single cell analysis reveals a subset of cytotoxic-like plasmacytoid dendritic cells in people with HIV-1 Open
View article: Analysis of circulating tumor DNA during checkpoint inhibition in metastatic melanoma using a tumor-agnostic panel
Analysis of circulating tumor DNA during checkpoint inhibition in metastatic melanoma using a tumor-agnostic panel Open
Immunotherapy has revolutionized treatment of patients diagnosed with metastatic melanoma, where nearly half of patients receive clinical benefit. However, immunotherapy is also associated with immune-related adverse events, which may be s…
View article: Data from Classifying cGAS-STING Activity Links Chromosomal Instability with Immunotherapy Response in Metastatic Bladder Cancer
Data from Classifying cGAS-STING Activity Links Chromosomal Instability with Immunotherapy Response in Metastatic Bladder Cancer Open
The cGAS-STING pathway serves a critical role in anticancer therapy. Particularly, response to immunotherapy is likely driven by both active cGAS-STING signaling that attracts immune cells, and by the presence of cancer neoantigens that pr…
View article: Data from Classifying cGAS-STING Activity Links Chromosomal Instability with Immunotherapy Response in Metastatic Bladder Cancer
Data from Classifying cGAS-STING Activity Links Chromosomal Instability with Immunotherapy Response in Metastatic Bladder Cancer Open
The cGAS-STING pathway serves a critical role in anticancer therapy. Particularly, response to immunotherapy is likely driven by both active cGAS-STING signaling that attracts immune cells, and by the presence of cancer neoantigens that pr…
View article: Supplementary Data from Classifying cGAS-STING Activity Links Chromosomal Instability with Immunotherapy Response in Metastatic Bladder Cancer
Supplementary Data from Classifying cGAS-STING Activity Links Chromosomal Instability with Immunotherapy Response in Metastatic Bladder Cancer Open
Supplementary data
View article: Supplementary Data from Classifying cGAS-STING Activity Links Chromosomal Instability with Immunotherapy Response in Metastatic Bladder Cancer
Supplementary Data from Classifying cGAS-STING Activity Links Chromosomal Instability with Immunotherapy Response in Metastatic Bladder Cancer Open
Supplementary data
View article: T-cell derived extracellular vesicles prime macrophages for improved STING based cancer immunotherapy
T-cell derived extracellular vesicles prime macrophages for improved STING based cancer immunotherapy Open
Summary A key phenomenon in cancer is the establishment of a highly immunosuppressive tumor microenvironment (TME). Despite advances in immunotherapy, where the purpose is to induce tumor recognition and hence hereof tumor eradication, the…
View article: Plasmacytoid Dendritic Cells as a Novel Cell-Based Cancer Immunotherapy
Plasmacytoid Dendritic Cells as a Novel Cell-Based Cancer Immunotherapy Open
Plasmacytoid dendritic cells (pDCs) are multifaceted immune cells with a wide range of innate and adaptive immunological functions. They constitute the first line of defence against multiple viral infections and have also been reported to …
View article: Classifying cGAS-STING Activity Links Chromosomal Instability with Immunotherapy Response in Metastatic Bladder Cancer
Classifying cGAS-STING Activity Links Chromosomal Instability with Immunotherapy Response in Metastatic Bladder Cancer Open
The cGAS-STING pathway serves a critical role in anticancer therapy. Particularly, response to immunotherapy is likely driven by both active cGAS-STING signaling that attracts immune cells, and by the presence of cancer neoantigens that pr…
View article: Increased Soluble PD-1 Predicts Response to Nivolumab plus Ipilimumab in Melanoma
Increased Soluble PD-1 Predicts Response to Nivolumab plus Ipilimumab in Melanoma Open
Background: Checkpoint inhibitors have revolutionized the treatment of metastatic melanoma, yielding long-term survival in a considerable proportion of the patients. Yet, 40–60% of patients do not achieve a long-term benefit from such ther…
View article: Plasmacytoid dendritic cells during COVID-19: Ally or adversary?
Plasmacytoid dendritic cells during COVID-19: Ally or adversary? Open
Plasmacytoid dendritic cells (pDCs) are specialized cells of the immune system that are thought to be the main cellular source of type I interferon alpha (IFNα) in response to viral infections. IFNs are powerful antivirals, whereas defects…
View article: IFI16 Impacts Metabolic Reprogramming during Human Cytomegalovirus Infection
IFI16 Impacts Metabolic Reprogramming during Human Cytomegalovirus Infection Open
Human cytomegalovirus (HCMV) gathers all the substrates and enzymes necessary for the assembly of new virions from its host cell. For instance, HCMV is known to induce cellular metabolism of infected cells to favor virion assembly.
View article: Cell-Extrinsic Priming Increases Permissiveness of CD4+ T Cells to Human Immunodeficiency Virus Infection by Increasing C–C Chemokine Receptor Type 5 Co-receptor Expression and Cellular Activation Status
Cell-Extrinsic Priming Increases Permissiveness of CD4+ T Cells to Human Immunodeficiency Virus Infection by Increasing C–C Chemokine Receptor Type 5 Co-receptor Expression and Cellular Activation Status Open
The chemokine receptor CCR5 is expressed on multiple cell types, including macrophages, dendritic cells, and T cells, and is the major co-receptor used during HIV transmission. Using a standard αCD3/CD28 in vitro stimulation protocol to re…
View article: Phenotypic and functional characterization of synovial fluid-derived fibroblast-like synoviocytes in rheumatoid arthritis
Phenotypic and functional characterization of synovial fluid-derived fibroblast-like synoviocytes in rheumatoid arthritis Open
Fibroblast-like synoviocytes (FLS) play an important pathological role in persistent inflammatory joint diseases such as rheumatoid arthritis (RA). These cells have primarily been characterized in the RA synovial membrane. Here we aim to p…
View article: 27 Cytokine signature of PD-1, CXCL10, and TNF-alpha predicts response to nivolumab and ipilimumab
27 Cytokine signature of PD-1, CXCL10, and TNF-alpha predicts response to nivolumab and ipilimumab Open
Background Checkpoint inhibitors have significantly improved treatment of metastatic melanoma. Yet, 40–60% of the patients do not achieve a long-term benefit from such immunotherapy. Thus, there is an urgent need to identify biomarkers tha…
View article: Ascorbic acid supports ex vivo generation of plasmacytoid dendritic cells from circulating hematopoietic stem cells
Ascorbic acid supports ex vivo generation of plasmacytoid dendritic cells from circulating hematopoietic stem cells Open
Plasmacytoid dendritic cells (pDCs) constitute a rare type of immune cell with multifaceted functions, but their potential use as a cell-based immunotherapy is challenged by the scarce cell numbers that can be extracted from blood. Here, w…
View article: Author response: Ascorbic acid supports ex vivo generation of plasmacytoid dendritic cells from circulating hematopoietic stem cells
Author response: Ascorbic acid supports ex vivo generation of plasmacytoid dendritic cells from circulating hematopoietic stem cells Open
View article: Hyaluronic acid is a negative regulator of mucosal fibroblast-mediated enhancement of HIV infection
Hyaluronic acid is a negative regulator of mucosal fibroblast-mediated enhancement of HIV infection Open
View article: Evasion of Innate Cytosolic DNA Sensing by a Gammaherpesvirus Facilitates Establishment of Latent Infection
Evasion of Innate Cytosolic DNA Sensing by a Gammaherpesvirus Facilitates Establishment of Latent Infection Open
Herpesviruses are DNA viruses harboring the capacity to establish lifelong latent-recurrent infections. There is currently limited knowledge on viruses targeting the innate DNA sensing pathway and also on how the innate system impacts on t…
View article: Proteasomal Degradation of Herpes Simplex Virus Capsids in Macrophages Releases DNA to the Cytosol for Recognition by DNA Sensors
Proteasomal Degradation of Herpes Simplex Virus Capsids in Macrophages Releases DNA to the Cytosol for Recognition by DNA Sensors Open
The innate immune system is important for control of infections, including herpesvirus infections. Intracellular DNA potently stimulates antiviral IFN responses. It is known that plasmacytoid dendritic cells sense herpesvirus DNA in endoso…
View article: Author Correction: SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate
Author Correction: SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate Open