Martina Bonelli
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View article: Proteomic Characterization of Changes in Mouse Brain Cortex Protein Expression at Different Post-Mortem Intervals: A Preliminary Study for Forensic Biomarker Identification
Proteomic Characterization of Changes in Mouse Brain Cortex Protein Expression at Different Post-Mortem Intervals: A Preliminary Study for Forensic Biomarker Identification Open
Accuracy in the evaluation of death-induced tissue degradation for thanato-chronological purposes is strictly dependent on the condition of the biological source as well as on the precision of post-mortem interval (PMI) estimation. Thus, t…
View article: Use of cadaveric stem cells: analysis of literature
Use of cadaveric stem cells: analysis of literature Open
Determination of Post Mortem Interval (PMI) has always been based on empirical analysis of microdata not always endowed with sufficient reliability. Due to its significancy in medico-legal issues, PMI estimation needs to be assessed by app…
View article: Liquid chromatographic method for extracellular Guanosine 5′-triphosphate and tetrahydrobiopterin pathway products analysis from cadaveric samples and human biofluids
Liquid chromatographic method for extracellular Guanosine 5′-triphosphate and tetrahydrobiopterin pathway products analysis from cadaveric samples and human biofluids Open
To gain a deep insight and to obtain a superior understanding about guanosine-based pathway, this paper reports an innovative approach to study this critical subject. Firstly, after an exhaustive analysis of literature with a focus in lega…
View article: When the Helmet Is Not Enough: Forensic Multidisciplinary Reconstruction of a Deadly Motorcycle Accident
When the Helmet Is Not Enough: Forensic Multidisciplinary Reconstruction of a Deadly Motorcycle Accident Open
We report the case of a 54-year-old man who died in a motorcycle accident due to loss of control of the vehicle on a viaduct. No other vehicles were apparently involved, except for a car hit by the motorcycle after it fell. A post-mortem C…
View article: Analytical Chemistry: Tasks, Resolutions and Future Standpoints of the Quantitative Analyses of Environmental Complex Sample Matrices
Analytical Chemistry: Tasks, Resolutions and Future Standpoints of the Quantitative Analyses of Environmental Complex Sample Matrices Open
Currently, the challenges that analytical chemistry has to face are ever greater and more complex both from the point of view of the selectivity of analytical methods and their sensitivity. This is especially true in quantitative analysis,…
View article: Fabric Phase Sorptive Extraction (FPSE) as an efficient sample preparation platform for the extraction of antidepressant drugs from biological fluids
Fabric Phase Sorptive Extraction (FPSE) as an efficient sample preparation platform for the extraction of antidepressant drugs from biological fluids Open
The quantification and interpretation of drug concentrations in biological matrices to optimize pharmacotherapy and to perform the therapeutic drug monitoring (TDM) is particularly important for compounds with narrow therapeutic ranges, kn…
View article: New Perspectives for Postmortem Human Satellite Cells of Different Embryological Origin
New Perspectives for Postmortem Human Satellite Cells of Different Embryological Origin Open
Human postmortem skeletal muscles are a unique source of satellite cells for skeletal muscle regenerative studies. Presomite and somite satellite cells obtained by postmortem muscles have been established as populations of human skeletal m…
View article: Novel Applications of Microextraction Techniques Focused on Biological and Forensic Analyses
Novel Applications of Microextraction Techniques Focused on Biological and Forensic Analyses Open
In recent years, major attention has been focused on microextraction procedures that allow high recovery of target analytes, regardless of the complexity of the sample matrices. The most used techniques included liquid-liquid extraction (L…
View article: Fast Quantitative LC-MS/MS Determination of Illicit Substances in Solid and Liquid Unknown Seized Samples
Fast Quantitative LC-MS/MS Determination of Illicit Substances in Solid and Liquid Unknown Seized Samples Open
Narcotic and psychotropic substances are natural, synthetic, or semisynthetic compounds that are present in both solid and liquid illicit products. The alterations effects on the central nervous system related to their use can be psycholep…
View article: Forensic Biochemical Markers to Evaluate the Agonal Period: A Literature Review
Forensic Biochemical Markers to Evaluate the Agonal Period: A Literature Review Open
Currently, forensic research is multidisciplinary with new methods and parameters useful to define the cause and time of death as well as survival/agony times. The identification of biochemical markers able to estimate agonal period has be…
View article: A fatal case of post endobronchial ultrasound transbronchial needle aspiration endobronchial haemorrhage: a case report and review of the literature
A fatal case of post endobronchial ultrasound transbronchial needle aspiration endobronchial haemorrhage: a case report and review of the literature Open
Notwithstanding life-threatening haemorrhagic complications, endobronchial ultrasound-guided transbronchial needle aspiration represents a cornerstone in the evaluation of NSCLC patients. Due to its low invasiveness and satisfactory tolera…
View article: A Rare Fatal Case of Cardiac Perforation During Cardioverter-Defibrillator Implantation
A Rare Fatal Case of Cardiac Perforation During Cardioverter-Defibrillator Implantation Open
Right ventricular perforation is a rare but fatal complication during implantation and removal of cardiac devices. The causes of such an event are not well defined, although among the various factors involved, the thickness of the ventricu…