Martina Tesařová
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View article: Localization of heme biosynthesis in the diatom Phaeodactylum tricornutum and differential expression of multi-copy enzymes
Localization of heme biosynthesis in the diatom Phaeodactylum tricornutum and differential expression of multi-copy enzymes Open
Heme is essential for all organisms. The composition and location of the pathway for heme biosynthesis, have been influenced by past endosymbiotic events and organelle evolution in eukaryotes. Endosymbioses led to temporary redundancy of t…
View article: Haptoglobin is dispensable for haemoglobin uptake by Trypanosoma brucei
Haptoglobin is dispensable for haemoglobin uptake by Trypanosoma brucei Open
Haptoglobin is a plasma protein of mammals that plays a crucial role in vascular homeostasis by binding free haemoglobin released from ruptured red blood cells. Trypanosoma brucei can exploit this by internalising haptoglobin-haemoglobin c…
View article: Identification and Validation of Compounds Targeting <i>Leishmania major</i> Leucyl-Aminopeptidase M17
Identification and Validation of Compounds Targeting <i>Leishmania major</i> Leucyl-Aminopeptidase M17 Open
Leishmaniasis is a neglected tropical disease; there is currently no vaccine and treatment is reliant upon a handful of drugs suffering from multiple issues including toxicity and resistance. There is a critical need for development of new…
View article: A novel nabelschnur protein regulates segregation of the kinetoplast DNA in<i>Trypanosoma brucei</i>
A novel nabelschnur protein regulates segregation of the kinetoplast DNA in<i>Trypanosoma brucei</i> Open
The kinetoplast DNA (kDNA), a distinctive arrangement of mitochondrial DNA found in trypanosomatid protists, comprises a concatenated network of minicircles and maxicircles that undergo division and segregation once during each cell cycle.…
View article: An ABC transporter Wzm–Wzt catalyzes translocation of lipid-linked galactan across the plasma membrane in mycobacteria
An ABC transporter Wzm–Wzt catalyzes translocation of lipid-linked galactan across the plasma membrane in mycobacteria Open
Significance The cell envelope of Mycobacterium tuberculosis serves as a primary protective barrier of the pathogen, which claims more than a million lives each year. Its basis, the unique mycobacterial cell wall core, is composed of coval…
View article: Vickermania gen. nov., trypanosomatids that use two joined flagella to resist midgut peristaltic flow within the fly host
Vickermania gen. nov., trypanosomatids that use two joined flagella to resist midgut peristaltic flow within the fly host Open
Background The family Trypanosomatidae encompasses parasitic flagellates, some of which cause serious vector-transmitted diseases of humans and domestic animals. However, insect-restricted parasites represent the ancestral and most diverse…
View article: Motility analysis dataset for Vickermania
Motility analysis dataset for Vickermania Open
This is a collection of videos with tracked cells, the table data with tracking results and further processing (estimation of displacement, velocity etc.).
View article: Cell cycle analysis dataset for Vickermania
Cell cycle analysis dataset for Vickermania Open
This are fluorescent images of two species of Vickermania used to analyze the cell cycle and the organelle counts on this images.
View article: Cell cycle analysis dataset for Vickermania
Cell cycle analysis dataset for Vickermania Open
This are fluorescent images of two species of Vickermania used to analyze the cell cycle and the organelle counts on this images.
View article: Molecular mechanisms of thermal resistance of the insect trypanosomatid Crithidia thermophila
Molecular mechanisms of thermal resistance of the insect trypanosomatid Crithidia thermophila Open
In the present work, we investigated molecular mechanisms governing thermal resistance of a monoxenous trypanosomatid Crithidia luciliae thermophila, which we reclassified as a separate species C. thermophila. We analyzed morphology, growt…