Martin V. Appleby
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View article: Testing the limits: serial crystallography using unpatterned fixed targets
Testing the limits: serial crystallography using unpatterned fixed targets Open
Sheet-on-sheet (SOS) fixed-target chips are arguably the most versatile, cheapest and simplest sample-delivery method for ambient-temperature data acquisition using serial crystallography approaches at synchrotrons and X-ray free-electron …
View article: Time-resolved structures of β<sub>2</sub>-adrenergic receptor modulation by a photoswitchable beta-blocker
Time-resolved structures of β<sub>2</sub>-adrenergic receptor modulation by a photoswitchable beta-blocker Open
G protein-coupled receptors (GPCRs) regulate essential physiological responses and are important drug targets, yet their ligand-induced conformational dynamics remain poorly understood. The β 2 -adrenergic receptor (β 2 AR) is a prominent …
View article: Circular Dichroism and Multiphoton Circularly Polarized Luminescence Switching Using a Bis‐perylene Diimide Macrocycle
Circular Dichroism and Multiphoton Circularly Polarized Luminescence Switching Using a Bis‐perylene Diimide Macrocycle Open
Chiroptical switches exhibit stimuli‐induced changes in the sign or strength of their circular dichroism (CD) or circularly polarized luminescence (CPL) and are materials with significant potential for chiroptical sensing and biological im…
View article: Integrated structural dynamics uncover new modes of B<sub>12</sub> photoreceptor activation
Integrated structural dynamics uncover new modes of B<sub>12</sub> photoreceptor activation Open
Photoreceptor proteins initiate, regulate and control fundamental biological processes such as vision, photosynthesis and circadian rhythms 1 . A large photoreceptor subfamily uses vitamin B 12 derivatives for light sensing 2 , contrasting…
View article: Damage before destruction? X-ray-induced changes in single-pulse serial femtosecond crystallography
Damage before destruction? X-ray-induced changes in single-pulse serial femtosecond crystallography Open
Serial femtosecond crystallography (SFX) exploits extremely brief X-ray free-electron laser pulses to obtain diffraction data before destruction of the crystal. However, during the pulse X-ray-induced site-specific radiation damage can occ…
View article: Anion Localization on Termini of a Non‐Fullerene Acceptor Aids Charge Transport
Anion Localization on Termini of a Non‐Fullerene Acceptor Aids Charge Transport Open
Non‐fullerene acceptors have revolutionised organic photovoltaics. However, greater fundamental understanding is needed of the crucial relationships between molecular structure and photophysical mechanisms. Herein, a combination of spectro…
View article: Correction: Cu(<scp>i</scp>) diimine complexes as immobilised antibacterial photosensitisers operating in water under visible light
Correction: Cu(<span>i</span>) diimine complexes as immobilised antibacterial photosensitisers operating in water under visible light Open
Correction for ‘Cu( i ) diimine complexes as immobilised antibacterial photosensitisers operating in water under visible light’ by Martin V. Appleby et al. , Mater. Adv. , 2020, 1 , 3417–3427, https://doi.org/10.1039/D0MA00642D.
View article: CCDC 2239630: Experimental Crystal Structure Determination
CCDC 2239630: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2239632: Experimental Crystal Structure Determination
CCDC 2239632: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2239631: Experimental Crystal Structure Determination
CCDC 2239631: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2143431: Experimental Crystal Structure Determination
CCDC 2143431: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Direct Determination of the Rate of Intersystem Crossing in a Near-IR Luminescent Cr(III) Triazolyl Complex
Direct Determination of the Rate of Intersystem Crossing in a Near-IR Luminescent Cr(III) Triazolyl Complex Open
A detailed understanding of the dynamics of photoinduced processes occurring in the electronic excited state is essential in informing the rational design of photoactive transition-metal complexes. Here, the rate of intersystem crossing in…
View article: Ultrafast electronic, infrared, and X-ray absorption spectroscopy study of Cu(<scp>i</scp>) phosphine diimine complexes
Ultrafast electronic, infrared, and X-ray absorption spectroscopy study of Cu(<span>i</span>) phosphine diimine complexes Open
The study aims to understand the role of the transient bonding in the interplay between the structural and electronic changes in heteroleptic Cu( i ) diimine diphosphine complexes.
View article: Ruthenium–rhenium and ruthenium–palladium supramolecular photocatalysts for photoelectrocatalytic CO<sub>2</sub> and H<sup>+</sup> reduction
Ruthenium–rhenium and ruthenium–palladium supramolecular photocatalysts for photoelectrocatalytic CO<sub>2</sub> and H<sup>+</sup> reduction Open
Photoelectrocatalysis offers the opportunity to close the carbon loop and convert captured CO 2 back into useful fuels and feedstocks, mitigating against anthropogenic climate change.
View article: Solvent-Mediated Activation/Deactivation of Photoinduced Electron-Transfer in a Molecular Dyad
Solvent-Mediated Activation/Deactivation of Photoinduced Electron-Transfer in a Molecular Dyad Open
Herein is presented a molecular dyad comprised of a [Ru(bpy)3]2+ photosensitizer and an anthraquinone (AQ) acceptor coupled by an ethynyl linker ([Ru(bpy)2(bpy-cc-AQ)]2+) in which activation/deac…
View article: Cu(<scp>i</scp>) diimine complexes as immobilised antibacterial photosensitisers operating in water under visible light
Cu(<span>i</span>) diimine complexes as immobilised antibacterial photosensitisers operating in water under visible light Open
A simple complex of copper immobilised on silica exemplifies how lighter transition metal complexes can efficiently kill both Gram-positive and Gram-negative bacteria in water – in some cases in only 15 min – under visible light.
View article: High-throughput structures of protein–ligand complexes at room temperature using serial femtosecond crystallography
High-throughput structures of protein–ligand complexes at room temperature using serial femtosecond crystallography Open
High-throughput X-ray crystal structures of protein–ligand complexes are critical to pharmaceutical drug development. However, cryocooling of crystals and X-ray radiation damage may distort the observed ligand binding. Serial femtosecond c…
View article: Dose-resolved serial synchrotron and XFEL structures of radiation-sensitive metalloproteins
Dose-resolved serial synchrotron and XFEL structures of radiation-sensitive metalloproteins Open
An approach is demonstrated to obtain, in a sample- and time-efficient manner, multiple dose-resolved crystal structures from room-temperature protein microcrystals using identical fixed-target supports at both synchrotrons and X-ray free-…
View article: Resolving polymorphs and radiation-driven effects in microcrystals using fixed-target serial synchrotron crystallography
Resolving polymorphs and radiation-driven effects in microcrystals using fixed-target serial synchrotron crystallography Open
The ability to determine high-quality, artefact-free structures is a challenge in micro-crystallography, and the rapid onset of radiation damage and requirement for a high-brilliance X-ray beam mean that a multi-crystal approach is essenti…
View article: Copper nitrite reductase from Achromobacter cycloclastes: non-polymorph separated dataset 1
Copper nitrite reductase from Achromobacter cycloclastes: non-polymorph separated dataset 1 Open
The ability to determine high-quality, artefact-free structures is a challenge in micro-crystallography, and the rapid onset of radiation damage and requirement for a high-brilliance X-ray beam mean that a multi-crystal approach is essenti…