Martina Dicker
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View article: Crohn’s Disease-associated variant in laccase domain containing 1 (LACC1) modulates T cell gene expression, metabolism and T cell function
Crohn’s Disease-associated variant in laccase domain containing 1 (LACC1) modulates T cell gene expression, metabolism and T cell function Open
Genome wide association studies (GWAS) identify many risks for Crohn's disease (CD), including a site near the metabolism gene laccase domain containing 1 (LACC1). We previously found this site near LACC1 was associated with decreased LACC…
View article: Linoleoyl-lysophosphatidylcholine suppresses immune-related adverse events due to immune checkpoint blockade
Linoleoyl-lysophosphatidylcholine suppresses immune-related adverse events due to immune checkpoint blockade Open
Immune related adverse events (irAEs) after immune checkpoint blockade (ICB) therapy occur in a significant proportion of cancer patients. To date, the circulating mediators of ICB-irAEs remain poorly understood. Using non-targeted mass sp…
View article: Bio-active lipids protect against immune-related adverse events due to immune checkpoint blockade therapy
Bio-active lipids protect against immune-related adverse events due to immune checkpoint blockade therapy Open
Introduction Immune checkpoint blockade (ICB) therapy has been revolutionary in its ability to treat advanced malignancies. Yet many patients receiving ICB develop Immune related adverse events (IRAEs), a leading cause for patients to disc…
View article: CD4+-mediated colitis in mice is independent of the GPR183 and GPR18 pathways
CD4+-mediated colitis in mice is independent of the GPR183 and GPR18 pathways Open
Colitis is characterized by an exacerbated intestinal immune response, but the genetic and other mechanisms regulating immune activation remain incompletely understood. In order to identify new pathways leading to colitis, we sought to ide…
View article: Metabolic activation and colitis pathogenesis is prevented by lymphotoxin β receptor expression in neutrophils
Metabolic activation and colitis pathogenesis is prevented by lymphotoxin β receptor expression in neutrophils Open
Inflammatory bowel disease is characterized by an exacerbated intestinal immune response, but the critical mechanisms regulating immune activation remain incompletely understood. We previously reported that the TNF-superfamily molecule TNF…
View article: Reduced paucimannosidic <i>N</i>‐glycan formation by suppression of a specific β‐hexosaminidase from <i>Nicotiana benthamiana</i>
Reduced paucimannosidic <i>N</i>‐glycan formation by suppression of a specific β‐hexosaminidase from <i>Nicotiana benthamiana</i> Open
Summary Plants are attractive hosts for the production of recombinant glycoproteins for therapeutic use. Recent advances in glyco‐engineering facilitate the elimination of nonmammalian‐type glycosylation and introduction of missing pathway…
View article: Glyco-engineering for the production of recombinant IgA1 with distinct mucin-type O-glycans in plants
Glyco-engineering for the production of recombinant IgA1 with distinct mucin-type O-glycans in plants Open
IgA nephropathy (IgAN) is a common autoimmune disease that is characterized by formation and deposition of IgA1-containing immune complexes frequently leading to end-stage kidney disease. The IgA1 in these immune complexes carries aberrant…
View article: Transient Glyco-Engineering to Produce Recombinant IgA1 with Defined N- and O-Glycans in Plants
Transient Glyco-Engineering to Produce Recombinant IgA1 with Defined N- and O-Glycans in Plants Open
The production of therapeutic antibodies to combat pathogens and treat diseases, such as cancer is of great interest for the biotechnology industry. The recent development of plant-based expression systems has demonstrated that plants are …