Martin Siegemund
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View article: Rebound of Respiratory Virus Activity and Seasonality to Pre‐Pandemic Patterns
Rebound of Respiratory Virus Activity and Seasonality to Pre‐Pandemic Patterns Open
The emergence of SARS‐CoV‐2 and the implementation of non‐pharmaceutical interventions (NPIs) profoundly disrupted the transmission dynamics of respiratory viruses, altering their epidemiology and seasonality. However, comprehensive long‐t…
View article: Comparison of Propofol and Dexmedetomidine Infused Overnight to Treat Hyperactive and Mixed ICU Delirium: A Prospective Randomised Controlled Clinical Trial
Comparison of Propofol and Dexmedetomidine Infused Overnight to Treat Hyperactive and Mixed ICU Delirium: A Prospective Randomised Controlled Clinical Trial Open
Background: Delirium is a frequent yet pathophysiologically still poorly understood complication in the intensive care unit (ICU) and is associated with adverse outcomes for the patients. Currently, guidelines give several recommendations …
View article: <scp>INCEPT</scp>: The Intensive Care Platform Trial—Design and protocol
<span>INCEPT</span>: The Intensive Care Platform Trial—Design and protocol Open
Background Adult intensive care unit (ICU) patients receive many interventions, but few are supported by high‐certainty evidence. Randomised clinical trials (RCTs) are essential for trustworthy comparisons of intervention effects, but conv…
View article: Preferences for thromboprophylaxis in the intensive care unit: An international survey
Preferences for thromboprophylaxis in the intensive care unit: An international survey Open
Background Venous thromboembolism (VTE) is a frequent complication in critically ill patients, who often have multiple risk factors. Pharmacological thromboprophylaxis is widely applied to lower this risk, but guidelines lack dosing recomm…
View article: Sex disparities in ICU care and outcomes after cardiac arrest: a Swiss nationwide analysis
Sex disparities in ICU care and outcomes after cardiac arrest: a Swiss nationwide analysis Open
This study highlights sex disparities in short-term mortality and ICU resource allocation among cardiac arrest patients, with women potentially facing disadvantages, in particular after OHCA. The limitations of ICU registry data, particula…
View article: Preoperative Non-Invasive Mapping for Targeted Concomitant Surgical Ablation of Non-Paroxysmal Atrial Fibrillation (PreMap Study)
Preoperative Non-Invasive Mapping for Targeted Concomitant Surgical Ablation of Non-Paroxysmal Atrial Fibrillation (PreMap Study) Open
Background/Objectives: The present study introduces our targeted approach for concomitant surgical ablation (CSA) using non-invasive phase mapping (NIPM) and describes its effectiveness regarding freedom from atrial fibrillation (AF). Meth…
View article: Intra-abdominal pressure, renal resistive index, sublingual microcirculation and total body water for guidance of volume resuscitation to avoid acute kidney injury during shock therapy
Intra-abdominal pressure, renal resistive index, sublingual microcirculation and total body water for guidance of volume resuscitation to avoid acute kidney injury during shock therapy Open
Background/objectives Shock and accompanying acute kidney injury (AKI) as a frequent complication is a well-known cause of morbidity and mortality worldwide. The current standard parameters to guide fluid resuscitation therapy (i.e., cardi…
View article: Target Attainment and Population Pharmacokinetics of Cefazolin in Patients with Invasive Staphylococcus aureus Infections: A Prospective Cohort Study
Target Attainment and Population Pharmacokinetics of Cefazolin in Patients with Invasive Staphylococcus aureus Infections: A Prospective Cohort Study Open
This study aimed to determine cefazolin target attainment in patients with invasive Staphylococcus aureus (S. aureus) infections and to develop a population pharmacokinetic (PK) model. Adult patients with invasive S. aureus infections trea…
View article: Conservative fluid resuscitation protocol does not reduce the incidence of reoperation for bleeding after emergency CABG
Conservative fluid resuscitation protocol does not reduce the incidence of reoperation for bleeding after emergency CABG Open
View article: Long-term mortality and health-related quality of life with lower versus higher oxygenation targets in intensive care unit patients with COVID-19 and severe hypoxaemia
Long-term mortality and health-related quality of life with lower versus higher oxygenation targets in intensive care unit patients with COVID-19 and severe hypoxaemia Open
View article: Platelet inhibitor withdrawal and outcomes after coronary artery surgery: an individual patient data meta-analysis
Platelet inhibitor withdrawal and outcomes after coronary artery surgery: an individual patient data meta-analysis Open
OBJECTIVES To evaluate the association between guideline-conforming as compared to shorter than recommended withdrawal period of P2Y12 receptor inhibitors prior to isolated on-pump coronary artery bypass grafting (CABG) and the incidence o…
View article: Sex differences in the SOFA score of ICU patients with sepsis or septic shock: a nationwide analysis
Sex differences in the SOFA score of ICU patients with sepsis or septic shock: a nationwide analysis Open
Background The Sequential Organ Failure Assessment (SOFA) score is an important tool in diagnosing sepsis and quantifying organ dysfunction. However, despite emerging evidence of differences in sepsis pathophysiology between women and men,…
View article: Isavuconazole for the Treatment of Fungal Infections: A Real-life Experience From the Fungal Infection Network of Switzerland (FUNGINOS)
Isavuconazole for the Treatment of Fungal Infections: A Real-life Experience From the Fungal Infection Network of Switzerland (FUNGINOS) Open
This analysis of 116 isavuconazole therapy courses shows that hepatic test disturbances (HTDs) were relatively frequent (29% of cases) but rarely led to treatment interruption (5%). Importantly, patients with baseline HTDs, including those…
View article: Lower vs Higher Oxygenation Target and Days Alive Without Life Support in COVID-19
Lower vs Higher Oxygenation Target and Days Alive Without Life Support in COVID-19 Open
Importance Supplemental oxygen is ubiquitously used in patients with COVID-19 and severe hypoxemia, but a lower dose may be beneficial. Objective To assess the effects of targeting a Pa o 2 of 60 mm Hg vs 90 mm Hg in patients with COVID-19…
View article: Serial monitoring of pancreatic stone protein for the detection of sepsis in intensive care unit patients with complicated abdominal surgery: A prospective, longitudinal cohort study
Serial monitoring of pancreatic stone protein for the detection of sepsis in intensive care unit patients with complicated abdominal surgery: A prospective, longitudinal cohort study Open
View article: The Effect of Albumin Administration in Critically Ill Patients: A Retrospective Single-Center Analysis
The Effect of Albumin Administration in Critically Ill Patients: A Retrospective Single-Center Analysis Open
OBJECTIVES: The aim of this study was to analyze the development of albumin administration in patients admitted to the adult ICU. In addition, we assessed the impact of albumin administration on serum hemoglobin concentration. DESIGN: We c…
View article: Historic methicillin-resistant Staphylococcus aureus: expanding current knowledge using molecular epidemiological characterization of a Swiss legacy collection
Historic methicillin-resistant Staphylococcus aureus: expanding current knowledge using molecular epidemiological characterization of a Swiss legacy collection Open
Background Few methicillin-resistant Staphylococcus aureus (MRSA) from the early years of its global emergence have been sequenced. Knowledge about evolutionary factors promoting the success of specific MRSA multi-locus sequence types (MLS…
View article: Impact of sex and gender on post-COVID-19 syndrome, Switzerland, 2020
Impact of sex and gender on post-COVID-19 syndrome, Switzerland, 2020 Open
Background Women are overrepresented among individuals with post-acute sequelae of SARS-CoV-2 infection (PASC). Biological (sex) as well as sociocultural (gender) differences between women and men might account for this imbalance, yet thei…
View article: Conservative Fluid Resuscitation Protocol Does Not Reduce the Incidence of Reoperation for Bleeding during the First 48 Hours after Emergency CABG
Conservative Fluid Resuscitation Protocol Does Not Reduce the Incidence of Reoperation for Bleeding during the First 48 Hours after Emergency CABG Open
BACKGROUND Reoperation for bleeding (ROB) after emergency coronary artery bypass grafting (CABG) has been identified as an independent risk factor for mortality with the incidence of in-hospital death ranging from 9–22%. A potential cause …
View article: Hydroxyethyl starch and Ringer’s lactate for volume resuscitation in sepsis and septic shock – The BaSES Trial
Hydroxyethyl starch and Ringer’s lactate for volume resuscitation in sepsis and septic shock – The BaSES Trial Open
Study objective: Shock develops in one third of ICU patients. Uncertainty remains about the ideal amount and choice of resuscitation fluid to avoid consequences of fluid overload. Design: The BaSES (Ba sel S tarch E valuation in S epsis) T…
View article: Identification of microorganisms by a rapid PCR panel from positive blood cultures leads to faster optimal antimicrobial therapy – a before-after study
Identification of microorganisms by a rapid PCR panel from positive blood cultures leads to faster optimal antimicrobial therapy – a before-after study Open
View article: A survey of preferences for respiratory support in the intensive care unit for patients with acute hypoxaemic respiratory failure
A survey of preferences for respiratory support in the intensive care unit for patients with acute hypoxaemic respiratory failure Open
Background When caring for mechanically ventilated adults with acute hypoxaemic respiratory failure (AHRF), clinicians are faced with an uncertain choice between ventilator modes allowing for spontaneous breaths or ventilation fully contro…
View article: Evaluation of the clinical relevance of the Biofire© FilmArray pneumonia panel among hospitalized patients
Evaluation of the clinical relevance of the Biofire© FilmArray pneumonia panel among hospitalized patients Open
View article: Factors associated with non-carbapenemase mediated carbapenem resistance of Gram-negative bacteria: a retrospective case-control study
Factors associated with non-carbapenemase mediated carbapenem resistance of Gram-negative bacteria: a retrospective case-control study Open
View article: Impact of Additional Administration of von Willebrand Factor Concentrates to Thrombocyte Transfusion in Perioperative Bleeding in Cardiac Surgery
Impact of Additional Administration of von Willebrand Factor Concentrates to Thrombocyte Transfusion in Perioperative Bleeding in Cardiac Surgery Open
Background: Von Willebrand factor (vWF) is an important part of blood coagulation since it binds platelets to each other and to endothelial cells. In traumatic and surgical haemorrhage, both blood cells and plasmatic factors …
View article: Bacterial genome wide association study substantiates<i>papGII</i>of<i>Escherichia coli</i>as a patient independent driver of urosepsis
Bacterial genome wide association study substantiates<i>papGII</i>of<i>Escherichia coli</i>as a patient independent driver of urosepsis Open
Urinary tract infections are extremely common and often caused by Escherichia coli . Bacterial virulence factors and patient characteristics have been linked separately to progressive, invasive infection. The interaction of these factors h…
View article: Microcirculatory dysfunction in cardiogenic shock
Microcirculatory dysfunction in cardiogenic shock Open
View article: Ancient methicillin-resistant<i>Staphylococcus aureus</i>: expanding current knowledge using molecular epidemiological characterization of a Swiss legacy collection
Ancient methicillin-resistant<i>Staphylococcus aureus</i>: expanding current knowledge using molecular epidemiological characterization of a Swiss legacy collection Open
Few methicillin-resistant Staphylococcus aureus (MRSA) from the early years of its global emergence have been sequenced. Knowledge about evolutionary factors promoting the success of specific MRSA multi-locus sequence types (MLSTs) remains…
View article: Atrial Fibrillation (AFIB) in the ICU: Incidence, Risk Factors, and Outcomes: The International AFIB-ICU Cohort Study*
Atrial Fibrillation (AFIB) in the ICU: Incidence, Risk Factors, and Outcomes: The International AFIB-ICU Cohort Study* Open
OBJECTIVES: To assess the incidence, risk factors, and outcomes of atrial fibrillation (AF) in the ICU and to describe current practice in the management of AF. DESIGN: Multicenter, prospective, inception cohort study. SETTING: Forty-four …
View article: A bedside swallowing screen for the identification of post-extubation dysphagia on the intensive care unit – validation of the Gugging Swallowing Screen (GUSS)—ICU
A bedside swallowing screen for the identification of post-extubation dysphagia on the intensive care unit – validation of the Gugging Swallowing Screen (GUSS)—ICU Open