Martin Wolley
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View article: Plasma Potassium Negatively Correlates With Sodium Chloride Cotransporter Abundance and Phosphorylation in Urinary Extracellular Vesicles From Patients With Chronic Kidney Disease
Plasma Potassium Negatively Correlates With Sodium Chloride Cotransporter Abundance and Phosphorylation in Urinary Extracellular Vesicles From Patients With Chronic Kidney Disease Open
Aim Using urinary extracellular vesicles (uEVs), we have demonstrated the functional ‘renal‐K switch’ mechanism (the WNK‐SPAK‐NCC pathway) in both healthy subjects and those with primary aldosteronism. The close relationship between blood …
View article: Protocol for a hybrid effectiveness-implementation clinical trial evaluating video-assisted electronic consent vs standard consent for patients initiating and continuing haemodialysis in Australia (eConsent HD)
Protocol for a hybrid effectiveness-implementation clinical trial evaluating video-assisted electronic consent vs standard consent for patients initiating and continuing haemodialysis in Australia (eConsent HD) Open
Introduction Communicating complex information about haemodialysis (HD) and ensuring it is well understood remains a challenge for clinicians. Informed consent is a high-impact checkpoint in augmenting patients’ decision awareness and enga…
View article: Structural Equation Modelling to Identify Psychometric Determinants of Medication Adherence in a Survey of Kidney Dialysis Patients
Structural Equation Modelling to Identify Psychometric Determinants of Medication Adherence in a Survey of Kidney Dialysis Patients Open
Interventions that reduce patients' concerns about their medications are likely to improve adherence, rather than interventions that increase patients' perceived necessity for medication. Improving patients' general health literacy and fac…
View article: Incremental versus standard dialysis for people with kidney failure
Incremental versus standard dialysis for people with kidney failure Open
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To compare the benefits and harms of incremental versus full‐dose dialysis in patients with kidney failure at commencement of KRT.
View article: Randomized Trial on the Effect of Oral Potassium Chloride Supplementation on the Thiazide-Sensitive Sodium Chloride Cotransporter in Healthy Adults
Randomized Trial on the Effect of Oral Potassium Chloride Supplementation on the Thiazide-Sensitive Sodium Chloride Cotransporter in Healthy Adults Open
The lower NCC and pNCC in uEVs in response to oral KCl supplementation provide evidence to support the hypothesis of a functional "renal-K switch" in healthy human subjects.
View article: Creatinine index: a retrospective cohort study in an urban Australian dialysis context
Creatinine index: a retrospective cohort study in an urban Australian dialysis context Open
Aim This study aimed to described the relationship between the CI and mortality in an Australian context. Introduction Maintenance haemodialysis is a catabolic state associated with a significant decrease in lean body mass (LBM) and protei…
View article: PS-BPC10-7: EFFECT OF ORAL POTASSIUM CHLORIDE SUPPLEMENTATION ON THE THIAZIDE-SENSITIVE SODIUM CHLORIDE COTRANSPORTER (NCC) IN HEALTHY HUMANS: A RANDOMISED CROSSOVER TRIAL
PS-BPC10-7: EFFECT OF ORAL POTASSIUM CHLORIDE SUPPLEMENTATION ON THE THIAZIDE-SENSITIVE SODIUM CHLORIDE COTRANSPORTER (NCC) IN HEALTHY HUMANS: A RANDOMISED CROSSOVER TRIAL Open
Objective: The putative “renal-K + switch’’ mechanism links low K + intake with Na + -dependent Na + retention and involves activation of NCC in the distal convoluted tubule in response to low K + intake and suppression in response to high…
View article: Using human urinary extracellular vesicles to study physiological and pathophysiological states and regulation of the sodium chloride cotransporter
Using human urinary extracellular vesicles to study physiological and pathophysiological states and regulation of the sodium chloride cotransporter Open
The thiazide-sensitive sodium chloride cotransporter (NCC), expressed in the renal distal convoluted tubule, plays a major role in Na + , Cl - and K + homeostasis and blood pressure as exemplified by the symptoms of patients with non-funct…
View article: In Primary Aldosteronism Acute Potassium Chloride Supplementation Suppresses Abundance and Phosphorylation of the Sodium-Chloride Cotransporter
In Primary Aldosteronism Acute Potassium Chloride Supplementation Suppresses Abundance and Phosphorylation of the Sodium-Chloride Cotransporter Open
Key Points Potassium chloride intake induced a reduction in sodium-chloride cotransporter (NCC) and phosphorylated NCC in urinary extracellular vesicles from patients with primary aldosteronism during a significantly raised level of endoge…
View article: REDUCED NACL COTRANSPORTER ABUNDANCE AND PHOSPHORYLATION IN URINARY EXTRACELLULAR VESICLES IN RESPONSE TO KCL SUPPLEMENTS IN HEALTHY ADULTS MAINTAINED ON A HIGH-NA+ LOW-K+ DIET: A
REDUCED NACL COTRANSPORTER ABUNDANCE AND PHOSPHORYLATION IN URINARY EXTRACELLULAR VESICLES IN RESPONSE TO KCL SUPPLEMENTS IN HEALTHY ADULTS MAINTAINED ON A HIGH-NA+ LOW-K+ DIET: A Open
Objective: A renal-K switch mechanism has been established in rodent models and demonstrates that a low K+ intake acts as a trigger that links K+ and Na+-dependent blood pressure. This mechanism involves activation (phosphorylation) of the…
View article: Human T-cell leukaemia virus type 1 and Adult T-cell leukaemia/lymphoma in Queensland, Australia: a retrospective cross-sectional study
Human T-cell leukaemia virus type 1 and Adult T-cell leukaemia/lymphoma in Queensland, Australia: a retrospective cross-sectional study Open
Objectives Human T-cell leukaemia virus type 1 (HTLV-1), an STI, is reported to be highly prevalent in Indigenous communities in Central Australia. HTLV-1 is an incurable, chronic infection which can cause Adult T-cell leukaemia/lymphoma (…
View article: Acute Intravenous NaCl and Volume Expansion Reduces Sodium-Chloride Cotransporter Abundance and Phosphorylation in Urinary Extracellular Vesicles
Acute Intravenous NaCl and Volume Expansion Reduces Sodium-Chloride Cotransporter Abundance and Phosphorylation in Urinary Extracellular Vesicles Open
Key Points Volume expansion induced a clear reduction in aquaporin 2 abundance in urinary extracellular vesicles. Changes in sodium-chloride cotransporter (NCC) and phosphorylated NCC may have been primarily due to diluted post-test urine …
View article: Biochemical, Histopathological, and Genetic Characterization of Posture-Responsive and Unresponsive APAs
Biochemical, Histopathological, and Genetic Characterization of Posture-Responsive and Unresponsive APAs Open
Context and Objective Posture-responsive and posture-unresponsive aldosterone-producing adenomas (APAs) account for approximately 40% and 60% of APAs, respectively. Somatic gene mutations have been recently reported to exist in approximate…
View article: Screening for primary aldosteronism: How to adjust existing antihypertensive medications to avoid diagnostic errors
Screening for primary aldosteronism: How to adjust existing antihypertensive medications to avoid diagnostic errors Open
The ideal time to screen for primary aldosteronism is prior to initiating antihypertensive medications. If the patient is already undergoing treatment, replacing commonly used medications with sustained-release verapamil, prazosin, moxonid…
View article: Diagnosis of Primary Aldosteronism by Seated Saline Suppression Test—Variability Between Immunoassay and HPLC-MS/MS
Diagnosis of Primary Aldosteronism by Seated Saline Suppression Test—Variability Between Immunoassay and HPLC-MS/MS Open
Background In primary aldosteronism (PA), excessive, autonomous secretion of aldosterone is not suppressed by salt loading or fludrocortisone. For seated saline suppression testing (SSST), the recommended diagnostic cutoff 4-hour plasma al…
View article: MON-074 INNOCENT UNTIL PROVEN GUILTY: A CLOUDY BAG DOES NOT ALWAYS EQUAL PERITONITIS
MON-074 INNOCENT UNTIL PROVEN GUILTY: A CLOUDY BAG DOES NOT ALWAYS EQUAL PERITONITIS Open
Peritonitis is a serious complication of peritoneal dialysis (PD) requiring prompt treatment with intraperitoneal (IP) antibiotics. PD peritonitis is diagnosed when at least two of the following are present: 1) clinical features consistent…
View article: SUN-090 TEMPORAL CHANGES IN CAUSE-SPECIFIC MORTALITY IN THE AUSTRALIAN AND NEW ZEALAND HAEMODIALYSIS POPULATION
SUN-090 TEMPORAL CHANGES IN CAUSE-SPECIFIC MORTALITY IN THE AUSTRALIAN AND NEW ZEALAND HAEMODIALYSIS POPULATION Open
Haemodialysis patients have a high mortality rate relative to the general population, and cause-specific mortality rates are also different. As the age and comorbid burden of incident dialysis patients has increased, the causes of death on…
View article: MON-060 A SNAPSHOT OF DIALYSIS UPTAKE: THE FEASIBILITY OF INCREMENTAL HAEMODIALYSIS INITIATION
MON-060 A SNAPSHOT OF DIALYSIS UPTAKE: THE FEASIBILITY OF INCREMENTAL HAEMODIALYSIS INITIATION Open
Most haemodialysis (HD) patients are conventionally prescribed a thrice weekly schedule at initiation. An incremental approach to dialysis initiation (i.e. starting at 1-2/week and increasing as needed) may offer potential benefits includi…
View article: Bile Cast Nephropathy in a Patient With Obstructive Jaundice
Bile Cast Nephropathy in a Patient With Obstructive Jaundice Open
Acute kidney injury (AKI) is common in patients with severe hepatic failure and is associated with significant morbidity and mortality. Ischemia and inflammation are the hallmarks of the pathophysiology of kidney injury in cirrhosis.1 Addi…
View article: Comparison of Seated With Recumbent Saline Suppression Testing for the Diagnosis of Primary Aldosteronism
Comparison of Seated With Recumbent Saline Suppression Testing for the Diagnosis of Primary Aldosteronism Open
SSST is highly sensitive and superior to RSST in identifying both unilateral and bilateral forms of PA and has a low rate of false positives and inconclusive results. It therefore offers a reliable and much less complicated and expensive a…
View article: Aldosterone LC-MS/MS Assay-Specific Threshold Values in Screening and Confirmatory Testing for Primary Aldosteronism
Aldosterone LC-MS/MS Assay-Specific Threshold Values in Screening and Confirmatory Testing for Primary Aldosteronism Open
Context Current threshold values for primary aldosteronism (PA) diagnostic testing are based on measuring aldosterone (PAC) using immunoassays. Quantification of PAC by liquid chromatography-tandem mass spectrometry (LC-MS/MS) yields lower…
View article: Vitamin D Deficiency in Chronic Kidney Disease: Recent Evidence and Controversies
Vitamin D Deficiency in Chronic Kidney Disease: Recent Evidence and Controversies Open
Vitamin D (VD) is a pro-hormone essential for life in higher animals. It is present in few types of foods and is produced endogenously in the skin by a photochemical reaction. The final step of VD activation occurs in the kidneys involving…
View article: Vitamin D Deficiency in Chronic Kidney Disease: Recent Evidence and Controversies
Vitamin D Deficiency in Chronic Kidney Disease: Recent Evidence and Controversies Open
Vitamin D (VD) is a pro-hormone essential for life in higher animals. It is present in few types of foods and is produced endogenously in the skin by a photochemical reaction. The final step of VD activation occurs in the kidneys involving…
View article: Large uremic toxins: an unsolved problem in end-stage kidney disease
Large uremic toxins: an unsolved problem in end-stage kidney disease Open
Patients with end-stage kidney disease (ESKD) on maintenance hemodialysis are subject to a high burden of inflammation and cardiovascular disease, driven at least in part by retention of uremic solutes. Existing dialysis technologies using…
View article: Exploring the Clinical Relevance of Providing Increased Removal of Large Middle Molecules
Exploring the Clinical Relevance of Providing Increased Removal of Large Middle Molecules Open
Dialysis technologies have continued to advance over recent decades; however, these advancements have not always been met with improved patient outcomes. In part, the high morbidity and mortality associated with dialysis have been attribut…
View article: Effect of Combined Hormonal Replacement Therapy on the Aldosterone/Renin Ratio in Postmenopausal Women
Effect of Combined Hormonal Replacement Therapy on the Aldosterone/Renin Ratio in Postmenopausal Women Open
Background: Plasma aldosterone/renin ratio (ARR) is the most popular screening test for primary aldosteronism (PA). Because both estrogen and progesterone (including in oral contraceptive agents) affect aldosterone and renin levels, we stu…