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View article: Impact of Preeclampsia Duration on Long-Term Cardiovascular Disease Risk
Impact of Preeclampsia Duration on Long-Term Cardiovascular Disease Risk Open
BACKGROUND: Preeclampsia is associated with increased risk of subsequent maternal cardiovascular diseases (CVD) compared with normotensive pregnancies. We examined whether prolonging the duration between preeclampsia diagnosis and delivery…
View article: Exploring penetrance of clinically relevant variants in over 800,000 humans from the Genome Aggregation Database
Exploring penetrance of clinically relevant variants in over 800,000 humans from the Genome Aggregation Database Open
Incomplete penetrance, or absence of disease phenotype in an individual with a disease-associated variant, is a major challenge in variant interpretation. Studying individuals with apparent incomplete penetrance can shed light on underlyin…
View article: Ultrasound for the Detection of Gallbladder Malignancy in Primary Sclerosing Cholangitis
Ultrasound for the Detection of Gallbladder Malignancy in Primary Sclerosing Cholangitis Open
Background and Aims In primary sclerosing cholangitis (PSC), the risk for gallbladder malignancy is increased. Surveillance imaging is used for early diagnosis. The study aims to assess the reliability of ultrasound and magnetic resonance …
View article: Large-scale genome-wide analyses with proteomics integration reveal novel loci and biological insights into frailty
Large-scale genome-wide analyses with proteomics integration reveal novel loci and biological insights into frailty Open
Frailty is a clinically relevant phenotype with notable gaps in our understanding of its etiology. Using the Hospital Frailty Risk Score (HFRS) to define frailty, we performed a genome-wide association study in FinnGen ( N = 500,737), repl…
View article: Cirrhosis and age are key determinants of HCC risk in individuals with primary sclerosing cholangitis: A multicenter longitudinal cohort study
Cirrhosis and age are key determinants of HCC risk in individuals with primary sclerosing cholangitis: A multicenter longitudinal cohort study Open
Background and Aims: The risk of HCC in primary sclerosing cholangitis (PSC) is unclear. Studies indicate a low risk for HCC, questioning the rationale for current HCC surveillance guidelines. This study explores the risk of HCC in a longi…
View article: Genetic Risk Factors for Steatotic Liver Disease After Liver Transplantation
Genetic Risk Factors for Steatotic Liver Disease After Liver Transplantation Open
Background The role of genetic risk factors for steatotic liver disease (SLD) is intriguing in liver transplantation (LT), as both donor and recipient genetic factors may play a role. There are only a few small‐scale studies published so f…
View article: Narcolepsy as a potential risk factor for Schizophrenia
Narcolepsy as a potential risk factor for Schizophrenia Open
View article: The use of ELF in predicting liver fibrosis prevalence and fibrosis progression in the general population
The use of ELF in predicting liver fibrosis prevalence and fibrosis progression in the general population Open
Liver fibrosis progression is difficult to predict based on single risk factors or liver enzymes. ELF had limited value to predict fibrosis progression. The CLivD score, based on multiple risk factors, predicted both occurrence of baseline…
View article: Genome-wide meta-analysis conducted in three large biobanks expands the genetic landscape of lumbar disc herniations
Genome-wide meta-analysis conducted in three large biobanks expands the genetic landscape of lumbar disc herniations Open
Given that lumbar disc herniation (LDH) is a prevalent spinal condition that causes significant individual suffering and societal costs, the genetic basis of LDH has received relatively little research. Our aim is to increase understanding…
View article: Comparison of Endoscopic Ultrasound and CT Scan in the Diagnosis of Esophageal Duplication Cysts
Comparison of Endoscopic Ultrasound and CT Scan in the Diagnosis of Esophageal Duplication Cysts Open
The patients referred for surgery were younger (p = 0.0001) and had larger lesions (> 2 cm; p = 0.005) than the patients who had non-operative follow-up. From thirty-one operated patients, eighteen (58%) had post-operative histological dia…
View article: The impact of genome-wide histocompatibility on liver transplantation outcomes
The impact of genome-wide histocompatibility on liver transplantation outcomes Open
Liver transplantation (LT) is the standard treatment for end-stage liver diseases. However, the role of human leukocyte antigen (HLA)-matching in LT remains unclear. Immunological allograft injury and rejection are ongoing concerns, partic…
View article: Surrogate markers of bile duct disease progression in primary sclerosing cholangitis – A prospective study with repeated ERCP examinations
Surrogate markers of bile duct disease progression in primary sclerosing cholangitis – A prospective study with repeated ERCP examinations Open
Validated prognostic tools for estimating short-term bile duct disease progression in primary sclerosing cholangitis are lacking. In this prospective study, based on sequential endoscopic retrograde cholangiopancreatography examinations, b…
View article: The new definition of dominant stricture in primary sclerosing cholangitis: Prevalence and clinical significance
The new definition of dominant stricture in primary sclerosing cholangitis: Prevalence and clinical significance Open
Background and Aims A new definition of dominant stricture (NDS) has recently been defined for patients with primary sclerosing cholangitis (PSC). Prevalence and clinical features of this, compared to traditional dominant stricture (TDS), …
View article: Dominant stricture in paediatric‐onset primary sclerosing cholangitis is associated with impaired prognosis in a long‐term follow‐up
Dominant stricture in paediatric‐onset primary sclerosing cholangitis is associated with impaired prognosis in a long‐term follow‐up Open
Background and Objectives The impact of dominant stricture (DS) on the outcomes of paediatric‐onset primary sclerosing cholangitis (PSC) is unknown. This study was aimed at investigating the impact of DS on the clinical course and prognosi…
View article: NGS of brush cytology samples improves the detection of high-grade dysplasia and cholangiocarcinoma in patients with primary sclerosing cholangitis: A retrospective and prospective study
NGS of brush cytology samples improves the detection of high-grade dysplasia and cholangiocarcinoma in patients with primary sclerosing cholangitis: A retrospective and prospective study Open
Background: Biliary dysplasia, a precursor of cholangiocarcinoma (CCA), is a common complication of primary sclerosing cholangitis. Patients with high-grade dysplasia (HGD) or early CCA who have received oncological treatment are candidate…
View article: Patterns of reproductive health in inflammatory rheumatic diseases and other immune-mediated diseases: a nationwide registry study
Patterns of reproductive health in inflammatory rheumatic diseases and other immune-mediated diseases: a nationwide registry study Open
Objectives Rheumatic diseases may impair reproductive success and pregnancy outcomes, but systematic evaluations across diseases are lacking. We conducted a nationwide cohort study to examine the impact of rheumatic diseases on reproductiv…
View article: Protocol liver biopsy predicts graft survival after liver transplantation
Protocol liver biopsy predicts graft survival after liver transplantation Open
Background The use of protocol liver biopsy to monitor liver allograft status remains controversial. There is limited data from modern transplantation populations that includes protocol biopsies to evaluate its value in predicting clinical…
View article: Author Correction: A genomic mutational constraint map using variation in 76,156 human genomes
Author Correction: A genomic mutational constraint map using variation in 76,156 human genomes Open
View article: Genome-wide polygenic risk scores for colorectal cancer have implications for risk-based screening
Genome-wide polygenic risk scores for colorectal cancer have implications for risk-based screening Open
View article: DOP14 Proctocolectomy is associated with improved transplant-free survival in patients with primary sclerosing cholangitis: results from a pooled collaborative international study
DOP14 Proctocolectomy is associated with improved transplant-free survival in patients with primary sclerosing cholangitis: results from a pooled collaborative international study Open
Background It is hypothesized that the gut-liver axis plays a pivotal role in the aetiology of primary sclerosing cholangitis (PSC). Colectomy before liver transplantation is associated with decreased rates of recurrent PSC.1 We previously…
View article: A genomic mutational constraint map using variation in 76,156 human genomes
A genomic mutational constraint map using variation in 76,156 human genomes Open
View article: Inferring compound heterozygosity from large-scale exome sequencing data
Inferring compound heterozygosity from large-scale exome sequencing data Open
View article: Maternal liver-related symptoms during pregnancy in primary sclerosing cholangitis
Maternal liver-related symptoms during pregnancy in primary sclerosing cholangitis Open
View article: Non-erosive gastro-oesophageal reflux disease and incidence of oesophageal adenocarcinoma in three Nordic countries: population based cohort study
Non-erosive gastro-oesophageal reflux disease and incidence of oesophageal adenocarcinoma in three Nordic countries: population based cohort study Open
Objective To assess the incidence rate of oesophageal adenocarcinoma among patients with non-erosive gastro-oesophageal reflux disease compared with the general population. Design Population based cohort study. Setting All patients in hosp…
View article: Waist-hip ratio is superior to BMI in predicting liver-related outcomes and synergizes with harmful alcohol use
Waist-hip ratio is superior to BMI in predicting liver-related outcomes and synergizes with harmful alcohol use Open
View article: Erratum to: “Enhanced Liver Fibrosis® test predicts liver-related outcomes in the general population” (JHEP Reports 2023; 5: 100765)
Erratum to: “Enhanced Liver Fibrosis® test predicts liver-related outcomes in the general population” (JHEP Reports 2023; 5: 100765) Open
View article: Combined use of the ELF test and CLivD score improves prediction of liver‐related outcomes in the general population
Combined use of the ELF test and CLivD score improves prediction of liver‐related outcomes in the general population Open
Background and Aims Effective and feasible population screening strategies are needed for the early detection of individuals at high risk of future severe liver‐related outcomes. We evaluated the predictive performance of the combination o…
View article: The role of serology, liver function tests and imaging in screening of primary sclerosing cholangitis: the HelPSCreen score
The role of serology, liver function tests and imaging in screening of primary sclerosing cholangitis: the HelPSCreen score Open
At present, no sensitive or specific screening test exists for primary sclerosing cholangitis (PSC). PSC screening is mainly based on elevated alkaline phosphatase (ALP) in patients with inflammatory bowel disease (IBD). We aimed to produc…
View article: Magnitude and Time-Trends of Post-Endoscopy Esophageal Adenocarcinoma and Post-Endoscopy Esophageal Neoplasia in a Population-Based Cohort Study: The Nordic Barrett’s Esophagus Study
Magnitude and Time-Trends of Post-Endoscopy Esophageal Adenocarcinoma and Post-Endoscopy Esophageal Neoplasia in a Population-Based Cohort Study: The Nordic Barrett’s Esophagus Study Open
View article: Enhanced liver Fibrosis® test predicts liver-related outcomes in the general population
Enhanced liver Fibrosis® test predicts liver-related outcomes in the general population Open
The Enhanced Liver Fibrosis test exhibits good performance for predicting liver-related outcomes (hospitalisation, liver cancer, or liver-related death) in the general population, especially in those with risk factors.