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View article: Refractory Thrombectomy: Incidence and Related Factors in a Third-Level Stroke Treatment Center
Refractory Thrombectomy: Incidence and Related Factors in a Third-Level Stroke Treatment Center Open
Background/Objectives: The efficacy of mechanical thrombectomy in large vessel occlusion has been established in multiple clinical trials as the standard of care for acute ischemic stroke. However, the incidence of refractory thrombectomy …
View article: Proinflammatory macrophage secretome enhances temozolomide sensitivity in glioblastoma via pSTAT3-mediated downregulation of DNA repair enzymes
Proinflammatory macrophage secretome enhances temozolomide sensitivity in glioblastoma via pSTAT3-mediated downregulation of DNA repair enzymes Open
The mechanisms by which tumor-associated macrophages, key components of the glioblastoma (GBM) microenvironment, impair chemotherapy efficacy remain poorly understood. Resistance to temozolomide (TMZ), the standard chemotherapeutic agent f…
View article: Plasma proteomics uncovers divergent molecular signatures in ischemic stroke and intracerebral hemorrhage
Plasma proteomics uncovers divergent molecular signatures in ischemic stroke and intracerebral hemorrhage Open
View article: Transcriptomic profiling of thrombus-derived extracellular vesicles reveals PECAM-1 as a potential inflammatory marker for cardioembolic stroke patients
Transcriptomic profiling of thrombus-derived extracellular vesicles reveals PECAM-1 as a potential inflammatory marker for cardioembolic stroke patients Open
View article: Mapping the causal chain from genetic risk variants to lipid dysmetabolism in Parkinson’s disease
Mapping the causal chain from genetic risk variants to lipid dysmetabolism in Parkinson’s disease Open
Risk variants in multiple genes, including GBA1 , strongly implicate lipid metabolism in Parkinson’s disease (PD) onset and progression. We show that common PD risk variants at the serine palmitoyltransferase small subunit B ( SPTSSB ) loc…
View article: Dual Inhibition of HIF-1α and HIF-2α as a Promising Treatment for VHL-Associated Hemangioblastomas: A Pilot Study Using Patient-Derived Primary Cell Cultures
Dual Inhibition of HIF-1α and HIF-2α as a Promising Treatment for VHL-Associated Hemangioblastomas: A Pilot Study Using Patient-Derived Primary Cell Cultures Open
Background: Von Hippel-Lindau (VHL) disease, a hereditary cancer syndrome, is characterized by mutations in the VHL gene, which result in the stabilization of hypoxia-inducible factors (HIF)-1α and -2α, ultimately leading to the developmen…
View article: Case Report: Mechanical thrombectomy using stent retriever devices in deep cerebral venous thrombosis: illustrative cases
Case Report: Mechanical thrombectomy using stent retriever devices in deep cerebral venous thrombosis: illustrative cases Open
Background Treatment of cerebral venous thrombosis has traditionally been based on anticoagulant therapy. However, in certain circumstances, such as deep cerebral venous thrombosis, anticoagulation may be insufficient, so endovascular trea…
View article: Serum angiotensin type-1 receptor autoantibodies and neurofilament light chain as markers of neuroaxonal damage in post-COVID patients
Serum angiotensin type-1 receptor autoantibodies and neurofilament light chain as markers of neuroaxonal damage in post-COVID patients Open
Introduction Dysregulation of autoimmune responses and the presence of autoantibodies (AA), particularly those related to the renin-angiotensin system (RAS), have been implicated in the acute phase of COVID-19, and persistent dysregulation…
View article: Dual Inhibition of HIF-1α and HIF-2α as a Promising Treatment for VHL-Associated Hemangioblastomas: A Pilot Study Using Patient-Derived Primary Cell Cultures
Dual Inhibition of HIF-1α and HIF-2α as a Promising Treatment for VHL-Associated Hemangioblastomas: A Pilot Study Using Patient-Derived Primary Cell Cultures Open
Background: Von Hippel-Lindau (VHL) disease, a hereditary cancer syndrome, is characterized by mutations in the VHL gene, which result in the stabilization of hypoxia-inducible factors (HIF)-1α and -2α, ultimately leading to th…
View article: Histopathological composition of thrombus material in a large cohort of patients with acute ischemic stroke: a study of atypical clots
Histopathological composition of thrombus material in a large cohort of patients with acute ischemic stroke: a study of atypical clots Open
Introduction Clot composition appears to be associated with outcomes in stroke recanalization therapy. This study aims to analyze thrombus composition and assess the relationship between atypical clot composition and clinical parameters, l…
View article: Proinflammatory macrophage-derived medium enhances temozolomide sensitivity in glioblastoma via pSTAT3-mediated downregulation of DNA repair enzymes
Proinflammatory macrophage-derived medium enhances temozolomide sensitivity in glioblastoma via pSTAT3-mediated downregulation of DNA repair enzymes Open
Chemoresistance to temozolomide (TMZ), the main agent in glioblastoma (GBM) treatment, negatively impacts prognosis due to efficient repair of TMZ-induced DNA lesions. Reduced expression of the DNA repair enzyme O6-methylguanine DNA-methyl…
View article: Iatrogenic cerebral amyloid angiopathy and Alzheimer's disease co‐pathology
Iatrogenic cerebral amyloid angiopathy and Alzheimer's disease co‐pathology Open
Iatrogenic cerebral amyloid angiopathy, a disease caused by contact with neurosurgical material or human growth hormone contaminated by beta‐amyloid peptide (Aβ), has a prion‐like transmission mechanism. We present a series of three patien…
View article: 20939. PERCEPCIONES ACERCA DE LA IMPLEMENTACIÓN DE FÁRMACOS ANTIAMILOIDE EN LOS SERVICIOS DE NEUROLOGÍA: ESTUDIO DE INFORMADORES CLAVE
20939. PERCEPCIONES ACERCA DE LA IMPLEMENTACIÓN DE FÁRMACOS ANTIAMILOIDE EN LOS SERVICIOS DE NEUROLOGÍA: ESTUDIO DE INFORMADORES CLAVE Open
View article: 21544. ICTUS PEDIÁTRICO SECUNDARIO A ARTERIOPATÍA CEREBRAL FOCAL. TROMBECTOMÍA MECÁNICA URGENTE Y REVISIÓN DE LA LITERATURA
21544. ICTUS PEDIÁTRICO SECUNDARIO A ARTERIOPATÍA CEREBRAL FOCAL. TROMBECTOMÍA MECÁNICA URGENTE Y REVISIÓN DE LA LITERATURA Open
View article: 20057. ERRORES DIAGNÓSTICOS EN MIASTENIA GRAVIS AUTOINMUNE, SERIE RETROSPECTIVA DE CASOS EN UN HOSPITAL TERCIARIO
20057. ERRORES DIAGNÓSTICOS EN MIASTENIA GRAVIS AUTOINMUNE, SERIE RETROSPECTIVA DE CASOS EN UN HOSPITAL TERCIARIO Open
View article: Plasma Levels of Neuron/Glia-Derived Apoptotic Bodies, an In Vivo Biomarker of Apoptosis, Predicts Infarct Growth and Functional Outcome in Patients with Ischemic Stroke
Plasma Levels of Neuron/Glia-Derived Apoptotic Bodies, an In Vivo Biomarker of Apoptosis, Predicts Infarct Growth and Functional Outcome in Patients with Ischemic Stroke Open
View article: Plasma levels of neuron/glia-derived apoptotic bodies, an in vivo biomarker of apoptosis, predicts infarct growth and functional outcome in patients with ischemic stroke
Plasma levels of neuron/glia-derived apoptotic bodies, an in vivo biomarker of apoptosis, predicts infarct growth and functional outcome in patients with ischemic stroke Open
Evidence demonstrating the involvement of apoptosis in the death of the potentially salvageable area (penumbra zone) in patients during stroke remains limited. Our aim was to investigate whether apoptotic processes occur in penumbral brain…
View article: Endovascular treatment in Danon disease: a case report
Endovascular treatment in Danon disease: a case report Open
View article: Ultrasonographic study of the orbit as an early diagnostic tool in Vogt Koyanagi Harada disease (VKH): A case report
Ultrasonographic study of the orbit as an early diagnostic tool in Vogt Koyanagi Harada disease (VKH): A case report Open
In recent years, ultrasound has demonstrated its usefulness in the approach to vascular structures and other tissues such as the orbit, facilitating the early diagnosis of various diseases without having to rely on other more invasive or l…
View article: A multitrait genetic study of hemostatic factors and hemorrhagic transformation after stroke treatment
A multitrait genetic study of hemostatic factors and hemorrhagic transformation after stroke treatment Open
View article: Increased vertebral canal diameter measured by ultrasonography as a sign of vasculitis in patients with giant cell arteritis
Increased vertebral canal diameter measured by ultrasonography as a sign of vasculitis in patients with giant cell arteritis Open
Introduction The diagnosis of giant cell arteritis (GCA) by ultrasonography including large vessels, apart from the temporal artery increases the sensibility of the study and informs about the risk of specific complications. However, there…
View article: Genetic Architecture of Ischaemic Strokes after COVID-19 Shows Similarities with Large Vessel Strokes
Genetic Architecture of Ischaemic Strokes after COVID-19 Shows Similarities with Large Vessel Strokes Open
We aimed to analyse whether patients with ischaemic stroke (IS) occurring within eight days after the onset of COVID-19 (IS-COV) are associated with a specific aetiology of IS. We used SUPERGNOVA to identify genome regions that correlate b…
View article: A series of patients with refractory myasthenia gravis
A series of patients with refractory myasthenia gravis Open
The percentage of patients with refractory MG in our series (13%) is similar to those reported in previous studies; these patients were often women and presented early onset, severe forms of onset, and repeated relapses requiring hospital …
View article: Ulnar nerve thickness at the elbow on longitudinal ultrasound view in control subjects
Ulnar nerve thickness at the elbow on longitudinal ultrasound view in control subjects Open
View article: Symptoms timeline and outcomes in amyotrophic lateral sclerosis using artificial intelligence
Symptoms timeline and outcomes in amyotrophic lateral sclerosis using artificial intelligence Open
Amyotrophic lateral sclerosis (ALS) is a fatal, neurodegenerative motor neuron disease. Although an early diagnosis is crucial to provide adequate care and improve survival, patients with ALS experience a significant diagnostic delay. This…
View article: Potenciales evocados somatosensoriales, electroencefalograma y coma postanóxico: utilidad en el pronóstico neurológico
Potenciales evocados somatosensoriales, electroencefalograma y coma postanóxico: utilidad en el pronóstico neurológico Open
RESUMENIntroducción: tras un coma postanóxico, el reto de los profesionales de la salud es valorar de forma temprana el pronóstico neurológico a medio y largo plazo.A pesar de la mejoría en la atención de los servicios prehospitalarios y d…
View article: Outcomes and drivers of inappropriate dosing of non-vitamin K antagonist oral anticoagulants (NOACs) in patients with atrial fibrillation: a systematic review and meta-analysis
Outcomes and drivers of inappropriate dosing of non-vitamin K antagonist oral anticoagulants (NOACs) in patients with atrial fibrillation: a systematic review and meta-analysis Open
Objective There has been limited systematic evaluation of outcomes and drivers of inappropriate non-vitamin K antagonist oral anticoagulants (NOACs) dosing among patients with atrial fibrillation (AF). This review identified and systematic…
View article: Case report: Endovascular embolization of a cerebral pseudoaneurysm caused by SARS-CoV2 infection
Case report: Endovascular embolization of a cerebral pseudoaneurysm caused by SARS-CoV2 infection Open
Background Severe COVID-19 has been shown to produce convulsions, encephalitis, Guillain-Barré syndrome, or cerebrovascular disease. However, only 4 case reports described subarachnoid or brain hemorrhage caused by ruptured cerebral aneury…
View article: Ischemia preconditioning induces an adaptive response that defines a circulating metabolomic signature in ischemic stroke patients
Ischemia preconditioning induces an adaptive response that defines a circulating metabolomic signature in ischemic stroke patients Open
Transient ischemic attacks (TIAs) before an acute ischemic stroke (AIS) could induce ischemic tolerance (IT) phenomena. with an endogenous neuroprotective role (Ischemic preconditioning. IPC). A consecutive prospective cohort of patients w…
View article: Functional and Prognostic Assessment in Comatose Patients: A Study Using Somatosensory Evoked Potentials
Functional and Prognostic Assessment in Comatose Patients: A Study Using Somatosensory Evoked Potentials Open
Aim The functional prognosis of patients after coma following either cardiac arrest (CA) or acute structural brain injury (ABI) is often uncertain. These patients are associated with high mortality and disability. N20 and N70 somatosensory…