Martin Swain
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View article: Use of a cytochrome P450 humanised mouse model to refine schistosomiasis drug discovery
Use of a cytochrome P450 humanised mouse model to refine schistosomiasis drug discovery Open
Control of schistosomiasis, a neglected tropical disease caused by infection with Schistosoma spp ., remains reliant on a single chemotherapy, praziquantel (PZQ). This strategy presents a risk to global health should PZQ-resistant schistos…
View article: Investigating within-host population diversity of Cryptosporidium parvum using BlooMine
Investigating within-host population diversity of Cryptosporidium parvum using BlooMine Open
View article: A review of recent Cryptosporidium hominis and Cryptosporidium parvum gp60 subtypes
A review of recent Cryptosporidium hominis and Cryptosporidium parvum gp60 subtypes Open
Cryptosporidium spp. are known to cause gastroenteritis (cryptosporidiosis) in numerous hosts, including humans. Understanding the diversity within this genus of parasites requires accurate subtyping, which is frequently performed b…
View article: The RNA cargo of <i>Myxococcus</i> outer membrane vesicles
The RNA cargo of <i>Myxococcus</i> outer membrane vesicles Open
Vesicles secreted by predatory myxobacteria contain RNA transcripts. Many transcripts seem to be packaged passively, but others seem to be specifically loaded onto vesicles.
View article: Sequence features do not drive karyotypic evolution: what are the missing correlates of genome evolution?
Sequence features do not drive karyotypic evolution: what are the missing correlates of genome evolution? Open
Genome rearrangements are prevalent across the tree of life and even within species. After two decades of research, various suggestions have been proposed to explain which features of the genome are associated with rearrangements and the b…
View article: Interpreting alignment-free sequence comparison: what makes a score a good score?
Interpreting alignment-free sequence comparison: what makes a score a good score? Open
Alignment-free methods are alternatives to alignment-based methods when searching sequence data sets. The output from an alignment-free sequence comparison is a similarity score, the interpretation of which is not straightforward. We propo…
View article: Complementary protein extraction methods increase the identification of the Park Grass Experiment metaproteome
Complementary protein extraction methods increase the identification of the Park Grass Experiment metaproteome Open
View article: Identification of the Park Grass Experiment soil metaproteome
Identification of the Park Grass Experiment soil metaproteome Open
The Park Grass Experiment, is an international reference soil with an impressive repository of temperate grassland (meta)data, however, it still lacks documentation of its soil metaproteome. The identification of these proteins is crucial …
View article: Evidence of Immune Modulators in the Secretome of the Equine Tapeworm Anoplocephala perfoliata
Evidence of Immune Modulators in the Secretome of the Equine Tapeworm Anoplocephala perfoliata Open
Anoplocephala perfoliata is a neglected gastro-intestinal tapeworm, commonly infecting horses worldwide. Molecular investigation of A. perfoliata is hampered by a lack of tools to better understand the host–parasite interface. This interfa…
View article: Genotyping and Whole-Genome Resequencing of Welsh Sheep Breeds Reveal Candidate Genes and Variants for Adaptation to Local Environment and Socioeconomic Traits
Genotyping and Whole-Genome Resequencing of Welsh Sheep Breeds Reveal Candidate Genes and Variants for Adaptation to Local Environment and Socioeconomic Traits Open
Background Advances in genetic tools applied to livestock breeding has prompted research into the previously neglected breeds adapted to harsh local environments. One such group is the Welsh mountain sheep breeds, which can be farmed at al…
View article: Streptomyces Isolates from the Soil of an Ancient Irish Cure Site, Capable of Inhibiting Multi-Resistant Bacteria and Yeasts
Streptomyces Isolates from the Soil of an Ancient Irish Cure Site, Capable of Inhibiting Multi-Resistant Bacteria and Yeasts Open
Traditional Irish medicines are often intertwined with ritual and spirituality, making it difficult to substantiate the validity of their claims. In this manuscript, we use molecular and microscopic techniques to investigate some microorga…
View article: Identifying and validating the presence of Guanine-Quadruplexes (G4) within the blood fluke parasite Schistosoma mansoni
Identifying and validating the presence of Guanine-Quadruplexes (G4) within the blood fluke parasite Schistosoma mansoni Open
Schistosomiasis is a neglected tropical disease that currently affects over 250 million individuals worldwide. In the absence of an immunoprophylactic vaccine and the recognition that mono-chemotherapeutic control of schistosomiasis by pra…
View article: The Genetics of Prey Susceptibility to Myxobacterial Predation: A Review, Including an Investigation into <b><i>Pseudomonas aeruginosa</i></b> Mutations Affecting Predation by <b><i>Myxococcus xanthus</i></b>
The Genetics of Prey Susceptibility to Myxobacterial Predation: A Review, Including an Investigation into <b><i>Pseudomonas aeruginosa</i></b> Mutations Affecting Predation by <b><i>Myxococcus xanthus</i></b> Open
Bacterial predation is a ubiquitous and fundamental biological process, which influences the community composition of microbial ecosystems. Among the best characterised bacterial predators are the myxobacteria, which include the model orga…
View article: The Isolation of a Novel Streptomyces sp. CJ13 from a Traditional Irish Folk Medicine Alkaline Grassland Soil that Inhibits Multiresistant Pathogens and Yeasts
The Isolation of a Novel Streptomyces sp. CJ13 from a Traditional Irish Folk Medicine Alkaline Grassland Soil that Inhibits Multiresistant Pathogens and Yeasts Open
The World Health Organization recently stated that new sources of antibiotics are urgently required to stem the global spread of antibiotic resistance, especially in multiresistant Gram-negative bacteria. Although it was thought that many …
View article: Resequencing and signatures of selection scan in two Siberian native sheep breeds point to candidate genetic variants for adaptation and economically important traits
Resequencing and signatures of selection scan in two Siberian native sheep breeds point to candidate genetic variants for adaptation and economically important traits Open
Summary Russian sheep breeds represent an important economic asset by providing meat and wool, whilst being adapted to extreme climates. By resequencing two Russian breeds from Siberia: Tuva ( n = 20) and Baikal ( n = 20); and comparing th…
View article: Genetic and Methylome Variation in Turkish Brachypodium Distachyon Accessions Differentiate Two Geographically Distinct Subpopulations
Genetic and Methylome Variation in Turkish Brachypodium Distachyon Accessions Differentiate Two Geographically Distinct Subpopulations Open
Brachypodium distachyon (Brachypodium) is a non-domesticated model grass species that can be used to test if variation in genetic sequence or methylation are linked to environmental differences. To assess this, we collected seeds from 12 s…
View article: Identifying and validating the presence of Guanine-Quadruplexes (G4) within the blood fluke parasite<i>Schistosoma mansoni</i>
Identifying and validating the presence of Guanine-Quadruplexes (G4) within the blood fluke parasite<i>Schistosoma mansoni</i> Open
Background Schistosomiasis is a neglected tropical disease that currently affects over 250 million individuals worldwide. In the absence of an immunoprophylactic vaccine and the recognition that mono-chemotherapeutic control of schistosomi…
View article: A survey of non-coding RNAs in the social and predatory myxobacterium <i>Myxococcus xanthus</i> DK1622
A survey of non-coding RNAs in the social and predatory myxobacterium <i>Myxococcus xanthus</i> DK1622 Open
Identification and characterisation of non-coding RNAs in the bacterial predator Myxococcus xanthus.
View article: Genome-Wide Identification of Myxobacterial Predation Genes and Demonstration of Formaldehyde Secretion as a Potentially Predation-Resistant Trait of Pseudomonas aeruginosa
Genome-Wide Identification of Myxobacterial Predation Genes and Demonstration of Formaldehyde Secretion as a Potentially Predation-Resistant Trait of Pseudomonas aeruginosa Open
Despite widespread use in human biology, genome-wide association studies (GWAS) of bacteria are few and have, to date, focused primarily on pathogens. Myxobacteria are predatory microbes with large patchwork genomes, with individual strain…
View article: Mendel’s pea crosses: varieties, traits and statistics
Mendel’s pea crosses: varieties, traits and statistics Open
View article: Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes
Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes Open
Expanded genomic discoveries reveal the genetics underlying Glossina biology and provide a rich body of knowledge for basic science and disease control. They also provide insight into the evolutionary biology underlying novel adaptations a…
View article: Transcriptional and Metabolomic Analyses Indicate that Cell Wall Properties are Associated with Drought Tolerance in Brachypodium distachyon
Transcriptional and Metabolomic Analyses Indicate that Cell Wall Properties are Associated with Drought Tolerance in Brachypodium distachyon Open
Brachypodium distachyon is an established model for drought tolerance. We previously identified accessions exhibiting high tolerance, susceptibility and intermediate tolerance to drought; respectively, ABR8, KOZ1 and ABR4. Transcriptomics …
View article: Evolutionary genomics of anthroponosis in Cryptosporidium
Evolutionary genomics of anthroponosis in Cryptosporidium Open
View article: The importance of extracellular vesicle purification for downstream analysis: A comparison of differential centrifugation and size exclusion chromatography for helminth pathogens
The importance of extracellular vesicle purification for downstream analysis: A comparison of differential centrifugation and size exclusion chromatography for helminth pathogens Open
The data suggests that DC and SEC purification methods do not isolate equivalent EV population profiles and caution should be taken in the choice of EV purification utilised, with certain protocols for DC preparations including more free E…
View article: The Glossina Genome Cluster: Comparative Genomic Analysis of the Vectors of African Trypanosomes
The Glossina Genome Cluster: Comparative Genomic Analysis of the Vectors of African Trypanosomes Open
Background: Tsetse flies (Glossina sp.) are the sole vectors of human and animal trypanosomiasis throughout sub-Saharan Africa. Tsetse are distinguished from other Diptera by unique adaptations, including lactation and the birthing of live…
View article: Genome Sequencing and Comparative Transcriptomics Provide a Holistic View of 4-Nitrophenol Degradation and Concurrent Fatty Acid Catabolism by Rhodococcus sp. Strain BUPNP1
Genome Sequencing and Comparative Transcriptomics Provide a Holistic View of 4-Nitrophenol Degradation and Concurrent Fatty Acid Catabolism by Rhodococcus sp. Strain BUPNP1 Open
Rhodococcus sp.strain BUPNP1 can utilize the priority environmental pollutant 4-nitrophenol (4-NP) as its sole source of carbon and energy. In this study, genome and transcriptome sequencing were used to gain mechanistic insights in…
View article: Identifying and Resolving Genome Misassembly Issues Important for Biomarker Discovery in the Protozoan Parasite, Cryptosporidium
Identifying and Resolving Genome Misassembly Issues Important for Biomarker Discovery in the Protozoan Parasite, Cryptosporidium Open
View article: Polyomic tools for an emerging livestock parasite, the rumen fluke Calicophoron daubneyi; identifying shifts in rumen functionality
Polyomic tools for an emerging livestock parasite, the rumen fluke Calicophoron daubneyi; identifying shifts in rumen functionality Open
The resulting data provide a discovery platform (transcriptome, proteomes, EV isolation pipeline and in vitro fermentation system) to further study C. daubneyi-host interaction. In addition, the acetate: propionate ratio has been demonstra…
View article: Corrigendum to ‘the anti-fecundity effect of 5-azacytidine (5-AzaC) on Schistosoma mansoni is linked to dis-regulated transcription, translation and stem cell activities’ [Int. J. Parasitol. Drugs and Drug Resist. 8 (2018) 213–222]
Corrigendum to ‘the anti-fecundity effect of 5-azacytidine (5-AzaC) on Schistosoma mansoni is linked to dis-regulated transcription, translation and stem cell activities’ [Int. J. Parasitol. Drugs and Drug Resist. 8 (2018) 213–222] Open
View article: Identification of <i>Stipules reduced,</i> a leaf morphology gene in pea (<i>Pisum sativum</i>)
Identification of <i>Stipules reduced,</i> a leaf morphology gene in pea (<i>Pisum sativum</i>) Open
Summary Pea ( Pisum sativum ) is one of relatively few genetically amenable plant species with compound leaves. Pea leaves have a variety of specialized organs: leaflets, tendrils, pulvini and stipules, which enable the identification of m…