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Multi-center screening of the Pathogen Box collection for schistosomiasis drug discovery Open

Martina Maccesi, Pedro Henrique Nascimento de Aguiar, Valérian Pasche, Melody Padilla, Brian M. Suzuki , et al. · 2019

New Antimicrobials Targeting Bacterial RNA Polymerase Holoenzyme Assembly Identified with an <i>in Vivo</i> BRET-Based Discovery Platform Open

Sara Sartini, Elisabetta Levati, Martina Maccesi, Matteo Guerra, Gilberto Spadoni , et al. · 2019

Bacterial resistance represents a major health threat worldwide, and the development of new therapeutics, including innovative antibiotics, is urgently needed. We describe a discovery platform, centered on in silico screening and

MOESM1 of Multi-center screening of the Pathogen Box collection for schistosomiasis drug discovery Open

Martina Maccesi, Pedro Aguiar, Valérian Pasche, Melody Padilla, Brian M. Suzuki , et al. · 2019

Additional file 1: Table S1. Descriptors and associated severity scores applied by UCSD. Table S2. Concordance between the 3 groups for active and inactive compounds. Table S3. Data transformation. Table S4. Unique hits per group. Table S5…

Effects of Pimozide Derivatives on pSTAT5 in K562 Cells Open

Riccardo Rondanin, Daniele Simoni, Martina Maccesi, Romeo Romagnoli, Stefania Grimaudo , et al. · 2017

STAT5 is a transcription factor, a member of the STAT family of signaling proteins. STAT5 is involved in many types of cancer, including chronic myelogenous leukemia (CML), in which this protein is found constitutively activated as a conse…