Marvin Gunawan
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View article: Mechanisms of Arrhythmogenicity of Hypertrophic Cardiomyopathy-Associated Troponin T (TNNT2) Variant I79N
Mechanisms of Arrhythmogenicity of Hypertrophic Cardiomyopathy-Associated Troponin T (TNNT2) Variant I79N Open
Hypertrophic cardiomyopathy (HCM) is the most common heritable cardiovascular disease and often results in cardiac remodeling and an increased incidence of sudden cardiac arrest (SCA) and death, especially in youth and young adults. Among …
View article: Defining cellular complexity in human autosomal dominant polycystic kidney disease by multimodal single cell analysis
Defining cellular complexity in human autosomal dominant polycystic kidney disease by multimodal single cell analysis Open
Autosomal dominant polycystic kidney disease (ADPKD) is the leading genetic cause of end stage renal disease and is characterized by the formation and progressive expansion of kidney cysts. Most ADPKD cases arise from mutations in either t…
View article: Drug screening platform using human induced pluripotent stem cell-derived atrial cardiomyocytes and optical mapping
Drug screening platform using human induced pluripotent stem cell-derived atrial cardiomyocytes and optical mapping Open
Current drug development efforts for the treatment of atrial fibrillation are hampered by the fact that many preclinical models have been unsuccessful in reproducing human cardiac physiology and its response to medications. In this study, …
View article: Drug Screening Platform Using Human Induced Pluripotent Stem Cell-Derived Atrial Cardiomyocytes and Optical Mapping
Drug Screening Platform Using Human Induced Pluripotent Stem Cell-Derived Atrial Cardiomyocytes and Optical Mapping Open
A bstract Current drug development efforts for the treatment of atrial fibrillation (AF) are hampered by the fact that many preclinical models have been unsuccessful in reproducing human cardiac atrial physiology and its response to medica…
View article: The hERG channel activator, RPR260243, enhances protective <i>I</i><sub>Kr</sub> current early in the refractory period reducing arrhythmogenicity in zebrafish hearts
The hERG channel activator, RPR260243, enhances protective <i>I</i><sub>Kr</sub> current early in the refractory period reducing arrhythmogenicity in zebrafish hearts Open
hERG channel dysfunction causes long QT syndrome and arrhythmia. Activator compounds have been of significant interest due to their therapeutic potential. We used the whole organ zebrafish heart model to demonstrate the antiarrhythmic bene…
View article: Investigating the utility of adult zebrafish ex vivo whole hearts to pharmacologically screen hERG channel activator compounds
Investigating the utility of adult zebrafish ex vivo whole hearts to pharmacologically screen hERG channel activator compounds Open
There is significant interest in the potential utility of small-molecule activator compounds to mitigate cardiac arrhythmia caused by loss of function of hERG1a voltage-gated potassium channels. Zebrafish ( Danio rerio) have been proposed …
View article: Investigating the function and pharmacology of human induced pluripotent stem cell-derived atrial cardiomyocytes (hiPSC-aCMs)
Investigating the function and pharmacology of human induced pluripotent stem cell-derived atrial cardiomyocytes (hiPSC-aCMs) Open
Atrial fibrillation (AF) is the most common form of cardiac arrhythmia that causes the irregular and uncoordinated contractions of the atrial chambers. Current first-line pharmacological treatments are limited in efficacy with side effects…