Marvin Xia
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View article: Ovarian Tumor FAK Inhibition Releases Omega-3 Fatty Acids Stimulating GATA6 Peritoneal Macrophage CXCL13 Production Enhancing Immunotherapy
Ovarian Tumor FAK Inhibition Releases Omega-3 Fatty Acids Stimulating GATA6 Peritoneal Macrophage CXCL13 Production Enhancing Immunotherapy Open
SUMMARY High grade serous ovarian cancer (HGSOC) is the most lethal gynecologic malignancy in the USA due to chemo- and immuno-therapy resistance. We show that focal adhesion kinase (FAK) inhibition with ifebemtinib or tumor genetic FAK kn…
View article: Figure 2 from Nuclear Focal Adhesion Kinase Protects against Cisplatin Stress in Ovarian Carcinoma
Figure 2 from Nuclear Focal Adhesion Kinase Protects against Cisplatin Stress in Ovarian Carcinoma Open
Nuclear FAK accumulation occurs upon cisplatin treatment of human and murine ovarian tumor cells. A, Nuclear and cytoplasmic cell fractionation of human OVCAR4 cells treated with DMSO (control) or cisplatin (1 μmol/L) for 12 hours followed…
View article: Figure 3 from Nuclear Focal Adhesion Kinase Protects against Cisplatin Stress in Ovarian Carcinoma
Figure 3 from Nuclear Focal Adhesion Kinase Protects against Cisplatin Stress in Ovarian Carcinoma Open
FAK nuclear localization enhances murine ovarian tumor cell survival to cisplatin. A, FAK-KO, FAK-WT, and FAK-NLS− KMF cells were evaluated for cisplatin cytotoxicity after 48 hours in culture. Shown is percent cell viability vs. cisplatin…
View article: Data from Nuclear Focal Adhesion Kinase Protects against Cisplatin Stress in Ovarian Carcinoma
Data from Nuclear Focal Adhesion Kinase Protects against Cisplatin Stress in Ovarian Carcinoma Open
Tumor chemotherapy resistance arises frequently and limits high-grade serous ovarian cancer (HGSOC) patient survival. Focal adhesion kinase (FAK) is an intracellular protein–tyrosine kinase encoded by PTK2, a gene that is often gained in H…
View article: Figure 4 from Nuclear Focal Adhesion Kinase Protects against Cisplatin Stress in Ovarian Carcinoma
Figure 4 from Nuclear Focal Adhesion Kinase Protects against Cisplatin Stress in Ovarian Carcinoma Open
FAK KO and reexpression show that nuclear FAK promotes cisplatin but not paclitaxel resistance in human OVCAR3 cells. A, Immunoblots of cultured FAK KO OVCAR3 (clone AB21) and GFP-FAK-WT or FAK-NLS− reconstituted AB21 cells for HA-tag (at …
View article: Figure 6 from Nuclear Focal Adhesion Kinase Protects against Cisplatin Stress in Ovarian Carcinoma
Figure 6 from Nuclear Focal Adhesion Kinase Protects against Cisplatin Stress in Ovarian Carcinoma Open
Prevention of FAK expression, activity, or nuclear localization results in elevated cisplatin-stimulated ERK activation. A, KMF FAK-WT and FAK-NLS− cells were treated for 0 or 12 hours with cisplatin (20 μmol/L), and cell lysates were immu…
View article: Figure 7 from Nuclear Focal Adhesion Kinase Protects against Cisplatin Stress in Ovarian Carcinoma
Figure 7 from Nuclear Focal Adhesion Kinase Protects against Cisplatin Stress in Ovarian Carcinoma Open
Nuclear FAK regulation of MKP1 expression is associated with cisplatin resistance. A, KMF FAK-WT and FAK-NLS− cells were treated with increased concentrations of cisplatin (0, 10, or 20 μmol/L) for 12 hours and protein lysates were immunob…
View article: Figure 5 from Nuclear Focal Adhesion Kinase Protects against Cisplatin Stress in Ovarian Carcinoma
Figure 5 from Nuclear Focal Adhesion Kinase Protects against Cisplatin Stress in Ovarian Carcinoma Open
FAK nuclear localization supports KMF tumor cisplatin resistance in vivo with effects on downstream signaling. A, Experimental schematic: 7.5 million luciferase-expressing KMF FAK-WT or FAK-NLS− cells were intraperitoneally injected into C…
View article: Figure 1 from Nuclear Focal Adhesion Kinase Protects against Cisplatin Stress in Ovarian Carcinoma
Figure 1 from Nuclear Focal Adhesion Kinase Protects against Cisplatin Stress in Ovarian Carcinoma Open
Active FAK staining increases in the nucleus of HGSOC patient tumors after neoadjuvant chemotherapy. A, IHC staining of paraffin-embedded serial initial tumor biopsy sections (patient 1014109 and patient 3000276) and corresponding tumor re…
View article: Nuclear Focal Adhesion Kinase Protects against Cisplatin Stress in Ovarian Carcinoma
Nuclear Focal Adhesion Kinase Protects against Cisplatin Stress in Ovarian Carcinoma Open
Tumor chemotherapy resistance arises frequently and limits high-grade serous ovarian cancer (HGSOC) patient survival. Focal adhesion kinase (FAK) is an intracellular protein–tyrosine kinase encoded by PTK2, a gene that is often gained in H…
View article: Investigation into Microstructure, Wear Resistance in Air and NaCl Solution of AlCrCoNiFeCTax High-Entropy Alloy Coatings Fabricated by Laser Cladding
Investigation into Microstructure, Wear Resistance in Air and NaCl Solution of AlCrCoNiFeCTax High-Entropy Alloy Coatings Fabricated by Laser Cladding Open
AlCrCoNiFeCTax (x = 0, 0.5 and 1.0) high-entropy alloys coatings were synthesized on 45# steel by laser cladding. The microstructural evolution of the coatings with the change in x was analyzed in detail. The effect of Ta content on the we…
View article: Investigation into electrochemical performance of NiO/graphene composite nanofibers synthesized by a simple method as anode materials for high-performance lithium ion batteries
Investigation into electrochemical performance of NiO/graphene composite nanofibers synthesized by a simple method as anode materials for high-performance lithium ion batteries Open
The NiO/graphene (NiO/G) composite nanofibers were successfully synthesized by simple electrospinning followed by heat treatment. They as anode materials for lithium ion batteries demonstrated the more outstanding electrochemical performan…
View article: The Evolution in Electrochemical Performance of Honeycomb-Like Ni(OH)2 Derived from MOF Template with Morphology as a High-Performance Electrode Material for Supercapacitors
The Evolution in Electrochemical Performance of Honeycomb-Like Ni(OH)2 Derived from MOF Template with Morphology as a High-Performance Electrode Material for Supercapacitors Open
Ni(OH)2 derived from an MOF template was synthesized as an electrode material for supercapacitors. The electrochemical performance of the electrode was adjusted by effectively regulating the morphology of Ni(OH)2. The evolution of electroc…