Explanipedia

Cardiac Circular RNAs CDR1as, Circ-RCAN2, Circ-C12orf29 Show Cell-Specific Hypoxia-Induced Dysregulation and Distinct In Vitro Effects Open

Ena Hašimbegović, Dominika Lukovic, Nina Kastner, Benedikt Hofer, Andreas Spannbauer , et al. · 2025

Circular RNAs (circRNAs) are looped RNA molecules with regulatory roles in myocardial infarction and post-infarction cascades. We aimed to (i) confirm the circularity of novel circRNAs (CDR1as, circ-RCAN2, circ-C12orf29) implicated in myoc…

Prognostic Value of Biomarkers in Cancer Patients Treated With Immune Checkpoint Inhibitor Therapy Open

Christopher Mann, Ulrike Pailer, Andreas Spannbauer, Fardin Hamidi, Aliza Veronika Braser , et al. · 2025

MiR-132 inhibition improves myocardial strain in a large animal model of chronic left ventricular adverse remodelling Open

Sándor Bátkai, Andreas Spannbauer, Janika Viereck, Celina Genschel, Steffen Rump , et al. · 2025

Aims Cardiac miR-132 has been proposed as a target for heart failure (HF) therapy. CDR132L, a rationally designed synthetic oligonucleotide inhibitor of miR-132 has proved pre-clinical efficacy in non-ischaemic and ischaemic large animal H…

Critical analysis of descriptive microRNA data in the translational research on cardioprotection and cardiac repair: lost in the complexity of bioinformatics Open

Mariann Gyöngyösi, Julia Guthrie, Ena Hašimbegović, Emilie Han, Martin Riesenhuber , et al. · 2025

The unsuccessful translation of cardiac regeneration and cardioprotection from animal experiments to clinical applications in humans has raised the question of whether microRNA bioinformatics can narrow the gap between animal and human res…

Circulating Autoantibodies Against Vasoactive Biomarkers Related to Orthostatic Intolerance in Long COVID Patients Compared to No-Long-COVID Populations: A Case-Control Study Open

Emilie Han, Katrin Zlabinger, Ena Hašimbegović, Laura Poschenreithner, Nina Kastner , et al. · 2025

Endothelial dysfunction mediated by elevated levels of autoantibodies against vasoactive peptides occurring after COVID-19 infection is proposed as a possible pathomechanism for orthostatic intolerance in long COVID patients. This case-con…

Heart Failure with Preserved Ejection Fraction Correlates with Fibrotic Atrial Myopathy in Patients Undergoing Atrial Fibrillation Ablation Open

Jonghui Lee, Michael Sponder, Stefan Stojković, Martin Riesenhuber, Andreas Hammer , et al. · 2024

Background: The incidence of atrial fibrillation (AF) in patients with heart failure with preserved ejection fraction (HFpEF) is high. Impaired left atrial (LA) function is a major determinant in HFpEF. However, the extent of electrical LA…

In-vivo blood pressure sensing with bi-filler nanocomposite Open

C. B. Kushwah, Martin Riesenhuber, Søren Asmul, Mariann Gyöngyösi, Alain Nogaret · 2024

Conductive elastomers present desirable qualities for sensing pressure in-vivo, such as high piezoresistance in tiny volumes, conformability and, biocompatibility. Many electrically conductive nanocomposites however, are susceptible to ele…

In-vivo blood pressure sensing with bi-filler nanocomposite Open

C. B. Kushwah, Martin Riesenhuber, Søren Aasmul, Mariann Gyöngyösi, Alain Nogaret · 2024

Conductive elastomers present desirable qualities for sensing pressure in-vivo, such as high piezoresistance in tiny volumes, conformability and, biocompatibility. Many PDMS-based electrically conductive nanocomposites however, are suscept…

Improvement of Symptoms and Cardiac Magnetic Resonance Abnormalities in Patients with Post-Acute Sequelae of SARS-CoV-2 Cardiovascular Syndrome (PASC-CVS) after Guideline-Oriented Therapy Open

Mariann Gyöngyösi, Ena Hašimbegović, Emilie Han, Katrin Zlabinger, Andreas Spannbauer , et al. · 2023

Cardiac magnetic resonance (CMR) studies reported CMR abnormalities in patients with mild–moderate SARS-CoV-2 infection, suggesting ongoing myocardial inflammation. Patients (n = 278, 43 ± 13 years, 70.5% female) with post-acute sequelae o…

Sequential activation of DNA viruses by the RNA virus SARS-CoV-2 in patients with long COVID syndrome Open

Mariann Gyöngyösi, Ena Hašimbegović, Dominika Lukovic, Katrin Zlabinger, Andreas Spannbauer , et al. · 2023

Background Reactivation of Epstein-Barr virus (EBV) has been suggested to play role in long lasting multiorgan symptoms several months after the initial COVID-19 illness. Purpose The aim of our prospective study was to 1) to evaluate the r…

Effect of monovalent COVID-19 vaccines on viral interference between SARS-CoV-2 and several DNA viruses in patients with long-COVID syndrome Open

Mariann Gyöngyösi, Dominika Lukovic, Julia Mester-Tonczar, Katrin Zlabinger, Patrick Einzinger , et al. · 2023

Epstein–Barr virus (EBV) reactivation may be involved in long-COVID symptoms, but reactivation of other viruses as a factor has received less attention. Here we evaluated the reactivation of parvovirus-B19 and several members of the Herpes…

Improvement of clinical symptoms and cardiac abnormalities detected by cardiac magnetic resonance imaging in patients with long COVID syndrome after guideline-oriented therapy Open

Mariann Gyöngyösi, Ena Hašimbegović, Dominika Lukovic, Emilie Han, Katrin Zlabinger , et al. · 2023

Patients with cardiovascular long COVID syndrome and cardiac magnetic resonance (CMR) scans were included prospectively into the Vienna PostCoV Registry between March 2021 and March 2023 (EC: 1008/2021, clinicaltrials.gov NCT05398952; n=24…

Electrophysiological findings in HFpEF patients presenting for AF ablation Open

Jong Min Lee, Michael Sponder, Stefan Stojković, Martin Riesenhuber, Alexandra Hammer , et al. · 2023

Funding Acknowledgements Type of funding sources: None. Aims The prevalence of atrial fibrillation (AF) in heart failure with preserved ejection fraction (HFpEF) patients is high. Impaired left atrial (LA) function is a major determinant i…

Interruption of viral interference by anti-SARS-CoV-2 vaccination Open

Mariann Gyöngyösi, Dominika Lukovic, Julia Mester Tonczar, Katrin Zlabinger, Patrick Einzinger , et al. · 2023

Epstein-Barr virus (EBV) reactivation may be involved in long-COVID symptoms. Here we evaluated reactivation of parvovirus B19 and several viruses of the herpes family in patients with long-COVID syndrome, how vaccination affected viral in…

Comparison of the prevalence of SARS-CoV-2 nucleoprotein antibodies in healthcare workers and an unselected adult and paediatric all-comer patient population: insights from a longitudinal study of healthcare workers and concurrent serial cross-sectional studies of patients at an academic medical centre in Austria Open

Martin Riesenhuber, Christian Nitsche, Christoph J. Binder, Eva Schernhammer, Tanja Stamm , et al. · 2023

Objectives This study aimed to estimate and compare the prevalence of the virus-specific antibodies against the SARS-CoV-2 nucleoprotein antigen (anti-SARS-CoV-2 N) in healthcare workers and an all-comer paediatric and adult patient popula…

Frontmatter Open

Stefan Grundmann, Hugh Collins, Fernando Gómez, Barcelona Martijn, W Hesselink , et al. · 2022

Comparison of the Prevalence of SARS-CoV-2 Nucleoprotein Antibodies in Healthcare Workers and an Unselected Adult and Pediatric All-Comer Patient Population in Austria Open

Martin Riesenhuber, Christian Nitsche, Christoph J. Binder, Eva Schernhammer, Tanja Stamm , et al. · 2022

The role of community pharmacists in immunisation: a national cross-sectional study Open

Nikolaus Lindner, Martin Riesenhuber, Thomas Müller-Uri, Anita Elaine Weidmann · 2021

Frontmatter Open

Stefan Grundmann, Hugh Collins, Fernando Gómez, Barcelona Martijn, W Hesselink , et al. · 2021

Clinical outcomes of pacemaker implantations before and after cancer diagnosis Open

Martin Riesenhuber, Andreas Spannbauer, Marianne Gwechenberger, Thomas Pezawas, Christoph Schukro , et al. · 2021

Background Cardiotoxicity caused by anticancer treatment affects cardiac conduction. Clinical outcomes of pacemaker patients with newly diagnosed cancer are insufficiently understood. Purpose The aim was to investigate the effect of antica…

Frontmatter Open

Stefan Grundmann, Hugh Collins, Fernando Gómez, Barcelona Martijn, W Hesselink , et al. · 2021

Pacemaker lead-associated tricuspid regurgitation in patients with or without pre-existing right ventricular dilatation Open

Martin Riesenhuber, Andreas Spannbauer, Marianne Gwechenberger, Thomas Pezawas, Christoph Schukro , et al. · 2021

Filamentous Fungal Infections in a Tertiary Care Setting: Epidemiology and Clinical Outcome Open

Miriam Van den Nest, Gernot Wagner, Martin Riesenhuber, Constantin Dolle, Elisabeth Presterl , et al. · 2021

Information on the distribution of filamentous fungal pathogens, which cause potential life-threatening invasive infections mostly in immunocompromised persons, is of great importance. The aim of this study was to evaluate the epidemiology…

Large Animal Models of Cell-Free Cardiac Regeneration Open

Andreas Spannbauer, Julia Mester-Tonczar, Denise Traxler, Nina Kastner, Katrin Zlabinger , et al. · 2020

The adult mammalian heart lacks the ability to sufficiently regenerate itself, leading to the progressive deterioration of function and heart failure after ischemic injuries such as myocardial infarction. Thus far, cell-based therapies hav…

Sex Differences and Long-Term Outcome in Patients With Pacemakers Open

Martin Riesenhuber, Andreas Spannbauer, F Rauscha, Herwig Schmidinger, Adelinde Boszotta , et al. · 2020

Introduction: Evidence of sex-related differences in patients with pacemakers regarding comorbidities is insufficiently investigated. The aim of this study was to determine the relationship of cardiovascular comorbidities and sex ca…

CDR132L improves systolic and diastolic function in a large animal model of chronic heart failure Open

Sándor Bátkai, Celina Genschel, Janika Viereck, Steffen Rump, Christian Bär , et al. · 2020

Aims Cardiac miR-132 activation leads to adverse remodelling and pathological hypertrophy. CDR132L is a synthetic lead-optimized oligonucleotide inhibitor with proven preclinical efficacy and safety in heart failure (HF) early after myocar…

Heart Failure With Reduced Ejection Fraction Is Characterized by Systemic NEP Downregulation Open

Imre Pávó, Noémi Pávó, Nina Kastner, Denise Traxler, Dominika Lukovic , et al. · 2020

Based on the investigation of neprilysin (NEP) regulation in a translational porcine model of chronic heart failure (HF), this study concluded: 1) that kidneys might play a crucial part in systemic NEP regulation based on 20 to 100 higher …

Quantitative Hybrid Cardiac [18F]FDG-PET-MRI Images for Assessment of Cardiac Repair by Preconditioned Cardiosphere-Derived Cells Open

Johannes Winkler, Dominika Lukovic, Julia Mester-Tonczar, Katrin Zlabinger, Alfred Gugerell , et al. · 2020

Preclinical development of a miR-132 inhibitor for heart failure treatment Open

Ariana Foinquinos, Sándor Bátkai, Celina Genschel, Janika Viereck, Steffen Rump , et al. · 2020

P223 Cat bite with unexpected consequences Open

Manuel Moser, Alexander Koenig, Varius Dannenberg, Walter S. Speidl, Martin Riesenhuber , et al. · 2020

A 25 y/o female patient with corrected tetralogy of Fallot (1995), pulmonary valve bio-prosthesis (1999) with consequent stenosis, and finally implantation of a pulmonary valve Hancock-conduit (2005), presented to our department with night…

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