Neil M Davies
YOU?
Author Swipe
View article: Risk of major adverse cardiovascular events with aripiprazole versus olanzapine, quetiapine, and risperidone in severe mental illness: a target trial emulation
Risk of major adverse cardiovascular events with aripiprazole versus olanzapine, quetiapine, and risperidone in severe mental illness: a target trial emulation Open
Initiating aripiprazole as antipsychotic monotherapy rather than olanzapine, quetiapine, or risperidone, might prevent/delay major adverse cardiovascular events (MACEs) over the long-term in people diagnosed with severe mental illness. Usi…
View article: Acute effects of daylight saving time clock changes on mental and physical health in England: population based retrospective cohort study
Acute effects of daylight saving time clock changes on mental and physical health in England: population based retrospective cohort study Open
Objective To explore the acute effects of daylight saving time clock changes on mental and physical health events in primary and secondary care in England. Design Population based retrospective cohort study. Setting English primary care pr…
View article: Evaluating transportability of in vitro cellular models to in vivo human phenotypes using gene perturbation data
Evaluating transportability of in vitro cellular models to in vivo human phenotypes using gene perturbation data Open
Gene perturbation screens (e.g. CRISPR-Cas9) assess the impact of gene disruption on in-vitro cellular phenotypes (e.g., proliferation, anti-viral response). In-vitro experiments can be useful models for in-vivo (organismal) phenotypes (e.…
View article: Longitudinal relationships between psychological distress and subsequent cognitive decline and dementia: a multi‐cohort study
Longitudinal relationships between psychological distress and subsequent cognitive decline and dementia: a multi‐cohort study Open
Background Psychological distress has shown links with cognitive functioning in late‐life, although the nature of the association remains unclear. Using a multi‐cohort approach, we examined longitudinal associations of psychological distre…
View article: Disentangling the Causal Effects of Education and Participation Bias on Alzheimer Disease Using Mendelian Randomization
Disentangling the Causal Effects of Education and Participation Bias on Alzheimer Disease Using Mendelian Randomization Open
Univariable MR analyses indicated that education and participation reduced the risk of AD. However, MR also suggested that education increased the risk of AD/ADRD, highlighting the inconsistencies between clinical and proxy diagnoses of AD…
View article: Strengthening the reporting of observational studies in epidemiology using Mendelian randomization (STROBE-MR): a Korean translation of explanation and elaboration
Strengthening the reporting of observational studies in epidemiology using Mendelian randomization (STROBE-MR): a Korean translation of explanation and elaboration Open
멘델 무작위화(Mendelian randomization, MR) 연구는 조절 가능한 노출(modifiable exposure)이 건강결과에 미치는 인과효과(causal effect)를 더 잘 이해하게 해 주지만, 그 근거는 종종 보고가 불충분함으로 인하여연구 결과의 해석과 적용에 한계가 있을 수 있다. 보고지침은 흔히 무슨 연구를 하고 무엇을 발견했는지 독자가 쉽게 이해하도록 돕는다. STROBE-MR(관찰연구의 멘델 무작…
View article: Eight decades of follow-up link life course exposures to proteomic organ ageing and longevity
Eight decades of follow-up link life course exposures to proteomic organ ageing and longevity Open
The pace of organ ageing varies substantially between individuals, yet drivers of variability remain poorly understood. This gap is critical, given only 20-30% of longevity is genetically inherited 1,2 and age-related diseases are leading …
View article: The contribution of Apoliproprotein E genetic variation to dementia risk in British South Asians
The contribution of Apoliproprotein E genetic variation to dementia risk in British South Asians Open
INTRODUCTION Understanding the genetic basis of dementia in diverse populations is essential to ensure that efforts to predict, prevent, and treat dementia are equitable. The strongest genetic risk factor for dementia - APOE genotype - has…
View article: Anti-tumor necrosis factor treatment from diagnosis is more effective and less costly than conventional “step-up” care for patients with active Crohn’s disease: a cost-effectiveness analysis from the PROFILE trial
Anti-tumor necrosis factor treatment from diagnosis is more effective and less costly than conventional “step-up” care for patients with active Crohn’s disease: a cost-effectiveness analysis from the PROFILE trial Open
Background The PROFILE trial demonstrated that “top-down” therapy in Crohn’s disease, with combination infliximab and immunomodulator from diagnosis, had superior efficacy and safety over 1 year compared to conventional “accelerated step-u…
View article: Longitudinal associations of psychological distress with subsequent cognitive decline and dementia: a multi-cohort study
Longitudinal associations of psychological distress with subsequent cognitive decline and dementia: a multi-cohort study Open
Background Psychological distress has been linked with later cognitive impairment and dementia, although the nature of the association remains unclear. Using a multi-cohort approach, we examined longitudinal associations of psychological d…
View article: Assessing the repurposing potential of disease-modifying antirheumatic drug targets to reduce Alzheimer’s disease risk: a pQTL-based Mendelian randomization and colocalization analysis
Assessing the repurposing potential of disease-modifying antirheumatic drug targets to reduce Alzheimer’s disease risk: a pQTL-based Mendelian randomization and colocalization analysis Open
Background Current literature has implicated systemic inflammation in the pathogenesis of Alzheimer’s disease (AD). However, the viability of anti-inflammatory drug targets as repurposed treatment candidates for AD remains unclear. We util…
View article: The association between parental BMI and offspring adiposity: A genetically informed analysis of trios
The association between parental BMI and offspring adiposity: A genetically informed analysis of trios Open
Background Children with obesity are more likely to have parents with obesity than those without. Several environmental explanations have been proposed for this correlation, including foetal programming and parenting practices. However, bo…
View article: Associations between epigenetic age and brain age in young people
Associations between epigenetic age and brain age in young people Open
Recent research suggests biological age, based on epigenetic or neuroimaging measures, may predict health traits in adulthood more accurately than chronological age. However, it is unclear if these findings apply earlier in life. We aimed …
View article: Causes and consequences of vascular dementia across the life course: Evidence from a UK Biobank phenome-wide and Mendelian randomization study
Causes and consequences of vascular dementia across the life course: Evidence from a UK Biobank phenome-wide and Mendelian randomization study Open
Background Vascular dementia (VaD) is the second most common cause of dementia, yet its risk factors and biological mechanisms remain poorly understood. Objective To identify causes and consequences of VaD by developing a polygenic risk sc…
View article: Effects of alcohol consumption on employment and social outcomes: a Mendelian randomisation study
Effects of alcohol consumption on employment and social outcomes: a Mendelian randomisation study Open
Aims Alcohol consumption is associated with socioeconomic disadvantage, but causality is unclear. We used Mendelian randomisation (MR) to estimate the effect of alcohol consumption on socioeconomic and employment-related outcomes. Methods …
View article: The Effects of Daylight Saving Time Clock Changes on Mental and Physical Health in England: Evidence from the Clinical Practice Research Datalink (CPRD)
The Effects of Daylight Saving Time Clock Changes on Mental and Physical Health in England: Evidence from the Clinical Practice Research Datalink (CPRD) Open
OBJECTIVES To explore the effects of daylight saving time clock changes on mental and physical health events in primary and secondary care in England. DESIGN Population-based study using linked electronic health records. SETTING English pr…
View article: Repurposing drugs for the prevention of vascular dementia: Evidence from drug target Mendelian randomization
Repurposing drugs for the prevention of vascular dementia: Evidence from drug target Mendelian randomization Open
Importance Vascular dementia (VaD) is a devastating cerebrovascular disease with no disease-modifying treatments available. Repurposing existing drugs for VaD risk factors could have an important clinical impact. Objective To determine whe…
View article: The association between body dissatisfaction, depression, eating disorders and BMI: a prospective twin cohort study
The association between body dissatisfaction, depression, eating disorders and BMI: a prospective twin cohort study Open
Introduction Body dissatisfaction is becoming more common among adolescents and is a putative risk factor for adverse mental (e.g., eating disorder and depressive symptoms) and physical health outcomes (e.g., excessive weight gain), both o…
View article: Co-prescription of metformin and antipsychotics in severe mental illness: a UK primary care cohort study
Co-prescription of metformin and antipsychotics in severe mental illness: a UK primary care cohort study Open
Background Metformin is a pharmacological candidate to mitigate second-generation antipsychotic (SGA)-induced weight gain in patients diagnosed with severe mental illnesses (SMI). Objective To determine the incidence, prevalence and demogr…
View article: Life course trajectories of maternal cardiovascular disease risk factors by obstetric history: a UK cohort study using electronic health records
Life course trajectories of maternal cardiovascular disease risk factors by obstetric history: a UK cohort study using electronic health records Open
Background Women who experience adverse pregnancy outcomes (APOs; gestational hypertension, preeclampsia (PE), gestational diabetes (GD), preterm birth (PTB), small or large for gestational age, miscarriage, multiple miscarriages, stillbir…
View article: The Effects of Hospital Delivery Volume and Travel Time on Perinatal Mortality and Delivery in Transit: Causal Inference with Triangulation
The Effects of Hospital Delivery Volume and Travel Time on Perinatal Mortality and Delivery in Transit: Causal Inference with Triangulation Open
Background: Hospital regionalization involves balancing hospital volume and travel time. We investigated how hospital volume and travel time affect perinatal mortality and the risk of delivery in transit using three different study designs…
View article: Comparative cardiometabolic safety and effectiveness of aripiprazole in people with severe mental illness: A target trial emulation
Comparative cardiometabolic safety and effectiveness of aripiprazole in people with severe mental illness: A target trial emulation Open
Background There is limited and conflicting evidence on the comparative cardiometabolic safety and effectiveness of aripiprazole in the management of severe mental illness. We investigated the hypothesis that aripiprazole has a favourable …
View article: The Genetic Architecture of Differentiating Behavioral and Emotional Problems in Early Life
The Genetic Architecture of Differentiating Behavioral and Emotional Problems in Early Life Open
We uncovered genomic signal in the differentiation process, mostly related to common variants associated with neurodevelopmental conditions. Investigating the differentiation of early-life behavioral and emotional problems may enhance our …