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View article: Rationale for Incorporating Short-Term Endpoints in Interim Futility Analysis of Phase 3 Oncology Trials: A Simulation Study
Rationale for Incorporating Short-Term Endpoints in Interim Futility Analysis of Phase 3 Oncology Trials: A Simulation Study Open
Background: Futility analysis is a critical component of phase III oncology trials, enabling early termination of ineffective treatments to save resources and time. However, these interim analyses are often challenged by insufficient data …
View article: MeP Induces Metabolic Disorder and Liver Damage at Human-Relevant Exposure Levels: Role of the Gut Microbiota
MeP Induces Metabolic Disorder and Liver Damage at Human-Relevant Exposure Levels: Role of the Gut Microbiota Open
Methylparaben (MeP) is a widely used preservative found in many consumer products that leads to extensive human exposure. Despite some health concerns, our understanding of MeP's effects on metabolic homeostasis remains limited. This study…
View article: A retrospective analysis of unprotected ultraviolet tolerance and influencing factors in 1036 participants evaluating the efficacy of cosmetic sunscreen products
A retrospective analysis of unprotected ultraviolet tolerance and influencing factors in 1036 participants evaluating the efficacy of cosmetic sunscreen products Open
Objective: To more rapidly and accurately obtain minimal erythema dose (MED) and minimal persistent pigment dose (MPPD) values in sun protection testing, we conducted a retrospective exploration of previous test data. Methods: This retrosp…
View article: High plant diversity alleviates the negative effects of nitrogen deposition on soil nitrogen cycling multifunctionality
High plant diversity alleviates the negative effects of nitrogen deposition on soil nitrogen cycling multifunctionality Open
Introduction Changes in plant diversity and increased atmospheric nitrogen deposition independently influence soil nitrogen cycling in terrestrial ecosystems. However, the interactive effects of plant diversity and nitrogen deposition on s…
View article: A Bibliometric Analysis and Systematic Review of Research Advances in In Situ Gel Drug Delivery Systems from 2003 to 2023
A Bibliometric Analysis and Systematic Review of Research Advances in In Situ Gel Drug Delivery Systems from 2003 to 2023 Open
Objective: We aimed analyze research trends in in situ gel drug delivery systems. Methods: Studies from 2003 to 2023 were systematically obtained from the Web of Science database and analyzed using VOSviewer software to evaluate publicatio…
View article: Thermal-hydraulic-mechanical-chemical multiphysics coupling for geothermal energy development
Thermal-hydraulic-mechanical-chemical multiphysics coupling for geothermal energy development Open
View article: The Logic of Pan-securitization: A Investigation of the EU’s Resilience Construction Policy
The Logic of Pan-securitization: A Investigation of the EU’s Resilience Construction Policy Open
View article: Improving the Catalytic Activity and Thermostability of Mariniflexile Fucanivorans Fucoidanase by Rational Design
Improving the Catalytic Activity and Thermostability of Mariniflexile Fucanivorans Fucoidanase by Rational Design Open
View article: Characteristics and Mechanisms of Spring Tidal Mixing and Sediment Transport in a Microtidal Funnel-Shaped Estuary
Characteristics and Mechanisms of Spring Tidal Mixing and Sediment Transport in a Microtidal Funnel-Shaped Estuary Open
Information about estuarine mixing and its control of sediment transport is crucial to elucidating the dynamics and evolution of estuaries. Here, the microtidal and funnel-shaped Zhenhai Estuary, located in the southwestern Pearl River Del…
View article: Impact of Anthropogenic Activities on Sedimentary Records in the Lingdingyang Estuary of the Pearl River Delta, China
Impact of Anthropogenic Activities on Sedimentary Records in the Lingdingyang Estuary of the Pearl River Delta, China Open
High-intensity anthropogenic activities have greatly altered the estuarine-shelf depositional processes of sediments, and the intensity and frequency of the impacts of human interventions have far exceeded the natural development of estuar…
View article: From Plastic Waste to Treasure: Selective Upcycling through Catalytic Technologies (Adv. Energy Mater. 41/2023)
From Plastic Waste to Treasure: Selective Upcycling through Catalytic Technologies (Adv. Energy Mater. 41/2023) Open
Plastics Upcycling Innovative catalytic technologies for plastics upcycling into high-value chemicals and fuels are recognized as a pivotal approach in realizing a sustainable carbon cycle. In article number 2302008, Pengfei Wang, Sihui Zh…
View article: Effects of a lotion containing probiotic ferment lysate as the main functional ingredient on enhancing skin barrier: a randomized, self-control study
Effects of a lotion containing probiotic ferment lysate as the main functional ingredient on enhancing skin barrier: a randomized, self-control study Open
There is an emergent need to develop functional cosmetic ingredients for the topical management of skin barrier function. This study aimed to investigate the efficacy of a lotion containing fermented lysates VHProbi® Mix R for enhancing th…
View article: Issue Information
Issue Information Open
Aim and scopeThe aim of the journal since its inception has been the accurate and fast presentation of new data in reproductive immunology.As reproductive immunology evolved from an initially laboratory oriented science toward increasing c…
View article: A New GFSv15 based Climate Model Large Ensemble and Its Application to Understanding Climate Variability, and Predictability
A New GFSv15 based Climate Model Large Ensemble and Its Application to Understanding Climate Variability, and Predictability Open
Data and analysis scripts for figures of Journal article (A New GFSv15 based Climate Model Large Ensemble and Its Application to Understanding Climate Variability, and Predictability)
View article: A New GFSv15 based Climate Model Large Ensemble and Its Application to Understanding Climate Variability, and Predictability
A New GFSv15 based Climate Model Large Ensemble and Its Application to Understanding Climate Variability, and Predictability Open
Data and analysis scripts for figures of Journal article (A New GFSv15 based Climate Model Large Ensemble and Its Application to Understanding Climate Variability, and Predictability)
View article: A New GFSv15 based Climate Model Large Ensemble and Its Application to Understanding Climate Variability, and Predictability
A New GFSv15 based Climate Model Large Ensemble and Its Application to Understanding Climate Variability, and Predictability Open
Data and analysis scripts for figures of Journal article (A New GFSv15 based Climate Model Large Ensemble and Its Application to Understanding Climate Variability, and Predictability)
View article: Changing on the Concentrations of Neonicotinoids in Rice and Drinking Water through Heat Treatment Process
Changing on the Concentrations of Neonicotinoids in Rice and Drinking Water through Heat Treatment Process Open
Neonicotinoids (NEOs) have become the most widely used insecticides in the world since the mid-1990s. According to Chinese dietary habits, rice and water are usually heated before being consumed, but the information about the alteration th…
View article: Issue Information
Issue Information Open
Aim and scopeThe aim of the journal since its inception has been the accurate and fast presentation of new data in reproductive immunology.As reproductive immunology evolved from an initially laboratory oriented science toward increasing c…
View article: Quantitative Identification of the Co-Exposure Effects of E-Waste Pollutants on Human Oxidative Stress by Explainable Machine Learning
Quantitative Identification of the Co-Exposure Effects of E-Waste Pollutants on Human Oxidative Stress by Explainable Machine Learning Open
View article: Changing on the Concentrations of Neonicotinoids in Rice and Drinking Water Through Heating Treatment Process: An Unusual Increase in Imidacloprid
Changing on the Concentrations of Neonicotinoids in Rice and Drinking Water Through Heating Treatment Process: An Unusual Increase in Imidacloprid Open
View article: Contamination of Neonicotinoid Insecticides in Source Water and Their Fate During Drinking Water Treatment in the Dongguan Section of the Pearl River
Contamination of Neonicotinoid Insecticides in Source Water and Their Fate During Drinking Water Treatment in the Dongguan Section of the Pearl River Open
View article: Modeling Storage Particle Delamination and Electrolyte Cracking in Cathodes of Solid State Batteries
Modeling Storage Particle Delamination and Electrolyte Cracking in Cathodes of Solid State Batteries Open
View article: Masticatory system–inspired microneedle theranostic platform for intelligent and precise diabetic management
Masticatory system–inspired microneedle theranostic platform for intelligent and precise diabetic management Open
Integrated systems for diabetic theranostics present advanced technology to regulate diabetes yet still have critical challenges in terms of accuracy, long-term monitoring, and minimal invasiveness. Inspired by the feature and functions of…
View article: Placental transfer of bisphenol diglycidyl ethers (BDGEs) and its association with maternal health in a population in South of China
Placental transfer of bisphenol diglycidyl ethers (BDGEs) and its association with maternal health in a population in South of China Open
View article: Mathematical and Machine Learning Models for Groundwater Level Changes: A Systematic Review and Bibliographic Analysis
Mathematical and Machine Learning Models for Groundwater Level Changes: A Systematic Review and Bibliographic Analysis Open
With the effects of climate change such as increasing heat, higher rainfall, and more recurrent extreme weather events including storms and floods, a unique approach to studying the effects of climatic elements on groundwater level variati…
View article: The association of serum phthalate metabolites with biomarkers of ovarian reserve in women of childbearing age
The association of serum phthalate metabolites with biomarkers of ovarian reserve in women of childbearing age Open
View article: Effects of salinity on reproductive characteristics and embryo quality of <i>Eriocheir sinensis</i>
Effects of salinity on reproductive characteristics and embryo quality of <i>Eriocheir sinensis</i> Open
In order to find out the effects of salinity on the reproductive characteristics and embryo quality of female E. sinensis broodstock, the mating and spawning experiments of broodstock under different salinities (3, 6, 9, 12, 15, 18, and 21…
View article: Tea saponin extracted from seed pomace of Camellia oleifera Abel ameliorates DNCB-induced atopic dermatitis-like symptoms in BALB/c mice
Tea saponin extracted from seed pomace of Camellia oleifera Abel ameliorates DNCB-induced atopic dermatitis-like symptoms in BALB/c mice Open
Tea saponin (TS) has antibacterial and anti-inflammatory properties. However, the antipruritic and anti-inflammatory effects on atopic dermatitis (AD) are unknown. This study, therefore, evaluated the therapeutic effects of TS from seed po…
View article: A review of properties, production, human exposure, biomonitoring, toxicity, and regulation of bisphenol A diglycidyl ethers and novolac glycidyl ethers
A review of properties, production, human exposure, biomonitoring, toxicity, and regulation of bisphenol A diglycidyl ethers and novolac glycidyl ethers Open
View article: Impact of air pollution exposure on the risk of Alzheimer's disease in China: A community-based cohort study
Impact of air pollution exposure on the risk of Alzheimer's disease in China: A community-based cohort study Open