Martin Vališ
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View article: Serum Alpha-Linolenic Acid and Long-Term Multiple Sclerosis Activity and Progression
Serum Alpha-Linolenic Acid and Long-Term Multiple Sclerosis Activity and Progression Open
Higher serum ALA levels were associated with a lower risk of CDMS, relapses, and disability progression in a large prospective cohort. The results were null or inconsistent for other fatty acids.
View article: Correction: The effect of single and repeated doses of rivastigmine on gastric myoelectric activity in experimental pigs
Correction: The effect of single and repeated doses of rivastigmine on gastric myoelectric activity in experimental pigs Open
[This corrects the article DOI: 10.1371/journal.pone.0286386.].
View article: RETRACTED: Ali et al. A Novel Herbal Hydrogel Formulation of Moringa oleifera for Wound Healing. Plants 2021, 10, 25
RETRACTED: Ali et al. A Novel Herbal Hydrogel Formulation of Moringa oleifera for Wound Healing. Plants 2021, 10, 25 Open
The journal retracts the article, “A Novel Herbal Hydrogel Formulation of Moringa oleifera for Wound Healing” [...]
View article: Capillary zone electrophoresis method for quantification of therapeutic peptide glatiramer acetate
Capillary zone electrophoresis method for quantification of therapeutic peptide glatiramer acetate Open
This study presents the development and validation of a novel capillary zone electrophoresis method for the precise determination of glatiramer acetate and its amino acid constituents. A 120 mmol dm −3 phosphoric acid solution adjusted to …
View article: Intravenous Thrombolysis in Posterior versus Anterior Circulation Stroke: Clinical Outcome Differs Only in Patients with Large Vessel Occlusion
Intravenous Thrombolysis in Posterior versus Anterior Circulation Stroke: Clinical Outcome Differs Only in Patients with Large Vessel Occlusion Open
The safety and efficacy of intravenous thrombolysis (IVT) are well established in anterior circulation stroke (ACS) but are much less clear for posterior circulation stroke (PCS). The aim of this study was to evaluate the occurrence of par…
View article: The Benefits and Risks of Switching from Fingolimod to Siponimod for the Treatment of Relapsing–Remitting and Secondary Progressive Multiple Sclerosis
The Benefits and Risks of Switching from Fingolimod to Siponimod for the Treatment of Relapsing–Remitting and Secondary Progressive Multiple Sclerosis Open
Multiple sclerosis (MS) is a chronic neurodegenerative disease that affects the central nervous system (CNS). Currently, MS treatment is limited to several Food and Drug Administration (FDA)- and European Medicines Agency (EMA)-approved me…
View article: Corrigendum to “The measured CSF/plasma donepezil concentration ratio but not individually measured CSF and plasma concentrations significantly increase over 24 h after donepezil treatment in patients with Alzheimer’s disease” [Biomed. Pharmacother. 159 (2023) 114223]
Corrigendum to “The measured CSF/plasma donepezil concentration ratio but not individually measured CSF and plasma concentrations significantly increase over 24 h after donepezil treatment in patients with Alzheimer’s disease” [Biomed. Pharmacother. 159 (2023) 114223] Open
View article: Corrigendum: Anti-viral drug discovery against monkeypox and smallpox infection by natural curcumin derivatives: a computational drug design approach
Corrigendum: Anti-viral drug discovery against monkeypox and smallpox infection by natural curcumin derivatives: a computational drug design approach Open
[This corrects the article DOI: 10.3389/fcimb.2023.1157627.].
View article: The effect of single and repeated doses of rivastigmine on gastric myoelectric activity in experimental pigs
The effect of single and repeated doses of rivastigmine on gastric myoelectric activity in experimental pigs Open
Background Rivastigmine is a pseudo-irreversible cholinesterase inhibitor used for therapy of Alzheimer’s disease and non-Alzheimer dementia syndromes. In humans, rivastigmine can cause significant gastrointestinal side effects that can li…
View article: Binocular video head impulse test: Normative data study
Binocular video head impulse test: Normative data study Open
Introduction The video head impulse test (vHIT) evaluates the vestibulo-ocular reflex (VOR). It’s usually recorded from only one eye. Newer vHIT devices allow a binocular quantification of the VOR. Purpose (Aim) To investigate the advantag…
View article: Assessment of Functional Capacity of Immune System in Patients with Multiple Sclerosis using QuantiFERON Monitor
Assessment of Functional Capacity of Immune System in Patients with Multiple Sclerosis using QuantiFERON Monitor Open
Background. The QuantiFERON®-Monitor (QFM) is an assay that measures interferon-γ production and was developed to provide an objective marker of complex immune response. In this study, we evaluated the use of the QFM test in patients with …
View article: Anti-viral drug discovery against monkeypox and smallpox infection by natural curcumin derivatives: A Computational drug design approach
Anti-viral drug discovery against monkeypox and smallpox infection by natural curcumin derivatives: A Computational drug design approach Open
Background In the last couple of years, viral infections have been leading the globe, considered one of the most widespread and extremely damaging health problems and one of the leading causes of mortality in the modern period. Although se…
View article: Cognitive changes associated with cerebral emboli during coronary intervention
Cognitive changes associated with cerebral emboli during coronary intervention Open
Cardiac catheterization was associated with a high risk of cerebral embolism in our patients. A higher number of solid MES and combinations of solid and gaseous MES was associated with the deterioration in cognitive tests (Tab. 5, Fig. 3, …
View article: Wireless Monitoring of Gastrointestinal Transit Time, Intra-luminal pH, Pressure and Temperature in Experimental Pigs: A Pilot Study
Wireless Monitoring of Gastrointestinal Transit Time, Intra-luminal pH, Pressure and Temperature in Experimental Pigs: A Pilot Study Open
Background: There is no single gold standard for investigation of gastrointestinal motility function. Wireless motility monitoring involves a novel concept which provides a complex information on gastrointestinal function (gastrointestinal…
View article: Interferon Beta-1a versus Glatiramer Acetate: Changes of Innate Immunity in a Group of Women with Multiple Sclerosis
Interferon Beta-1a versus Glatiramer Acetate: Changes of Innate Immunity in a Group of Women with Multiple Sclerosis Open
Introduction: Multiple sclerosis (MS) is a chronic inflammatory autoimmune demyelinating disease that secondarily leads to axonal loss and associated brain atrophy. Disease-modifying drugs (DMDs) have previously been studied …
View article: Anastrozole-mediated modulation of mitochondrial activity by inhibition of mitochondrial permeability transition pore opening: an initial perspective
Anastrozole-mediated modulation of mitochondrial activity by inhibition of mitochondrial permeability transition pore opening: an initial perspective Open
The mitochondrial permeability transition pore (mtPTP) plays a vital role in altering the structure and function of mitochondria. Cyclophilin D (CypD) is a mitochondrial protein that regulates mtPTP function and a known drug target for the…
View article: Supplementary Material for: Interferon beta-1a vs. glatiramer acetate: changes of innate immunity in a group of women with multiple sclerosis
Supplementary Material for: Interferon beta-1a vs. glatiramer acetate: changes of innate immunity in a group of women with multiple sclerosis Open
Introduction: Multiple sclerosis is a chronic inflammatory autoimmune demyelinating disease that secondarily leads to the axonal loss and associated brain atrophy. Disease-modifying drugs (DMDs) have previously been studied for their abili…
View article: Discovery of small molecule mechanistic target of rapamycin inhibitors as anti-aging and anti-cancer therapeutics
Discovery of small molecule mechanistic target of rapamycin inhibitors as anti-aging and anti-cancer therapeutics Open
To date, the most studied drug in anti-aging research is the mTOR inhibitor – rapamycin. Despite its almost perfect anti-aging profile, rapamycin exerts one significant limitation – inappropriate physicochemical properties. Therefore, we h…
View article: Privileged multi-target directed propargyl-tacrines combining cholinesterase and monoamine oxidase inhibition activities
Privileged multi-target directed propargyl-tacrines combining cholinesterase and monoamine oxidase inhibition activities Open
Twenty-four novel compounds bearing tetrahydroacridine and N-propargyl moieties have been designed, synthesised, and evaluated in vitro for their anti-cholinesterase and anti-monoamine oxidase activities. Propargyltacrine …
View article: Head-shaking-induced nystagmus reflects dynamic vestibular compensation: A 2-year follow-up study
Head-shaking-induced nystagmus reflects dynamic vestibular compensation: A 2-year follow-up study Open
Purpose We aimed to assess the ability of a head-shaking test (HST) to reflect vestibular compensation in patients after unilateral peripheral vestibular loss and to provide missing evidence and new insights into the features of head-shaki…
View article: Exploring the role of nanomedicines for the therapeutic approach of central nervous system dysfunction: At a glance
Exploring the role of nanomedicines for the therapeutic approach of central nervous system dysfunction: At a glance Open
In recent decades, research scientists, molecular biologists, and pharmacologists have placed a strong emphasis on cutting-edge nanostructured materials technologies to increase medicine delivery to the central nervous system (CNS). The ap…
View article: Long‑term effect of siponimod on MRI outcomes in patients with secondary‑progressive multiple sclerosis
Long‑term effect of siponimod on MRI outcomes in patients with secondary‑progressive multiple sclerosis Open
UK a FN Hradec
View article: Analysis of the Group of Pediatric Patients With Relapsing-Remitting Multiple Sclerosis: Data From the Czech National Registry
Analysis of the Group of Pediatric Patients With Relapsing-Remitting Multiple Sclerosis: Data From the Czech National Registry Open
Importance Multiple sclerosis can also affect children. Approximately 3–10% of patients develop multiple sclerosis before the age of 16. Objective The aim of this analysis is to describe the characteristics of pediatric patients with multi…
View article: Marine Invertebrate Peptides: Antimicrobial Peptides
Marine Invertebrate Peptides: Antimicrobial Peptides Open
Antimicrobial peptides are an important component of many organisms’ innate immune system, with a good inhibitory or killing effect against the invading pathogens. As a type of biological polypeptide with natural immune activities, antimic…
View article: Treatment satisfaction, safety, and tolerability of cladribine tablets in patients with highly active relapsing multiple sclerosis: CLARIFY-MS study 6-month interim analysis
Treatment satisfaction, safety, and tolerability of cladribine tablets in patients with highly active relapsing multiple sclerosis: CLARIFY-MS study 6-month interim analysis Open
View article: <scp>THN</scp> 102 for Excessive Daytime Sleepiness Associated with Parkinson's Disease: A Phase 2a Trial
<span>THN</span> 102 for Excessive Daytime Sleepiness Associated with Parkinson's Disease: A Phase 2a Trial Open
Background Excessive daytime sleepiness (EDS) is a frequent and disabling symptom of Parkinson's disease (PD) without approved treatment. THN102 is a novel combination drug of modafinil and low‐dose flecainide. Objective The aim of this st…
View article: Rapid and sustained B-cell depletion with subcutaneous ofatumumab in relapsing multiple sclerosis: APLIOS, a randomized phase-2 study
Rapid and sustained B-cell depletion with subcutaneous ofatumumab in relapsing multiple sclerosis: APLIOS, a randomized phase-2 study Open
Background: Ofatumumab, the first fully human anti-CD20 monoclonal antibody, is approved in several countries for relapsing multiple sclerosis (RMS). Objective: To demonstrate the bioequivalence of ofatumumab administered by an autoinjecto…
View article: Long-term management of oral cladribine treatment in multiple sclerosis
Long-term management of oral cladribine treatment in multiple sclerosis Open
Neurologická klinika LF UK a FN, Hradec Králové Autoři jsou uvedeni v abecedním pořadí Perorální kladribin patří mezi vysoce účinné léky modifikující průběh onemocnění používané v léčbě roztroušené sklerózy.Jeho mechanismus spočívá v navoz…
View article: Acute Recanalization of Large Vessel Occlusion in the Anterior Circulation Stroke: Is Mechanical Thrombectomy Alone Better in Patients over 80 Years of Age? Findings from a Retrospective Observational Study
Acute Recanalization of Large Vessel Occlusion in the Anterior Circulation Stroke: Is Mechanical Thrombectomy Alone Better in Patients over 80 Years of Age? Findings from a Retrospective Observational Study Open
Real-world data report worse 3-month clinical outcomes in elderly patients with acute ischemic stroke (AIS) treated with mechanical thrombectomy (MT). The aim was to identify factors influencing clinical outcome in elderly patients with an…
View article: Novelty detection-based approach for Alzheimer’s disease and mild cognitive impairment diagnosis from EEG
Novelty detection-based approach for Alzheimer’s disease and mild cognitive impairment diagnosis from EEG Open