Martin Sidler
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View article: Spontaneous urinary bladder regeneration after subtotal cystectomy increases YAP/WWTR1 signaling and downstream BDNF expression: Implications for smooth muscle injury responses
Spontaneous urinary bladder regeneration after subtotal cystectomy increases YAP/WWTR1 signaling and downstream BDNF expression: Implications for smooth muscle injury responses Open
Rodents have the capacity for spontaneous bladder regeneration and bladder smooth muscle cell (BSMC) migration following a subtotal cystectomy (STC). YAP/WWTR1 and BDNF (Brain-derived neurotrophic factor) play crucial roles in development …
View article: EZH2 and matrix co-regulate phenotype and KCNB2 expression in bladder smooth muscle cells.
EZH2 and matrix co-regulate phenotype and KCNB2 expression in bladder smooth muscle cells. Open
Regulation of KCNB2 at the promoter demonstrated dynamic changes in H3K27me3 during COBD and obstruction. In vitro models suggest that matrix plays a role in regulation of EZH2, H3K27me3 and KCNB2, which may play a role in the regul…
View article: Human - murine concordance of molecular signatures in nerve-sparing murine partial bladder outlet obstruction (NeMO)
Human - murine concordance of molecular signatures in nerve-sparing murine partial bladder outlet obstruction (NeMO) Open
Recently we demonstrated the utility of a nerve-sparing mid-urethra model of partial outlet obstruction (NeMO) that has high consistency and minimal mortalities, unlike the traditional model proximal to the bladder neck. Our goal was to un…
View article: Inhibition of DNA methylation during chronic obstructive bladder disease (COBD) improves function, pathology and expression
Inhibition of DNA methylation during chronic obstructive bladder disease (COBD) improves function, pathology and expression Open
View article: Favorable Outcome of Electively Delayed Elongation Procedure in Long-Gap Esophageal Atresia
Favorable Outcome of Electively Delayed Elongation Procedure in Long-Gap Esophageal Atresia Open
The ideal approach to long gap esophageal atresia is still controversial. On one hand, preserving a patient's native esophagus may require several steps and can be fraught with complications. On the other hand, most replacement procedures …
View article: Endoscopic treatment of a tracheal mucosal tunnel after multiple recurrences of a trachea-esophageal fistula
Endoscopic treatment of a tracheal mucosal tunnel after multiple recurrences of a trachea-esophageal fistula Open
View article: Supplementary Material for: Gut It Out: Laxative Abuse Mimicking Distal Renal Tubular Acidosis
Supplementary Material for: Gut It Out: Laxative Abuse Mimicking Distal Renal Tubular Acidosis Open
Background: Distal renal tubular acidosis (dRTA) can be inherited or acquired. Case Presentation: Here, we describe the case of a 45-year-old female patient with non-anion gap metabolic acidosis, hypokalemia, an…
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Table of Contents Open
View article: DNA Methylation Reduces the Yes-Associated Protein 1/WW Domain Containing Transcription Regulator 1 Pathway and Prevents Pathologic Remodeling during Bladder Obstruction by Limiting Expression of BDNF
DNA Methylation Reduces the Yes-Associated Protein 1/WW Domain Containing Transcription Regulator 1 Pathway and Prevents Pathologic Remodeling during Bladder Obstruction by Limiting Expression of BDNF Open
View article: Non-invasive voiding assessment in conscious mice
Non-invasive voiding assessment in conscious mice Open
OBJECTIVE: To review available options of assessing murine bladder function and to evaluate a non-invasive technique suitable for long-term recording. METHODS: We reviewed previously described methods to record rodent bladder fun…
View article: MP81-07 REGENERATION AFTER PARTIAL CYSTECTOMY IS ASSOCIATED WITH PARTICULAR BDNF DOSEAGES AND ISOFORMS
MP81-07 REGENERATION AFTER PARTIAL CYSTECTOMY IS ASSOCIATED WITH PARTICULAR BDNF DOSEAGES AND ISOFORMS Open
You have accessJournal of UrologyStem Cell Research: Stem Cell Research II1 Apr 2018MP81-07 REGENERATION AFTER PARTIAL CYSTECTOMY IS ASSOCIATED WITH PARTICULAR BDNF DOSEAGES AND ISOFORMS Karen Aitken, Martin Sidler, Aliza Siebenaller, Prat…
View article: Augmented latissimus dorsi transfer: initial results in patients with massive irreparable posterosuperior rotator cuff tears
Augmented latissimus dorsi transfer: initial results in patients with massive irreparable posterosuperior rotator cuff tears Open
Background The surgical treatment of irreparable massive rotator cuff tears is challenging. The purpose of the present study was to report the initial outcomes after a modified latissimus dorsi transfer (LDT) augmented by acellular dermal …
View article: Establishing a new rodent model of partial bladder outlet obstruction and the role of macrophages in bladder obstruction
Establishing a new rodent model of partial bladder outlet obstruction and the role of macrophages in bladder obstruction Open
Partial bladder outlet obstruction has a high prevalence, develops insidiously, and can severely affect quality of life and health of patients. Obstruction leads to bladder hypertrophy and ultimately to fibrosis. While macrophages are know…
View article: Nerve-sparing Mid-urethral Obstruction (NeMO) in Female Small Rodents
Nerve-sparing Mid-urethral Obstruction (NeMO) in Female Small Rodents Open
Partial bladder outlet obstruction (pBOO) has a high prevalence, causes significant patient burden, and immense health care costs. The most common animal model to investigate bladder remodeling in pBOO are female rodents undergoing partial…
View article: Uropathogenic E.coli (UPEC) Infection Induces Proliferation through Enhancer of Zeste Homologue 2 (EZH2)
Uropathogenic E.coli (UPEC) Infection Induces Proliferation through Enhancer of Zeste Homologue 2 (EZH2) Open
Uropathogen-induced paracrine factors act epigenetically by altering expression of EZH2, which plays a key role in early host cell proliferative responses to infection.